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Cancer Publications


Modifiable Failures in the Colorectal Cancer Screening Process and Their Association with Risk of Death

Colorectal cancer (CRC) deaths occur when patients do not receive screening or have inadequate follow up of abnormal results, or when the screening test itself fails. We have few data on the contribution of each to CRC-associated deaths or factors associa...
Author(s): Doubeni CA; Levin TR; Jensen CD; Corley DA; et al.

Gastroenterology. 2018 Sep 27.

PubMed abstract

Factors That Influence Selectionof Urinary Diversion Among Bladder Cancer Patients in 3 Community-based Integrated Health Care Systems.

OBJECTIVE: To assess the relative contributions of patient and surgeon factors for predicting selection of ileal conduit (IC), neobladder (NB), or continent pouch (CP) urinary diversions (UD) for patients diagn...
Author(s): Kwan, Marilyn L ML; Leo, Michael C MC; Danforth, Kim N KN; Weinmann, Sheila S; Lee, Valerie S VS; Munneke, Julie R JR; Bulkley, Joanna E JE; Rosetti, Maureen O'Keeffe MO; Yi, David K DK; Banegas, Matthew P MP; Wagner, Matthew D MD; Williams, Stephen G SG; Aaronson, David S DS; Grant, Marcia M; Krouse, Robert S RS; Gilbert, Scott M SM; McMullen, Carmit K CK

Urology. 2018 Nov 22;169(12):855-865. Epub 2018-11-22.

PubMed abstract

Associations of Intimate Partner Violence, Sexual Assault, and Posttraumatic Stress Disorder With Menopause Symptoms Among Midlife and Older Women

Little is known about the prevalence of traumatic exposures among midlife and older women and the association of these traumatic exposures with health issues. To examine the associations of intimate partner violence (IPV), sexual assault, and posttraumati...
Author(s): Gibson CJ; Huang AJ; McCaw B; Subak LL; Thom DH; Van Den Eeden SK

JAMA Intern Med. 2018 Nov 19.

PubMed abstract

Non-alcoholic fatty liver disease and colorectal cancer survival

Liver diseases including non-alcoholic fatty liver disease (NAFLD) and ensuing alterations to the micro-environment may affect development of liver metastasis. Mirroring the rise in obesity rates, prevalence of NAFLD is increasing globally. Our objective ...
Author(s): Wu K; Zhai MZ; Weltzien EK; Cespedes Feliciano EM; Meyerhardt JA; Giovannucci E; Caan BJ

Cancer Causes Control. 2018 Nov 15.

PubMed abstract

Examining the role of access to care: Racial/ethnic differences in receipt of resection for early-stage non-small cell lung cancer among integrated system members and non-members

To examine the role of uniform access to care in reducing racial/ethnic disparities in receipt of resection for early stage non-small cell lung cancer (NSCLC) by comparing integrated health system member patients to demographically similar non-member pati...
Author(s): Check DK; Albers KB; Uppal KM; Suga JM; Adams AS; Habel LA; Quesenberry CP; Sakoda LC

Lung Cancer. 2018 Nov;125:51-56. Epub 2018-09-11.

PubMed abstract

Perioperative Intravesical Chemotherapy for Patients with Non-Muscle Invasive Bladder Cancer: Understanding the Extent of and Sources of Variation in Guideline-Recommended Use

To examine intravesical chemotherapy (IVC) use according to non-muscle invasive bladder cancer (NMIBC) patient disease risk, and the contributions of multi-level factors to variation in proficient use among patients with low-intermediate disease. This stu...
Author(s): Check DK; Aaronson DS; Nielsen ME; Lee VS; Ergas IJ; Roh JM; Kushi LH; Tang L; Kwan ML

Urology. 2018 Oct 22.

PubMed abstract

Patterns of medication adherence in a multi-ethnic cohort of prevalent statin users diagnosed with breast, prostate, or colorectal cancer

To investigate the implications of a cancer diagnosis on medication adherence for pre-existing comorbid conditions, we explored statin adherence patterns prior to and following a new diagnosis of breast, colorectal, or prostate cancer among a multi-ethnic...
Author(s): Banegas MP; Emerson MA; Adams AS; Achacoso NS; Chawla N; Alexeeff S; Habel LA

J Cancer Surviv. 2018 Oct 18.

PubMed abstract

Genetic variation in the SIM1 locus is associated with erectile dysfunction

Erectile dysfunction affects millions of men worldwide. Twin studies support the role of genetic risk factors underlying erectile dysfunction, but no specific genetic variants have been identified. We conducted a large-scale genome-wide association study ...
Author(s): Jorgenson E; Yin J; Shan J; Hoffmann TJ; Thai KK; Van Den Eeden SK; et al.

