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Behavioral Health and Aging Studies

 

ICLIC-MS for Enhancing Outcomes Research and Clinical Care in Multiple Sclerosis

The goal of this project is 1) to collect longitudinal measures of cognitive function, quality of life, and physical disability on a multi-ethnic sample of 3,000 individuals with multiple sclerosis (MS), using a web-based interface, Clinical and Longitudi...
Funder: National Institute of Nursing Research
Investigator: Schaefer, Catherine

Investigating the Effects of KIR and HLA Gene Polymorphisms on Psoriasis

The goal of this project is to investigate the effects of genetic polymorphisms in the KIR and HLA genes on psoriasis and psoriatic arthritis.
Funder: University of California, Los Angeles
Investigator: Jorgenson, Eric

Evaluating the Impact of Changes in Opioid Prescribing Across Health Systems Implementing Zero Suicide

Henry Ford Health System, Kaiser Permanente Colorado, Kaiser Permanente Northern California, Kaiser Permanente Northwest, and Kaiser Permanente Southern California are implementing the National Zero Suicide Model (NZSM), and have received funding from the...
Funder: National Institute of Mental Health
Investigator: Sterling, Stacy

A Pragmatic Trial of Parent-Focused Prevention in Pediatric Primary Care: Implementation and Adolescent Health Outcomes in Three Health Systems

This study involves a partnership between Kaiser Permanente Northern California, Kaiser Permanente Colorado, Henry Ford Health System, and the University of Washington Social Development Research Group. The collaborators will conduct a pragmatic trial tes...
Funder: National Center for Complementary and Integrative Health
Investigator: Sterling, Stacy

A Prospective, Observational Study Designed to Quantify the Serious Risks of Misuse, Abuse and Addiction Associated with Long-Term Use of Opioid Analgesics for Management of Chronic Pain Among Patients Prescribed ER/LA Opioid Analgesics

​The goal of this Food and Drug Administration-mandated study is to provide quantitative estimates of the serious risks of misuse, abuse, addiction, overdose, and death associated with long-term use of opioid analgesics for management of chronic pain, ...
Funder: Syneos Health
Investigator: Campbell, Cynthia

Developing a Prescription Opioid Registry in Diverse Health Systems

​Building on past research, this project will establish the infrastructure to expand a prescription opioid registry across diverse health systems in the Addiction Research Network. Harmonized electronic health record data elements will be used to exami...
Funder: National Institute on Drug Abuse
Investigator: Campbell, Cynthia

Antidepressant Use and the Risk of Primary Open Angle Glaucoma

​The goal of this project is to address the following research question: Does the use of antidepressant treatment, specifically, selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), reduce th...
Funder: Northern California Community Benefit Programs
Investigator: Jorgenson, Eric

Genetic Etiology of Abdominal Hernia Susceptibility

​The objective of this project is to investigate the genetic mechanisms that drive the development of abdominal hernias. This study has three major aims: 1) to investigate the shared and individual genetic risks of different types of abdominal hern...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Choquet, Helene; Jorgenson, Eric

Impact of the Regional Opioid Safety Initiative on Patients and the Health System


Funder: The Permanente Medical Group
Investigator: Campbell, Cynthia

The Bipolar Sequencing Consortium for Combined Analyses and Follow-Up

The International Bipolar Sequencing Consortium brings together whole-genome and exome sequence data from multiple case-control and family studies of bipolar disorder for the purpose of investigating the genetic architecture of this condition. Data from m...
Funder: National Institute of Mental Health
Investigator: Schaefer, Catherine

Evaluation of a Clinical Quality Improvement Pilot of Adverse Childhood Experiences Screening and Brief Intervention in Pediatric Primary Care

This study will evaluate a quality improvement pilot project being conducted at pediatrics departments in the greater Kaiser Permanente Southern Alameda County area. The pilot project involves screening children at 1-to-5-year-old well child visits for ad...
Funder: The Permanente Medical Group
Investigator: Sterling, Stacy

Risk-Based Breast Cancer Screening and Surveillance in Community Settings

The major goal of this project is to maintain and expand the San Francisco Mammography Registry and to evaluate the performance of mammography in an ethnically diverse population.
Funder: National Cancer Institute
Investigator: Avins, Andrew

An Evaluation of the National Zero Suicide Model Across Learning Health Care Systems

