Editorial Expression of Concern: Exposure to Magnetic Field Non-Ionizing Radiation and the Risk of Miscarriage: A Prospective Cohort Study
Author(s): Li DK; Chen H; Ferber JR; Odouli R; Quesenberry C
Sci Rep. 2021 03 10;11(1):6021. Epub 2021-03-10.
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Particulate Matter and Cardiovascular Risk in Adults with Chronic Obstructive Pulmonary Disease
People with chronic obstructive pulmonary disease have increased risk of cardiovascular disease and may be more susceptible to air pollution exposure. However, no study has examined the association between long-term fine particulate matter exposure (<2.5 ...
Author(s): Alexeeff SE; Deosaransingh K; Liao NS; Van Den Eeden SK; Schwartz J; Sidney S
Am J Respir Crit Care Med. 2021 Mar 04.
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Association of Pregnancy Intentions With Substance Use During Early Pregnancy
The goal of this study was to evaluate the association between pregnancy intentions and substance use in early pregnancy among pregnant women receiving prenatal care in a large, integrated healthcare system. The sample comprised 29,787 Kaiser Permanente N...
Author(s): Young-Wolff KC; Slama N; Sarovar V; Conway A; Tucker LY; Goler N; Terplan M; Ansley D; Adams SR; Armstrong MA
J Addict Med. 2021 Feb 16.
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Racial Disparities in COVID-19 Testing and Outcomes : Retrospective Cohort Study in an Integrated Health System
Racial disparities exist in outcomes after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To evaluate the contribution of race/ethnicity in SARS-CoV-2 testing, infection, and outcomes. Retrospective cohort study (1 February 2020 t...
Author(s): Escobar GJ; Adams AS; Liu VX; Soltesz L; Chen YI; Parodi SM; Ray GT; Myers LC; Ramaprasad CM; Dlott R; Lee C
Ann Intern Med. 2021 Feb 09.
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Fitting a shared frailty illness-death model to left-truncated semi-competing risks data to examine the impact of education level on incident dementia
Semi-competing risks arise when interest lies in the time-to-event for some non-terminal event, the observation of which is subject to some terminal event. One approach to assessing the impact of covariates on semi-competing risks data is through the illn...
Author(s): Lee C; Gilsanz P; Haneuse S
BMC Med Res Methodol. 2021 Jan 11;21(1):18. Epub 2021-01-11.
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Long-Term PM2.5 Exposure and Risks of Ischemic Heart Disease and Stroke Events: Review and Meta-Analysis
Background Fine particulate matter <2.5 µm in diameter (PM2.5) has known effects on cardiovascular morbidity and mortality. However, no study has quantified and compared the risks of incident myocardial infarction, incident stroke, ischemic heart disease ...
Author(s): Alexeeff SE; Liao NS; Liu X; Van Den Eeden SK; Sidney S
J Am Heart Assoc. 2020 Dec 31:e016890.
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Exercise During the First Trimester of Pregnancy and the Risks of Abnormal Screening and Gestational Diabetes Mellitus
To estimate the effects of exercise during the first trimester on the risks of abnormal screening and gestational diabetes mellitus (GDM). Data come from PETALS, a prospectively followed pregnancy cohort (n = 2,246, 79% minorities) receiving care at Kaise...
Author(s): Ehrlich SF; Ferrara A; Hedderson MM; Feng J; Neugebauer R
Diabetes Care. 2020 Dec 21.
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Bisphosphonate Treatment Beyond 5 Years and Hip Fracture Risk in Older Women
Clinical trials have demonstrated the antifracture efficacy of bisphosphonate drugs for the first 3 to 5 years of therapy. However, the efficacy of continuing bisphosphonate for as long as 10 years is uncertain. To examine the association of discontinuing...
Author(s): Izano MA; Lo JC; Adams AL; Ettinger B; Ott SM; Chandra M; Hui RL; Niu F; Li BH; Neugebauer RS
JAMA Netw Open. 2020 Dec 01;3(12):e2025190. Epub 2020-12-01.
