The Be-Well Study: a prospective cohort study of lifestyle and genetic factors to reduce the risk of recurrence and progression of non-muscle-invasive bladder cancer.
PURPOSE: Bladder cancer is one of the top five cancers diagnosed in the U.S. with a high recurrence rate, and also one of the most expensive cancers to treat over the life-course. However, there are few observational, pros...
Author(s): Kwan, Marilyn L ML; Kushi, Lawrence H LH; Danforth, Kim N KN; Roh, Janise M JM; Ergas, Isaac J IJ; Lee, Valerie S VS; Cannavale, Kimberly L KL; Harrison, Teresa N TN; Contreras, Richard R; Loo, Ronald K RK; Aaronson, David S DS; Quesenberry, Charles P CP; Tritchler, David D; Ghai, Nirupa R NR; Quinn, Virginia P VP; Ambrosone, Christine B CB; Zhang, Yuesheng Y; Tang, Li L
Cancer causes & control : CCC. 2019 Feb ;30(2):187-193. Epub 2019-01-17.
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Long-term Risk of Colorectal Cancer and Related Deaths After a Colonoscopy With Normal Findings
Guidelines recommend a 10-year rescreening interval after a colonoscopy with normal findings (negative colonoscopy results), but evidence supporting this recommendation is limited. To examine the long-term risks of colorectal cancer and colorectal cancer ...
Author(s): Lee JK; Jensen CD; Levin TR; Udaltsova N; Zhao WK; Fireman BH; Quesenberry CP; Corley DA; et al.
JAMA Intern Med. 2018 Dec 17.
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The evolution of body composition in oncology-epidemiology, clinical trials, and the future of patient care: facts and numbers
There is growing interest from the oncology community to understand how body composition measures can be used to improve the delivery of clinical care for the 18.1 million individuals diagnosed with cancer annually. Methods that distinguish muscle from su...
Author(s): Brown JC; Cespedes Feliciano EM; Caan BJ
J Cachexia Sarcopenia Muscle. 2018 Dec;9(7):1200-1208. Epub 2019-01-13.
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Opportunities to Improve Detection and Treatment of Depression among Patients with Breast Cancer Treated in an Integrated Delivery System
Patients with cancer commonly experience depression. If not addressed, depression can lead to reduced quality of life and survival. Given the introduction of national initiatives to improve management of psychiatric symptoms among patients with cancer, we...
Author(s): Check DK; Kwan ML; Chawla N; Dusetzina SB; Valice E; Ergas IJ; Roh JM; Kolevska T; Rosenstein DL; Kushi LH
J Pain Symptom Manage. 2018 Nov 30.
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Modifiable Failures in the Colorectal Cancer Screening Process and Their Association with Risk of Death
Colorectal cancer (CRC) deaths occur when patients do not receive screening or have inadequate follow up of abnormal results, or when the screening test itself fails. We have few data on the contribution of each to CRC-associated deaths or factors associa...
Author(s): Doubeni CA; Levin TR; Jensen CD; Corley DA; et al.
Gastroenterology. 2018 Sep 27.
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Factors That Influence Selectionof Urinary Diversion Among Bladder Cancer Patients in 3 Community-based Integrated Health Care Systems.
OBJECTIVE: To assess the relative contributions of patient and surgeon factors for predicting selection of ileal conduit (IC), neobladder (NB), or continent pouch (CP) urinary diversions (UD) for patients diagn...
Author(s): Kwan, Marilyn L ML; Leo, Michael C MC; Danforth, Kim N KN; Weinmann, Sheila S; Lee, Valerie S VS; Munneke, Julie R JR; Bulkley, Joanna E JE; Rosetti, Maureen O'Keeffe MO; Yi, David K DK; Banegas, Matthew P MP; Wagner, Matthew D MD; Williams, Stephen G SG; Aaronson, David S DS; Grant, Marcia M; Krouse, Robert S RS; Gilbert, Scott M SM; McMullen, Carmit K CK
Urology. 2018 Nov 22;169(12):855-865. Epub 2018-11-22.
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Associations of Intimate Partner Violence, Sexual Assault, and Posttraumatic Stress Disorder With Menopause Symptoms Among Midlife and Older Women
Little is known about the prevalence of traumatic exposures among midlife and older women and the association of these traumatic exposures with health issues. To examine the associations of intimate partner violence (IPV), sexual assault, and posttraumati...
Author(s): Gibson CJ; Huang AJ; McCaw B; Subak LL; Thom DH; Van Den Eeden SK
JAMA Intern Med. 2018 Nov 19.
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Non-alcoholic fatty liver disease and colorectal cancer survival
Liver diseases including non-alcoholic fatty liver disease (NAFLD) and ensuing alterations to the micro-environment may affect development of liver metastasis. Mirroring the rise in obesity rates, prevalence of NAFLD is increasing globally. Our objective ...
