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Behavioral Health and Aging Studies

 

Alcohol-Related Care and HCV Treatment among Patients with Problematic Alcohol Use and HCV

This study will examine substance use treatment among patients with hepatitis C who have unhealthy alcohol use and how well they engage in appropriate and timely hepatitis C care. The findings will be used to conduct an intervention study aimed at improvi...
Funder: Northern California Community Benefit Programs
Investigator: Campbell, Cynthia

Statin Treatment and Incident Alzheimer’s Disease and Related Dementias in a Large, Multi-ethnic Health Plan

The study will assess the effects of statin treatment on risk of Alzheimer's disease and related dementias, controlling for potential confounding and examining potential mediating factors among Kaiser Permanente Northern California members during the year...
Funder: National Institute on Aging
Investigator: Schaefer, Catherine

Addiction Telemedicine Consultation in Primary Care: Increasing Access to Pharmacotherapy and Specialty Treatment for Alcohol Problems

A cluster-randomized trial of Addiction Medicine consultation (AMC) for primary care physicians (PCPs) and patients examining the effectiveness of a telehealth AMC intervention on initiation of alcohol use treatment, anti-craving medication and/or special...
Funder: National Institute on Alcohol Abuse and Alcoholism
Investigator: Sterling, Stacy

Maternal Marijuana Use During Pregnancy, Marijuana Legalization, and Adverse Obstetrical and Neonatal Outcomes: A 12-year Cohort Study (COVID-19 Revision)

As of March 26, 2020, there have been more than 80,000 cases and 1,000 deaths in the US due to COVID-19. Because it attacks the lungs, COVID-19 could be an especially serious threat to those who smoke or vape tobacco or cannabis. This study will use data ...
Funder: National Institute on Drug Abuse
Investigator: Young-Wolff, Kelly; Avalos, Lyndsay

Smoking as a Risk Factor for COVID-19 Onset and Severity

This pilot study will use data from Kaiser Permanente Northern California electronic health records to examine whether current and former smokers are at elevated risk for COVID-19 infection and disease severity relative to never smokers. We will also look...
Funder: Tobacco-Related Disease Research Program
Investigator: Young-Wolff, Kelly

Impact of In Utero Marijuana Exposure on Neurodevelopment, Behavior and Mental Health: A Longitudinal Birth Cohort Study

This study will investigate whether maternal prenatal marijuana use increases the risk of impairments in a child's executive functioning and mental health, after accounting for other factors such as tobacco, alcohol, and other drug use; socioeconomic stat...
Funder: National Institute on Drug Abuse
Investigator: Avalos, Lyndsay; Young-Wolff, Kelly

Glycemic Control and Dementia: The Role of Pharmacotherapy and Vascular Complications

About 25% of people over the age of 65 are living with diabetes, with 90% of them managing type 2 diabetes. Studies have shown that older individuals with type 2 diabetes have a 51-62% higher risk of dementia than those without type 2 diabetes. This study...
Funder: 
Investigator: Gilsanz, Paola

Mental Health Research Network III

The Mental Health Research Network (MHRN) is a consortium of 13 health system research centers, embedded in large and diverse healthcare systems, dedicated to improving patient mental health through research, practice, and policy; with expertise in mental...
Funder: National Institute of Mental Health
Investigator: Sterling, Stacy

Genetics at an Extreme: An Efficient Genomic Study of Individuals with Clinically Severe Major Depression Receiving ECT

This study brings together investigators from around the world to carry out a genetics study of severe major depressive disorder (MDD) treated with electroconvulsive therapy (ECT). The National Network of Depression Centers and allied centers in t...
Funder: National Institute of Mental Health
Investigator: Schaefer, Catherine

Pragmatic Trial of Acupuncture for Chronic Low Back Pain in Older Adults

The goal of this project is to conduct a three-arm parallel-group randomized clinical trial of two acupuncture interventions vs. a usual-care control group for change in low back pain symptoms among adults at least 65 years of age.
Funder: National Center for Complementary and Integrative Health
Investigator: Avins, Andrew

Contributions of Educational Quality and Occupational Complexity on Racial and Ethnic Inequities in Brain Health and Alzheimer's Disease and Related Dementia

This study utilizes a lifecourse approach to evaluate the roles of education quality and occupational complexity on dementia risk and cognitive decline and to examine if patterns of educational quality and occupational complexity across the lifecourse dri...
Funder: National Institute on Aging
Investigator: Gilsanz, Paola

Effects of Medical Products on Suicidal Ideation and Behavior: Real World Evidence

This study will provide a comprehensive program of infrastructure development, methods development, and innovative research to generate real-world evidence addressing critical gaps in the regulation of medical products. We will explore four related issues...
Funder: U.S. Food and Drug Administration
Investigator: Sterling, Stacy

A Randomized, Double-Blind, Noninferiority Trial of Adductor Canal Catheters for Postoperative Pain Management among Patients Undergoing Elective Unilateral Total Knee Arthroplasty

