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Behavioral Health and Aging Publications


Meta-analysis of 26,638 Individuals Identifies Two Genetic Loci Associated with Left Ventricular Ejection Fraction

Background - Left ventricular ejection fraction (EF) is an indicator of cardiac function, usually assessed in individuals with heart failure and other cardiac conditions. Although family studies indicate that EF has an important genetic component with her...
Author(s): Choquet H; Thai KK; Jiang C; Ranatunga DK; Hoffmann TJ; Go AS; Lindsay AC; Ehm MG; Waterworth DM; Risch N; Schaefer C

Circ Genom Precis Med. 2020 Jun 30.

PubMed abstract

Prospective development of a prostate cancer risk calculator in a racially diverse population: The Kaiser Permanente Prostate Cancer Risk Calculator

To prospectively develop a prostate cancer (CaP) risk calculator in a racially diverse population. All patients referred for prostate biopsy due to an elevated prostate-specific antigen or abnormal digital rectal exam in a 19-months period at Kaiser Perma...
Author(s): Presti J; Alexeeff S; Horton B; Prausnitz S; Avins AL

Urol Oncol. 2020 Jun 12.

PubMed abstract

Genome-wide Genotyping of Cerebral Cavernous Malformation Type 1 Individuals to Identify Genetic Modifiers of Disease Severity

Familial cerebral cavernous malformation type 1 (CCM1) is an autosomal dominant disease caused by mutations in the Krev Interaction Trapped 1 (KRIT1/CCM1) gene, and characterized by brain lesions that can cause hemorrhagic strokes, seizures, and neurologi...
Author(s): Choquet H; Kim H

Methods Mol Biol. 2020;2152:77-84.

PubMed abstract

A multiethnic genome-wide analysis of 44,039 individuals identifies 41 new loci associated with central corneal thickness

Central corneal thickness (CCT) is one of the most heritable human traits, with broad-sense heritability estimates ranging between 0.68 to 0.95. Despite the high heritability and numerous previous association studies, only 8.5% of CCT variance is currentl...
Author(s): Choquet H; Schaefer C; Jorgenson E; et al.

Commun Biol. 2020 Jun 11;3(1):301. Epub 2020-06-11.

PubMed abstract

A Telemedicine Approach to Increase Treatment of Alcohol Use Disorder in Primary Care: A Pilot Feasibility Study

Unhealthy drinking is a leading threat to health, yet few people with alcohol use disorder (AUD) receive treatment. This pilot tested the feasibility of addiction medicine video consultations in primary care for improving AUD medication adoption and speci...
Author(s): Leibowitz A; Satre DD; Lu W; Weisner C; Corriveau C; Gizzi E; Sterling S

J Addict Med. 2020 May 27.

PubMed abstract

Genetic and environmental factors underlying keratinocyte carcinoma risk

Recent large-scale GWAS and large epidemiologic studies have accelerated the discovery of genes and environmental factors that contribute to the risk of keratinocyte carcinoma (KC), which includes basal cell carcinoma (BCC) and squamous cell carcinoma (SC...
Author(s): Choquet H; Ashrafzadeh S; Kim Y; Asgari MM; Jorgenson E

JCI Insight. 2020 May 21;5(10). Epub 2020-05-21.

PubMed abstract

Associations Between Medical Conditions and Alcohol Consumption Levels in an Adult Primary Care Population

Excessive alcohol consumption is associated with increased incidence of several medical conditions, but few nonveteran, population-based studies have assessed levels of alcohol use across medical conditions. To examine associations between medical conditi...
Author(s): Sterling SA; Palzes VA; Lu Y; Kline-Simon AH; Parthasarathy S; Ross T; Elson J; Weisner C; Maxim C; Chi FW

JAMA Netw Open. 2020 May 01;3(5):e204687. Epub 2020-05-01.

PubMed abstract

Addressing Problems With Alcohol and Other Substances Among Older Adults During the COVID-19 Pandemic

Author(s): Satre DD; Hirschtritt ME; Silverberg MJ; Sterling SA

Am J Geriatr Psychiatry. 2020 Apr 22.

