Risk of heart failure with preserved versus reduced ejection fraction in women with breast cancer
While clinical heart failure (HF) is recognized as an adverse effect from breast cancer (BC) treatment, sparse data exist on specific HF phenotypes in affected BC survivors. We examined risk of HF by left ventricular ejection fraction (LVEF) status in wom...
Author(s): Kwan ML; Cheng RK; Iribarren C; Shen H; Laurent CA; Roh JM; Hershman DL; Kushi LH; Greenlee H; Rana JS
Breast Cancer Res Treat. 2022 Apr 16.
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Risk of Cardiovascular Disease in Women With and Without Breast Cancer: The Pathways Heart Study
To examine cardiovascular disease (CVD) and mortality risk in women with breast cancer (BC) by cancer therapy received relative to women without BC. The study population comprised Kaiser Permanente Northern California members. Cases with invasive BC diagn...
Author(s): Greenlee H; Iribarren C; Nguyen-Huynh M; Kushi LH; Neugebauer R; Kwan ML; et al.
J Clin Oncol. 2022 Apr 06:JCO2101736.
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Associations between infant growth and pubertal onset timing in a multiethnic prospective cohort of girls
Early puberty increases risk of adverse health conditions throughout the life course. US girls are experiencing earlier puberty without clear reasons. Studies suggest early life factors, such as infant growth, may influence pubertal timing. We assessed th...
Author(s): Aghaee S; Quesenberry CP; Deardorff J; Kushi LH; Greenspan LC; Ferrara A; Kubo A
BMC Pediatr. 2022 Mar 31;22(1):171. Epub 2022-03-31.
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Declining Colectomy Rates for Nonmalignant Colorectal Polyps in a Large, Ethnically Diverse, Community-based Population
Author(s): Alam A; Corley DA; Lee JK; et al.
Clin Transl Gastroenterol. 2022 Mar 28.
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UACA locus is associated with breast cancer chemoresistance and survival
Few germline genetic variants have been robustly linked with breast cancer outcomes. We conducted trans-ethnic meta genome-wide association study (GWAS) of overall survival (OS) in 3973 breast cancer patients from the Pathways Study, one of the largest pr...
Author(s): Zhu Q; Kwan ML; Kushi LH; et al.
NPJ Breast Cancer. 2022 Mar 23;8(1):39. Epub 2022-03-23.
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Association between residential green cover and direct healthcare costs in Northern California: An individual level analysis of 5 million persons
Prior studies have shown higher green cover levels are associated with beneficial health outcomes. We sought to determine if residential green cover was also associated with direct healthcare costs. We linked residential Normalized Difference Vegetation I...
Author(s): Van Den Eeden SK; H E M Browning M; Becker DA; Shan J; Alexeeff SE; Thomas Ray G; Quesenberry CP; Kuo M
Environ Int. 2022 Mar 17;163:107174. Epub 2022-03-17.
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Comparison of Electronic Frailty Metrics for Prediction of Adverse Outcomes of Abdominal Surgery
Electronic frailty metrics have been developed for automated frailty assessment and include the Hospital Frailty Risk Score (HFRS), the Electronic Frailty Index (eFI), the 5-Factor Modified Frailty Index (mFI-5), and the Risk Analysis Index (RAI). Despite...
Author(s): Le ST; Liu VX; Kipnis P; Zhang J; Peng PD; Cespedes Feliciano EM
JAMA Surg. 2022 Mar 16:e220172.
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Association between Improved Colorectal Screening and Racial Disparities
Author(s): Doubeni CA; Corley DA; Zhao W; Lau Y; Jensen CD; Levin TR
N Engl J Med. 2022 02 24;386(8):796-798.
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Social Isolation and Incident Heart Failure Hospitalization in Older Women: Women's Health Initiative Study Findings
Background The association of social isolation or lack of social network ties in older adults is unknown. This knowledge gap is important since the risk of heart failure (HF) and social isolation increase with age. The study examines whether social isolat...
