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Cancer Studies

 

Informatics approaches to assessing patient frailty in surgical care

Patient frailty increases the risk for surgical complications, which are common, costly, and deadly, especially for older Americans. To improve surgical care for older adults, we will investigate whether electronic measures of frailty can help reduce comp...
Funder: National Institute on Aging
Investigator: Feliciano, Elizabeth

Understanding Racial/Ethnic Disparities in Lung Cancer Screening Utilization

This study proposes to understand patterns and multilevel determinants of racial/ethnic disparities in Lung Cancer Screening utilization from 2017 onward at KPNC.
Funder: Northern California Community Benefit Programs
Investigator: Sakoda, Lori

The Colonic Microbiome Preceding Parkinson's Disease: A Pilot Study

Gut changes, including evidence of alpha synuclein and the microbiome, appear to differ between people with and without Parkinson's disease. This pilot study will use colonic biospecimens from deceased patients with Parkinson's disease and control pati...
Funder: University of California, San Francisco, Project Grant
Investigator: Van Den Eeden, Stephen

Bipolar Disease and Parkinson's Disease

This study, along with a parallel effort at the University of California, San Francisco, will focus on the relationship between bipolar disease and Parkinson's disease.


Funder: Michael J. Fox Foundation
Investigator: Van Den Eeden, Stephen

Breast White Adipose Tissue Inflammation and Breast Cancer Outcomes

We will assess the incidence and severity of breast white adipose tissue (B-WAT) inflammation in mastectomy specimens from approximately 1,900 Pathways Study participants to examine associations of various factors with B-WAT inflammation incidence and ...
Funder: National Cancer Institute
Investigator: Kushi, Lawrence

Body Composition and Breast Cancer Survival: Immune and Metabolic Biomarkers in Breast Tumors

We previously found that one third of nonmetastatic breast cancer patients had sarcopenia (age-related loss of muscle tissue) at the time of their diagnosis and that having sarcopenia and obesity was associated with an 89% increased risk of death. This...
Funder: National Cancer Institute
Investigator: Feliciano, Elizabeth

Recurrence, Treatment, and Complication Patterns of Intermediate Risk Non-muscle Invasive Bladder Cancer

This study will comprehensively assess the clinical course of intermediate risk non-muscle invasive bladder cancer (NMIBC) in 291 patients diagnosed at Kaiser Permanente Northern California who are enrolled in the Be-Well Study. Intermediate risk NMIBC is...
Funder: UroGen Pharma, Inc.
Investigator: Kwan, Marilyn

NRG Oncology NCORP Research Base

This is a non-inferiority trial design comparing colorectal cancer incidence in trial participants with 1-2 non-advanced adenomas randomized to recommendation for a 5- and 10-year surveillance colonoscopy exam vs. a 10-year surveillance colonoscopy exam.
Funder: National Cancer Institute
Investigator: Corley, Douglas

Kaiser Permanente Interregional Cancer Statistics Project

A Kaiser Permanente interregional cancer statistics report will be developed to include incidence and 5-year relative survival rates for breast, colorectal, and lung cancer. The development of new mortality measures will be explored, along with improved r...
Funder: Center for Effectiveness and Safety Research
Investigator: Kushi, Lawrence

PREDICT PCCC: PREDICTing Post Colonoscopy Colorectal Cancer

We are using post-polypectomy surveillance, an increasingly common indication for colonoscopy in clinical practice at TPMG and across the United States, as a model for how we might risk-stratify patients for care. Patients and physicians desire more preci...
Funder: The Permanente Medical Group
Investigator: Levin, Theodore

D3-creatine dilution to assess skeletal muscle mass in colon cancer patients

Among colon cancer patients participating in a resistance training intervention during chemotherapy, this study will examine whether a new method to evaluate skeletal muscle mass (d3-creatine dilution) is associated with the key cancer outcomes of stre...
Funder: National Cancer Institute
Investigator: Feliciano, Elizabeth

Pediatric obstructive sleep apnea: predictive modeling to streamline care

To prioritize pediatric attended polysomnography and treatment for children most in need while reducing the unnecessary use of overnight sleep studies, we propose to build and rigorously evaluate a clinical risk prediction model. We will combine data f...
Funder: The Permanente Medical Group
Investigator: Feliciano, Elizabeth

Healthful dietary patterns, intermediate biomarkers and long-term breast cancer prognosis

To strengthen the dietary guidelines for breast cancer survivors, we examine whether at-diagnosis concordance with healthful dietary patterns is associated with recurrence or breast cancer death, or with prognostic biomarkers (i.e., body composition, infl...
Funder: American Institute for Cancer Research
Investigator: Feliciano, Elizabeth

