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Behavioral Health and Aging Publications


Association of Pregnancy Intentions With Substance Use During Early Pregnancy

The goal of this study was to evaluate the association between pregnancy intentions and substance use in early pregnancy among pregnant women receiving prenatal care in a large, integrated healthcare system. The sample comprised 29,787 Kaiser Permanente N...
Author(s): Young-Wolff KC; Slama N; Sarovar V; Conway A; Tucker LY; Goler N; Terplan M; Ansley D; Adams SR; Armstrong MA

J Addict Med. 2021 Feb 16.

PubMed abstract

Three-Year Outcomes After Brief Treatment of Substance Use and Mood Symptoms

Screening, brief intervention, and referral to treatment (SBIRT) for adolescents exhibiting co-occurring substance use and mental health problems may improve outcomes and have long-lasting effects. This study examined the relationship between access to SB...
Author(s): Parthasarathy S; Kline-Simon AH; Jones A; Hartman L; Saba K; Weisner C; Sterling S

Pediatrics. 2021 Jan;147(1).

PubMed abstract

Treatment for Anxiety and Substance Use Disorders During the COVID-19 Pandemic: Challenges and Strategies

: The COVID-19 pandemic is likely to exacerbate existing anxiety and substance use disorders (SUDs) and increase vulnerability among individuals previously free of these conditions. Numerous pandemic-related stressors-coronavirus infection fears, social d...
Author(s): Satre DD; Iturralde E; Ghadiali M; Young-Wolff KC; Campbell CI; Leibowitz AS; Sterling SA

J Addict Med. 2020 12;14(6):e293-e296.

PubMed abstract

Health care utilization and HIV clinical outcomes among newly enrolled patients following Affordable Care Act implementation in a California integrated health system: a longitudinal study

The Affordable Care Act (ACA) has increased insurance coverage for people with HIV (PWH) in the United States. To inform health policy, it is useful to investigate how enrollment through ACA Exchanges, deductible levels, and demographic factors are associ...
Author(s): Satre DD; Parthasarathy S; Silverberg MJ; Horberg M; Young-Wolff KC; Williams EC; Volberding P; Campbell CI

BMC Health Serv Res. 2020 Nov 11;20(1):1030. Epub 2020-11-11.

PubMed abstract

Premature mortality associated with severe mental illness or substance use disorder in an integrated health care system

Research has reported shortened lifespans (by 15-30 years) for those with severe mental illness (SMI) or substance use disorder (SUD), particularly among public mental health treatment consumers. We assessed SMI- and SUD-associated mortality in the unders...
Author(s): Iturralde E; Slama N; Kline-Simon AH; Young-Wolff KC; Mordecai D; Sterling SA

Gen Hosp Psychiatry. 2020 Nov 10;68:1-6. Epub 2020-11-10.

PubMed abstract

Associations Between Psychiatric Disorders and Alcohol Consumption Levels in an Adult Primary Care Population

Unhealthy alcohol use frequently co-occurs with psychiatric disorders; however, little is known about the relationship between psychiatric disorders and alcohol consumption levels. Understanding varying levels of unhealthy alcohol use among individuals wi...
Author(s): Palzes VA; Parthasarathy S; Chi FW; Kline-Simon AH; Lu Y; Weisner C; Ross TB; Elson J; Sterling SA

Alcohol Clin Exp Res. 2020 Nov 05.

PubMed abstract

Changing Provider PSA Screening Behavior Using Best Practice Advisories: Interventional Study in a Multispecialty Group Practice

Most guidelines recommend against PSA-based screening for prostate cancer in men ≥ 70 years of age. Adherence to these guidelines is variable. To determine whether the use of a "Best Practice Advisory" (BPA) intervention within the electronic medical reco...
Author(s): Presti J; Alexeeff S; Horton B; Prausnitz S; Avins AL

J Gen Intern Med. 2020 Oct 26.

PubMed abstract

Adverse Childhood Experiences and Pregnancy Intentions among Pregnant Women Seeking Prenatal Care

This study examined whether adverse childhood experiences (ACEs) are associated with increased risk of having an unwanted or mistimed pregnancy. Women in two medical centers within an integrated health system were screened for ACEs during standard prenata...
Author(s): Young-Wolff KC; Wei J; Varnado N; Rios N; Staunton M; Watson C

Womens Health Issues. 2020 Oct 05.