Author(s): Cené CW; Kroenke CH; et al.
J Am Heart Assoc. 2022 Feb 22:e022907.
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Ambient UVR and Environmental Arsenic Exposure in Relation to Cutaneous Melanoma in Iowa
Intermittent sun exposure is the major environmental risk factor for cutaneous melanoma (CM). Cumulative sun exposure and other environmental agents, such as environmental arsenic exposure, have not shown consistent associations. Ambient ultraviolet radia...
Author(s): Langston ME; Brown HE; Lynch CF; Roe DJ; Dennis LK
Int J Environ Res Public Health. 2022 02 03;19(3). Epub 2022-02-03.
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Quantifying cancer risk from exposures to medical imaging in the Risk of Pediatric and Adolescent Cancer Associated with Medical Imaging (RIC) Study: research methods and cohort profile
The Risk of Pediatric and Adolescent Cancer Associated with Medical Imaging (RIC) Study is quantifying the association between cumulative radiation exposure from fetal and/or childhood medical imaging and subsequent cancer risk. This manuscript describes ...
Author(s): Kwan ML; Kushi LH; Smith-Bindman R; et al.
Cancer Causes Control. 2022 Feb 02.
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Risk of Cardiometabolic Risk Factors in Women With and Without a History of Breast Cancer: The Pathways Heart Study
The incidence of cardiometabolic risk factors in breast cancer (BC) survivors has not been well described. Thus, we compared risk of hypertension, diabetes, and dyslipidemia in women with and without BC. Women with invasive BC diagnosed from 2005 to 2013 ...
Author(s): Kwan ML; Iribarren C; Neugebauer R; Nguyen-Huynh M; Kushi LH; Greenlee H; et al.
J Clin Oncol. 2022 Jan 13:JCO2101738.
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Diet- and Lifestyle-Based Prediction Models to Estimate Cancer Recurrence and Death in Patients With Stage III Colon Cancer (CALGB 89803/Alliance)
Current tools in predicting survival outcomes for patients with colon cancer predominantly rely on clinical and pathologic characteristics, but increasing evidence suggests that diet and lifestyle habits are associated with patient outcomes and should be ...
Author(s): Cheng E; Fuchs CS; et al.
J Clin Oncol. 2022 Jan 07:JCO2101784.
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Factors influencing genetic counseling and testing for hereditary breast and ovarian cancer syndrome in a large US health care system
Investigate whether disparities and other factors influence referral to genetic counseling and testing for hereditary breast and ovarian cancer syndrome (HBOC) in a large health care system. Examination of clinical, demographic, and socioeconomic factors ...
Author(s): Powell CB; Laurent C; Garcia C; Hoodfar E; Karlea A; Kobelka C; Lee J; Roh J; Kushi LH
Clin Genet. 2021 Dec 20.
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Neighborhood and Individual Socioeconomic Disadvantage and Survival Among Patients With Nonmetastatic Common Cancers
Disadvantaged neighborhood-level and individual-level socioeconomic status (SES) have each been associated with suboptimal cancer care and inferior outcomes. However, independent or synergistic associations between neighborhood and individual socioeconomi...
Author(s): Cheng E; Soulos PR; Irwin ML; Cespedes Feliciano EM; Presley CJ; Fuchs CS; Meyerhardt JA; Gross CP
JAMA Netw Open. 2021 12 01;4(12):e2139593. Epub 2021-12-01.
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TP53 Gain-of-Function and Non-Gain-of-Function Mutations Are Differentially Associated With Sidedness-Dependent Prognosis in Metastatic Colorectal Cancer
To examine the association of gain-of-function (GOF) and non-gain-of-function (non-GOF) TP53 mutations with prognosis of metastatic right-sided (RCC) versus left-sided colorectal cancer (LCC). This cohort study included patients with metastatic colorectal...
Author(s): Pan M; Alexeeff S; Habel LA; et al.
J Clin Oncol. 2021 Nov 29:JCO2102014.