Sex and Race/Ethnicity-specific Multilevel Factors Influencing Pubertal Trajectories: A Population-based Study

The goal of this project is to describe the normative distributions of pubertal development among boys and girls by race/ethnicity and to investigate early-life risk factors affecting pubertal onset and tempo (velocity of transition between onset and matu...
Funder: National Institute of Child Health and Human Development
Investigator: Kubo, Ai

Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC) and the National Community Oncology Research Program (NCORP)

The New-Onset Diabetes Cohort Study is designed to help develop and test early detection tests and processes. Kaiser Permanente Northern California is collaborating in this multi-site study to identify, recruit, and follow up with members who have recentl...
Funder: National Cancer Institute
Investigator: Van Den Eeden, Stephen

PRISM-EXT: An Open-Label Extension of CP101 Trials Evaluating Oral Full-Spectrum Microbiota (CP101) in Subjects with Recurrence of Clostridium difficile Infection

This study evaluates the safety and efficacy in reducing recurrence of Clostridium difficile infection in adults who had a recurrence within 8 weeks of receiving CP101 or placebo in PRISM3. Subjects who are experiencing recurrent Clostridium difficile inf...
Funder: Finch Research and Development, LLC
Investigator: Levin, Theodore

Cancer and Body Composition Webinar Series

This monthly webinar series, attended by approximately 200 people from diverse disciplines, is ongoing and focuses on topics relevant to body composition and cancer. The Division of Research will host 10 webinar speakers who are prominent in the field; ar...
Funder: National Cancer Institute
Investigator: Caan, Bette

Body Composition and the Obesity Paradox in Clear-Cell Renal Cell Carcinoma

Aim 1: Determine associations among body mass index (BMI), body composition variables, and tumor subtype. The amount and quality of muscle, visceral adipose tissue, and subcutaneous adipose tissue will be derived from existing pre-surgical CT scans; a...
Funder: National Cancer Institute
Investigator: Caan, Bette

Geospatial, Multilevel, and Contextual Approaches in Cancer Control and Population Sciences

This funding expands on neighborhood resources developed under the U01 grant (geocoded residential histories, linkage to census and area databases, virtual neighborhood audits). Aim 1: Develop methods to use remote sensing data and machine learning te...
Funder: National Cancer Institute
Investigator: Kushi, Lawrence

A Multicenter Phase 2 Study of the Efficacy, Safety, and Tolerability of Oral Full-Spectrum Microbiota (CP101) in Subjects with Recurrence of Clostridium Difficile Infection

The objectives of this Phase 2 study are to evaluate the safety and tolerability of CP101 treatment compared to placebo in adults with previously treated, recurrent Clostridium difficile infection, and to evaluate the efficacy of CP101 treatment relative ...
Funder: Finch Research and Development, LLC
Investigator: Levin, Theodore

Social Networks and Disparities in Health Behaviors and Breast Cancer Outcomes in Immigrant Women

The goals of this study are to evaluate associations between: 1) immigrant status and social networks at the neighborhood level and at the individual level, overall and by race/ethnicity, further evaluating associations among Asian/Pacific Islander an...
Funder: National Cancer Institute
Investigator: Kroenke, Candyce

Comprehensive Translational Science Analytics Tools for the Global Health Agenda

This project builds on a previous Community Benefit grant award to examine changes in cervical and colorectal cancer screening as a result of the implementation of the Patient Protection and Affordable Care Act. It will exami...
Funder: National Institute of Environmental Health Sciences
Investigator: Kushi, Lawrence

Circulating Biomarker Consortium for Pancreatic Early Detection

This is a retrospective case-control study to examine the timing and magnitude of loss of muscle and adiposity prior to diagnosis of pancreatic cancer.
Funder: Dana Farber Cancer Institute
Investigator: Caan, Bette

System-Level Capture of Family History Data to Assess Risk of Cancer and Provide Longitudinal Care Coordination

Genetic risk and family history, which includes personal medical history, increasingly influence medical care, but optimal methods for capturing the hereditary risk of disease and the outcomes of such assessments are unknown. Using inherited cancer as a m...
Funder: Patient-Centered Outcomes Research Institute
Investigator: Corley, Douglas

Gene Dependent Cancer Risk and Optimal Cancer Prevention Strategies in Lynch Syndrome

As part of a “K” training award from the National Institutes of Health, and within the overall colorectal cancer research program at Kaiser Permanente Northern California, this project will support additional analyses regarding the identification of perso...
Funder: National Cancer Institute
Investigator: Corley, Douglas
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