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Cancer Studies

 

Radiomic and genomic predictors of breast cancer risk

Creating more personalized breast cancer risk prediction models would enhance the benefits and limit the harms of routine breast cancer screening. This study aims to evaluate the performance of multi-feature image risk score (radiomics) models in a large ...
Funder: National Cancer Institute
Investigator: Habel, Laurel

COmprehensive risk Model for Predicting Advanced neoplasia on Surveillance Study (COMPASS)

The goals of this project are to develop and validate a colorectal neoplasia risk prediction model among average-risk patients who underwent a baseline colonoscopy; estimate the risk of advanced neoplasia among patients with newly diagnosed Lynch Syndrome...
Funder: Janssen Pharmaceuticals, Inc.
Investigator: Lee, Jeffrey

What Factors Affect Time to Surgery for Lung Cancer and Moderate its Associations with Patient Outcomes

This study will determine factors that influence time to surgery and its associations with outcomes in patients with early-stage non-small cell lung cancer.
Funder: TPMG Delivery Science Projects Program
Investigator: Sakoda, Lori

Utilization and Impact of Extended-Interval Dosing of Immunotherapy on Outcomes in Patients with Locally Advanced NSCLC

This study will evaluate the utilization and dosing of durvalumab and associations with treatment outcomes among patients with unresectable stage III non-small cell lung cancer in an integrated health care system.
Funder: AstraZeneca PLC
Investigator: Sakoda, Lori

Multilevel Determinants of Racial/Ethnic Disparities in Lung Cancer Screening Utilization

Lung cancer screening has been underutilized nationally to date, with growing evidence suggesting that screening rates differ by race. This research aims to identify multilevel factors that influence disparities in utilization of lung cancer screening fro...
Funder: National Cancer Institute
Investigator: Sakoda, Lori

Long-term effectiveness of BPH/LUTS pharmacological therapies and using machine learning based predictive analytics to tailor treatment

This project will compare the effectiveness of pharmacological therapy for benign prostatic hyperplasia/lower urinary tract symptoms in preventing long-term disease progression and will develop and validate predictive models using demographic, clinical, a...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Van Den Eeden, Stephen

Characterizing the Risk of Chemotherapy Side Effects Based on Epigenetic Age and Modification by Resistance Training Intervention

This study is investigating whether an individual's epigenetic age — a molecular marker of biological age — at the start of chemotherapy is associated with chemotoxicity in patients receiving treatment for colon cancer and whether resistance training duri...
Funder: National Cancer Institute
Investigator: Caan, Bette

Ms. LILAC: Muscle Mass in the Life and Longevity After Cancer (LILAC) Study

In WHI, we use the LILAC study and the Long Life Study 2 to collect D-3 creatine to measure muscle mass in older women who are cancer survivors and a matched control group of older women who have not had cancer. Specifically, we will develop age-standardi...
Funder: National Cancer Institute
Investigator: Caan, Bette

CANcer Cachexia Action Network/CANCAN

This study will include 1500 patients with advanced lung, pancreatic, or colorectal cancer at high risk of cachexia for detailed measurement via biospecimen collection, remote monitoring, questionnaire, and medical record review. The aims are to: identify...
Funder: Cancer Research UK
Investigator: Caan, Bette

Precision Prostate Cancer Screening with Genetically Adjusted Prostate-Specific Antigen Levels

This is a project more comprehensively determine the genetic factors associated with PSA levels, and to develop and apply prediction models for PCa outcomes based on genetically-adjusted PSA levels throughout life, by executing the following specific aims...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Van Den Eeden, Stephen

Comparative Effectiveness of Pretreatment Lung Cancer Nodal Staging

The proposed project will determine whether a guideline-recommended nodal staging strategy is superior to a guideline-discordant nodal staging strategy, and whether a validated risk-based nodal staging strategy that reduces unnecessary biopsies is an equi...
Funder: National Cancer Institute
Investigator: Sakoda, Lori

Characterizing Colon Cancer Chemotoxicity Risk based on Epigenetic Age and Modification by Resistance Training Intervention

This study will investigate whether epigenetic aging — a molecular marker of biological age — at the start of chemotherapy is associated with chemotoxicity in patients receiving treatment for colon cancer. We will also look at whether chemotherapy treatme...
Funder: National Cancer Institute
Investigator: Caan, Bette

NRG Oncology NCORP Research Base - NRG-CC005 FORTE (supplement)

In the initial phase of this study, we will manually review patients for eligibility for initial contact; complete a patient identification and tracking database; and develop and submit supplemental electronic IRB/email consent documents.
Funder: National Cancer Institute
Investigator: Corley, Douglas