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Survival Associated With Consolidated Multidisciplinary Care in Head and Neck Cancer: A Retrospective Cohort Study
To compare survival among patients with head and neck cancer before and after implementing a weekly multidisciplinary clinic and case conference. A retrospective cohort study with chart review was conducted of 3081 patients (1431 preimplementation, 1650 p...
Author(s): Meltzer C; Nguyen NT; Zhang J; Aguilar J; Blatchins MA; Quesenberry CP; Wang Y; Sakoda LC
Otolaryngol Head Neck Surg. 2021 Nov 09:1945998211057852.
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Scaling of computed tomography body composition to height: relevance of height-normalized indices in patients with colorectal cancer
Body weight scales to height with a power of ≈2 (weight/height2 ), forming the basis of body mass index (BMI). The corresponding scaling of body composition measured by abdominal computed tomography (CT) to height has not been established. The objective o...
Author(s): Brown JC; Heymsfield SB; Caan BJ
J Cachexia Sarcopenia Muscle. 2021 Nov 06.
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Description of Major Osteoporotic Fractures in Women with Invasive Breast Cancer Who Received Endocrine Therapy
Author(s): Lo JC; Laurent CA; Roh JM; Lee J; Chandra M; Yao S; Kwan ML
JAMA Netw Open. 2021 Nov 01;4(11):e2133861. Epub 2021-11-01.
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Systematic review with meta-analysis: the prevalence of post-colonoscopy colorectal cancers using the World Endoscopy Organization nomenclature
Post-colonoscopy colorectal cancers (PCCRCs) have been proposed as a performance metric for colonoscopy quality assurance programs. Previously, there was no standardised terminology or reporting methods. In 2018, the World Endoscopy Organization (WEO) adv...
Author(s): Kang JH; Evans N; Singh S; Samadder NJ; Lee JK
Aliment Pharmacol Ther. 2021 Sep 29.
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Plant-Based Dietary Patterns and Breast Cancer Recurrence and Survival in the Pathways Study
Plant-based diets are recommended for cancer survivors, but their relationship with breast cancer outcomes has not been examined. We evaluated whether long-term concordance with plant-based diets reduced the risk of recurrence and mortality among a prospe...
Author(s): Anyene IC; Ergas IJ; Kwan ML; Roh JM; Ambrosone CB; Kushi LH; Cespedes Feliciano EM
Nutrients. 2021 Sep 25;13(10). Epub 2021-09-25.
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Rising Early-Onset Colorectal Cancer Incidence is Not an Artifact of Increased Screening Colonoscopy Use in a Large, Diverse Healthcare System
Author(s): Lee JK; Merchant SA; Jensen CD; Murphy CC; Udaltsova N; Corley DA
Gastroenterology. 2021 Sep 20.
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Abdominal adipose tissue radiodensity is associated with survival after colorectal cancer
Adipose tissue radiodensity may have prognostic importance for colorectal cancer (CRC) survival. Lower radiodensity is indicative of larger adipocytes, while higher radiodensity may represent adipocyte atrophy, inflammation, or edema. We investigated asso...
Author(s): Feliciano EMC; Winkels RM; Meyerhardt JA; Prado CM; Afman LA; Caan BJ
Am J Clin Nutr. 2021 Sep 12.
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Individual- and neighborhood-level socioeconomic status and risk of aggressive breast cancer subtypes in a pooled cohort of women from Kaiser Permanente Northern California
Low socioeconomic status (SES) has been associated with a higher risk of aggressive breast cancer (BC) subtypes, but few studies have examined the independent effects of both neighborhood-level socioeconomic status (nSES) and individual-level SES measures...
Author(s): Aoki RF; Alexeeff SE; Caan BJ; Kushi LH; Kroenke CH; et al.
Cancer. 2021 Aug 20.
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The learning health system: the tools are here, why aren't we moving forward? Embedding researchers and delivery science for accelerating health care change
Author(s): Corley DA; Kilbourne A
Gastroenterology. 2021 Aug 09.
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