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Behavioral Health and Aging Publications


Associations of CYP2C9 and CYP2C19 pharmacogenetic variation with phenytoin-induced cutaneous adverse drug reactions

The role of CYP2C9 and CYP2C19 genetic variation in risk for phenytoin-induced cutaneous adverse drug events is not well understood independently of the HLA-B*15:02 risk allele. In the multiethnic Resource for Genetic Epidemiology Research on Adult He...
Author(s): Fohner AE; Rettie AE; Thai KK; Ranatunga DK; Lawson BL; Liu VX; Schaefer CA

Clin Transl Sci. 2020 Mar 26.

PubMed abstract

The role of substance use disorders in experiencing a repeat opioid overdose, and substance use treatment patterns among patients with a non-fatal opioid overdose

A non-fatal opioid overdose (NFOO) increases the risk of another overdose and identifies high-risk patients. We estimated the risk of repeat opioid overdose for patients with and without substance use disorder (SUD) diagnoses and the change in substance u...
Author(s): Karmali RN; Ray GT; Rubinstein AL; Sterling SA; Weisner CM; Campbell CI

Drug Alcohol Depend. 2020 Feb 20;209:107923. Epub 2020-02-20.

PubMed abstract

Correlates of Pregnant Women's Participation in a Substance Use Assessment and Counseling Intervention Integrated into Prenatal Care

Screening and referral for substance use are essential components of prenatal care. However, little is known about barriers to participation in substance use interventions that are integrated within prenatal care. Our study examines demographic and clinic...
Author(s): Young-Wolff KC; Tucker LY; Armstrong MA; Conway A; Weisner C; Goler N

Matern Child Health J. 2020 Feb 13.

PubMed abstract

The Association Between the Supply of Nonpharmacologic Providers, Use of Nonpharmacologic Pain Treatments and High-risk Opioid Prescription Patterns Among Medicare Beneficiaries With Persistent Musculoskeletal Pain

Opioids are prescribed more frequently than nonpharmacologic treatments for persistent musculoskeletal pain (MSP). We estimate the association between the supply of physical therapy (PT) and mental health (MH) providers and early nonpharmacologic service ...
Author(s): Karmali RN; Skinner AC; Trogdon JG; Weinberger M; George SZ; Hassmiller Lich K

Med Care. 2020 Feb 05.

PubMed abstract

Association of Depression, Anxiety, and Trauma With Cannabis Use During Pregnancy

Author(s): Young-Wolff KC; Sarovar V; Tucker LY; Goler NC; Alexeeff SE; Ridout KK; Avalos LA

JAMA Netw Open. 2020 Feb 05;3(2):e1921333. Epub 2020-02-05.

PubMed abstract

Women's Questions About Perinatal Cannabis Use and Health Care Providers' Responses

Background: Cannabis use is common among individuals of reproductive age. We examined publicly posted questions about perinatal cannabis use and licensed United States health care provider responses. Materials and Methods: Data were medical quest...
Author(s): Young-Wolff KC; Gali K; Sarovar V; Rutledge GW; Prochaska JJ

J Womens Health (Larchmt). 2020 Jan 30.

PubMed abstract

Long-term opioid therapy definitions and predictors: A systematic review

This review sought to (a) describe definitions of long-term opioid therapy (LTOT) outcome measures, and (b) identify the predictors associated with the transition from short-term opioid use to LTOT for opioid-naïve individuals. We conducted a systematic r...
Author(s): Karmali RN; Bush C; Raman SR; Campbell CI; Skinner AC; Roberts AW

Pharmacoepidemiol Drug Saf. 2019 Dec 18.

PubMed abstract

Changes in Prostate Cancer Presentation Following the 2012 USPSTF Screening Statement: Observational Study in a Multispecialty Group Practice

In 2012, the US Preventive Services Task Force (USPSTF) recommended against PSA-based screening for prostate cancer in men of all ages. Following this change, screening declined yet the complete impact on clinical presentation is not well defined in the s...
Author(s): Presti J; Alexeeff S; Horton B; Prausnitz S; Avins AL

J Gen Intern Med. 2019 Dec 09.

