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Cancer Publications


Adipose tissue radiodensity and mortality among patients with nonmetastatic breast cancer.

BACKGROUND & AIMS: Computed tomography (CT) scans can measure quantity and distribution of adipose tissue, which are associated with breast cancer prognosis. As a novel prognostic marker, radiodensity of adipose tissue has been examined in multiple cancer...
Author(s): Cheng, En; Caan, Bette J; Chen, Wendy Y; Irwin, Melinda L; Prado, Carla M; Cespedes Feliciano, Elizabeth M

Clin Nutr. 2022 Oct 4;41(12):2607-2613. doi: 10.1016/j.clnu.2022.09.016.

PubMed abstract

Adiposity and cancer survival: a systematic review and meta-analysis.

PURPOSE: The increasing availability of clinical imaging tests (especially CT and MRI) that directly quantify adipose tissue has led to a rapid increase in studies examining the relationship of visceral, subcutaneous, and overall adiposity to cancer survi...
Author(s): Cheng, En; Kirley, Jocelyn; Cespedes Feliciano, Elizabeth M; Caan, Bette J

Cancer Causes Control. 2022 Oct;33(10):1219-1246. doi: 10.1007/s10552-022-01613-7. Epub 2022 Aug 15.

PubMed abstract

Risk of heart failure with preserved versus reduced ejection fraction in women with breast cancer

While clinical heart failure (HF) is recognized as an adverse effect from breast cancer (BC) treatment, sparse data exist on specific HF phenotypes in affected BC survivors. We examined risk of HF by left ventricular ejection fraction (LVEF) status in wom...
Author(s): Kwan ML; Cheng RK; Iribarren C; Shen H; Laurent CA; Roh JM; Hershman DL; Kushi LH; Greenlee H; Rana JS

Breast Cancer Res Treat. 2022 Apr 16.

PubMed abstract

Risk of Cardiovascular Disease in Women With and Without Breast Cancer: The Pathways Heart Study

To examine cardiovascular disease (CVD) and mortality risk in women with breast cancer (BC) by cancer therapy received relative to women without BC. The study population comprised Kaiser Permanente Northern California members. Cases with invasive BC diagn...
Author(s): Greenlee H; Iribarren C; Nguyen-Huynh M; Kushi LH; Neugebauer R; Kwan ML; et al.

J Clin Oncol. 2022 Apr 06:JCO2101736.

PubMed abstract

Associations between infant growth and pubertal onset timing in a multiethnic prospective cohort of girls

Early puberty increases risk of adverse health conditions throughout the life course. US girls are experiencing earlier puberty without clear reasons. Studies suggest early life factors, such as infant growth, may influence pubertal timing. We assessed th...
Author(s): Aghaee S; Quesenberry CP; Deardorff J; Kushi LH; Greenspan LC; Ferrara A; Kubo A

BMC Pediatr. 2022 Mar 31;22(1):171. Epub 2022-03-31.

PubMed abstract

Declining Colectomy Rates for Nonmalignant Colorectal Polyps in a Large, Ethnically Diverse, Community-based Population

Author(s): Alam A; Corley DA; Lee JK; et al.

Clin Transl Gastroenterol. 2022 Mar 28.

PubMed abstract

UACA locus is associated with breast cancer chemoresistance and survival.

Few germline genetic variants have been robustly linked with breast cancer outcomes. We conducted trans-ethnic meta genome-wide association study (GWAS) of overall survival (OS) in 3973 breast cancer patients from the Pathways Study, one of the largest pr...
Author(s): Zhu, Qianqian; Schultz, Emily; Long, Jirong; Roh, Janise M; Valice, Emily; Laurent, Cecile A; Radimer, Kelly H; Yan, Li; Ergas, Isaac J; Davis, Warren; Ranatunga, Dilrini; Gandhi, Shipra; Kwan, Marilyn L; Bao, Ping-Ping; Zheng, Wei; Shu, Xiao-Ou; Ambrosone, Christine; Yao, Song; Kushi, Lawrence H

NPJ Breast Cancer. 2022 Mar 23;8(1):39. doi: 10.1038/s41523-022-00401-5.

PubMed abstract

Association between residential green cover and direct healthcare costs in Northern California: An individual level analysis of 5 million persons

Prior studies have shown higher green cover levels are associated with beneficial health outcomes. We sought to determine if residential green cover was also associated with direct healthcare costs. We linked residential Normalized Difference Vegetation I...
Author(s): Van Den Eeden SK; H E M Browning M; Becker DA; Shan J; Alexeeff SE; Thomas Ray G; Quesenberry CP; Kuo M

Environ Int. 2022 Mar 17;163:107174. Epub 2022-03-17.

