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Cancer Studies

 

Loneliness, isolation and associations with cancer and factors predictive of cancer-specific mortality

In 2020, the Kaiser Permanente Research Biobank collected survey data on the effects of the pandemic, including questions on loneliness, living situation, and changes in social contact. We propose to examine these changes in KP members with and without ca...
Funder: Northern California Community Benefit Programs
Investigator: Kroenke, Candyce

Empowering Latinas to Obtain Guideline-Concordant Breast Cancer Screenings

This project will compare the effects of 2 intervention approaches (empowerment+navigation, education+navigation) and underlying mechanisms on guideline concordant breast cancer screening among non-adherent Latinas. We will also compare the effects of the...
Funder: National Cancer Institute
Investigator: Kroenke, Candyce

Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer

This Bayesian, two-stage, response-adaptive, dose-ranging trial of aerobic exercise during chemotherapy will include 219 stage II-III colon cancer survivors recruited from three diverse racial, and geographic regions (Baton Rouge, LA; Boston, MA; Oakland,...
Funder: National Cancer Institute
Investigator: Caan, Bette

Association between pre-diagnosis hepatic fat infiltration and risk of liver metastasis and mortality in a large cohort of stage I-III colorectal cancer survivors

The first aims of this study are to radiologically confirm and classify liver metastasis according to size, location and number using CT scans obtained post-diagnosis during follow-up and to confirm and identify previously undetected NAFLD/NASH cases and ...
Funder: National Cancer Institute
Investigator: Caan, Bette

Understanding the role of adipose tissue distribution and adipokine-related RNA expression in the tumor microenvironment on breast cancer outcomes in a racially and ethnically diverse sample

We will test the central hypothesis that adipose tissue depots (visceral vs. subcutaneous), measured using computed tomography scans, have differing associations with adipokine and adipokine receptor gene expression profiles and related gene signatures in...
Funder: National Cancer Institute
Investigator: Feliciano, Elizabeth

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial of the Efficacy, Safety, and Tolerability of a Single Oral Administration of CP101 for the Prevention of Recurrent Clostridioides difficile Infection (PRISM4)

Phase 3 trial will evaluate the efficacy of CP101 treatment relative to placebo in adults with previously treated recurrent Clostridioides difficile infection (CDI) and evaluate the safety and tolerability of CP101 treatment compared to placebo in adults ...
Funder: Finch Research and Development, LLC
Investigator: Levin, Theodore

Improving Shared Decision Making for Prostate Cancer Screening

To create an optimized E-visit by engaging with member stakeholders; and implement a randomized study in select facilities with a revised E-visit that follows a personalized-medicine approach and compares it to the recently activated E-visit.
Funder: TPMG Delivery Science Projects Program
Investigator: Presti, Joseph

Patterns, determinants, and outcomes of guideline-recommended imaging surveillance after surgical resection of early-stage lung cancer

High-quality evidence is limited on the utilization and outcomes of imaging surveillance after definitive surgery for early-stage lung cancer. This study examines patterns and factors associated with guideline-recommended imaging surveillance of lung canc...
Funder: KP National Office of Community Health
Investigator: Sakoda, Lori

Develop and Validate Novel Body Composition Scores to Predict Survival in Breast Cancer Patients

Researchers have typically investigated how each body compartment may be individually associated with poor survival and other cancer outcomes. This ignores synergistic effects of adipose tissue and muscle on inflammation, oxidative stress, insulin resista...
Funder: Section Pilot Grants
Investigator: Cheng, En

Assess Inflammatory Potential of Diet Among Breast Cancer Patients: Novel Index and Short-Form Questionnaire

Inflammation impacts cancer progression via stimulating tumor proliferation, migration, and angiogenesis. As a key regulator of inflammation, post-diagnosis diet strongly influences risk of breast cancer recurrence and mortality. We propose to develop an ...
Funder: The Permanente Medical Group
Investigator: Cheng, En

Identifying Barriers to Lung Cancer Screening among Asian Americans

This study will identify key barriers to lung cancer screening as well as develop tailored strategies and materials to increase the uptake of lung cancer screening and smoking cessation services among Asian Americans.
Funder: Tobacco-Related Disease Research Program
Investigator: Sakoda, Lori

Comparison of Survival Rates Across Racial/Ethnic Groups Among Young Adults Diagnosed with Early-Onset Colorectal Cancer in a Large, Community-Based Population.