Influence of Comorbidities and Inflammatory Biomarkers in Disparities in Ovarian Cancer Treatment, Treatment Response, and Survival

This project examines racial and ethnic disparities in ovarian cancer patients diagnosed and treated in KPNC from 2000 to 2023. It is an ancillary study to an NCI-funded research project (R01 CA243188) led by MPIs Kushi, Doherty (University of Utah), Band...
Funder: The V Foundation for Cancer Research
Investigator: Kushi, Lawrence

Treatment Patterns and Clinical Outcomes in Patients with HR+/HER2- and HR+/HER2+ Metastatic Breast Cancer in an Integrated Health Care System

This is an observational, retrospective cohort study of patients diagnosed with HR+/HER2 - and HR+/HER2+ metastatic breast cancer (mBC) who initiated first-line systemic therapy in the metastatic setting. Study aims are: 1) Among HR+/HER2- mBC patients di...
Funder: Pfizer Inc.
Investigator: Kwan, Marilyn

Rates and Risk Factors of Post-Colonoscopy Colorectal Cancer in a Large, United States Population-based Cohort Study

Colorectal cancer (CRC) is the third leading cause of cancer death in the United States. Colonoscopy can reduce CRC incidence and deaths through removal of precancerous adenomatous polyps (adenomas) and detection of cancer at an earlier, more treatable st...
Funder: Northern California Community Benefit Programs
Investigator: Lee, Jeffrey

Comparative Effectiveness Trial of Non-invasive vs. Invasive Strategies (FIT vs Colonoscopy) for Older Adults with a History of Pre-neoplastic Colon Polyps

This comparative effectiveness trial will evaluate detection of significant neoplasia between the strategies of low threshold annual FIT vs. colonoscopy for older adults with a history of colon polyps. We will investigate whether the FIT strategy is non-i...
Funder: Patient-Centered Outcomes Research Institute
Investigator: Levin, Theodore

A Prospective Study to Establish a New Onset Diabetes (NOD) Cohort

In this study we are estimating the risk of pancreatic ductal adenocarcinoma among individuals NOD (New Onset Diabetes) Protocol defined hyperglycemia by study status (enrolled, not enrolled, not recruited). We will also participate in a national multi-si...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Van Den Eeden, Stephen

Pyroaeromycoses: fundamental discovery and modeling in an unexplored phenomenon

We are examining the risk from the pyroaeromyobiome from a public health perspective. In particular, our goals are to determine: the association between exposure to wildfire smoke and mycoses diagnose; the mechanisms of fungal biota acquisition, maintenan...
Funder: 
Investigator: Van Den Eeden, Stephen

Radiomic and genomic predictors of breast cancer risk

Improving breast cancer risk prediction models could enable more personalized screening. This would enhance the benefits of screening while limiting the harms. This study will evaluate the performance of multi-feature image risk score models in a large po...
Funder: National Cancer Institute
Investigator: Habel, Laurel

Developing a TPMG Pathway for Selective Oncotype DX Testing in Early Breast Cancer

The goal of this project is to determine whether Ki-67 testing, using newer methods, could be used as a replacement for Oncotype DX testing in selected patients with HR+/HER2- breast cancer.
Funder: TPMG Delivery Science Projects Program
Investigator: Habel, Laurel

Improved Selection of BRCA-negative High-Risk Women for Breast MRI Screening through Validation of IBIS Risk Model Variants

The goal of this project is to identify the optimal IBIS model that maximizes screening benefits and minimizes harms. We hypothesize that the “full” model (with all breast cancer risk factors) has better calibration/discrimination compared to a reduced mo...
Funder: TPMG Delivery Science Projects Program
Investigator: Habel, Laurel

Genomic and Transcriptomic Analysis of Mammographic Density

This study will combine functional data from gene expression and co-expression networks with GWAS data to elucidate the genetic determinants of mammographic density, an important risk factor for breast cancer.
Funder: National Cancer Institute
Investigator: Habel, Laurel

NCI Community Oncology Research Program (NCORP) – KP Community Site

The overarching goal of the KP NCORP Community Site is to bring the benefits of medical advances to our racially and ethnically diverse membership and to the community at large by increasing clinical trial access/accrual and by conducting cancer care deli...
Funder: National Cancer Institute
Investigator: Habel, Laurel

Multi-panel Gene Mutation Testing and Targeted Therapy -STRATA Program

Identify KPNC patients with metastatic/incurable cancer for testing of tumors by next generation sequencing (NGS). NGS screening protocol is aligned to a portfolio of pharma-sponsored therapeutic protocols open now or theoretically open in the future, in...
Funder: The Permanente Medical Group
Investigator: Habel, Laurel
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