PubMed abstract

Benzodiazepine and unhealthy alcohol use among adult outpatients

Concomitant excessive alcohol consumption and benzodiazepine use is associated with adverse health outcomes. We examined associations of unhealthy alcohol use and other patient characteristics with benzodiazepine use. A cross-sectional analysis of 2,089,5...
Author(s): Hirschtritt ME; Palzes VA; Kline-Simon AH; Kroenke K; Campbell CI; Sterling SA

Am J Manag Care. 2019 Dec 01;25(12):e358-e365. Epub 2019-12-01.

PubMed abstract

Changing Results-Engage and Activate to Enhance Wellness: A Randomized Clinical Trial to Improve Cardiovascular Risk Management

Background Despite the success of current cardiovascular disease (CVD) management programs, many patients do not achieve optimal control of CVD-related risk factors. New strategies are needed to better activate and engage these patients. Methods and Resul...
Author(s): Iturralde E; Sterling SA; Uratsu CS; Mishra P; Ross TB; Grant RW

J Am Heart Assoc. 2019 Dec 03;8(23):e014021. Epub 2019-11-30.

PubMed abstract

Changes in Days of Unhealthy Alcohol Use and Antiretroviral Therapy Adherence, HIV RNA Levels, and Condomless Sex: A Secondary Analysis of Clinical Trial Data

In a sample of people with HIV (PWH) enrolled in an alcohol intervention trial and followed for 12 months, we examined the association of changes in days (i.e., decrease, increase, no change [reference]) of unhealthy drinking (consuming ≥ 4/≥ 5 drink...
Author(s): Satre DD; Sarovar V; Leyden W; Hare CB; Catz SL; Bryant KJ; Williams EC; Hojilla JC; Horberg MA; Silverberg MJ

AIDS Behav. 2019 Nov 26.

PubMed abstract

Validity of Self-reported Cannabis Use Among Pregnant Females in Northern California

Most clinical and epidemiologic estimates of prenatal cannabis use are based on self-report, and the validity of self-reported cannabis use has not been examined in a large, representative population of pregnant women. We determined the validity of self-r...
Author(s): Young-Wolff KC; Sarovar V; Tucker LY; Goler N; Conway A; Weisner C; Armstrong MA; Alexeeff S

J Addict Med. 2019 Nov 04.

PubMed abstract

Sleep Quality and Cognitive Function in Type 1 Diabetes: Findings From the Study of Longevity in Diabetes (SOLID)

The objective was to examine the association between sleep quality and global and domain-specific cognitive function among older individuals with type 1 diabetes (T1D). We evaluated 695 individuals with T1D aged 60 years or above who participated in the b...
Author(s): Gilsanz P; Lacy ME; Beeri MS; Karter AJ; Eng C; Whitmer RA

Alzheimer Dis Assoc Disord. 2019 Sep 26.

PubMed abstract

Routes of cannabis administration among females in the year before and during pregnancy: Results from a pilot project

Use of cannabis during pregnancy is on the rise, yet little is known about how women administer cannabis during the perinatal period. This study examined self-reported modes of cannabis administration among women in the year before and during pregnancy, a...
Author(s): Young-Wolff KC; Adams SR; Wi S; Weisner C; Conway A

Addict Behav. 2019 Sep 09;100:106125. Epub 2019-09-09.

PubMed abstract

Assessing the clinical impact of CYP2C9 pharmacogenetic variation on phenytoin prescribing practice and patient response in an integrated health system

To assess the impact of CYP2C9 variation on phenytoin patient response and clinician prescribing practice where genotype was unknown during treatment. A retrospective analysis of Resource on Genetic Epidemiology Research on Adult Health and Aging cohort p...
Author(s): Fohner AE; Ranatunga DK; Thai KK; Lawson BL; Risch N; Oni-Orisan A; Jelalian AT; Rettie AE; Liu VX; Schaefer CA

Pharmacogenet Genomics. 2019 Oct;29(8):192-199.

PubMed abstract

Genetic ancestry does not explain increased atopic dermatitis susceptibility or worse disease control among African American subjects in 2 large US cohorts

Atopic dermatitis (AD) is more common among African American children. Whether there are racial/ethnic difference among adults with AD and the causes for those disparities are unclear. We sought to examine the relationship between self-reported race/ethni...
Author(s): Abuabara K; You Y; Margolis DJ; Hoffmann TJ; Risch N; Jorgenson E

J Allergy Clin Immunol. 2019 Jul 29.

