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Behavioral Health and Aging Publications


Assessing the clinical impact of CYP2C9 pharmacogenetic variation on phenytoin prescribing practice and patient response in an integrated health system

To assess the impact of CYP2C9 variation on phenytoin patient response and clinician prescribing practice where genotype was unknown during treatment. A retrospective analysis of Resource on Genetic Epidemiology Research on Adult Health and Aging cohort p...
Author(s): Fohner AE; Ranatunga DK; Thai KK; Lawson BL; Risch N; Oni-Orisan A; Jelalian AT; Rettie AE; Liu VX; Schaefer CA

Pharmacogenet Genomics. 2019 Oct;29(8):192-199.

PubMed abstract

Genetic ancestry does not explain increased atopic dermatitis susceptibility or worse disease control among African American subjects in 2 large US cohorts

Atopic dermatitis (AD) is more common among African American children. Whether there are racial/ethnic difference among adults with AD and the causes for those disparities are unclear. We sought to examine the relationship between self-reported race/ethni...
Author(s): Abuabara K; You Y; Margolis DJ; Hoffmann TJ; Risch N; Jorgenson E

J Allergy Clin Immunol. 2019 Jul 29.

PubMed abstract

Intimate Partner Violence and Psychological Distress: Opportunities for Prevention and Early Intervention Among Emerging Adult Women

Author(s): Young-Wolff KC; McCaw B

J Womens Health (Larchmt). 2019 Jul 16.

PubMed abstract

Self-reported Daily, Weekly, and Monthly Cannabis Use Among Women Before and During Pregnancy

As the overall prevalence of prenatal cannabis use rises, it is vital to also monitor trends in the frequency of cannabis use in the period leading up to and during pregnancy because more frequent use may confer greater health risks for mothers and their ...
Author(s): Young-Wolff KC; Sarovar V; Tucker LY; Conway A; Alexeeff S; Weisner C; Armstrong MA; Goler N

JAMA Netw Open. 2019 Jul 03;2(7):e196471. Epub 2019-07-03.

PubMed abstract

Association of Anxiety With High-Cost Health Care Use Among Individuals With Type 2 Diabetes

People with type 2 diabetes vary greatly in their use of high-cost health care resources. We examined the association of anxiety with high-cost use after accounting for depression and medical comorbidity. Using electronic health record data, we assessed p...
Author(s): Iturralde E; Chi FW; Grant RW; Weisner C; Van Dyke L; Pruzansky A; Bui S; Madvig P; Pearl R; Sterling SA

Diabetes Care. 2019 Jun 18.

PubMed abstract

Conducting a pilot randomized controlled trial of community-based mindfulness-based stress reduction versus usual care for moderate-to-severe migraine: protocol for the Mindfulness and Migraine Study (M&M)

Migraine is one of the most common neurological disorders in clinical practice and is a substantial cause of disability worldwide. Current approaches to therapy are primarily based on medication but are often limited by inadequate effectiveness and common...
Author(s): Pressman A; Law H; Stahl R; Scott A; Jacobson A; Dean L; Sudat S; Obillo A; Avins A

Trials. 2019 May 06;20(1):257. Epub 2019-05-06.

PubMed abstract

Stressors in Midlife and Risk of Dementia: The Role of Race and Education

Posttraumatic stress disorder is associated with increased dementia risk but less is known about stress because of everyday problems in diverse populations. A total of 9605 health care plan members who provided information regarding midlife stressors in 1...
Author(s): Gilsanz P; Quesenberry CP; Mayeda ER; Glymour MM; Farias ST; Whitmer RA

Alzheimer Dis Assoc Disord. 2019 May 01.

PubMed abstract

Health Care Use Over 3 Years After Adolescent SBIRT

Most studies on adolescent screening, brief intervention, and referral to treatment (SBIRT) have examined substance use outcomes. However, it may also impact service use and comorbidity-an understudied topic. We address this gap by examining effects of SB...
Author(s): Sterling S; Kline-Simon AH; Jones A; Hartman L; Saba K; Weisner C; Parthasarathy S

Pediatrics. 2019 May;143(5).

PubMed abstract

Implementing a Multifaceted Perioperative Smoking Cessation Intervention in a Large Healthcare System

Author(s): Young-Wolff KC; Fogelberg R; Preston PG

Nicotine Tob Res. 2019 Apr 04.