PubMed abstract

Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia

Refractive errors, in particular myopia, are a leading cause of morbidity and disability worldwide. Genetic investigation can improve understanding of the molecular mechanisms that underlie abnormal eye development and impaired vision. We conducted a meta...
Author(s): Hysi PG†; Choquet H†; Consortium for Refractive Error and Myopia; UK Eye and Vision Consortium; 23andMe Inc.; Jorgenson E; Hammond CJ; et al.
† These authors jointly led this work.

Nat Genet. 2020 Apr;52(4):401-407. Epub 2020-03-30.

PubMed abstract

Associations of CYP2C9 and CYP2C19 pharmacogenetic variation with phenytoin-induced cutaneous adverse drug reactions

The role of CYP2C9 and CYP2C19 genetic variation in risk for phenytoin-induced cutaneous adverse drug events is not well understood independently of the HLA-B*15:02 risk allele. In the multiethnic Resource for Genetic Epidemiology Research on Adult He...
Author(s): Fohner AE; Rettie AE; Thai KK; Ranatunga DK; Lawson BL; Liu VX; Schaefer CA

Clin Transl Sci. 2020 Mar 26.

PubMed abstract

The role of substance use disorders in experiencing a repeat opioid overdose, and substance use treatment patterns among patients with a non-fatal opioid overdose

A non-fatal opioid overdose (NFOO) increases the risk of another overdose and identifies high-risk patients. We estimated the risk of repeat opioid overdose for patients with and without substance use disorder (SUD) diagnoses and the change in substance u...
Author(s): Karmali RN; Ray GT; Rubinstein AL; Sterling SA; Weisner CM; Campbell CI

Drug Alcohol Depend. 2020 Feb 20;209:107923. Epub 2020-02-20.

PubMed abstract

Correlates of Pregnant Women's Participation in a Substance Use Assessment and Counseling Intervention Integrated into Prenatal Care

Screening and referral for substance use are essential components of prenatal care. However, little is known about barriers to participation in substance use interventions that are integrated within prenatal care. Our study examines demographic and clinic...
Author(s): Young-Wolff KC; Tucker LY; Armstrong MA; Conway A; Weisner C; Goler N

Matern Child Health J. 2020 Feb 13.

PubMed abstract

Association of Depression, Anxiety, and Trauma With Cannabis Use During Pregnancy

Author(s): Young-Wolff KC; Sarovar V; Tucker LY; Goler NC; Alexeeff SE; Ridout KK; Avalos LA

JAMA Netw Open. 2020 Feb 05;3(2):e1921333. Epub 2020-02-05.

PubMed abstract

Women's Questions About Perinatal Cannabis Use and Health Care Providers' Responses

Background: Cannabis use is common among individuals of reproductive age. We examined publicly posted questions about perinatal cannabis use and licensed United States health care provider responses. Materials and Methods: Data were medical quest...
Author(s): Young-Wolff KC; Gali K; Sarovar V; Rutledge GW; Prochaska JJ

J Womens Health (Larchmt). 2020 Jan 30.

PubMed abstract

Changes in Prostate Cancer Presentation Following the 2012 USPSTF Screening Statement: Observational Study in a Multispecialty Group Practice

In 2012, the US Preventive Services Task Force (USPSTF) recommended against PSA-based screening for prostate cancer in men of all ages. Following this change, screening declined yet the complete impact on clinical presentation is not well defined in the s...
Author(s): Presti J; Alexeeff S; Horton B; Prausnitz S; Avins AL

J Gen Intern Med. 2019 Dec 09.

PubMed abstract

Benzodiazepine and unhealthy alcohol use among adult outpatients

Concomitant excessive alcohol consumption and benzodiazepine use is associated with adverse health outcomes. We examined associations of unhealthy alcohol use and other patient characteristics with benzodiazepine use. A cross-sectional analysis of 2,089,5...
Author(s): Hirschtritt ME; Palzes VA; Kline-Simon AH; Kroenke K; Campbell CI; Sterling SA

Am J Manag Care. 2019 Dec 01;25(12):e358-e365. Epub 2019-12-01.

PubMed abstract

Changing Results-Engage and Activate to Enhance Wellness: A Randomized Clinical Trial to Improve Cardiovascular Risk Management

Background Despite the success of current cardiovascular disease (CVD) management programs, many patients do not achieve optimal control of CVD-related risk factors. New strategies are needed to better activate and engage these patients. Methods and Resul...
Author(s): Iturralde E; Sterling SA; Uratsu CS; Mishra P; Ross TB; Grant RW

J Am Heart Assoc. 2019 Dec 03;8(23):e014021. Epub 2019-11-30.

