Joint associations between neighborhood walkability, greenness, and particulate air pollution on cardiovascular mortality among adults with a history of stroke or acute myocardial infarction
Fine particulate matter (PM2.5) is a known risk factor for cardiovascular disease (CVD). Neighborhood walkability and greenness may also be associated with CVD, but there is limited evidence on their joint or interacting effects with PM2.5. Cox proportion...
Author(s): Liao NS; Van Den Eeden SK; Sidney S; Deosaransingh K; Schwartz J; Uong SP; Alexeeff SE
Environ Epidemiol. 2022 Apr;6(2):e200. Epub 2022-02-18.
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Exploratory analysis of novel electronic health record variables for quantification of healthcare delivery strain, prediction of mortality, and prediction of imminent discharge
To explore the relationship between novel, time-varying predictors for healthcare delivery strain (eg, counts of patient orders per hour) and imminent discharge and in-hospital mortality. We conducted a retrospective cohort study using data from adults ho...
Author(s): Lee C; Lawson BL; Mann AJ; Liu VX; Myers LC; Schuler A; Escobar GJ
J Am Med Inform Assoc. 2022 Mar 15.
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Association of Glyburide and Subcutaneous Insulin With Perinatal Complications Among Women With Gestational Diabetes
Nearly 30% of individuals with gestational diabetes (GDM) do not achieve glycemic control with lifestyle modification alone and require medication treatment. Oral agents, such as glyburide, have several advantages over insulin for the treatment of GDM, in...
Author(s): Hedderson MM; Badon SE; Pimentel N; Xu F; Regenstein A; Ferrara A; Neugebauer R
JAMA Netw Open. 2022 Mar 01;5(3):e225026. Epub 2022-03-01.
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Waning 2-Dose and 3-Dose Effectiveness of mRNA Vaccines Against COVID-19-Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variant Predominance - VISION Network, 10 States, August 2021-January 2022
CDC recommends that all persons aged ≥12 years receive a booster dose of COVID-19 mRNA vaccine ≥5 months after completion of a primary mRNA vaccination series and that immunocompromised persons receive a third primary dose.* Waning of vaccine protection a...
Author(s): Ferdinands JM; Klein NP; Zerbo O; Fireman B; et al.
MMWR Morb Mortal Wkly Rep. 2022 Feb 18;71(7):255-263. Epub 2022-02-18.
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Association of the Timing of Postpartum Intrauterine Device Insertion and Breastfeeding With Risks of Intrauterine Device Expulsion
Intrauterine device (IUD) expulsion increases the risk of unintended pregnancy; how timing of postpartum IUD insertion and breastfeeding are associated with risk of expulsion is relevant to the benefit-risk profile. To evaluate the association of postpart...
Author(s): Armstrong MA; Anthony MS; et al.
JAMA Netw Open. 2022 Feb 01;5(2):e2148474. Epub 2022-02-01.
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Early Pregnancy Blood Pressure Patterns Identify Risk of Hypertensive Disorders of Pregnancy Among Racial and Ethnic Groups
Hypertensive disorders of pregnancy are a leading cause of severe maternal morbidity and mortality and 4-fold higher perinatal mortality in Black women. Early pregnancy blood pressure patterns may differentiate risk of hypertensive disorders of pregnancy....
Author(s): Gunderson EP; Greenberg M; Nguyen-Huynh MN; Tierney C; Roberts JM; Go AS; Tao W; Alexeeff SE
Hypertension. 2021 Dec 29:HYPERTENSIONAHA12118568.
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Impact of the Affordable Care Act on Colorectal Cancer Incidence and Mortality
The Patient Protection and Affordable Care Act eliminated cost sharing for preventive services, including colorectal cancer screening for individuals aged 50-75 years with private health insurance. This study examines the impact of the Affordable Care Act...
Author(s): Lee C; Kushi LH; Reed ME; Eldridge EH; Lee JK; Zhang J; Spiegelman D
Am J Prev Med. 2021 Nov 08.
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Treatment and Follow-up Care Associated With Patient-Scheduled Primary Care Telemedicine and In-Person Visits in a Large Integrated Health System
Telemedicine visits can offer patients convenient access to a clinician, but it is unclear whether treatment differs from that with in-person visits or how often patients require in-person follow-up. To examine whether physician prescribing and orders dif...