PubMed abstract

Intimate Partner Violence and Psychological Distress: Opportunities for Prevention and Early Intervention Among Emerging Adult Women

Author(s): Young-Wolff KC; McCaw B

J Womens Health (Larchmt). 2019 Jul 16.

PubMed abstract

Self-reported Daily, Weekly, and Monthly Cannabis Use Among Women Before and During Pregnancy

As the overall prevalence of prenatal cannabis use rises, it is vital to also monitor trends in the frequency of cannabis use in the period leading up to and during pregnancy because more frequent use may confer greater health risks for mothers and their ...
Author(s): Young-Wolff KC; Sarovar V; Tucker LY; Conway A; Alexeeff S; Weisner C; Armstrong MA; Goler N

JAMA Netw Open. 2019 Jul 03;2(7):e196471. Epub 2019-07-03.

PubMed abstract

Association of Anxiety With High-Cost Health Care Use Among Individuals With Type 2 Diabetes

People with type 2 diabetes vary greatly in their use of high-cost health care resources. We examined the association of anxiety with high-cost use after accounting for depression and medical comorbidity. Using electronic health record data, we assessed p...
Author(s): Iturralde E; Chi FW; Grant RW; Weisner C; Van Dyke L; Pruzansky A; Bui S; Madvig P; Pearl R; Sterling SA

Diabetes Care. 2019 Jun 18.

PubMed abstract

Conducting a pilot randomized controlled trial of community-based mindfulness-based stress reduction versus usual care for moderate-to-severe migraine: protocol for the Mindfulness and Migraine Study (M&M)

Migraine is one of the most common neurological disorders in clinical practice and is a substantial cause of disability worldwide. Current approaches to therapy are primarily based on medication but are often limited by inadequate effectiveness and common...
Author(s): Pressman A; Law H; Stahl R; Scott A; Jacobson A; Dean L; Sudat S; Obillo A; Avins A

Trials. 2019 May 06;20(1):257. Epub 2019-05-06.

PubMed abstract

Stressors in Midlife and Risk of Dementia: The Role of Race and Education

Posttraumatic stress disorder is associated with increased dementia risk but less is known about stress because of everyday problems in diverse populations. A total of 9605 health care plan members who provided information regarding midlife stressors in 1...
Author(s): Gilsanz P; Quesenberry CP; Mayeda ER; Glymour MM; Farias ST; Whitmer RA

Alzheimer Dis Assoc Disord. 2019 May 01.

PubMed abstract

Health Care Use Over 3 Years After Adolescent SBIRT

Most studies on adolescent screening, brief intervention, and referral to treatment (SBIRT) have examined substance use outcomes. However, it may also impact service use and comorbidity-an understudied topic. We address this gap by examining effects of SB...
Author(s): Sterling S; Kline-Simon AH; Jones A; Hartman L; Saba K; Weisner C; Parthasarathy S

Pediatrics. 2019 May;143(5).

PubMed abstract

Implementing a Multifaceted Perioperative Smoking Cessation Intervention in a Large Healthcare System

Author(s): Young-Wolff KC; Fogelberg R; Preston PG

Nicotine Tob Res. 2019 Apr 04.

PubMed abstract

Reproductive period and risk of dementia in a diverse cohort of health care members

Women have >50% greater lifetime risk of dementia than men but the role of female-specific endocrine milieu is not well-understood. This study evaluates associations between indicators of estrogen exposure from women's reproductive period and dementia ...
Author(s): Gilsanz P; Lee C; Corrada MM; Kawas CH; Quesenberry CP; Whitmer RA

Neurology. 2019 Mar 28.

PubMed abstract

Adverse childhood experiences, mental health, substance use, and HIV-related outcomes among persons with HIV

While persons with HIV (PWH) have benefited from significant advances in treatment and resulting longevity, mental health problems remain elevated in this population. Adverse childhood experiences (ACEs) are common among PWH and may negatively affect ment...
Author(s): Young-Wolff KC; Sarovar V; Sterling SA; Leibowitz A; McCaw B; Hare CB; Silverberg MJ; Satre DD

AIDS Care. 2019 Mar 19:1-9.

PubMed abstract