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Cancer Studies

 

Circulating Biomarker Consortium for Pancreatic Early Detection

This is a retrospective case-control study to examine the timing and magnitude of loss of muscle and adiposity prior to diagnosis of pancreatic cancer.
Funder: Dana Farber Cancer Institute
Investigator: Caan, Bette

System-Level Capture of Family History Data to Assess Risk of Cancer and Provide Longitudinal Care Coordination

Genetic risk and family history (including personal medical history) increasingly influence medical care, but optimal methods for capturing hereditary risk of disease and the outcomes of such assessments are unknown. Using inherited cancer as a model, thi...
Funder: Patient-Centered Outcomes Research Institute
Investigator: Corley, Douglas

Gene Dependent Cancer Risk and Optimal Cancer Prevention Strategies in Lynch Syndrome

As part of a “K” training award from the National Institutes of Health, and within the overall colorectal cancer research program at Kaiser Permanente Northern California, this project will support additional analyses regarding the identification of ...
Funder: National Cancer Institute
Investigator: Corley, Douglas

Validation and Extension of the Michigan Barrett’s Esophagus pREdiction Tool (M-BERET)

This project will validate whether a clinical tool can predict the presence of Barrett's esophagus and the development of esophageal adenocarcinoma.


Funder: U.S. Department of Veterans Affairs
Investigator: Corley, Douglas

Validation and Extension of the Michigan Barrett’s Esophagus pREdiction Tool (M-BERET)

This project will validate whether a clinical tool can predict the presence of Barrett's esophagus and the development of esophageal adenocarcinoma.


Funder: U.S. Department of Veterans Affairs
Investigator: Corley, Douglas

Germline and Tumor Genomic Analyses of Breast Cancer in Latinas

​This project expands a consortium of studies examining germline genetic mutations in breast cancer risk in Latinas. It builds on a study that will include approximately 550 Latina women with breast cancer in the Pathways Study; genetic data from Latin...
Funder: National Cancer Institute
Investigator: Kushi, Lawrence

Adolescent and Young Adult Female Cancer Survivors - Cancer Experience Survey

​​This study aims to: 1) assess reproductive intentions and receipt of fertility counseling or preservation in relation to post-diagnosis birth outcomes among adolescent and young adult cancer survivors in North Carolina and the Kaiser Permanente N...
Funder: University of North Carolina
Investigator: Kushi, Lawrence

Optimizing Long-Term Post-Polypectomy Surveillance for Colorectal Cancer Prevention Using a Prediction Rule Developed from a Large, Community-Based Cohort

​Screening has been shown to reduce colorectal cancer incidence and mortality. However, screening has resulted in a growing cohort of patients with adenomatous polyps (adenomas), and little is known about effectively managing their post-polypectomy sur...
Funder: National Cancer Institute
Investigator: Lee, Jeffrey

Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED)

The goal of the PROCEED study is to determine the early markers or predictors of progression among individuals with pancreatitis. Participants will undergo focused study-related procedures and questionnaires at enrollment and regularly during follow-up as...
Funder: National Institutes of Health
Investigator: Van Den Eeden, Stephen

Beyond Body Mass Index: Bringing Body Composition into Oncology Practice

This project consists of development of electronic tools to rapidly assess body composition in colorectal cancer and breast cancer patients and present this information to clinicians. It leverages Kaiser Permanente Northern California’s electronic medical...
Funder: National Cancer Institute
Investigator: Feliciano, Elizabeth

Obesity, Chemotherapy Dosing, and Breast Cancer Outcomes

Body size is associated with survival in women with breast cancer in complicated ways. Chemotherapy to treat breast cancer is typically dosed based on body size, often as a function of body surface area. Previously, there was concern that obese patients m...
Funder: National Cancer Institute
Investigator: Kushi, Lawrence

End-of-Life Care for Adolescents and Young Adults with Cancer: An Evaluation of Care and Development of Patient-Centered Quality Measures

This project examines aspects of end-of-life care for people diagnosed with adolescent and young adult cancers (ages 15 to 39 years). Current measures of end-of-life care quality were designed for older adults; a coherent set of measures to characterize ...
Funder: National Cancer Institute
Investigator: Kushi, Lawrence

Optimizing Colorectal Cancer Screening PREcision and Outcomes in CommunIty-baSEd Populations (PRECISE)

This study is part of the Population-Based Research Optimizing Screening through Personalized Regimens (PROSPR) program, which aims to enhance understanding of the implementation and effects of screening as practiced in multiple, heterogeneous health care...
Funder: National Cancer Institute
Investigator: Corley, Douglas