Author(s): Reed M; Huang J; Graetz I; Muelly E; Millman A; Lee C
JAMA Netw Open. 2021 Nov 01;4(11):e2132793. Epub 2021-11-01.
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Hypotonic-hyporesponsive Episodes After Diphtheria, Tetanus and Acellular Pertussis Vaccination
Hypotonic-hyporesponsive episode (HHE) after whole cell pertussis vaccination is a known adverse event. Less is known about the risk of HHE after administration of acellular pertussis vaccines. Using parental interviews, this study actively surveyed for H...
Author(s): Hansen J; Decker MD; Lewis E; Fireman B; Pool V; Greenberg DP; Johnson DR; Black S; Klein NP
Pediatr Infect Dis J. 2021 Aug 20.
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AUTOMATED ALERTS IN OBSTETRICS
Author(s): Escobar GJ; Schuler A; Lee C
Am J Obstet Gynecol. 2021 Apr 22.
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Editorial Expression of Concern: Exposure to Magnetic Field Non-Ionizing Radiation and the Risk of Miscarriage: A Prospective Cohort Study
Author(s): Li DK; Chen H; Ferber JR; Odouli R; Quesenberry C
Sci Rep. 2021 03 10;11(1):6021. Epub 2021-03-10.
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Particulate Matter and Cardiovascular Risk in Adults with Chronic Obstructive Pulmonary Disease
People with chronic obstructive pulmonary disease have increased risk of cardiovascular disease and may be more susceptible to air pollution exposure. However, no study has examined the association between long-term fine particulate matter exposure (<2.5 ...
Author(s): Alexeeff SE; Deosaransingh K; Liao NS; Van Den Eeden SK; Schwartz J; Sidney S
Am J Respir Crit Care Med. 2021 Mar 04.
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Association of Pregnancy Intentions With Substance Use During Early Pregnancy
The goal of this study was to evaluate the association between pregnancy intentions and substance use in early pregnancy among pregnant women receiving prenatal care in a large, integrated healthcare system. The sample comprised 29,787 Kaiser Permanente N...
Author(s): Young-Wolff KC; Slama N; Sarovar V; Conway A; Tucker LY; Goler N; Terplan M; Ansley D; Adams SR; Armstrong MA
J Addict Med. 2021 Feb 16.
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Racial Disparities in COVID-19 Testing and Outcomes : Retrospective Cohort Study in an Integrated Health System
Racial disparities exist in outcomes after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To evaluate the contribution of race/ethnicity in SARS-CoV-2 testing, infection, and outcomes. Retrospective cohort study (1 February 2020 t...
Author(s): Escobar GJ; Adams AS; Liu VX; Soltesz L; Chen YI; Parodi SM; Ray GT; Myers LC; Ramaprasad CM; Dlott R; Lee C
Ann Intern Med. 2021 Feb 09.
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Fitting a shared frailty illness-death model to left-truncated semi-competing risks data to examine the impact of education level on incident dementia
Semi-competing risks arise when interest lies in the time-to-event for some non-terminal event, the observation of which is subject to some terminal event. One approach to assessing the impact of covariates on semi-competing risks data is through the illn...
Author(s): Lee C; Gilsanz P; Haneuse S
BMC Med Res Methodol. 2021 Jan 11;21(1):18. Epub 2021-01-11.
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Long-Term PM2.5 Exposure and Risks of Ischemic Heart Disease and Stroke Events: Review and Meta-Analysis
Background Fine particulate matter <2.5 µm in diameter (PM2.5) has known effects on cardiovascular morbidity and mortality. However, no study has quantified and compared the risks of incident myocardial infarction, incident stroke, ischemic heart disease ...
Author(s): Alexeeff SE; Liao NS; Liu X; Van Den Eeden SK; Sidney S
J Am Heart Assoc. 2020 Dec 31:e016890.
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Exercise During the First Trimester of Pregnancy and the Risks of Abnormal Screening and Gestational Diabetes Mellitus
To estimate the effects of exercise during the first trimester on the risks of abnormal screening and gestational diabetes mellitus (GDM). Data come from PETALS, a prospectively followed pregnancy cohort (n = 2,246, 79% minorities) receiving care at Kaise...
Author(s): Ehrlich SF; Ferrara A; Hedderson MM; Feng J; Neugebauer R
Diabetes Care. 2020 Dec 21.