This study will examine racial differences in overall survival among young adults 50 years of age diagnosed with early-onset colorectal cancer in a large, community- based, fully insured population with access to complete primary and specialty care to ide...
Funder: Genentech, Inc.
Investigator: Lee, Jeffrey

Radiomic and genomic predictors of breast cancer risk

Creating more personalized breast cancer risk prediction models would enhance the benefits and limit the harms of routine breast cancer screening. This study aims to evaluate the performance of multi-feature image risk score (radiomics) models in a large ...
Funder: National Cancer Institute
Investigator: Habel, Laurel

COmprehensive risk Model for Predicting Advanced neoplasia on Surveillance Study (COMPASS)

The goals of this project are to develop and validate a colorectal neoplasia risk prediction model among average-risk patients who underwent a baseline colonoscopy; estimate the risk of advanced neoplasia among patients with newly diagnosed Lynch Syndrome...
Funder: Janssen Pharmaceuticals, Inc.
Investigator: Lee, Jeffrey

What Factors Affect Time to Surgery for Lung Cancer and Moderate its Associations with Patient Outcomes

This study will determine factors that influence time to surgery and its associations with outcomes in patients with early-stage non-small cell lung cancer.
Funder: TPMG Delivery Science Projects Program
Investigator: Sakoda, Lori

Utilization and Impact of Extended-Interval Dosing of Immunotherapy on Outcomes in Patients with Locally Advanced NSCLC

This study will evaluate the utilization and dosing of durvalumab and associations with treatment outcomes among patients with unresectable stage III non-small cell lung cancer in an integrated health care system.
Funder: AstraZeneca PLC
Investigator: Sakoda, Lori

Multilevel Determinants of Racial/Ethnic Disparities in Lung Cancer Screening Utilization

Lung cancer screening has been underutilized nationally to date, with growing evidence suggesting that screening rates differ by race. This research aims to identify multilevel factors that influence disparities in utilization of lung cancer screening fro...
Funder: National Cancer Institute
Investigator: Sakoda, Lori

Long-term effectiveness of BPH/LUTS pharmacological therapies and using machine learning based predictive analytics to tailor treatment

This project will compare the effectiveness of pharmacological therapy for benign prostatic hyperplasia/lower urinary tract symptoms in preventing long-term disease progression and will develop and validate predictive models using demographic, clinical, a...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Van Den Eeden, Stephen

Characterizing the Risk of Chemotherapy Side Effects Based on Epigenetic Age and Modification by Resistance Training Intervention

This study is investigating whether an individual's epigenetic age — a molecular marker of biological age — at the start of chemotherapy is associated with chemotoxicity in patients receiving treatment for colon cancer and whether resistance training duri...
Funder: National Cancer Institute
Investigator: Caan, Bette

Ms. LILAC: Muscle Mass in the Life and Longevity After Cancer (LILAC) Study

In WHI, we use the LILAC study and the Long Life Study 2 to collect D-3 creatine to measure muscle mass in older women who are cancer survivors and a matched control group of older women who have not had cancer. Specifically, we will develop age-standardi...
Funder: National Cancer Institute
Investigator: Caan, Bette

CANcer Cachexia Action Network/CANCAN

This study will include 1500 patients with advanced lung, pancreatic, or colorectal cancer at high risk of cachexia for detailed measurement via biospecimen collection, remote monitoring, questionnaire, and medical record review. The aims are to: identify...
Funder: Cancer Research UK
Investigator: Caan, Bette

Precision Prostate Cancer Screening with Genetically Adjusted Prostate-Specific Antigen Levels

This is a project more comprehensively determine the genetic factors associated with PSA levels, and to develop and apply prediction models for PCa outcomes based on genetically-adjusted PSA levels throughout life, by executing the following specific aims...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Van Den Eeden, Stephen

Comparative Effectiveness of Pretreatment Lung Cancer Nodal Staging

The proposed project will determine whether a guideline-recommended nodal staging strategy is superior to a guideline-discordant nodal staging strategy, and whether a validated risk-based nodal staging strategy that reduces unnecessary biopsies is an equi...
Funder: National Cancer Institute
Investigator: Sakoda, Lori

Characterizing Colon Cancer Chemotoxicity Risk based on Epigenetic Age and Modification by Resistance Training Intervention

This study will investigate whether epigenetic aging — a molecular marker of biological age — at the start of chemotherapy is associated with chemotoxicity in patients receiving treatment for colon cancer. We will also look at whether chemotherapy treatme...
Funder: National Cancer Institute
Investigator: Caan, Bette

NRG Oncology NCORP Research Base - NRG-CC005 FORTE (supplement)

In the initial phase of this study, we will manually review patients for eligibility for initial contact; complete a patient identification and tracking database; and develop and submit supplemental electronic IRB/email consent documents.
Funder: National Cancer Institute
Investigator: Corley, Douglas
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