Outreach for Colorectal Cancer Screening in African Americans Aged 45 to 49

This study aims to 1) evaluate uptake of fecal immunochemical testing among African Americans aged 45 to 49 who receive outreach for such testing by mail, 2) examine the yield of screening results, including advanced adenomas and colon cancers, and 3) des...
Funder: The Permanente Medical Group
Investigator: Levin, Theodore

mHealth Mindfulness Intervention for Women with Perinatal Depression: A Feasibility Study

The primary goal of this project is to assess the feasibility of conducting a mobile-health mindfulness intervention (mHealth) study among pregnant and postpartum women with depressive symptoms. Perinatal depression has numerous adverse health consequence...
Funder: Northern California Community Benefit Programs
Investigator: Kubo, Ai

Assessing Adherence to Follow-Up Care After Low-Dose Computed Tomography Screening for Lung Cancer

With the recent implementation of lung cancer screening in community-based practice, little is currently known about utilization patterns and outcomes in patients following the initial low-dose computed tomography (CT) screening exam. The primary goals of...
Funder: Northern California Community Benefit Programs
Investigator: Sakoda, Lori

Air Pollutants and Cardiovascular Risk: Investigating Thresholds with Pooled Cohorts and Electronic Health Records

This study will pool data from a set of well-established cohorts in the United States, each with appropriate outcome, residential history, and individual-level covariate detail, to study low-threshold exposures to criteria air pollutants and cardiovascula...
Funder: National Institute of Environmental Health Sciences
Investigator: Van Den Eeden, Stephen

Pilot Study of the Collection and Integration of Patient-Reported Outcomes in Those with Metastatic Pancreatic Cancer

This study seeks to 1) assess the feasibility and challenges associated with incorporating patient-reported outcomes into Kaiser Permanente HealthConnect, implement the collection of patient-reported-outcome measures among patients newly diagnosed with me...
Funder: The Permanente Medical Group
Investigator: Van Den Eeden, Stephen

Race Disparities in Social Networks, and Breast Cancer Treatment, Prognosis

The goal of this research is to determine, through the use of mixed qualitative and quantitative methods, how the social environment influences women's breast cancer treatment, decisions about treatment, and subsequent survival, and how these relationship...
Funder: American Cancer Society
Investigator: Kroenke, Candyce

Resistance Training to Reduce Chemotoxicity in Colon Cancer

The goal of this study is to test a randomized intervention of up to six months of home-based resistance training and protein supplementation versus a waitlist control. The intervention will begin during the first month of chemotherapy and continue throug...
Funder: National Cancer Institute
Investigator: Caan, Bette

Adherence to Oral Chemotherapy among Patients with Solid Tumors

Use of oral chemotherapy agents for the treatment of many solid tumors has been increasing. This project aims to examine the use of oral chemotherapy over the last 10 years, the proportion of patients who are adherent to their oral therapy, and the factor...
Funder: Northern California Community Benefit Programs
Investigator: Habel, Laurel

A Pilot Pragmatic Trial of mHealth Mindfulness Intervention to Improve Quality of Life Among Metastatic Cancer Patients and Their Caregivers

Screening for psychosocial distress is an accreditation requirement of the Commission on Cancer, underscoring the importance of addressing cancer patients’ psychosocial needs. Mindfulness-based training is one strategy that has been shown to help cancer p...
Funder: The Permanente Medical Group
Investigator: Kubo, Ai

Clinical Pregnancy Outcomes in Adolescent and Young Adult Female Cancer Survivors

Post-diagnosis fertility is a critical issue for adolescent and young adult cancer survivors (diagnosed at age 15 to 39 years), with little information on the impact of cancer diagnosis and treatment on pregnancy outcomes. This study focuses on five leadi...
Funder: National Cancer Institute
Investigator: Kushi, Lawrence

Effectiveness of Screening for Colorectal Cancer in Average Risk Adults: Colonoscopy vs. Fecal Immunochemical Test (FIT)

This project will evaluate the effectiveness of screening fecal immunochemical testing (FIT) versus screening colonoscopy in reducing the risk of death from colorectal cancer in average risk men and women who receive their care in community settings. We w...
Funder: National Cancer Institute
Investigator: Corley, Douglas

Predictors of CVD among Breast Cancer Survivors in an Integrated Health System

This study will comprehensively examine clinical and behavioral predictors of cardiovascular disease (CVD) outcomes among breast cancer survivors, and will maximize unique patient and data resources available at Kaiser Permanente Northern California (KPNC...
Funder: National Cancer Institute
Investigator: Kwan, Marilyn
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