Author(s): Wu K; Zhai MZ; Weltzien EK; Cespedes Feliciano EM; Meyerhardt JA; Giovannucci E; Caan BJ
Cancer Causes Control. 2018 Nov 15.
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Examining the role of access to care: Racial/ethnic differences in receipt of resection for early-stage non-small cell lung cancer among integrated system members and non-members
To examine the role of uniform access to care in reducing racial/ethnic disparities in receipt of resection for early stage non-small cell lung cancer (NSCLC) by comparing integrated health system member patients to demographically similar non-member pati...
Author(s): Check DK; Albers KB; Uppal KM; Suga JM; Adams AS; Habel LA; Quesenberry CP; Sakoda LC
Lung Cancer. 2018 Nov;125:51-56. Epub 2018-09-11.
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Diet-related inflammation and risk of prostate cancer in the California Men's Health Study
The purpose of the study was to examine the relationship between proinflammatory diet and prostate cancer risk. Energy-adjusted Dietary Inflammatory Index (E-DII) scores were computed among 40,161 participants in the California Men's Health Study. Over 9....
Author(s): McMahon DM; Burch JB; Hébert JR; Hardin JW; Zhang J; Wirth MD; Youngstedt SD; Shivappa N; Jacobsen SJ; Caan B; Van Den Eeden SK
Ann Epidemiol. 2018 Nov 02.
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Perioperative Intravesical Chemotherapy for Patients with Non-Muscle Invasive Bladder Cancer: Understanding the Extent of and Sources of Variation in Guideline-Recommended Use
To examine intravesical chemotherapy (IVC) use according to non-muscle invasive bladder cancer (NMIBC) patient disease risk, and the contributions of multi-level factors to variation in proficient use among patients with low-intermediate disease. This stu...
Author(s): Check DK; Aaronson DS; Nielsen ME; Lee VS; Ergas IJ; Roh JM; Kushi LH; Tang L; Kwan ML
Urology. 2018 Oct 22.
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Patterns of medication adherence in a multi-ethnic cohort of prevalent statin users diagnosed with breast, prostate, or colorectal cancer
To investigate the implications of a cancer diagnosis on medication adherence for pre-existing comorbid conditions, we explored statin adherence patterns prior to and following a new diagnosis of breast, colorectal, or prostate cancer among a multi-ethnic...
Author(s): Banegas MP; Emerson MA; Adams AS; Achacoso NS; Chawla N; Alexeeff S; Habel LA
J Cancer Surviv. 2018 Oct 18.
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Genetic variation in the SIM1 locus is associated with erectile dysfunction
Erectile dysfunction affects millions of men worldwide. Twin studies support the role of genetic risk factors underlying erectile dysfunction, but no specific genetic variants have been identified. We conducted a large-scale genome-wide association study ...
Author(s): Jorgenson E; Yin J; Shan J; Hoffmann TJ; Thai KK; Van Den Eeden SK; et al.
Proc Natl Acad Sci USA. 2018 Oct 23;115(43):11018-11023. Epub 2018-10-08.
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In Screening for Colorectal Cancer, Is the FIT Right for the Right Side of the Colon?
Author(s): Doubeni CA; Levin TR
Ann Intern Med. 2018 Oct 02.
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Negative withdrawal time: simple and efficient
Author(s): Kidambi TD; Terdiman JP; Lee JK
Gastrointest Endosc. 2018 Oct;88(4):781.
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Influence of Varying Quantitative Fecal Immunochemical Test Positivity Thresholds on Colorectal Cancer Detection: A Community-Based Cohort Study
The fecal immunochemical test (FIT) is commonly used for colorectal cancer (CRC) screening. Despite demographic variations in stool hemoglobin concentrations, few data exist regarding optimal positivity thresholds by age and sex. To identify programmatic ...
Author(s): Selby K; Jensen CD; Lee JK; Doubeni CA; Schottinger JE; Zhao WK; Chubak J; Halm E; Ghai NR; Contreras R; Skinner C; Kamineni A; Levin TR; Corley DA
Ann Intern Med. 2018 Sep 18.
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Index colonoscopy-related risk factors for postcolonoscopy colorectal cancers.
BACKGROUND AND AIMS: Postcolonoscopy colorectal cancers (PCCRCs) are those detected ≤10 years after an index colonoscopy negative for cancer, but modifiable risk factors are not well established in large, community-based population...
