Biostatistics Core Studies


Impact of wildfire air pollution on rates of cardiovascular events and mortality There is an increasing frequency of large wildfires in California. Smoke from these wildfires can drastically increase short-term exposure to harmful air pollutants, especially particulate matter (PM), and some KPNC members may be at greater risk of the a... Funder: Northern California Community Benefit Programs Investigator: Alexeeff, Stacey
Comparison of type 2 diabetes pharmacotherapy regimens using targeted learning This study is designed to help patients with type 2 diabetes and their clinicians identify which glucose-lowering medications among SGLT2 inhibitors, GLP-1 receptor agonists, DPP4 inhibitors, or Sulfonylureas have the most favorable effects on heart healt... Funder: Patient-Centered Outcomes Research Institute Investigator: Neugebauer, Romain
Leveraging Machine Learning to Improve Risk Prediction for Chemotherapy Induced Neuropathy Chemotherapy-associated peripheral neuropathy (CPN) affects nearly 70% of cancer patients. An estimated 30% of cancer survivors have persistent CPN, which can have a devastating impact on their quality of life and functioning. Our objective is to develop ... Funder: National Cancer Institute Investigator: Neugebauer, Romain
Evaluation of Complex Interventions on Drug (Re)Fill Behavior Using Electronic Health Care Data This study develops generalized per-protocol analyses based on Inverse Probability Weighting and Targeted Learning to control for or evaluate the effect of medication nonadherence in observational studies that use electronic health databases to inform the... Funder: Patient-Centered Outcomes Research Institute Investigator: Neugebauer, Romain
Kaiser Healthy Aging and Diverse Life Experiences Study (KHANDLE) Although there are marked ethnic disparities in rates of dementia, almost nothing is known about early-life contributors to dementia in ethnic minority groups, nor if the trajectory of cognitive decline or transition to cognitive impairment varies across ... Funder: National Institute on Aging Investigator: Quesenberry, Charles
Study of Longevity in Diabetes (SOLID) Type 1 diabetes is a complicated disease requiring constant adherence to glycemic targets and meticulous attention and vigilance of blood sugar. Individuals with type 1 diabetes are living longer than ever before, yet very little is known about how this g... Funder: National Institute on Aging Investigator: Quesenberry, Charles
Study of Healthy Aging in African Americans (STAR) Rates of dementia and Alzheimer’s disease are 40% to 100% higher among African Americans compared to non-Hispanic whites. STAR is a longitudinal cohort study of lifecourse vascular risk and brain aging in 700 African Americans ages 50 and older. The goals... Funder: National Institute on Aging Investigator: Quesenberry, Charles
Life After 90 Alzheimer’s disease and other dementias affect 15 percent of those aged 65 and older, by age 90 and older this number increases to a startling 40 to 50 percent. The oldest-old, people aged 90 and older, are the fastest growing segment of the elderly popul... Funder: National Institute on Aging Investigator: Quesenberry, Charles
Particulate Air Pollution, Cardiovascular Events, and Susceptibility Factors (PACES) This is a retrospective cohort study of 5 million adult members of Kaiser Permanente Northern California during 2000 to 2012, linked to state-of-the-art estimates of exposure to PM2.5 (particulate matter less than 2.5 micrometers in diameter) generated at... Funder: National Institute of Environmental Health Sciences Investigator: Alexeeff, Stacey
Mini-Sentinel Efforts to Develop the Sentinel Initiative: The Use of Propensity-Score Matching for Estimating Hazard Ratios in Post-Market Surveillance with Heavy Censoring Mini-Sentinel Task Order Funder: U.S. Food and Drug Administration Investigator: Fireman, Bruce
Feasibility and Performance Assessments of TMLE and hdPS Methodologies to Fit MSM in a Real-World CER Study This study aims to evaluate the practicability and practical advantages of: 1) Targeted Minimum Loss based Estimation (TMLE), and 2) a high-dimensional propensity score (hdPS) algorithm to fit dynamic Marginal Structural Models (MSM) in a longitudinal com... Funder: Agency for Healthcare Research and Quality Investigator: Neugebauer, Romain
Software to Automate Implementation of Causal Inference Methods with Time-Varying Interventions This project aims to develop SAS macros to automate the data structuring required for implementation of Causal Inference methods with electronic health records data in studies with time-varying exposures, confounding and selection bias (e.g., marginal str... Funder: Investigator: Neugebauer, Romain
M-S Evaluating the Performance of Mini-Sentinel Analytic Modules Using Simulation Experiments Funder: U.S. Food and Drug Administration Investigator: Fireman, Bruce
Causal Analyses of Electronic Health Record Data for Assessing the Comparative Effectiveness of Treatment Regimens This study aims to strengthen causal inferences based on Marginal Structural Modeling (MSM) and large healthcare databases for Comparative Effectiveness Research in Type 2 Diabetes Mellitus (T2DM), specifically, it aims to: 1) Develop a consensus for the... Funder: Patient-Centered Outcomes Research Institute Investigator: Neugebauer, Romain