Proc Natl Acad Sci USA. 2018 Oct 23;115(43):11018-11023. Epub 2018-10-08.

PubMed abstract

In Screening for Colorectal Cancer, Is the FIT Right for the Right Side of the Colon?

Author(s): Doubeni CA; Levin TR

Ann Intern Med. 2018 Oct 02.

PubMed abstract

Negative withdrawal time: simple and efficient

Author(s): Kidambi TD; Terdiman JP; Lee JK

Gastrointest Endosc. 2018 Oct;88(4):781.

PubMed abstract

Influence of Varying Quantitative Fecal Immunochemical Test Positivity Thresholds on Colorectal Cancer Detection: A Community-Based Cohort Study

The fecal immunochemical test (FIT) is commonly used for colorectal cancer (CRC) screening. Despite demographic variations in stool hemoglobin concentrations, few data exist regarding optimal positivity thresholds by age and sex. To identify programmatic ...
Author(s): Selby K; Jensen CD; Lee JK; Doubeni CA; Schottinger JE; Zhao WK; Chubak J; Halm E; Ghai NR; Contreras R; Skinner C; Kamineni A; Levin TR; Corley DA

Ann Intern Med. 2018 Sep 18.

PubMed abstract

Index colonoscopy-related risk factors for postcolonoscopy colorectal cancers.

BACKGROUND AND AIMS: Postcolonoscopy colorectal cancers (PCCRCs) are those detected ≤10 years after an index colonoscopy negative for cancer, but modifiable risk factors are not well established in large, community-based population...
Author(s): Tollivoro, Theodore A TA; Jensen, Christopher D CD; Marks, Amy R AR; Zhao, Wei K WK; Schottinger, Joanne E JE; Quinn, Virginia P VP; Ghai, Nirupa R NR; Zauber, Ann G AG; Doubeni, Chyke A CA; Levin, Theodore R TR; Fireman, Bruce B; Quesenberry, Charles P CP; Corley, Douglas A DA

Gastrointestinal endoscopy. 2018 Aug 22;():. Epub 2018-08-22.

PubMed abstract

Screening for low muscularity in colorectal cancer patients: a valid, clinic-friendly approach that predicts mortality

Low skeletal muscle quantified using computed tomography (CT) scans is associated with morbidity and mortality among cancer patients. However, existing methods to assess skeletal muscle from CT are time-consuming, expensive, and require training. Clinic-f...
Author(s): Cespedes Feliciano EM; Avrutin E; Caan BJ; Boroian A; Mourtzakis M

J Cachexia Sarcopenia Muscle. 2018 Jul 31.

PubMed abstract

Effects of Organized Colorectal Cancer Screening on Cancer Incidence and Mortality in a Large, Community-based Population.

BACKGROUND & AIMS: Little information is available on the effectiveness of organized colorectal cancer (CRC) screening on screening uptake, incidence, and mortality in community-based populations.

Author(s): Levin, Theodore R TR; Corley, Douglas A DA; Jensen, Christopher D CD; Schottinger, Joanne E JE; Quinn, Virginia P VP; Zauber, Ann G AG; Lee, Jeffrey K JK; Zhao, Wei K WK; Udaltsova, Natalia N; Ghai, Nirupa R NR; Lee, Alexander T AT; Quesenberry, Charles P CP; Fireman, Bruce H BH; Doubeni, Chyke A CA

Gastroenterology. 2018 Jul 19;():. Epub 2018-07-19.

PubMed abstract

A conceptual model of social networks and mechanisms of cancer mortality, and potential strategies to improve survival

Women with larger personal social networks have better breast cancer survival and a lower risk of mortality. However, little work has examined the mechanisms through which social networks influence breast cancer outcomes and cancer outcomes more generally...
Author(s): Kroenke CH

Transl Behav Med. 2018 Jul 17;8(4):629-642.

PubMed abstract

Effect of I-scan Electronic Chromoendoscopy on Detection of Adenomas During Colonoscopy.

BACKGROUND & AIMS: I-scan is an electronic chromoendoscopy technology that improves resolution of epithelial and mucosal surfaces and vessels. We performed a randomized controlled trial to compare detection of adenomas by i-sca...
Author(s): Kidambi, Trilokesh D TD; Terdiman, Jonathan P JP; El-Nachef, Najwa N; Singh, Aparajita A; Kattah, Michael G MG; Lee, Jeffrey K JK

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2018 Jun 20;():. Epub 2018-06-20.

