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Cancer Publications


Streamlining genetic testing for women with ovarian cancer in a Northern California health care system

Referral to Genetics for pre-testing counseling may be inefficient for women with ovarian cancer. This study assesses feasibility of gynecologic oncologists directly offering genetic testing. A prospective pilot study was conducted at two gynecologic onco...
Author(s): Powell CB; Lee J; Kushi LH; et al.

Gynecol Oncol. 2020 Aug 07.

PubMed abstract

Early Screening of African Americans (45-50 Years Old) in a Fecal Immunochemical Test-based Colorectal Cancer Screening Program

Some guidelines recommend starting colorectal cancer (CRC) screening before age 50 years for African Americans, but there are few data on screening uptake and yield in this population. We performed a prospective study of fecal immunochemical test (FIT) sc...
Author(s): Levin TR; Jensen CD; Chawla NM; Sakoda LC; Lee JK; Zhao WK; Landau MA; Herm A; Eby E; Quesenberry CP; Corley DA

Gastroenterology. 2020 Jul 15.

PubMed abstract

Standardized reporting and management of suspicious findings on chest computed tomography is associated with improved lung cancer diagnosis in an observational study

Follow-up of chest computed tomography (CT) findings suspicious for lung cancer may be delayed because of inadequate documentation. Standardized reporting and follow-up may reduce time to diagnosis and care for lung cancer. We implemented a reporting syst...
Author(s): Urbania TH; Dusendang JR; Herrinton LJ; Alexeeff S; Corley DA; Ely S; Patel A; Osinski T; Sakoda LC

Chest. 2020 Jun 17.

PubMed abstract

Association of Azithromycin Use With Cardiovascular Mortality

Azithromycin is one of the most commonly prescribed antibiotics in the US. It has been associated with an increased risk of cardiovascular death in some observational studies. To estimate the relative and absolute risks of cardiovascular and sudden cardia...
Author(s): Zaroff JG; Cheetham TC; Palmetto N; Almers L; Quesenberry C; Schneider J; Gatto N; Corley DA

JAMA Netw Open. 2020 Jun 01;3(6):e208199. Epub 2020-06-01.

PubMed abstract

Validation of an Algorithm to Identify Patients at Risk for Colorectal Cancer Based on Laboratory Test and Demographic Data in Diverse, Community-Based Population

Approximately 30%-40% of screening-eligible adults in the United States are not up to date with colorectal cancer (CRC) screening. We aimed to validate a predictive score, generated by a machine learning algorithm with common laboratory test data, to iden...
Author(s): Schneider J; Layefsky E; Udaltsova N; Levin TR; Corley DA

Clin Gastroenterol Hepatol. 2020 Apr 29.

PubMed abstract

COVID-19: What Should Clinicians and Scientists Do and When?

Author(s): Corley DA; Peek RM

Gastroenterology. 2020 Mar 19.

PubMed abstract

COVID-19: Long-term Planning for Procedure-based Specialties During Extended Mitigation and Suppression Strategies

Author(s): Rouillard S; Liu VX; Corley DA

Gastroenterology. 2020 May 18.

PubMed abstract

Evaluation of automated computed tomography segmentation to assess body composition and mortality associations in cancer patients

Body composition from computed tomography (CT) scans is associated with cancer outcomes including surgical complications, chemotoxicity, and survival. Most studies manually segment CT scans, but Automatic Body composition Analyser using Computed tomograph...
Author(s): Cespedes Feliciano EM; Liu V; Caan BJ; et al.

J Cachexia Sarcopenia Muscle. 2020 Apr 20.

PubMed abstract

What Is Organized Screening and What Is Its Value?

Most screening in the United States occurs in an opportunistic fashion, although organized screening occurs in some integrated health care systems. Organized colorectal cancer (CRC) screening consists of an explicit screening policy, defined target popula...
Author(s): Dominitz JA; Levin TR

Gastrointest Endosc Clin N Am. 2020 Jul;30(3):393-411. Epub 2020-04-16.

PubMed abstract

Proton Pump Inhibitor Use and Risk of Gastric, Colorectal, Liver, and Pancreatic Cancers in a Community-Based Population

Proton pump inhibitors (PPIs) are commonly used for gastrointestinal disorders; given they increase the systemic levels of gastrin, a trophic hormone, there is a concern about their carcinogenicity. This study evaluated the associations PPI use and the ri...
Author(s): Lee JK; Merchant SA; Schneider JL; Jensen CD; Fireman BH; Quesenberry CP; Corley DA

Am J Gastroenterol. 2020 Mar 20.

