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Behavioral Health and Aging Studies

 

A Model to Predict Psychosis Risk from Electronic Health Records Using Natural Language Processing and Machine Learning

This study will apply sentiment analysis — a form of natural language processing — to electronic health records to create a risk score for psychosis among adolescent and young adult Kaiser Permanente members. The findings will be used to establish a found...
Funder: Garfield Memorial Fund
Investigator: Hirschtritt, Matthew

Brain pathologies, reserve, and cognition in aging and dementia

This study is examining racial/ethnic group similarities and differences in brain mechanisms underlying cognitive reserve and functional reserve, and their life course determinants, by conducting secondary data analysis and harmonization of existing data ...
Funder: National Institute on Aging
Investigator: Gilsanz, Paola

Epidemiology of Age-related Dementia, Mild Cognitive Impairment and Brain Pathology in a Multiethnic Cohort of Oldest-Old

This study is following a diverse cohort of approximately 1,000 KPNC members over 90 years old to examine life-course risk and protective factors of healthy brain aging in order to 1) Evaluate differences in dementia incidence and rate of cognitive declin...
Funder: National Institute on Aging
Investigator: Gilsanz, Paola

Role of Health Care in Addressing Unhealthy Alcohol Use and Disparities among Aging Women

The use of alcohol among older women, particularly binge drinking, has been steadily increasing in recent years, leaving them vulnerable to associated health conditions. This mixed methods study uses KPNC's EHR based alcohol registry and screening data to...
Funder: National Institute on Alcohol Abuse and Alcoholism
Investigator: Campbell, Cynthia

Virtual SBIRT for Pediatric Primary Care: Increasing Access to Screening, Brief Intervention and Referral to Treatment for Alcohol and Other Drug Use via Telehealth

This type I hybrid effectiveness-implementation pragmatic randomized clinical trial will examine how virtually-delivered Screening, Brief Intervention and Referral to Treatment (V-SBIRT) can be cost-effectively implemented in pediatric primary care to imp...
Funder: National Institute on Alcohol Abuse and Alcoholism
Investigator: Sterling, Stacy

2021 Smoking and COVID-19 Onset and Severity in a US Integrated Healthcare Delivery System

This study examines 1) whether cigarette smoking and nicotine vaping are associated with elevated risk for onset of COVID-19 infection and worse disease severity, and 2) whether risks associated with cigarette smoking and nicotine vaping are greater among...
Funder: Tobacco-Related Disease Research Program
Investigator: Young-Wolff, Kelly

Naturalistic longitudinal examination of electroconvulsive therapy, transcranial magnetic stimulation, and intravenous ketamine for treatment-resistant depression in a large integrated healthcare system

This prospective observational study including 1,500 KPNC adult members with treatment-resistant depression will characterize factors related to selection of electroconvulsive therapy, transcranial magnetic stimulation, or ketamine; examine success rates ...
Funder: TPMG Delivery Science Projects Program
Investigator: Iturralde, Estibaliz

The Role of Genetic and Non-Genetic Factors and Causal Mechanisms Underlying Cataract Susceptibility For Risk Prediction

Cataract is a leading cause of blindness and a major cause of impaired vision worldwide. The overall objective of this study is to better understand the role of genetic and non-genetic factors and causal mechanisms underlying the etiology of cataract and ...
Funder: National Eye Institute
Investigator: Choquet, Helene

Epidemiology of Age-related Dementia, Mild Cognitive Impairment and Brain Pathology in a Multiethnic Cohort of Oldest-Old

The Life After 90 Study (LA90) is a collaborative study between DOR, UC Davis, and UC Irvine following a diverse cohort of approximately 1,000 KPNC members age 90 and over to examine life course risk factors of cognitive decline and dementia risk. This st...
Funder: National Institute on Aging
Investigator: Gilsanz, Paola

2021 Health Equity Research Supplement to Conduct Focus Groups with Black and White Women who Self-Report Cannabis Use During Pregnancy

Qualitative data are critically needed to better understand knowledge gaps, preferences, and social and cultural factors that differentially contribute to prenatal cannabis use among Black and White women. To address these important gaps in knowledge, we ...
Funder: Kaiser Permanente Division of Research
Investigator: Young-Wolff, Kelly

Assessing the Impact of Cannabis Legalization on Adolescent Cannabis Use and Cannabis-Related Health Conditions

Recreational cannabis legalization (RCL) has high potential to lead to increases in adolescent cannabis use and related health conditions, but few studies have examined this question and results are mixed. Using data from adolescents in KPNC''s large inte...
Funder: National Institute on Drug Abuse
Investigator: Young-Wolff, Kelly

Optimizing Care to Prevent Diabetes and Promote Cardiovascular Health Among Younger Adults with Severe Mental Illness

