This study will provide a comprehensive program of infrastructure development, methods development, and innovative research to generate real-world evidence addressing critical gaps in the regulation of medical products. We will explore four related issues...
Funder: U.S. Food and Drug Administration
Investigator: Sterling, Stacy
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This project examines the association between maternal marijuana use during pregnancy and adverse obstetrical and neonatal outcomes. We will examine trends in prenatal marijuana use following the legalization of marijuana for recreational purposes in Cali...
Funder: National Institute on Drug Abuse
Investigator: Young-Wolff, Kelly
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The goal of this project is 1) to collect longitudinal measures of cognitive function, quality of life, and physical disability on a multi-ethnic sample of 3,000 individuals with multiple sclerosis (MS), using a web-based interface, Clinical and Longitudi...
Funder: National Institute of Nursing Research
Investigator: Schaefer, Catherine
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The goal of this project is to investigate the effects of genetic polymorphisms in the KIR and HLA genes on psoriasis and psoriatic arthritis.
Funder: University of California, Los Angeles
Investigator: Jorgenson, Eric
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Henry Ford Health System, Kaiser Permanente Colorado, Kaiser Permanente Northern California, Kaiser Permanente Northwest, and Kaiser Permanente Southern California are implementing the National Zero Suicide Model (NZSM), and have received funding from the...
Funder: National Institute of Mental Health
Investigator: Sterling, Stacy
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This study involves a partnership between Kaiser Permanente Northern California, Kaiser Permanente Colorado, Henry Ford Health System, and the University of Washington Social Development Research Group. The collaborators will conduct a pragmatic trial tes...
Funder: National Center for Complementary and Integrative Health
Investigator: Sterling, Stacy
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The goal of this Food and Drug Administration-mandated study is to provide quantitative estimates of the serious risks of misuse, abuse, addiction, overdose, and death associated with long-term use of opioid analgesics for management of chronic pain, ...
Funder: Syneos Health
Investigator: Campbell, Cynthia
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Building on past research, this project will establish the infrastructure to expand a prescription opioid registry across diverse health systems in the Addiction Research Network. Harmonized electronic health record data elements will be used to exami...
Funder: National Institute on Drug Abuse
Investigator: Campbell, Cynthia
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The goal of this project is to address the following research question: Does the use of antidepressant treatment, specifically, selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), reduce th...
Funder: Northern California Community Benefit Programs
Investigator: Jorgenson, Eric
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The objective of this project is to investigate the genetic mechanisms that drive the development of abdominal hernias. This study has three major aims: 1) to investigate the shared and individual genetic risks of different types of abdominal hern...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Choquet, Helene; Jorgenson, Eric
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Funder: The Permanente Medical Group
Investigator: Campbell, Cynthia
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The International Bipolar Sequencing Consortium brings together whole-genome and exome sequence data from multiple case-control and family studies of bipolar disorder for the purpose of investigating the genetic architecture of this condition. Data from m...
Funder: National Institute of Mental Health
Investigator: Schaefer, Catherine
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This study will evaluate a quality improvement pilot project being conducted at pediatrics departments in the greater Kaiser Permanente Southern Alameda County area. The pilot project involves screening children at 1-to-5-year-old well child visits for ad...
Funder: The Permanente Medical Group
Investigator: Sterling, Stacy
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The major goal of this project is to maintain and expand the San Francisco Mammography Registry and to evaluate the performance of mammography in an ethnically diverse population.
Funder: National Cancer Institute
Investigator: Avins, Andrew
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This study seeks to develop metrics for evaluation of the Zero Suicide model across five integrated health care systems. These metrics will be used to investigate model fidelity and suicide behavior outcomes across sites. More specifically, this project a...
Funder: National Institute of Mental Health
Investigator: Sterling, Stacy
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In June 2013, Kaiser Permanente Northern California incorporated alcohol screening, brief intervention, and referral to treatment (SBIRT) into the clinical workflow of its Adult Medicine program, alongside other preventive health measures (e.g., smoking s...
Funder: National Institute on Alcohol Abuse and Alcoholism
Investigator: Sterling, Stacy
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This study will survey a sample of patients with pain about their use of medical marijuana. The goal is to describe patterns of use, mode, medical conditions, or symptoms for which medical marijuana is used, as well as perceived benefits, side effects, an...
Funder: Northern California Community Benefit Programs
Investigator: Campbell, Cynthia
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The specific aims of this study are to: 1) Determine whether refractive error predicts the development of glaucoma due to direct effects or shared etiology, or both, by conducting a series of genetic analyses of the two conditions; and 2) Determine th...
Funder: National Eye Institute
Investigator: Choquet, Helene; Jorgenson, Eric
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The overarching goal of this K01 study is to identify recent trends in prenatal substance use and develop data-driven, evidence-based, generalizable predictive models to identify women at greatest risk for continued substance use in pregnancy. Specificall...
Funder: National Institute on Drug Abuse
Investigator: Young-Wolff, Kelly
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Cognitive impairment, physical disability and progressive disease are common but understudied clinical outcomes that substantially impact quality of life for individuals with multiple sclerosis (MS). Systematic assessment of cognitive function, disability...
Funder: National Multiple Sclerosis Society
Investigator: Schaefer, Catherine
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This randomized clinical trial uses a health plan’s electronic medical record (EMR) alcohol screen and examines innovative behavioral interventions and their cost effectiveness for hazardous drinking within a large HIV primary care clinic.
Funder: National Institute on Alcohol Abuse and Alcoholism
Investigator: Weisner, Constance
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This study examines the impact of the Affordable Care Act (ACA) on substance use disorder (SUD) treatment, including SUD patients with HIV, in the context of a large health care delivery system
Funder: National Institute on Drug Abuse
Investigator: Weisner, Constance
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This randomized trial of a patient activation approach to self-management is based in primary care and focuses on management of prescription opioids among patients with chronic pain.
Funder: Patient-Centered Outcomes Research Institute
Investigator: Weisner, Constance
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This study is a randomized trial of adjunctive substance abuse services in combination with buprenorphine treatment for opioid abuse/dependence.
Funder: National Institute on Drug Abuse
Investigator: Weisner, Constance
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The overall goal of the Addictions Research Network (ARN) node of the Clinical Trials Network is to conduct research to improve outcomes in all patients with substance use disorders (SUDs) who are seen in medical settings. The ARN includes 15 large health...
Funder: National Institute on Drug Abuse
Investigator: Weisner, Constance
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