PubMed abstract

Election of Anil Rustgi and Raymond DuBois to the National Academy of Medicine

Author(s): Corley DE; Peek RM

Gastroenterology. 2020 Apr;158(5):1196. Epub 2020-03-04.

PubMed abstract

Impact of observational training on endoscopic mucosal resection outcomes and competency for large colorectal polyps: single endoscopist experience

Background and study aims  Endoscopic mucosal resection (EMR) is standard treatment for large colorectal polyps. However, it is a specialized technique with limited data on the effectiveness of training methods to acquire this skill. The aim of this study...
Author(s): Lee JK; Kidambi TD; Kaltenbach T; Bhat YM; Shergill A; McQuaid KR; Terdiman JP; Soetikno RM

Endosc Int Open. 2020 Mar;8(3):E346-E353. Epub 2020-02-21.

PubMed abstract

Natural language processing for the accurate identification of colorectal cancer mismatch repair status in Lynch syndrome screening

Author(s): Li D; Udaltsova N; Layefsky E; Doan C; Corley DA

Clin Gastroenterol Hepatol. 2020 Feb 06.

PubMed abstract

Prediagnosis social support, social integration, living status, and colorectal cancer mortality in postmenopausal women from the women's health initiative

We evaluated associations between perceived social support, social integration, living alone, and colorectal cancer (CRC) outcomes in postmenopausal women. The study included 1431 women from the Women's Health Initiative who were diagnosed from 1993 throu...
Author(s): Kroenke CH; Paskett ED; Cené CW; Caan BJ; Luo J; Shadyab AH; Robinson JRM; Nassir R; Lane DS; Anderson GL

Cancer. 2020 Jan 23.

PubMed abstract

Adjuvant endocrine therapy for breast cancer patients: impact of a health system outreach program to improve adherence

Reports suggest that up to 50% of women with hormone receptor-positive (HR+) breast cancer (BC) do not complete the recommended 5 years of adjuvant endocrine therapy (AET). We examined the impact of an outreach program at Kaiser Permanente Northern Califo...
Author(s): Lee C; Check DK; Manace Brenman L; Kushi LH; Epstein MM; Neslund-Dudas C; Pawloski PA; Achacoso N; Laurent C; Fehrenbacher L; Habel LA

Breast Cancer Res Treat. 2020 Jan 23.

PubMed abstract

Serum bone markers and risk of osteoporosis and fragility fractures in women who received endocrine therapy for breast cancer: a prospective study

Osteoporosis and fragility fracture are major bone toxicities of aromatase inhibitors (AIs) for postmenopausal hormone receptor-positive breast cancer. Except for a few small studies on bone turnover markers and reduced bone mineral density after AI treat...
Author(s): Yao S; Laurent CA; Roh JM; Lo J; Tang L; Hahn T; Ambrosone CB; Kushi LH; Kwan ML

Breast Cancer Res Treat. 2020 Jan 07.

PubMed abstract

Body Composition, Adherence to Anthracycline and Taxane-Based Chemotherapy, and Survival After Nonmetastatic Breast Cancer

Although most chemotherapies are dosed on body surface area or weight, body composition (ie, the amount and distribution of muscle and adipose tissues) is thought to be associated with chemotherapy tolerance and adherence. To evaluate whether body composi...
Author(s): Cespedes Feliciano EM; Chen WY; Lee V; Albers KB; Prado CM; Alexeeff S; Xiao J; Shachar SS; Caan BJ

JAMA Oncol. 2019 Dec 05.

PubMed abstract

Environmental Tobacco Smoke Exposure in Relation to Family Characteristics, Stressors and Chemical Co-Exposures in California Girls

Childhood environmental tobacco smoke (ETS) exposure is a risk factor for adverse health outcomes and may disproportionately burden lower socioeconomic status groups, exacerbating health disparities. We explored associations of demographic factors, stress...
Author(s): Windham GC; Soriano JW; Dobraca D; Sosnoff CS; Hiatt RA; Kushi LH

Int J Environ Res Public Health. 2019 Oct 30;16(21). Epub 2019-10-30.