PubMed abstract

Reproductive period and risk of dementia in a diverse cohort of health care members

Women have >50% greater lifetime risk of dementia than men but the role of female-specific endocrine milieu is not well-understood. This study evaluates associations between indicators of estrogen exposure from women's reproductive period and dementia ...
Author(s): Gilsanz P; Lee C; Corrada MM; Kawas CH; Quesenberry CP; Whitmer RA

Neurology. 2019 Mar 28.

PubMed abstract

Adverse childhood experiences, mental health, substance use, and HIV-related outcomes among persons with HIV

While persons with HIV (PWH) have benefited from significant advances in treatment and resulting longevity, mental health problems remain elevated in this population. Adverse childhood experiences (ACEs) are common among PWH and may negatively affect ment...
Author(s): Young-Wolff KC; Sarovar V; Sterling SA; Leibowitz A; McCaw B; Hare CB; Silverberg MJ; Satre DD

AIDS Care. 2019 Mar 19:1-9.

PubMed abstract

Disparities in knowledge and use of tobacco treatment among smokers in California following healthcare reform

The Affordable Care Act (ACA) promised to narrow smoking disparities by expanding access to healthcare and mandating comprehensive coverage for tobacco treatment starting in 2014. We examined whether two years after ACA implementation disparities in recei...
Author(s): Young-Wolff KC; Adams SR; Tan ASL; Adams AS; Klebaner D; Campbell CI; Satre DD; Salloum RG; Carter-Harris L; Prochaska JJ

Prev Med Rep. 2019 Jun;14:100847. Epub 2019-03-15.

PubMed abstract

Capsule Commentary on Anthenelli et al., Predictors of Neuropsychiatric Adverse Events with Smoking Cessation Medications in the Randomized Controlled EAGLES Trial

Author(s): Satre DD; Young-Wolff KC

J Gen Intern Med. 2019 Mar 11.

PubMed abstract

Reply to Liu et al.: Tissue specificity of SIM1 gene expression and erectile dysfunction

Author(s): Jorgenson E; Yin J; Shan J; Hoffmann TJ; Thai KK; Van Den Eeden SK; et al.

Proc Natl Acad Sci USA. 2019 Feb 26;116(9):3349-3350. Epub 2019-02-12.

PubMed abstract

Incidence of dementia after age 90 in a multiracial cohort

Little is known about dementia incidence in diverse populations of oldest-old, the age group with highest dementia incidence. Incident dementia diagnoses from 1/1/2010 to 9/30/2015 were abstracted from medical records for 2350 members of an integrated hea...
Author(s): Gilsanz P; Corrada MM; Kawas CH; Mayeda ER; Glymour MM; Quesenberry CP; Lee C; Whitmer RA

Alzheimers Dement. 2019 Feb 08.

PubMed abstract

Predictors of Healthcare Effectiveness Data and Information Set (HEDIS) treatment initiation and engagement among patients with opioid use disorder across 7 health systems

The prevalence of opioid use disorder (OUD) has increased rapidly in the United States and improving treatment access is critical. Among patients with OUD, we examined factors associated with the Healthcare Effectiveness Data and Information Set (HEDIS) p...
Author(s): Campbell CI; Weisner C; Binswanger IA; Lapham GT; Ahmedani BK; Yarborough BJH; Haller IV; Altschuler A; Hechter RC; Loree AM; Kline-Simon AH

Subst Abus. 2019 Jan 24:1-7.

PubMed abstract

Factors associated with Healthcare Effectiveness Data and Information Set (HEDIS) alcohol and other drug measure performance in 2014-2015

Only 10% of patients with alcohol and other drug (AOD) disorders receive treatment. The AOD Initiation and Engagement in Treatment (AOD-IET) measure was added to the national Healthcare Effectiveness Data and Information Set (HEDIS) to improve access to c...
Author(s): Weisner C; Campbell CI; Altschuler A; Sterling SA; Satre DD; Kline-Simon AH; et al.

Subst Abus. 2019 Jan 24:1-11.