PubMed abstract

Comparison of Electronic Frailty Metrics for Prediction of Adverse Outcomes of Abdominal Surgery

Electronic frailty metrics have been developed for automated frailty assessment and include the Hospital Frailty Risk Score (HFRS), the Electronic Frailty Index (eFI), the 5-Factor Modified Frailty Index (mFI-5), and the Risk Analysis Index (RAI). Despite...
Author(s): Le ST; Liu VX; Kipnis P; Zhang J; Peng PD; Cespedes Feliciano EM

JAMA Surg. 2022 Mar 16:e220172.

PubMed abstract

Long-Term Survival and Causes of Death After Diagnoses of Common Cancers in 3 Cohorts of US Health Professionals.

BACKGROUND: Few studies investigated long-term overall survival and causes of death among men and women diagnosed with most commonly occurring cancers. METHODS: We estimated long-term (>/=30-year) overall and cause-specific cumulative mortality for men di...
Author(s): Cheng, En; Lee, Dong Hoon; Tamimi, Rulla M; Hankinson, Susan E; Willett, Walter C; Giovannucci, Edward L; Eliassen, A Heather; Stampfer, Meir J; Mucci, Lorelei A; Fuchs, Charles S; Spiegelman, Donna

JNCI Cancer Spectr. 2022 Mar 2;6(2). pii: 6544595. doi: 10.1093/jncics/pkac021.

PubMed abstract

Association between Improved Colorectal Screening and Racial Disparities

Author(s): Doubeni CA; Corley DA; Zhao W; Lau Y; Jensen CD; Levin TR

N Engl J Med. 2022 02 24;386(8):796-798.

PubMed abstract

Social Isolation and Incident Heart Failure Hospitalization in Older Women: Women's Health Initiative Study Findings

Background The association of social isolation or lack of social network ties in older adults is unknown. This knowledge gap is important since the risk of heart failure (HF) and social isolation increase with age. The study examines whether social isolat...
Author(s): Cené CW; Kroenke CH; et al.

J Am Heart Assoc. 2022 Feb 22:e022907.

PubMed abstract

Quantifying cancer risk from exposures to medical imaging in the Risk of Pediatric and Adolescent Cancer Associated with Medical Imaging (RIC) Study: research methods and cohort profile

The Risk of Pediatric and Adolescent Cancer Associated with Medical Imaging (RIC) Study is quantifying the association between cumulative radiation exposure from fetal and/or childhood medical imaging and subsequent cancer risk. This manuscript describes ...
Author(s): Kwan ML; Kushi LH; Smith-Bindman R; et al.

Cancer Causes Control. 2022 Feb 02.

PubMed abstract

Risk of Cardiometabolic Risk Factors in Women With and Without a History of Breast Cancer: The Pathways Heart Study

The incidence of cardiometabolic risk factors in breast cancer (BC) survivors has not been well described. Thus, we compared risk of hypertension, diabetes, and dyslipidemia in women with and without BC. Women with invasive BC diagnosed from 2005 to 2013 ...
Author(s): Kwan ML; Iribarren C; Neugebauer R; Nguyen-Huynh M; Kushi LH; Greenlee H; et al.

J Clin Oncol. 2022 Jan 13:JCO2101738.

PubMed abstract

Diet- and Lifestyle-Based Prediction Models to Estimate Cancer Recurrence and Death in Patients With Stage III Colon Cancer (CALGB 89803/Alliance)

Current tools in predicting survival outcomes for patients with colon cancer predominantly rely on clinical and pathologic characteristics, but increasing evidence suggests that diet and lifestyle habits are associated with patient outcomes and should be ...
Author(s): Cheng E; Fuchs CS; et al.

J Clin Oncol. 2022 Jan 07:JCO2101784.

PubMed abstract

Factors influencing genetic counseling and testing for hereditary breast and ovarian cancer syndrome in a large US health care system

Investigate whether disparities and other factors influence referral to genetic counseling and testing for hereditary breast and ovarian cancer syndrome (HBOC) in a large health care system. Examination of clinical, demographic, and socioeconomic factors ...
Author(s): Powell CB; Laurent C; Garcia C; Hoodfar E; Karlea A; Kobelka C; Lee J; Roh J; Kushi LH

Clin Genet. 2021 Dec 20.