PubMed abstract

Changes in Days of Unhealthy Alcohol Use and Antiretroviral Therapy Adherence, HIV RNA Levels, and Condomless Sex: A Secondary Analysis of Clinical Trial Data

In a sample of people with HIV (PWH) enrolled in an alcohol intervention trial and followed for 12 months, we examined the association of changes in days (i.e., decrease, increase, no change [reference]) of unhealthy drinking (consuming ≥ 4/≥ 5 drink...
Author(s): Satre DD; Sarovar V; Leyden W; Hare CB; Catz SL; Bryant KJ; Williams EC; Hojilla JC; Horberg MA; Silverberg MJ

AIDS Behav. 2019 Nov 26.

PubMed abstract

Validity of Self-reported Cannabis Use Among Pregnant Females in Northern California

Most clinical and epidemiologic estimates of prenatal cannabis use are based on self-report, and the validity of self-reported cannabis use has not been examined in a large, representative population of pregnant women. We determined the validity of self-r...
Author(s): Young-Wolff KC; Sarovar V; Tucker LY; Goler N; Conway A; Weisner C; Armstrong MA; Alexeeff S

J Addict Med. 2019 Nov 04.

PubMed abstract

Sleep Quality and Cognitive Function in Type 1 Diabetes: Findings From the Study of Longevity in Diabetes (SOLID)

The objective was to examine the association between sleep quality and global and domain-specific cognitive function among older individuals with type 1 diabetes (T1D). We evaluated 695 individuals with T1D aged 60 years or above who participated in the b...
Author(s): Gilsanz P; Lacy ME; Beeri MS; Karter AJ; Eng C; Whitmer RA

Alzheimer Dis Assoc Disord. 2019 Sep 26.

PubMed abstract

Routes of cannabis administration among females in the year before and during pregnancy: Results from a pilot project

Use of cannabis during pregnancy is on the rise, yet little is known about how women administer cannabis during the perinatal period. This study examined self-reported modes of cannabis administration among women in the year before and during pregnancy, a...
Author(s): Young-Wolff KC; Adams SR; Wi S; Weisner C; Conway A

Addict Behav. 2019 Sep 09;100:106125. Epub 2019-09-09.

PubMed abstract

Assessing the clinical impact of CYP2C9 pharmacogenetic variation on phenytoin prescribing practice and patient response in an integrated health system

To assess the impact of CYP2C9 variation on phenytoin patient response and clinician prescribing practice where genotype was unknown during treatment. A retrospective analysis of Resource on Genetic Epidemiology Research on Adult Health and Aging cohort p...
Author(s): Fohner AE; Ranatunga DK; Thai KK; Lawson BL; Risch N; Oni-Orisan A; Jelalian AT; Rettie AE; Liu VX; Schaefer CA

Pharmacogenet Genomics. 2019 Oct;29(8):192-199.

PubMed abstract

Intimate Partner Violence and Psychological Distress: Opportunities for Prevention and Early Intervention Among Emerging Adult Women

Author(s): Young-Wolff KC; McCaw B

J Womens Health (Larchmt). 2019 Jul 16.

PubMed abstract

Self-reported Daily, Weekly, and Monthly Cannabis Use Among Women Before and During Pregnancy

As the overall prevalence of prenatal cannabis use rises, it is vital to also monitor trends in the frequency of cannabis use in the period leading up to and during pregnancy because more frequent use may confer greater health risks for mothers and their ...
Author(s): Young-Wolff KC; Sarovar V; Tucker LY; Conway A; Alexeeff S; Weisner C; Armstrong MA; Goler N

JAMA Netw Open. 2019 Jul 03;2(7):e196471. Epub 2019-07-03.

PubMed abstract

Association of Anxiety With High-Cost Health Care Use Among Individuals With Type 2 Diabetes

People with type 2 diabetes vary greatly in their use of high-cost health care resources. We examined the association of anxiety with high-cost use after accounting for depression and medical comorbidity. Using electronic health record data, we assessed p...
Author(s): Iturralde E; Chi FW; Grant RW; Weisner C; Van Dyke L; Pruzansky A; Bui S; Madvig P; Pearl R; Sterling SA

Diabetes Care. 2019 Jun 18.

PubMed abstract