Body mass index and early CD4 T-cell recovery among adults initiating antiretroviral therapy in North America, 1998-2010

Adipose tissue affects several aspects of the cellular immune system, but prior epidemiological studies have differed on whether a higher body mass index (BMI) promotes CD4 T-cell recovery on antiretroviral therapy (ART). The objective of this analysis was to assess the relationship between BMI at ART initiation and early changes in CD4 T-cell count. We used the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) data set to analyse the relationship between pre-treatment BMI and 12-month CD4 T-cell recovery among adults who started ART between 1998 and 2010 and maintained HIV-1 RNA levels ?30?kg/m(2) ). Pretreatment BMI was associated with 12-month CD4 T-cell change (P??30?kg/m(2) , the observed benefit was attenuated among men to a greater degree than among women, although this difference was not statistically significant. A BMI of approximately 30?kg/m(2) at ART initiation was associated with greater CD4 T-cell recovery at 12 months compared with higher or lower BMI values, suggesting that body composition may affect peripheral CD4 T-cell recovery.

0