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Bisphosphonate Treatment Beyond 5 Years and Hip Fracture Risk in Older Women
Clinical trials have demonstrated the antifracture efficacy of bisphosphonate drugs for the first 3 to 5 years of therapy. However, the efficacy of continuing bisphosphonate for as long as 10 years is uncertain. To examine the association of discontinuing...
Author(s): Izano MA; Lo JC; Adams AL; Ettinger B; Ott SM; Chandra M; Hui RL; Niu F; Li BH; Neugebauer RS
JAMA Netw Open. 2020 Dec 01;3(12):e2025190. Epub 2020-12-01.
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Development and Validation of Machine Learning Models: Electronic Health Record Data To Predict Visual Acuity After Cataract Surgery
To develop predictive models of final corrected distance visual acuity (CDVA) following cataract surgery using machine learning algorithms and electronic health record data. In this predictive modeling study we used decision tree, random forest, and gradi...
Author(s): Alexeeff SE; Uong S; Liu L; Shorstein NH; Carolan J; Amsden LB; Herrinton LJ
Perm J. 2020 Dec;25:1.
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PREDICTION OF OBSTETRIC AND FETAL COMPLICATIONS USING AUTOMATED ELECTRONIC HEALTH RECORD DATA
Increasing numbers of delivering women experience major morbidity and mortality. Limited work has been done on automated predictive models that could be used for prevention. Using only routinely collected obstetric data, we aimed to develop a predictive m...
Author(s): Escobar GJ; Soltesz L; Schuler A; Niki H; Malenica I; Lee C
Am J Obstet Gynecol. 2020 Oct 21.
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Consequences of depletion of susceptibles for hazard ratio estimators based on propensity scores
We use simulated data to examine the consequences of depletion of susceptibles for hazard ratio (HR) estimators based on a propensity score (PS). First, we show that the depletion of susceptibles attenuates marginal HRs toward the null by amounts that inc...
Author(s): Fireman B; Wyss R; et al.
Epidemiology. 2020 Aug 06.
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A telehealth lifestyle intervention to reduce excess gestational weight gain in pregnant women with overweight or obesity (GLOW): a randomised, parallel-group, controlled trial
Excess gestational weight gain (GWG) among women with overweight or obesity synergistically increases their already elevated risk of having gestational diabetes, a caesarean delivery, a large for gestational age infant, and post-partum weight retention, a...
Author(s): Ferrara A; Hedderson MM; Brown SD; Ehrlich SF; Tsai AL; Feng J; Galarce M; Marcovina S; Catalano P; Quesenberry CP
Lancet Diabetes Endocrinol. 2020 Jun;8(6):490-500.
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Comparative Effectiveness of 2 Diabetes Prevention Lifestyle Programs in the Workplace: The City and County of San Francisco Diabetes Prevention Trial
Data on the comparative effectiveness of Diabetes Prevention Programs (DPPs) in the workplace are limited. Between September 2015 and July 2016, employees of the City and County of San Francisco who were at risk for type 2 diabetes (N = 158) were randomly...
Author(s): Ferrara A; McDonald JC; Brown SD; Alexander JG; Christian-Herman JL; Fisher S; Quesenberry CP
Prev Chronic Dis. 2020 May 28;17:E38. Epub 2020-05-28.
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Exploiting nonsystematic covariate monitoring to broaden the scope of evidence about the causal effects of adaptive treatment strategies
In studies based on electronic health records (EHR), the frequency of covariate monitoring can vary by covariate type, across patients, and over time, which can limit the generalizability of inferences about the effects of adaptive treatment strategies. I...
Author(s): Kreif N; Sofrygin O; Schmittdiel JA; Adams AS; Grant RW; Zhu Z; van der Laan MJ; Neugebauer R
Biometrics. 2020 Apr 15.
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Adjuvant endocrine therapy for breast cancer patients: impact of a health system outreach program to improve adherence
Reports suggest that up to 50% of women with hormone receptor-positive (HR+) breast cancer (BC) do not complete the recommended 5 years of adjuvant endocrine therapy (AET). We examined the impact of an outreach program at Kaiser Permanente Northern Califo...
Author(s): Lee C; Check DK; Manace Brenman L; Kushi LH; Epstein MM; Neslund-Dudas C; Pawloski PA; Achacoso N; Laurent C; Fehrenbacher L; Habel LA
Breast Cancer Res Treat. 2020 Jan 23.
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