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Development and Validation of Machine Learning Models: Electronic Health Record Data To Predict Visual Acuity After Cataract Surgery
To develop predictive models of final corrected distance visual acuity (CDVA) following cataract surgery using machine learning algorithms and electronic health record data. In this predictive modeling study we used decision tree, random forest, and gradi...
Author(s): Alexeeff SE; Uong S; Liu L; Shorstein NH; Carolan J; Amsden LB; Herrinton LJ
Perm J. 2020 Dec;25:1.
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PREDICTION OF OBSTETRIC AND FETAL COMPLICATIONS USING AUTOMATED ELECTRONIC HEALTH RECORD DATA
Increasing numbers of delivering women experience major morbidity and mortality. Limited work has been done on automated predictive models that could be used for prevention. Using only routinely collected obstetric data, we aimed to develop a predictive m...
Author(s): Escobar GJ; Soltesz L; Schuler A; Niki H; Malenica I; Lee C
Am J Obstet Gynecol. 2020 Oct 21.
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Consequences of depletion of susceptibles for hazard ratio estimators based on propensity scores
We use simulated data to examine the consequences of depletion of susceptibles for hazard ratio (HR) estimators based on a propensity score (PS). First, we show that the depletion of susceptibles attenuates marginal HRs toward the null by amounts that inc...
Author(s): Fireman B; Wyss R; et al.
Epidemiology. 2020 Aug 06.
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A telehealth lifestyle intervention to reduce excess gestational weight gain in pregnant women with overweight or obesity (GLOW): a randomised, parallel-group, controlled trial
Excess gestational weight gain (GWG) among women with overweight or obesity synergistically increases their already elevated risk of having gestational diabetes, a caesarean delivery, a large for gestational age infant, and post-partum weight retention, a...
Author(s): Ferrara A; Hedderson MM; Brown SD; Ehrlich SF; Tsai AL; Feng J; Galarce M; Marcovina S; Catalano P; Quesenberry CP
Lancet Diabetes Endocrinol. 2020 Jun;8(6):490-500.
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Comparative Effectiveness of 2 Diabetes Prevention Lifestyle Programs in the Workplace: The City and County of San Francisco Diabetes Prevention Trial
Data on the comparative effectiveness of Diabetes Prevention Programs (DPPs) in the workplace are limited. Between September 2015 and July 2016, employees of the City and County of San Francisco who were at risk for type 2 diabetes (N = 158) were randomly...
Author(s): Ferrara A; McDonald JC; Brown SD; Alexander JG; Christian-Herman JL; Fisher S; Quesenberry CP
Prev Chronic Dis. 2020 May 28;17:E38. Epub 2020-05-28.
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Exploiting nonsystematic covariate monitoring to broaden the scope of evidence about the causal effects of adaptive treatment strategies
In studies based on electronic health records (EHR), the frequency of covariate monitoring can vary by covariate type, across patients, and over time, which can limit the generalizability of inferences about the effects of adaptive treatment strategies. I...
Author(s): Kreif N; Sofrygin O; Schmittdiel JA; Adams AS; Grant RW; Zhu Z; van der Laan MJ; Neugebauer R
Biometrics. 2020 Apr 15.
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Learning to learn from data: Using deep adversarial learning to construct optimal statistical procedures
Traditionally, statistical procedures have been derived via analytic calculations whose validity often relies on sample size growing to infinity. We use tools from deep learning to develop a new approach, adversarial Monte Carlo meta-learning, for constru...
Author(s): Luedtke A; Carone M; Simon N; Sofrygin O
Sci Adv. 2020 Feb;6(9):eaaw2140. Epub 2020-02-26.
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Adjuvant endocrine therapy for breast cancer patients: impact of a health system outreach program to improve adherence
Reports suggest that up to 50% of women with hormone receptor-positive (HR+) breast cancer (BC) do not complete the recommended 5 years of adjuvant endocrine therapy (AET). We examined the impact of an outreach program at Kaiser Permanente Northern Califo...
Author(s): Lee C; Check DK; Manace Brenman L; Kushi LH; Epstein MM; Neslund-Dudas C; Pawloski PA; Achacoso N; Laurent C; Fehrenbacher L; Habel LA
Breast Cancer Res Treat. 2020 Jan 23.