PubMed abstract

Objective Sleep Characteristics and Cardiometabolic Health in Young Adolescents

Shorter sleep duration is associated with childhood obesity. Few studies measure sleep quantity and quality objectively or examine cardiometabolic biomarkers other than obesity. This cross-sectional study of 829 adolescents derived sleep duration, efficie...
Author(s): Cespedes Feliciano EM; Quante M; Rifas-Shiman SL; Redline S; Oken E; Taveras EM

Pediatrics. 2018 Jun 15.

PubMed abstract

Clinical implications of low skeletal muscle mass in early-stage breast and colorectal cancer

Although obesity has now been widely accepted to be an important risk factor for cancer survival, the associations between BMI and cancer mortality have not been consistently linear. Although morbid obesity has clearly been associated with worse survival,...
Author(s): Cespedes Feliciano E; Chen WY

Proc Nutr Soc. 2018 Jun 04:1-6.

PubMed abstract

Muscle radiodensity and mortality in patients with colorectal cancer

Low skeletal muscle radiodensity (SMD) is related to higher mortality in several cancers, but the association with colorectal cancer (CRC) prognosis is unclear. This observational study included 3262 men and women from the Kaiser Permanente Northern Calif...
Author(s): Kroenke CH; Prado CM; Meyerhardt JA; Weltzien EK; Xiao J; Cespedes Feliciano EM; Caan BJ

Cancer. 2018 May 24.

PubMed abstract

Novel variant of unknown significance in MUTYH in a patient with MUTYH-associated polyposis: a case to reclassify.

MUTYH-associated polyposis (MAP) is a hereditary cancer syndrome that is caused by biallelic pathogenic variants in the MUTYH gene and should be evaluated for in patients with an attenuated colonic polyposis phenotype. Monoallelic pathogenic variants i...
Author(s): Kidambi, Trilokesh D TD; Goldberg, Dena D; Nussbaum, Robert R; Blanco, Amie A; Umetsu, Sarah E SE; Terdiman, Jonathan P JP; Lee, Jeffrey K JK

Clinical journal of gastroenterology. 2018 May 15;():. Epub 2018-05-15.

PubMed abstract

The Obesity Paradox in Cancer: How Important Is Muscle?

Although higher body mass index (BMI) increases cancer incidence, it is associated with improved survival among patients with existing disease; thus, the relationship of BMI with mortality in cancer patients is often U-shaped, which is termed the obesity ...
Author(s): Cespedes Feliciano EM; Kroenke CH; Caan BJ

Annu Rev Nutr. 2018 May 04.

PubMed abstract

A Cohort Study of Metformin and Colorectal Cancer Risk among Patients with Diabetes Mellitus

Background: Several epidemiologic studies have reported strong inverse associations between metformin use and risk of colorectal cancer, although time-related biases, such as immortal time bias, may in part explain these findings. We reexamined this a...
Author(s): Bradley MC; Ferrara A; Achacoso N; Ehrlich SF; Quesenberry CP; Habel LA

Cancer Epidemiol Biomarkers Prev. 2018 May;27(5):525-530.

PubMed abstract

Lifestyle and nutritional modifiable factors in the prevention and treatment of bladder cancer

Bladder cancer is one of the top 5 most common cancers diagnosed in the U.S. It is also one of the most expensive cancers to treat through the life course given its high rate of recurrence. While cigarette smoking and occupational exposures have been firm...
Author(s): Kwan ML; Garren B; Nielsen ME; Tang L

Urol Oncol. 2018 Apr 24.

PubMed abstract

Personal and clinical social support and adherence to adjuvant endocrine therapy among hormone receptor-positive breast cancer patients in an integrated health care system

We evaluated associations between personal and clinical social support and non-adherence to adjuvant endocrine therapy (AET) in a large, Northern California breast cancer (BC) cohort from an integrated healthcare network. This study included 3382 women fr...
Author(s): Kroenke CH; Hershman DL; Gomez SL; Adams SR; Eldridge EH; Kwan ML; Ergas IJ; Kubo A; Kushi LH

Breast Cancer Res Treat. 2018 Apr 18.

PubMed abstract

The Importance of Body Composition in Explaining the Overweight Paradox in Cancer-Counterpoint

Despite a greater risk of cancer associated with higher BMI, overweight (BMI 25-
Author(s): Caan BJ; Cespedes Feliciano EM; Kroenke CH

Cancer Res. 2018 Apr 15;78(8):1906-1912.

PubMed abstract