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Cancer Studies

 

Sex and Race/Ethnicity-specific Multilevel Factors Influencing Pubertal Trajectories: A Population-based Study

The goal of this project is to describe the normative distributions of pubertal development among boys and girls by race/ethnicity and to investigate early-life risk factors affecting pubertal onset and tempo (velocity of transition between onset and matu...
Funder: National Institute of Child Health and Human Development
Investigator: Kubo, Ai

Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC) and the National Community Oncology Research Program (NCORP)

The New-Onset Diabetes Cohort Study is designed to help develop and test early detection tests and processes. Kaiser Permanente Northern California is collaborating in this multi-site study to identify, recruit, and follow up with members who have recentl...
Funder: National Cancer Institute
Investigator: Van Den Eeden, Stephen

A Multicenter Phase 2 Study of the Efficacy, Safety, and Tolerability of Oral Full-Spectrum Microbiota (CP101) in Subjects with Recurrence of Clostridium Difficile Infection

The objectives of this Phase 2 study are to evaluate the safety and tolerability of CP101 treatment compared to placebo in adults with previously treated, recurrent Clostridium difficile infection, and to evaluate the efficacy of CP101 treatment relative ...
Funder: Finch Research and Development, LLC
Investigator: Levin, Theodore

Social Networks and Disparities in Health Behaviors and Breast Cancer Outcomes in Immigrant Women

The goals of this study are to evaluate associations between: 1) immigrant status and social networks at the neighborhood level and at the individual level, overall and by race/ethnicity, further evaluating associations among Asian/Pacific Islander an...
Funder: National Cancer Institute
Investigator: Kroenke, Candyce

Comprehensive Translational Science Analytics Tools for the Global Health Agenda

This project builds on a previous Community Benefit grant award to examine changes in cervical and colorectal cancer screening as a result of the implementation of the Patient Protection and Affordable Care Act. It will exami...
Funder: National Institute of Environmental Health Sciences
Investigator: Kushi, Lawrence

Circulating Biomarker Consortium for Pancreatic Early Detection

This is a retrospective case-control study to examine the timing and magnitude of loss of muscle and adiposity prior to diagnosis of pancreatic cancer.
Funder: Dana Farber Cancer Institute
Investigator: Caan, Bette

System-Level Capture of Family History Data to Assess Risk of Cancer and Provide Longitudinal Care Coordination

Genetic risk and family history (including personal medical history) increasingly influence medical care, but optimal methods for capturing hereditary risk of disease and the outcomes of such assessments are unknown. Using inherited cancer as a model, thi...
Funder: Patient-Centered Outcomes Research Institute
Investigator: Corley, Douglas

Gene Dependent Cancer Risk and Optimal Cancer Prevention Strategies in Lynch Syndrome

As part of a “K” training award from the National Institutes of Health, and within the overall colorectal cancer research program at Kaiser Permanente Northern California, this project will support additional analyses regarding the identification of ...
Funder: National Cancer Institute
Investigator: Corley, Douglas

Validation and Extension of the Michigan Barrett’s Esophagus pREdiction Tool (M-BERET)

This project will validate whether a clinical tool can predict the presence of Barrett's esophagus and the development of esophageal adenocarcinoma.


Funder: U.S. Department of Veterans Affairs
Investigator: Corley, Douglas

Validation and Extension of the Michigan Barrett’s Esophagus pREdiction Tool (M-BERET)

This project will validate whether a clinical tool can predict the presence of Barrett's esophagus and the development of esophageal adenocarcinoma.


Funder: U.S. Department of Veterans Affairs
Investigator: Corley, Douglas

Germline and Tumor Genomic Analyses of Breast Cancer in Latinas

​This project expands a consortium of studies examining germline genetic mutations in breast cancer risk in Latinas. It builds on a study that will include approximately 550 Latina women with breast cancer in the Pathways Study; genetic data from Latin...
Funder: National Cancer Institute
Investigator: Kushi, Lawrence

Adolescent and Young Adult Female Cancer Survivors - Cancer Experience Survey

​​This study aims to: 1) assess reproductive intentions and receipt of fertility counseling or preservation in relation to post-diagnosis birth outcomes among adolescent and young adult cancer survivors in North Carolina and the Kaiser Permanente N...
Funder: University of North Carolina
Investigator: Kushi, Lawrence

Optimizing Long-Term Post-Polypectomy Surveillance for Colorectal Cancer Prevention Using a Prediction Rule Developed from a Large, Community-Based Cohort