This K23 career development project seeks to leverage electronic health record data from KPNC and 2 health system collaborators within the Mental Health Research Network to investigate population health management strategies to prevent diabetes and improv...
Funder: National Institute of Mental Health
Investigator: Iturralde, Estibaliz

Lifecourse health, cerebral pathology and ethnic disparities in dementia (KHANDLE Study)

The Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) Study, a collaborative study between DOR and UC Davis, follows a diverse cohort of Kaiser Permanente Northern California members who participated in at least one optional check-up (Multiphasi...
Funder: National Institute on Aging
Investigator: Gilsanz, Paola

Genetic and non-genetic factors affecting weight loss variability after bariatric surgery

Bariatric surgery is currently the most effective long-term treatment for severe obesity. However, inter-individual variability in surgery outcomes has been observed, particularly in relation to postoperative weight loss. This study aims to assess the con...
Funder: Northern California Community Benefit Programs
Investigator: Choquet, Helene

Kaiser Permanente Northern California (KPNC) Alcohol Registry

This study will increase our understanding of the development of alcohol use disorders (AUD) and recovery from AUD, including factors that affect the likelihood of recovery success, such as quantity of alcohol consumed and the involvement of health and su...
Funder: National Institute on Alcohol Abuse and Alcoholism
Investigator: Weisner, Constance

Embedded Mental Health Services Postdoctoral Research Training in Health Systems

This program, funded by a National Institute of Mental Health Institutional Research Training Grant (T32), has 2

Kaiser Permanente Northern California Alcohol Registry

The registry will increase understanding of the development of alcohol use disorders (AUD) and recovery from AUD, including factors that affect the likelihood of recovery success, such as quantity of alcohol consumed and the involvement of health and subs...
Funder: National Institute on Alcohol Abuse and Alcoholism
Investigator: Weisner, Constance

Improve Quality and Overall Health Outcomes Through Population Management to Treat Schizophrenia, Schizoaffective Disorder and Bipolar Disorder

This study aims to use population management to improve the quality and overall health outcomes of people with schizophrenia, schizoaffective disorder, and bipolar disorder.
Funder: TPMG Delivery Science Projects Program
Investigator: Iturralde, Estibaliz

Identifying Best Practices of Early Phase Pediatric Eating Disorder Care

This study examines associations between different degrees of adherence to components of the Family Based Therapy model of care for adolescent eating disorders and clinical quality outcomes among the outpatient programs in medical centers across Kaiser Pe...
Funder: TPMG Delivery Science Projects Program
Investigator: Sterling, Stacy

Bipolar Disease and Parkinson's Disease

This study, being done with a parallel effort at UCSF, will focus on how bipolar disease is related to Parkinson's disease. We will look within the KPNC membership data, as well as focusing on a specific KP study population of bipolar disease.
Funder: Michael J. Fox Foundation
Investigator: Schaefer, Catherine; Van Den Eeden, Stephen

Buprenorphine Effect on Suicidal Behavior

Large observational study to evaluate the effects of initiating buprenorphine treatment on subsequent suicidal behavior among people with opioid use disorder.
Funder: National Institute of Mental Health
Investigator: Campbell, Cynthia

Identification of genetic loci and pathways underlying hidradenitis suppurativa risk

Hidradenitis suppurativa (also named: acne inversa) is a chronic inflammatory skin condition that causes painful lumps to form under the skin usually in areas where skin rubs together such as in the armpits, groin, buttocks and under breasts. The overall ...
Funder: National Institute of Arthritis and Musculoskeletal and Skin Diseases
Investigator: Choquet, Helene

Implementation of Alcohol Screening and Brief Intervention in a Health System: Sustainability, Fidelity and Patient Outcomes, Covid-19 Supplement

This study examines the increase in alcohol consumption during the Covid-19 pandemic and the major shift to virtual treatment modalities for alcohol problems, with a focus on potential disparities in treatment access, by race, ethnicity, age and gender. U...
Funder: National Institute on Alcohol Abuse and Alcoholism
Investigator: Sterling, Stacy

Alcohol-Related Care and HCV Treatment among Patients with Problematic Alcohol Use and HCV

This study will examine substance use treatment among patients with hepatitis C who have unhealthy alcohol use and how well they engage in appropriate and timely hepatitis C care. The findings will be used to conduct an intervention study aimed at improvi...
Funder: Northern California Community Benefit Programs
Investigator: Campbell, Cynthia

Statin Treatment and Incident Alzheimer’s Disease and Related Dementias in a Large, Multi-ethnic Health Plan

The study will assess the effects of statin treatment on risk of Alzheimer's disease and related dementias, controlling for potential confounding and examining potential mediating factors among Kaiser Permanente Northern California members during the year...
Funder: National Institute on Aging
Investigator: Schaefer, Catherine
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