This study seeks to develop metrics for evaluation of the Zero Suicide model across five integrated health care systems. These metrics will be used to investigate model fidelity and suicide behavior outcomes across sites. More specifically, this project a...
Funder: National Institute of Mental Health
Investigator: Sterling, Stacy

Population-Based Screening and Brief Intervention in Primary Care: Health and Drinking Outcomes, Cost and Utilization

In June 2013, Kaiser Permanente Northern California incorporated alcohol screening, brief intervention, and referral to treatment (SBIRT) into the clinical workflow of its Adult Medicine program, alongside other preventive health measures (e.g., smoking s...
Funder: National Institute on Alcohol Abuse and Alcoholism
Investigator: Sterling, Stacy

Recreational and Medical Use of Cannabis in a Time of Legalization and Changing Attitudes

This study will survey a sample of patients with pain about their use of medical marijuana. The goal is to describe patterns of use, mode, medical conditions, or symptoms for which medical marijuana is used, as well as perceived benefits, side effects, an...
Funder: Northern California Community Benefit Programs
Investigator: Campbell, Cynthia

The Role of Refractive Error in the Etiology of Glaucoma

The specific aims of this study are to: 1) Determine whether refractive error predicts the development of glaucoma due to direct effects or shared etiology, or both, by conducting a series of genetic analyses of the two conditions; and 2) Determine th...
Funder: National Eye Institute
Investigator: Choquet, Helene; Jorgenson, Eric

Identifying Risk Factors for Prenatal Substance and Polysubstance Use

The overarching goal of this K01 study is to identify recent trends in prenatal substance use and develop data-driven, evidence-based, generalizable predictive models to identify women at greatest risk for continued substance use in pregnancy. Specificall...
Funder: National Institute on Drug Abuse
Investigator: Young-Wolff, Kelly

Cognitive Function and Physical Disability in White, Black and Hispanic MS Patients

Cognitive impairment, physical disability and progressive disease are common but understudied clinical outcomes that substantially impact quality of life for individuals with multiple sclerosis (MS). Systematic assessment of cognitive function, disability...
Funder: National Multiple Sclerosis Society
Investigator: Schaefer, Catherine

Primary Care-Based Interventions to Reduce Alcohol Use among HIV Patients

This randomized clinical trial uses a health plan’s electronic medical record (EMR) alcohol screen and examines innovative behavioral interventions and their cost effectiveness for hazardous drinking within a large HIV primary care clinic.
Funder: National Institute on Alcohol Abuse and Alcoholism
Investigator: Weisner, Constance

The Impact of Health Care Reform on Addiction and HIV Series

This study examines the impact of the Affordable Care Act (ACA) on substance use disorder (SUD) treatment, including SUD patients with HIV, in the context of a large health care delivery system
Funder: National Institute on Drug Abuse
Investigator: Weisner, Constance

Prescription Opioid Management in Chronic Pain Patients: A Patient-Centered Activation Intervention

This randomized trial of a patient activation approach to self-management is based in primary care and focuses on management of prescription opioids among patients with chronic pain.
Funder: Patient-Centered Outcomes Research Institute
Investigator: Weisner, Constance

Buprenorphine and Substance Abuse Services for Prescription Opioid Dependence

This study is a randomized trial of adjunctive substance abuse services in combination with buprenorphine treatment for opioid abuse/dependence.
Funder: National Institute on Drug Abuse
Investigator: Weisner, Constance

Integrating Addiction Research in Health Systems: the Addiction Research Network

The overall goal of the Addictions Research Network (ARN) node of the Clinical Trials Network is to conduct research to improve outcomes in all patients with substance use disorders (SUDs) who are seen in medical settings. The ARN includes 15 large health...
Funder: National Institute on Drug Abuse
Investigator: Weisner, Constance

Supplement for Integrating Addiction Research in Health Systems: the Addiction Research Network

This study examines factors influencing performance measures of treatment initiation and engagement for alcohol and drugs across seven health care systems.
Funder: National Institute on Drug Abuse
Investigator: Weisner, Constance

Detection, Treatment and Follow-up of Unrecognized Behavioral Health Problems in the Emergency Department

Behavioral health (BH) problems frequently exacerbate medical conditions of emergency department (ED) patients and contribute to ongoing suboptimal healthcare utilization. Because non-crisis BH problems are often undetected in the ED, we evaluate an innov...
Funder: Northern California Community Benefit Programs
Investigator: Sterling, Stacy
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