A randomized, double-blind noninferiority trial of adductor canal catheters for postoperative pain management among patients undergoing elective, unilateral, total-knee arthroplasty.
Funder: The Permanente Medical Group
Investigator: Avins, Andrew

Expanding the Scope and Reach of Adolescent Substance Use Early Intervention Research

This study explores the enduring impact of screening, brief intervention, and referral to treatment (SBIRT) delivered in pediatric primary care, on young adults. We will examine substance use, mental health and medical outcomes, and health services utiliz...
Funder: Conrad N. Hilton Foundation
Investigator: Sterling, Stacy

Implementation of Alcohol Screening and Brief Intervention in a Health System: Sustainability, Fidelity, and Patient Outcomes

Using a theory-driven conceptual framework, this multimethod study examines factors that facilitate or impede the successful implementation and long-term sustainability of screening, brief intervention, and referral to treatment (SBIRT) for risky alcohol ...
Funder: National Institute on Alcohol Abuse and Alcoholism
Investigator: Sterling, Stacy

Maternal Marijuana Use During Pregnancy, Marijuana Legalization, and Adverse Obstetrical and Neonatal Outcomes: A 12-year Cohort Study

The goal of this application is to examine the association between maternal marijuana use during pregnancy and adverse obstetrical and neonatal outcomes. We aim to: 1) Examine trends in prenatal marijuana use following the legalization of marijuana for re...
Funder: National Institute on Drug Abuse
Investigator: Avalos, Lyndsay; Young-Wolff, Kelly

ICLIC-MS for Enhancing Outcomes Research and Clinical Care in Multiple Sclerosis

The goal of this project is 1) to collect longitudinal measures of cognitive function, quality of life, and physical disability on a multi-ethnic sample of 3,000 individuals with multiple sclerosis (MS), using a web-based interface, Clinical and Longitudi...
Funder: National Institute of Nursing Research
Investigator: Schaefer, Catherine

Evaluating the Impact of Changes in Opioid Prescribing Across Health Systems Implementing Zero Suicide

Henry Ford Health System, Kaiser Permanente Colorado, Kaiser Permanente Northern California, Kaiser Permanente Northwest, and Kaiser Permanente Southern California are implementing the National Zero Suicide Model (NZSM), and have received funding from the...
Funder: National Institute of Mental Health
Investigator: Sterling, Stacy

A Pragmatic Trial of Parent-Focused Prevention in Pediatric Primary Care: Implementation and Adolescent Health Outcomes in Three Health Systems

This study involves a partnership between Kaiser Permanente Northern California, Kaiser Permanente Colorado, Henry Ford Health System, and the University of Washington Social Development Research Group. The collaborators will conduct a pragmatic trial tes...
Funder: National Center for Complementary and Integrative Health
Investigator: Sterling, Stacy

A Prospective, Observational Study Designed to Quantify the Serious Risks of Misuse, Abuse and Addiction Associated with Long-Term Use of Opioid Analgesics for Management of Chronic Pain Among Patients Prescribed ER/LA Opioid Analgesics

​The goal of this Food and Drug Administration-mandated study is to provide quantitative estimates of the serious risks of misuse, abuse, addiction, overdose, and death associated with long-term use of opioid analgesics for management of chronic pain, amo...
Funder: Syneos Health
Investigator: Campbell, Cynthia

Developing a Prescription Opioid Registry in Diverse Health Systems

​Building on past research, this project will establish the infrastructure to expand a prescription opioid registry across diverse health systems in the Addiction Research Network. Harmonized electronic health record data elements will be used to examine ...
Funder: National Institute on Drug Abuse
Investigator: Campbell, Cynthia

Impact of the Regional Opioid Safety Initiative on Patients and the Health System


Funder: The Permanente Medical Group
Investigator: Campbell, Cynthia

The Bipolar Sequencing Consortium for Combined Analyses and Follow-Up

The International Bipolar Sequencing Consortium brings together whole-genome and exome sequence data from multiple case-control and family studies of bipolar disorder for the purpose of investigating the genetic architecture of this condition. Data from m...
Funder: National Institute of Mental Health
Investigator: Schaefer, Catherine

Evaluation of a Clinical Quality Improvement Pilot of Adverse Childhood Experiences Screening and Brief Intervention in Pediatric Primary Care

This study will evaluate a quality improvement pilot project being conducted at pediatrics departments in the greater Kaiser Permanente Southern Alameda County area. The pilot project involves screening children at 1-to-5-year-old well child visits for ad...
Funder: The Permanente Medical Group
Investigator: Sterling, Stacy

Risk-Based Breast Cancer Screening and Surveillance in Community Settings

The major goal of this project is to maintain and expand the San Francisco Mammography Registry and to evaluate the performance of mammography in an ethnically diverse population.
Funder: National Cancer Institute
Investigator: Avins, Andrew
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