PubMed abstract

Pilot pragmatic randomized trial of mHealth mindfulness-based intervention for advanced cancer patients and their informal caregivers

Assess the feasibility of conducting a cluster randomized trial (RCT) comparing technology-delivered mindfulness-based intervention (MBI) programs against a waitlist control arm targeting advanced cancer patients and their informal caregivers. Two-arm clu...
Author(s): Kubo A; Kurtovich E; McGinnis M; Aghaee S; Altschuler A; Quesenberry C; Kolevska T; Liu R; Greyz-Yusupov N; Avins A

Psychooncology. 2020 Sep 26.

PubMed abstract

Automated Extraction of Structured Data from Text Notes in the Electronic Medical Record

Author(s): C Flint A; Melles RB; Klingman JG; Chan SL; Rao VA; Avins AL

J Gen Intern Med. 2020 Aug 31.

PubMed abstract

Natural history of achondroplasia: A retrospective review of longitudinal clinical data

There are limited data on the longitudinal frequency and severity of the symptoms and complications of achondroplasia. We undertook a retrospective electronic chart review of 114 patients to develop a more thorough understanding of the lifetime impact of ...
Author(s): Okenfuss E; Moghaddam B; Avins AL

Am J Med Genet A. 2020 Aug 31.

PubMed abstract

Healthcare utilization of individuals with substance use disorders following Affordable Care Act implementation in a California healthcare system

Practitioners expected the Affordable Care Act (ACA) to increase availability of health services and access to treatment for Americans with substance use disorders (SUDs). Yet research has not examined the associations among ACA enrollment mechanisms, ded...
Author(s): Satre DD; Palzes VA; Young-Wolff KC; Parthasarathy S; Weisner C; Guydish J; Campbell CI

J Subst Abuse Treat. 2020 Nov;118:108097. Epub 2020-08-04.

PubMed abstract

The Kaiser Permanente Northern California Adult Alcohol Registry, an Electronic Health Records-Based Registry of Patients With Alcohol Problems: Development and Implementation

Electronic health record (EHR)-based disease registries have aided health care professionals and researchers in increasing their understanding of chronic illnesses, including identifying patients with (or at risk of developing) conditions and tracking tre...
Author(s): Palzes VA; Weisner C; Chi FW; Kline-Simon AH; Satre DD; Hirschtritt ME; Ghadiali M; Sterling S

JMIR Med Inform. 2020 Jul 22;8(7):e19081. Epub 2020-07-22.

PubMed abstract

Trends and correlates of self-reported alcohol and nicotine use among women before and during pregnancy, 2009-2017

To examine trends and correlates of frequency of self-reported alcohol and nicotine use among pregnant women. Cross-sectional study of 363,240 pregnancies from 2009 to 2017 screened for self-reported substance use at their first prenatal visit in Kaiser P...
Author(s): Young-Wolff KC; Sarovar V; Alexeeff SE; Adams SR; Tucker LY; Conway A; Ansley D; Goler N; Armstrong MA; Weisner C

Drug Alcohol Depend. 2020 Sep 01;214:108168. Epub 2020-07-15.

PubMed abstract

Meta-analysis of 26,638 Individuals Identifies Two Genetic Loci Associated with Left Ventricular Ejection Fraction

Background - Left ventricular ejection fraction (EF) is an indicator of cardiac function, usually assessed in individuals with heart failure and other cardiac conditions. Although family studies indicate that EF has an important genetic component with her...
Author(s): Choquet H; Thai KK; Jiang C; Ranatunga DK; Hoffmann TJ; Go AS; Lindsay AC; Ehm MG; Waterworth DM; Risch N; Schaefer C

Circ Genom Precis Med. 2020 Jun 30.

PubMed abstract

Prospective development of a prostate cancer risk calculator in a racially diverse population: The Kaiser Permanente Prostate Cancer Risk Calculator

To prospectively develop a prostate cancer (CaP) risk calculator in a racially diverse population. All patients referred for prostate biopsy due to an elevated prostate-specific antigen or abnormal digital rectal exam in a 19-months period at Kaiser Perma...
Author(s): Presti J; Alexeeff S; Horton B; Prausnitz S; Avins AL

Urol Oncol. 2020 Jun 12.

PubMed abstract

Genome-wide Genotyping of Cerebral Cavernous Malformation Type 1 Individuals to Identify Genetic Modifiers of Disease Severity

Familial cerebral cavernous malformation type 1 (CCM1) is an autosomal dominant disease caused by mutations in the Krev Interaction Trapped 1 (KRIT1/CCM1) gene, and characterized by brain lesions that can cause hemorrhagic strokes, seizures, and neurologi...
Author(s): Choquet H; Kim H

Methods Mol Biol. 2020;2152:77-84.