PubMed abstract

Neighborhood and Individual Socioeconomic Disadvantage and Survival Among Patients With Nonmetastatic Common Cancers

Disadvantaged neighborhood-level and individual-level socioeconomic status (SES) have each been associated with suboptimal cancer care and inferior outcomes. However, independent or synergistic associations between neighborhood and individual socioeconomi...
Author(s): Cheng E; Soulos PR; Irwin ML; Cespedes Feliciano EM; Presley CJ; Fuchs CS; Meyerhardt JA; Gross CP

JAMA Netw Open. 2021 12 01;4(12):e2139593. Epub 2021-12-01.

PubMed abstract

TP53 Gain-of-Function and Non-Gain-of-Function Mutations Are Differentially Associated With Sidedness-Dependent Prognosis in Metastatic Colorectal Cancer

To examine the association of gain-of-function (GOF) and non-gain-of-function (non-GOF) TP53 mutations with prognosis of metastatic right-sided (RCC) versus left-sided colorectal cancer (LCC). This cohort study included patients with metastatic colorectal...
Author(s): Pan M; Alexeeff S; Habel LA; et al.

J Clin Oncol. 2021 Nov 29:JCO2102014.

PubMed abstract

Survival Associated With Consolidated Multidisciplinary Care in Head and Neck Cancer: A Retrospective Cohort Study

To compare survival among patients with head and neck cancer before and after implementing a weekly multidisciplinary clinic and case conference. A retrospective cohort study with chart review was conducted of 3081 patients (1431 preimplementation, 1650 p...
Author(s): Meltzer C; Nguyen NT; Zhang J; Aguilar J; Blatchins MA; Quesenberry CP; Wang Y; Sakoda LC

Otolaryngol Head Neck Surg. 2021 Nov 09:1945998211057852.

PubMed abstract

Scaling of computed tomography body composition to height: relevance of height-normalized indices in patients with colorectal cancer

Body weight scales to height with a power of ≈2 (weight/height2 ), forming the basis of body mass index (BMI). The corresponding scaling of body composition measured by abdominal computed tomography (CT) to height has not been established. The objective o...
Author(s): Brown JC; Heymsfield SB; Caan BJ

J Cachexia Sarcopenia Muscle. 2021 Nov 06.

PubMed abstract

Description of Major Osteoporotic Fractures in Women with Invasive Breast Cancer Who Received Endocrine Therapy

Author(s): Lo JC; Laurent CA; Roh JM; Lee J; Chandra M; Yao S; Kwan ML

JAMA Netw Open. 2021 Nov 01;4(11):e2133861. Epub 2021-11-01.

PubMed abstract

Systematic review with meta-analysis: the prevalence of post-colonoscopy colorectal cancers using the World Endoscopy Organization nomenclature

Post-colonoscopy colorectal cancers (PCCRCs) have been proposed as a performance metric for colonoscopy quality assurance programs. Previously, there was no standardised terminology or reporting methods. In 2018, the World Endoscopy Organization (WEO) adv...
Author(s): Kang JH; Evans N; Singh S; Samadder NJ; Lee JK

Aliment Pharmacol Ther. 2021 Sep 29.

PubMed abstract

Plant-Based Dietary Patterns and Breast Cancer Recurrence and Survival in the Pathways Study.

Plant-based diets are recommended for cancer survivors, but their relationship with breast cancer outcomes has not been examined. We evaluated whether long-term concordance with plant-based diets reduced the risk of recurrence and mortality among a prospe...
Author(s): Anyene, Ijeamaka C; Ergas, Isaac J; Kwan, Marilyn L; Roh, Janise M; Ambrosone, Christine B; Kushi, Lawrence H; Cespedes Feliciano, Elizabeth M

Nutrients. 2021 Sep 25;13(10):3374. doi: 10.3390/nu13103374.

PubMed abstract

Rising Early-Onset Colorectal Cancer Incidence is Not an Artifact of Increased Screening Colonoscopy Use in a Large, Diverse Healthcare System

Author(s): Lee JK; Merchant SA; Jensen CD; Murphy CC; Udaltsova N; Corley DA

Gastroenterology. 2021 Sep 20.

PubMed abstract

Abdominal adipose tissue radiodensity is associated with survival after colorectal cancer

Adipose tissue radiodensity may have prognostic importance for colorectal cancer (CRC) survival. Lower radiodensity is indicative of larger adipocytes, while higher radiodensity may represent adipocyte atrophy, inflammation, or edema. We investigated asso...
Author(s): Feliciano EMC; Winkels RM; Meyerhardt JA; Prado CM; Afman LA; Caan BJ

Am J Clin Nutr. 2021 Sep 12.

PubMed abstract