​Screening has been shown to reduce colorectal cancer incidence and mortality. However, screening has resulted in a growing cohort of patients with adenomatous polyps (adenomas), and little is known about effectively managing their post-polypectomy sur...
Funder: National Cancer Institute
Investigator: Lee, Jeffrey

Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED)

The goal of the PROCEED study is to determine the early markers or predictors of progression among individuals with pancreatitis. Participants will undergo focused study-related procedures and questionnaires at enrollment and regularly during follow-up as...
Funder: National Institutes of Health
Investigator: Van Den Eeden, Stephen

Beyond Body Mass Index: Bringing Body Composition into Oncology Practice

This project consists of development of electronic tools to rapidly assess body composition in colorectal cancer and breast cancer patients and present this information to clinicians. It leverages Kaiser Permanente Northern California’s electronic medical...
Funder: National Cancer Institute
Investigator: Feliciano, Elizabeth

Obesity, Chemotherapy Dosing, and Breast Cancer Outcomes

Body size is associated with survival in women with breast cancer in complicated ways. Chemotherapy to treat breast cancer is typically dosed based on body size, often as a function of body surface area. Previously, there was concern that obese patients m...
Funder: National Cancer Institute
Investigator: Kushi, Lawrence

End-of-Life Care for Adolescents and Young Adults with Cancer: An Evaluation of Care and Development of Patient-Centered Quality Measures

This project examines aspects of end-of-life care for people diagnosed with adolescent and young adult cancers (ages 15 to 39 years). Current measures of end-of-life care quality were designed for older adults; a coherent set of measures to characterize ...
Funder: National Cancer Institute
Investigator: Kushi, Lawrence

Optimizing Colorectal Cancer Screening PREcision and Outcomes in CommunIty-baSEd Populations (PRECISE)

This study is part of the Population-Based Research Optimizing Screening through Personalized Regimens (PROSPR) program, which aims to enhance understanding of the implementation and effects of screening as practiced in multiple, heterogeneous health care...
Funder: National Cancer Institute
Investigator: Corley, Douglas

Outreach for Colorectal Cancer Screening in African Americans Aged 45 to 49

This study aims to 1) evaluate uptake of fecal immunochemical testing among African Americans aged 45 to 49 who receive outreach for such testing by mail, 2) examine the yield of screening results, including advanced adenomas and colon cancers, and 3) des...
Funder: The Permanente Medical Group
Investigator: Levin, Theodore

mHealth Mindfulness Intervention for Women with Perinatal Depression: A Feasibility Study

The primary goal of this project is to assess the feasibility of conducting a mobile-health mindfulness intervention (mHealth) study among pregnant and postpartum women with depressive symptoms. Perinatal depression has numerous adverse health consequence...
Funder: Northern California Community Benefit Programs
Investigator: Kubo, Ai

Assessing Adherence to Follow-Up Care After Low-Dose Computed Tomography Screening for Lung Cancer

With the recent implementation of lung cancer screening in community-based practice, little is currently known about utilization patterns and outcomes in patients following the initial low-dose computed tomography (CT) screening exam. The primary goals of...
Funder: Northern California Community Benefit Programs
Investigator: Sakoda, Lori

Air Pollutants and Cardiovascular Risk: Investigating Thresholds with Pooled Cohorts and Electronic Health Records

This study will pool data from a set of well-established cohorts in the United States, each with appropriate outcome, residential history, and individual-level covariate detail, to study low-threshold exposures to criteria air pollutants and cardiovascula...
Funder: National Institute of Environmental Health Sciences
Investigator: Van Den Eeden, Stephen

Pilot Study of the Collection and Integration of Patient-Reported Outcomes in Those with Metastatic Pancreatic Cancer

This study seeks to 1) assess the feasibility and challenges associated with incorporating patient-reported outcomes into Kaiser Permanente HealthConnect, implement the collection of patient-reported-outcome measures among patients newly diagnosed with me...
Funder: The Permanente Medical Group
Investigator: Van Den Eeden, Stephen

Race Disparities in Social Networks, and Breast Cancer Treatment, Prognosis

The goal of this research is to determine, through the use of mixed qualitative and quantitative methods, how the social environment influences women's breast cancer treatment, decisions about treatment, and subsequent survival, and how these relationship...
Funder: American Cancer Society
Investigator: Kroenke, Candyce

Resistance Training to Reduce Chemotoxicity in Colon Cancer

The goal of this study is to test a randomized intervention of up to six months of home-based resistance training and protein supplementation versus a waitlist control. The intervention will begin during the first month of chemotherapy and continue throug...
Funder: National Cancer Institute
Investigator: Caan, Bette
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