PubMed abstract

A multiethnic genome-wide analysis of 44,039 individuals identifies 41 new loci associated with central corneal thickness

Central corneal thickness (CCT) is one of the most heritable human traits, with broad-sense heritability estimates ranging between 0.68 to 0.95. Despite the high heritability and numerous previous association studies, only 8.5% of CCT variance is currentl...
Author(s): Choquet H; Schaefer C; Jorgenson E; et al.

Commun Biol. 2020 Jun 11;3(1):301. Epub 2020-06-11.

PubMed abstract

A Telemedicine Approach to Increase Treatment of Alcohol Use Disorder in Primary Care: A Pilot Feasibility Study

Unhealthy drinking is a leading threat to health, yet few people with alcohol use disorder (AUD) receive treatment. This pilot tested the feasibility of addiction medicine video consultations in primary care for improving AUD medication adoption and speci...
Author(s): Leibowitz A; Satre DD; Lu W; Weisner C; Corriveau C; Gizzi E; Sterling S

J Addict Med. 2020 May 27.

PubMed abstract

Genetic and environmental factors underlying keratinocyte carcinoma risk

Recent large-scale GWAS and large epidemiologic studies have accelerated the discovery of genes and environmental factors that contribute to the risk of keratinocyte carcinoma (KC), which includes basal cell carcinoma (BCC) and squamous cell carcinoma (SC...
Author(s): Choquet H; Ashrafzadeh S; Kim Y; Asgari MM; Jorgenson E

JCI Insight. 2020 May 21;5(10). Epub 2020-05-21.

PubMed abstract

Associations Between Medical Conditions and Alcohol Consumption Levels in an Adult Primary Care Population

Excessive alcohol consumption is associated with increased incidence of several medical conditions, but few nonveteran, population-based studies have assessed levels of alcohol use across medical conditions. To examine associations between medical conditi...
Author(s): Sterling SA; Palzes VA; Lu Y; Kline-Simon AH; Parthasarathy S; Ross T; Elson J; Weisner C; Maxim C; Chi FW

JAMA Netw Open. 2020 May 01;3(5):e204687. Epub 2020-05-01.

PubMed abstract

Addressing Problems With Alcohol and Other Substances Among Older Adults During the COVID-19 Pandemic

Author(s): Satre DD; Hirschtritt ME; Silverberg MJ; Sterling SA

Am J Geriatr Psychiatry. 2020 Apr 22.

PubMed abstract

Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia

Refractive errors, in particular myopia, are a leading cause of morbidity and disability worldwide. Genetic investigation can improve understanding of the molecular mechanisms that underlie abnormal eye development and impaired vision. We conducted a meta...
Author(s): Hysi PG†; Choquet H†; Consortium for Refractive Error and Myopia; UK Eye and Vision Consortium; 23andMe Inc.; Jorgenson E; Hammond CJ; et al.
† These authors jointly led this work.

Nat Genet. 2020 Apr;52(4):401-407. Epub 2020-03-30.

PubMed abstract

Associations of CYP2C9 and CYP2C19 pharmacogenetic variation with phenytoin-induced cutaneous adverse drug reactions

The role of CYP2C9 and CYP2C19 genetic variation in risk for phenytoin-induced cutaneous adverse drug events is not well understood independently of the HLA-B*15:02 risk allele. In the multiethnic Resource for Genetic Epidemiology Research on Adult Health...
Author(s): Fohner AE; Rettie AE; Thai KK; Ranatunga DK; Lawson BL; Liu VX; Schaefer CA

Clin Transl Sci. 2020 Mar 26.

PubMed abstract

The role of substance use disorders in experiencing a repeat opioid overdose, and substance use treatment patterns among patients with a non-fatal opioid overdose

A non-fatal opioid overdose (NFOO) increases the risk of another overdose and identifies high-risk patients. We estimated the risk of repeat opioid overdose for patients with and without substance use disorder (SUD) diagnoses and the change in substance u...
Author(s): Karmali RN; Ray GT; Rubinstein AL; Sterling SA; Weisner CM; Campbell CI

Drug Alcohol Depend. 2020 Feb 20;209:107923. Epub 2020-02-20.

PubMed abstract