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Biostatistics Core Studies

 

Kaiser Healthy Aging and Diverse Life Experiences Study (KHANDLE)

Although there are marked ethnic disparities in rates of dementia, almost nothing is known about early-life contributors to dementia in ethnic minority groups, nor if the trajectory of cognitive decline or transition to cognitive impairment varies across ...
Funder: National Institute on Aging
Investigator: Quesenberry, Charles

Study of Longevity in Diabetes (SOLID)

Type 1 diabetes is a complicated disease requiring constant adherence to glycemic targets and meticulous attention and vigilance of blood sugar. Individuals with type 1 diabetes are living longer than ever before, yet very little is known about how this g...
Funder: National Institute on Aging
Investigator: Quesenberry, Charles

Study of Healthy Aging in African Americans (STAR)

Rates of dementia and Alzheimer’s disease are 40% to 100% higher among African Americans compared to non-Hispanic whites. STAR is a longitudinal cohort study of lifecourse vascular risk and brain aging in 700 African Americans ages 50 and older. The ...
Funder: National Institute on Aging
Investigator: Quesenberry, Charles

Life After 90

Alzheimer’s disease and other dementias affect 15 percent of those aged 65 and older, by age 90 and older this number increases to a startling 40 to 50 percent. The oldest-old, people aged 90 and older, are the fastest growing segment of the elderly popul...
Funder: National Institute on Aging
Investigator: Quesenberry, Charles

Particulate Air Pollution, Cardiovascular Events, and Susceptibility Factors (PACES)

This is a retrospective cohort study of 5 million adult members of Kaiser Permanente Northern California during 2000 to 2012, linked to state-of-the-art estimates of exposure to PM2.5 (particulate matter less than 2.5 micrometers in diameter) generated at...
Funder: National Institute of Environmental Health Sciences
Investigator: Alexeeff, Stacey

Study on the Association of Uterine Perforation and IUD expulsion With Breastfeeding Status at the Time of IUD insertion and Postpartum Timing of IUD Insertion in Electronic Medical Record Databases - A Post-marketing Requirement for Mirena

The Food and Drug Administration (FDA) has required Bayer AG to conduct a post-marketing study in the U.S. to determine the incidence of uterine perforation and IUD expulsion by type of intrauterine device (IUD) used. The goal of this study is to quantify...
Funder: Bayer AG
Investigator: Armstrong, Mary Anne

Mini-Sentinel Efforts to Develop the Sentinel Initiative: The Use of Propensity-Score Matching for Estimating Hazard Ratios in Post-Market Surveillance with Heavy Censoring

Mini-Sentinel Task Order
Funder: U.S. Food and Drug Administration
Investigator: Fireman, Bruce

Feasibility and Performance Assessments of TMLE and hdPS Methodologies to Fit MSM in a Real-World CER Study

This study aims to evaluate the practicability and practical advantages of: 1) Targeted Minimum Loss based Estimation (TMLE), and 2) a high-dimensional propensity score (hdPS) algorithm to fit dynamic Marginal Structural Models (MSM) in a longitudinal...
Funder: Agency for Healthcare Research and Quality
Investigator: Neugebauer, Romain

Software to Automate Implementation of Causal Inference Methods with Time-Varying Interventions

This project aims to develop SAS macros to automate the data structuring required for implementation of Causal Inference methods with electronic health records data in studies with time-varying exposures, confounding and selection bias (e.g., marginal str...
Funder: 
Investigator: Neugebauer, Romain

M-S Evaluating the Performance of Mini-Sentinel Analytic Modules Using Simulation Experiments


Funder: U.S. Food and Drug Administration
Investigator: Fireman, Bruce

Risk of Uterine Perforation among Women Using different types of IUDs and the Association with Timing of Insertion and Breastfeeding

The goal of the study is to compare the incidence of uterine perforation within 12 months after IUD insertion between: (1) postpartum insertions within 12 months of delivery (with breastfeeding status), (2) post abortion or pregnancy loss IUD insertio...
Funder: Bayer AG
Investigator: Armstrong, Mary Anne

A Database Cohort Study to Assess the Risk of Developing non-Melanoma Skin Cancer in Adult Patients with Atopic Dermatitis Exposed to Topical Calcineurin Inhibitor

The primary objective of this study is to assess the long-term risk of developing melanoma in adult subjects aged 40 years with AD exposed to topical calcinuerin inhibitors (TCIs). To accomplish this objective, the long-term risk of developing melanoma w...
Funder: Valeant Pharmaceuticals International, Inc.
Investigator: Quesenberry, Charles

Causal Analyses of Electronic Health Record Data for Assessing the Comparative Effectiveness of Treatment Regimens

This study aims to strengthen causal inferences based on Marginal Structural Modeling (MSM) and large healthcare databases for Comparative Effectiveness Research in Type 2 Diabetes Mellitus (T2DM), specifically, it aims to: 1) Develop a consensus for...
Funder: Patient-Centered Outcomes Research Institute
Investigator: Neugebauer, Romain