PubMed abstract

Evaluation of a Pilot Perioperative Smoking Cessation Program: A Pre-Post Study

Surgical clinic and perioperative settings are critical touchpoints for treating smoking, yet health care systems have not typically prioritized smoking cessation among surgical patients. We evaluated the implementation of a pilot smoking cessation interv...
Author(s): Young-Wolff KC; Adams SR; Fogelberg R; Goldstein AA; Preston PG

J Surg Res. 2019 Jan 18;237:30-40. Epub 2019-01-18.

PubMed abstract

Trends in marijuana use among pregnant women with and without nausea and vomiting in pregnancy, 2009-2016

Cross-sectional studies indicate an elevated prevalence of prenatal marijuana use in women with nausea and vomiting in pregnancy (NVP). However, it is unknown whether differences in marijuana use by NVP status have persisted over time as marijuana becomes...
Author(s): Young-Wolff KC; Sarovar V; Tucker LY; Avalos LA; Alexeeff S; Conway A; Armstrong MA; Weisner C; Campbell CI; Goler N

Drug Alcohol Depend. 2019 Mar 01;196:66-70. Epub 2019-01-18.

PubMed abstract

A Randomized Controlled Trial of mHealth Mindfulness Intervention for Cancer Patients and Informal Cancer Caregivers: A Feasibility Study Within an Integrated Health Care Delivery System

To assess feasibility and preliminary efficacy of a mobile/online-based (mHealth) mindfulness intervention for cancer patients and their caregivers to reduce distress and improve quality of life (QoL). Two-arm randomized controlled trial within Kaiser Per...
Author(s): Kubo A; Kurtovich E; McGinnis M; Aghaee S; Altschuler A; Quesenberry C; Kolevska T; Avins AL

Integr Cancer Ther. 2019 Jan-Dec;18:1534735419850634.

PubMed abstract

Genetic variation in the SIM1 locus is associated with erectile dysfunction

Erectile dysfunction affects millions of men worldwide. Twin studies support the role of genetic risk factors underlying erectile dysfunction, but no specific genetic variants have been identified. We conducted a large-scale genome-wide association study ...
Author(s): Jorgenson E; Yin J; Shan J; Hoffmann TJ; Thai KK; Van Den Eeden SK; et al.

Proc Natl Acad Sci USA. 2018 Oct 23;115(43):11018-11023. Epub 2018-10-08.

PubMed abstract

Characteristics of patients with substance use disorder before and after the Affordable Care Act

The Affordable Care Act (ACA) offered an unprecedented opportunity to expand insurance coverage to patients with substance use disorders (SUDs). We explored the expectations of key stakeholders for the ACA's impact on SUD care, and examined how clinical c...
Author(s): Campbell CI; Parthasarathy S; Altschuler A; Young-Wolff KC; Satre DD

Drug Alcohol Depend. 2018 Oct 06;193:124-130. Epub 2018-10-06.

PubMed abstract

Traumatic brain injury associated with dementia risk among people with type 1 diabetes

To examine the association between traumatic brain injury (TBI) and dementia risk among a cohort of middle-aged and elderly individuals with type 1 diabetes (T1D). We evaluated 4,049 members of an integrated health care system with T1D ≥50 years old betwe...
Author(s): Gilsanz P; Albers K; Beeri MS; Karter AJ; Quesenberry CP; Whitmer RA

Neurology. 2018 Sep 26.

PubMed abstract

Evaluating the Impact of Eliminating Copayments for Tobacco Cessation Pharmacotherapy

We examined the impact of the Affordable Care Act-mandated elimination of tobacco cessation pharmacotherapy (TCP) copayments on patient use of TCP, overall and by income. Electronic health record data captured any and combination (eg, nicotine gum plus pa...
Author(s): Young-Wolff KC; Adams SR; Klebaner D; Adams AS; Campbell CI; Satre DD; Prochaska JJ

Med Care. 2018 Sep 18.

PubMed abstract

Adverse Childhood Experiences and Mental and Behavioral Health Conditions During Pregnancy: The Role of Resilience

Little is known about how exposure to adverse childhood experiences (ACEs) and protective factors, such as resilience, influence prenatal mental and behavioral health. This study examined associations between exposure to ACEs and mental and behavioral hea...
Author(s): Young-Wolff KC; Alabaster A; McCaw B; Stoller N; Watson C; Sterling S; Ridout KK; Flanagan T

J Womens Health (Larchmt). 2018 Sep 05.

PubMed abstract