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Comparison of Mortality and Major Cardiovascular Events Among Adults With Type 2 Diabetes Using Human vs Analogue Insulins
The comparative cardiovascular safety of analogue and human insulins in adults with type 2 diabetes who initiate insulin therapy in usual care settings has not been carefully evaluated using machine learning and other rigorous analytic methods. To examine...
Author(s): Neugebauer R; Schmittdiel JA; Dyer W; Pimentel N; O'Connor PJ; et al.
JAMA Netw Open. 2020 Jan 03;3(1):e1918554. Epub 2020-01-03.
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Depletion-of-susceptibles bias in influenza vaccine waning studies: how to ensure robust results
Vaccine effectiveness studies are subject to biases due to depletion-of-persons at risk of infection, or at especially high risk of infection, at different rates from different groups (depletion-of-susceptibles bias), a problem that can also lead to biase...
Author(s): Lipsitch M; Goldstein E; Ray GT; Fireman B
Epidemiol Infect. 2019 Nov 27;147:e306. Epub 2019-11-27.
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Validity of Self-reported Cannabis Use Among Pregnant Females in Northern California
Most clinical and epidemiologic estimates of prenatal cannabis use are based on self-report, and the validity of self-reported cannabis use has not been examined in a large, representative population of pregnant women. We determined the validity of self-r...
Author(s): Young-Wolff KC; Sarovar V; Tucker LY; Goler N; Conway A; Weisner C; Armstrong MA; Alexeeff S
J Addict Med. 2019 Nov 04.
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Use of Time-Dependent Propensity Scores to Adjust Hazard Ratio Estimates in Cohort Studies with Differential Depletion of Susceptibles
Estimating hazard ratios (HR) presents challenges for time-to-event analyses of cohorts with differential depletion of susceptibles. When the treatment effect is not null, cohorts that were balanced at baseline tend to become unbalanced on baseline charac...
Author(s): Wyss R; Fireman B; et al.
Epidemiology. 2019 Sep 26.
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Time-to-event analysis when the event is defined on a finite time interval
Acute graft-versus-host disease (GVHD) is a frequent complication following hematopoietic cell transplantation (HCT). Research on risk factors for acute GVHD has tended to ignore two important clinical issues. First, post-transplant mortality is high. In ...
Author(s): Lee C; Lee SJ; Haneuse S
Stat Methods Med Res. 2019 Aug 22:962280219869364.
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Depletion of Susceptibles Bias in Analyses of Intra-season Waning of Influenza Vaccine Effectiveness
Bias arises in studies of waning vaccine effectiveness when higher-risk individuals are depleted from the population at-risk, at different rates between study groups. We examine how this bias arises and how it can be avoided. Reanalysis of data from Calif...
Author(s): Ray GT; Lewis N; Klein NP; Daley MF; Lipsitch M; Fireman B
Clin Infect Dis. 2019 Jul 28.
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If Influenza Vaccines Wane Can We Delay Vaccination Without Compromising Coverage?
Author(s): Klein NP; Fireman B
Clin Infect Dis. 2019 Jun 29.
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Telomere length and socioeconomic status at neighborhood and individual levels among 80,000 adults in the Genetic Epidemiology Research on Adult Health and Aging cohort
Telomere length (TL) may serve as a biologic marker of aging. We examined neighborhood and individual-level socioeconomic status (SES) in relation to TL. The study included 84,996 non-Hispanic white subjects from the Genetic Epidemiology Research on Adult...
Author(s): Alexeeff SE; Schaefer CA; Jorgenson E; Sakoda LC; Quesenberry CP; Van Den Eeden SK; et al.
Environ Epidemiol. 2019 Jun;3(3):e049. Epub 2019-05-01.
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Targeted learning with daily EHR data
Electronic health records (EHR) data provide a cost- and time-effective opportunity to conduct cohort studies of the effects of multiple time-point interventions in the diverse patient population found in real-world clinical settings. Because the computat...
Author(s): Sofrygin O; Zhu Z; Schmittdiel JA; Adams AS; Grant RW; van der Laan MJ; Neugebauer R
Stat Med. 2019 Apr 25.
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