Author(s): Tollivoro, Theodore A TA; Jensen, Christopher D CD; Marks, Amy R AR; Zhao, Wei K WK; Schottinger, Joanne E JE; Quinn, Virginia P VP; Ghai, Nirupa R NR; Zauber, Ann G AG; Doubeni, Chyke A CA; Levin, Theodore R TR; Fireman, Bruce B; Quesenberry, Charles P CP; Corley, Douglas A DA
Gastrointestinal endoscopy. 2018 Aug 22;():. Epub 2018-08-22.
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Screening for low muscularity in colorectal cancer patients: a valid, clinic-friendly approach that predicts mortality
Low skeletal muscle quantified using computed tomography (CT) scans is associated with morbidity and mortality among cancer patients. However, existing methods to assess skeletal muscle from CT are time-consuming, expensive, and require training. Clinic-f...
Author(s): Cespedes Feliciano EM; Avrutin E; Caan BJ; Boroian A; Mourtzakis M
J Cachexia Sarcopenia Muscle. 2018 Jul 31.
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Effects of Organized Colorectal Cancer Screening on Cancer Incidence and Mortality in a Large, Community-based Population.
BACKGROUND & AIMS: Little information is available on the effectiveness of organized colorectal cancer (CRC) screening on screening uptake, incidence, and mortality in community-based populations. METHODS...
Author(s): Levin, Theodore R TR; Corley, Douglas A DA; Jensen, Christopher D CD; Schottinger, Joanne E JE; Quinn, Virginia P VP; Zauber, Ann G AG; Lee, Jeffrey K JK; Zhao, Wei K WK; Udaltsova, Natalia N; Ghai, Nirupa R NR; Lee, Alexander T AT; Quesenberry, Charles P CP; Fireman, Bruce H BH; Doubeni, Chyke A CA
Gastroenterology. 2018 Jul 19;():. Epub 2018-07-19.
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A conceptual model of social networks and mechanisms of cancer mortality, and potential strategies to improve survival
Women with larger personal social networks have better breast cancer survival and a lower risk of mortality. However, little work has examined the mechanisms through which social networks influence breast cancer outcomes and cancer outcomes more generally...
Author(s): Kroenke CH
Transl Behav Med. 2018 Jul 17;8(4):629-642.
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Effect of I-scan Electronic Chromoendoscopy on Detection of Adenomas During Colonoscopy.
BACKGROUND & AIMS: I-scan is an electronic chromoendoscopy technology that improves resolution of epithelial and mucosal surfaces and vessels. We performed a randomized controlled trial to compare detection of adenomas by i-sca...
Author(s): Kidambi, Trilokesh D TD; Terdiman, Jonathan P JP; El-Nachef, Najwa N; Singh, Aparajita A; Kattah, Michael G MG; Lee, Jeffrey K JK
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2018 Jun 20;():. Epub 2018-06-20.
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Objective Sleep Characteristics and Cardiometabolic Health in Young Adolescents
Shorter sleep duration is associated with childhood obesity. Few studies measure sleep quantity and quality objectively or examine cardiometabolic biomarkers other than obesity. This cross-sectional study of 829 adolescents derived sleep duration, efficie...
Author(s): Cespedes Feliciano EM; Quante M; Rifas-Shiman SL; Redline S; Oken E; Taveras EM
Pediatrics. 2018 Jun 15.
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Clinical implications of low skeletal muscle mass in early-stage breast and colorectal cancer
Although obesity has now been widely accepted to be an important risk factor for cancer survival, the associations between BMI and cancer mortality have not been consistently linear. Although morbid obesity has clearly been associated with worse survival,...
Author(s): Cespedes Feliciano E; Chen WY
Proc Nutr Soc. 2018 Jun 04:1-6.
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Muscle radiodensity and mortality in patients with colorectal cancer
Low skeletal muscle radiodensity (SMD) is related to higher mortality in several cancers, but the association with colorectal cancer (CRC) prognosis is unclear. This observational study included 3262 men and women from the Kaiser Permanente Northern Calif...
Author(s): Kroenke CH; Prado CM; Meyerhardt JA; Weltzien EK; Xiao J; Cespedes Feliciano EM; Caan BJ
Cancer. 2018 May 24.
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Novel variant of unknown significance in MUTYH in a patient with MUTYH-associated polyposis: a case to reclassify.
MUTYH-associated polyposis (MAP) is a hereditary cancer syndrome that is caused by biallelic pathogenic variants in the MUTYH gene and should be evaluated for in patients with an attenuated colonic polyposis phenotype. Monoallelic pathogenic variants i...
Author(s): Kidambi, Trilokesh D TD; Goldberg, Dena D; Nussbaum, Robert R; Blanco, Amie A; Umetsu, Sarah E SE; Terdiman, Jonathan P JP; Lee, Jeffrey K JK
Clinical journal of gastroenterology. 2018 May 15;():. Epub 2018-05-15.
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