In 2020, the Kaiser Permanente Research Biobank collected survey data on the effects of the pandemic, including questions on loneliness, living situation, and changes in social contact. We propose to examine these changes in KP members with and without ca...
Funder: Northern California Community Benefit Programs
Investigator: Kroenke, Candyce
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This project will compare the effects of 2 intervention approaches (empowerment+navigation, education+navigation) and underlying mechanisms on guideline concordant breast cancer screening among non-adherent Latinas. We will also compare the effects of the...
Funder: National Cancer Institute
Investigator: Kroenke, Candyce
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This Bayesian, two-stage, response-adaptive, dose-ranging trial of aerobic exercise during chemotherapy will include 219 stage II-III colon cancer survivors recruited from three diverse racial, and geographic regions (Baton Rouge, LA; Boston, MA; Oakland,...
Funder: National Cancer Institute
Investigator: Caan, Bette
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The first aims of this study are to radiologically confirm and classify liver metastasis according to size, location and number using CT scans obtained post-diagnosis during follow-up and to confirm and identify previously undetected NAFLD/NASH cases and ...
Funder: National Cancer Institute
Investigator: Caan, Bette
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We will test the central hypothesis that adipose tissue depots (visceral vs. subcutaneous), measured using computed tomography scans, have differing associations with adipokine and adipokine receptor gene expression profiles and related gene signatures in...
Funder: National Cancer Institute
Investigator: Feliciano, Elizabeth
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Phase 3 trial will evaluate the efficacy of CP101 treatment relative to placebo in adults with previously treated recurrent Clostridioides difficile infection (CDI) and evaluate the safety and tolerability of CP101 treatment compared to placebo in adults ...
Funder: Finch Research and Development, LLC
Investigator: Levin, Theodore
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To create an optimized E-visit by engaging with member stakeholders; and implement a randomized study in select facilities with a revised E-visit that follows a personalized-medicine approach and compares it to the recently activated E-visit.
Funder: TPMG Delivery Science Projects Program
Investigator: Presti, Joseph
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High-quality evidence is limited on the utilization and outcomes of imaging surveillance after definitive surgery for early-stage lung cancer. This study examines patterns and factors associated with guideline-recommended imaging surveillance of lung canc...
Funder: KP National Office of Community Health
Investigator: Sakoda, Lori
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Researchers have typically investigated how each body compartment may be individually associated with poor survival and other cancer outcomes. This ignores synergistic effects of adipose tissue and muscle on inflammation, oxidative stress, insulin resista...
Funder: Section Pilot Grants
Investigator: Cheng, En
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Inflammation impacts cancer progression via stimulating tumor proliferation, migration, and angiogenesis. As a key regulator of inflammation, post-diagnosis diet strongly influences risk of breast cancer recurrence and mortality. We propose to develop an ...
Funder: The Permanente Medical Group
Investigator: Cheng, En
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This study will identify key barriers to lung cancer screening as well as develop tailored strategies and materials to increase the uptake of lung cancer screening and smoking cessation services among Asian Americans.
Funder: Tobacco-Related Disease Research Program
Investigator: Sakoda, Lori
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This study will examine racial differences in overall survival among young adults 50 years of age diagnosed with early-onset colorectal cancer in a large, community- based, fully insured population with access to complete primary and specialty care to ide...
Funder: Genentech, Inc.
Investigator: Lee, Jeffrey
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Creating more personalized breast cancer risk prediction models would enhance the benefits and limit the harms of routine breast cancer screening. This study aims to evaluate the performance of multi-feature image risk score (radiomics) models in a large ...
Funder: National Cancer Institute
Investigator: Habel, Laurel
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The goals of this project are to develop and validate a colorectal neoplasia risk prediction model among average-risk patients who underwent a baseline colonoscopy; estimate the risk of advanced neoplasia among patients with newly diagnosed Lynch Syndrome...
Funder: Janssen Pharmaceuticals, Inc.
Investigator: Lee, Jeffrey
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This study will determine factors that influence time to surgery and its associations with outcomes in patients with early-stage non-small cell lung cancer.
Funder: TPMG Delivery Science Projects Program
Investigator: Sakoda, Lori
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This study will evaluate the utilization and dosing of durvalumab and associations with treatment outcomes among patients with unresectable stage III non-small cell lung cancer in an integrated health care system.
Funder: AstraZeneca PLC
Investigator: Sakoda, Lori
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Lung cancer screening has been underutilized nationally to date, with growing evidence suggesting that screening rates differ by race. This research aims to identify multilevel factors that influence disparities in utilization of lung cancer screening fro...
Funder: National Cancer Institute
Investigator: Sakoda, Lori
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This project will compare the effectiveness of pharmacological therapy for benign prostatic hyperplasia/lower urinary tract symptoms in preventing long-term disease progression and will develop and validate predictive models using demographic, clinical, a...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Van Den Eeden, Stephen
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This study is investigating whether an individual's epigenetic age — a molecular marker of biological age — at the start of chemotherapy is associated with chemotoxicity in patients receiving treatment for colon cancer and whether resistance training duri...
Funder: National Cancer Institute
Investigator: Caan, Bette
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In WHI, we use the LILAC study and the Long Life Study 2 to collect D-3 creatine to measure muscle mass in older women who are cancer survivors and a matched control group of older women who have not had cancer. Specifically, we will develop age-standardi...
Funder: National Cancer Institute
Investigator: Caan, Bette
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This study will include 1500 patients with advanced lung, pancreatic, or colorectal cancer at high risk of cachexia for detailed measurement via biospecimen collection, remote monitoring, questionnaire, and medical record review. The aims are to: identify...
Funder: Cancer Research UK
Investigator: Caan, Bette
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This is a project more comprehensively determine the genetic factors associated with PSA levels, and to develop and apply prediction models for PCa outcomes based on genetically-adjusted PSA levels throughout life, by executing the following specific aims...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Van Den Eeden, Stephen
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The proposed project will determine whether a guideline-recommended nodal staging strategy is superior to a guideline-discordant nodal staging strategy, and whether a validated risk-based nodal staging strategy that reduces unnecessary biopsies is an equi...
Funder: National Cancer Institute
Investigator: Sakoda, Lori
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This study will investigate whether epigenetic aging — a molecular marker of biological age — at the start of chemotherapy is associated with chemotoxicity in patients receiving treatment for colon cancer. We will also look at whether chemotherapy treatme...
Funder: National Cancer Institute
Investigator: Caan, Bette
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In the initial phase of this study, we will manually review patients for eligibility for initial contact; complete a patient identification and tracking database; and develop and submit supplemental electronic IRB/email consent documents.
Funder: National Cancer Institute
Investigator: Corley, Douglas
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