PubMed abstract

Morbidity and Mortality After Surgery for Nonmalignant Colorectal Polyps: A 10-Year Nationwide Analysis

Rates of surgery for nonmalignant colorectal polyps are increasing in the United States despite evidence that most polyps can be managed endoscopically. We aimed to determine nationally representative estimates and to identify predictors of in-hospital mo...
Author(s): Ma C; Teriaky A; Sheh S; Forbes N; Heitman SJ; Jue TL; Munroe CA; Jairath V; Corley DA; Lee JK

Am J Gastroenterol. 2019 Oct 11.

PubMed abstract

Long-term Risk of Colorectal Cancer and Related Death After Adenoma Removal in a Large, Community-based Population.

BACKGROUND & AIMS: The long-term risks of colorectal cancer (CRC) and CRC-related death following adenoma removal are uncertain. Data are needed to inform evidence-based surveillance guidelines, which vary in follow-up recommendations for some polyp types...
Author(s): Lee, Jeffrey K JK; Jensen, Christopher D CD; Levin, Theodore R TR; Doubeni, Chyke A CA; Zauber, Ann G AG; Chubak, Jessica J; Kamineni, Aruna S AS; Schottinger, Joanne E JE; Ghai, Nirupa R NR; Udaltsova, Natalia N; Zhao, Wei K WK; Fireman, Bruce H BH; Quesenberry, Charles P CP; Orav, E John EJ; Skinner, Celette Sugg CS; Halm, Ethan A EA; Corley, Douglas A DA

Gastroenterology. 2019 Oct 04;():. Epub 2019-10-04.

PubMed abstract

Chronotype, Social Jet Lag, and Cardiometabolic Risk Factors in Early Adolescence

Inadequate sleep duration and quality increase the risk of obesity. Sleep timing, while less studied, is important in adolescents because increasing evening preferences (chronotypes), early school start times, and irregular sleep schedules may cause circa...
Author(s): Cespedes Feliciano EM; Rifas-Shiman SL; Quante M; Redline S; Oken E; Taveras EM

JAMA Pediatr. 2019 Sep 16.

PubMed abstract

Effect of Sex, Age and Positivity Threshold on Fecal Immunochemical Test Accuracy: a Systematic Review and Meta-Analysis

Quantitative fecal immunochemical tests (FITs) for hemoglobin are commonly used for colorectal cancer (CRC) screening. We aimed to quantify the change in CRC and advanced adenoma detection and number of positive test results at different positivity thresh...
Author(s): Selby K; Levine EH; Doan C; Gies A; Brenner H; Quesenberry C; Lee JK; Corley DA

Gastroenterology. 2019 Aug 22.

PubMed abstract

Trichomonas vaginalis infection and prostate-specific antigen concentration: Insights into prostate involvement and prostate disease risk.

BACKGROUND: The protist Trichomonas vaginalis causes a common, sexually transmitted infection and has been proposed to contribute to the development of chronic prostate conditions, including benign prostatic hyperplasia and prostate cancer. However, few s...
Author(s): Langston, Marvin E ME; Bhalla, Ankita A; Alderete, John F JF; Nevin, Remington L RL; Pakpahan, Ratna R; Hansen, Johannah J; Elliott, Debra D; De Marzo, Angelo M AM; Gaydos, Charlotte A CA; Isaacs, William B WB; Nelson, William G WG; Sokoll, Lori J LJ; Zenilman, Jonathan M JM; Platz, Elizabeth A EA; Sutcliffe, Siobhan S

The Prostate. 2019 Oct ;79(14):1622-1628. Epub 2019-08-02.

PubMed abstract

Adipose Tissue Distribution and Cardiovascular Disease Risk Among Breast Cancer Survivors

Cardiovascular disease (CVD) is a major source of morbidity and mortality among breast cancer survivors. Although body mass index (BMI) is associated with CVD risk, adipose tissue distribution may better identify patients with a high risk of CVD after bre...
Author(s): Cespedes Feliciano EM; Chen WY; Bradshaw PT; Prado CM; Alexeeff S; Albers KB; Castillo AL; Caan BJ

J Clin Oncol. 2019 Aug 01:JCO1900286.

PubMed abstract

Trends in Medical Imaging During Pregnancy in the United States and Ontario, Canada, 1996 to 2016

The use of medical imaging has sharply increased over the last 2 decades. Imaging rates during pregnancy have not been quantified in a large, multisite study setting. To evaluate patterns of medical imaging during pregnancy. A retrospective cohort study w...
Author(s): Kwan ML; Deosaransingh KA; Kushi LH; Radiation-Induced Cancers Study Team; et al.

JAMA Netw Open. 2019 Jul 03;2(7):e197249. Epub 2019-07-03.

PubMed abstract