Creating more personalized breast cancer risk prediction models would enhance the benefits and limit the harms of routine breast cancer screening. This study aims to evaluate the performance of multi-feature image risk score (radiomics) models in a large ...
Funder: National Cancer Institute
Investigator: Habel, Laurel
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The goals of this project are to develop and validate a colorectal neoplasia risk prediction model among average-risk patients who underwent a baseline colonoscopy; estimate the risk of advanced neoplasia among patients with newly diagnosed Lynch Syndrome...
Funder: Janssen Pharmaceuticals, Inc.
Investigator: Lee, Jeffrey
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This study will determine factors that influence time to surgery and its associations with outcomes in patients with early-stage non-small cell lung cancer.
Funder: TPMG Delivery Science Projects Program
Investigator: Sakoda, Lori
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This study will evaluate the utilization and dosing of durvalumab and associations with treatment outcomes among patients with unresectable stage III non-small cell lung cancer in an integrated health care system.
Funder: AstraZeneca PLC
Investigator: Sakoda, Lori
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Lung cancer screening has been underutilized nationally to date, with growing evidence suggesting that screening rates differ by race. This research aims to identify multilevel factors that influence disparities in utilization of lung cancer screening fro...
Funder: National Cancer Institute
Investigator: Sakoda, Lori
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This project will compare the effectiveness of pharmacological therapy for benign prostatic hyperplasia/lower urinary tract symptoms in preventing long-term disease progression and will develop and validate predictive models using demographic, clinical, a...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Van Den Eeden, Stephen
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This study is investigating whether an individual's epigenetic age — a molecular marker of biological age — at the start of chemotherapy is associated with chemotoxicity in patients receiving treatment for colon cancer and whether resistance training duri...
Funder: National Cancer Institute
Investigator: Caan, Bette
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In WHI, we use the LILAC study and the Long Life Study 2 to collect D-3 creatine to measure muscle mass in older women who are cancer survivors and a matched control group of older women who have not had cancer. Specifically, we will develop age-standardi...
Funder: National Cancer Institute
Investigator: Caan, Bette
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This study will include 1500 patients with advanced lung, pancreatic, or colorectal cancer at high risk of cachexia for detailed measurement via biospecimen collection, remote monitoring, questionnaire, and medical record review. The aims are to: identify...
Funder: Cancer Research UK
Investigator: Caan, Bette
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This is a project more comprehensively determine the genetic factors associated with PSA levels, and to develop and apply prediction models for PCa outcomes based on genetically-adjusted PSA levels throughout life, by executing the following specific aims...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Van Den Eeden, Stephen
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The proposed project will determine whether a guideline-recommended nodal staging strategy is superior to a guideline-discordant nodal staging strategy, and whether a validated risk-based nodal staging strategy that reduces unnecessary biopsies is an equi...
Funder: National Cancer Institute
Investigator: Sakoda, Lori
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This study will investigate whether epigenetic aging — a molecular marker of biological age — at the start of chemotherapy is associated with chemotoxicity in patients receiving treatment for colon cancer. We will also look at whether chemotherapy treatme...
Funder: National Cancer Institute
Investigator: Caan, Bette
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In the initial phase of this study, we will manually review patients for eligibility for initial contact; complete a patient identification and tracking database; and develop and submit supplemental electronic IRB/email consent documents.
Funder: National Cancer Institute
Investigator: Corley, Douglas
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This project examines racial and ethnic disparities in ovarian cancer patients diagnosed and treated in KPNC from 2000 to 2023. It is an ancillary study to an NCI-funded research project (R01 CA243188) led by MPIs Kushi, Doherty (University of Utah), Band...
Funder: The V Foundation for Cancer Research
Investigator: Kushi, Lawrence
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This is an observational, retrospective cohort study of patients diagnosed with HR+/HER2 - and HR+/HER2+ metastatic breast cancer (mBC) who initiated first-line systemic therapy in the metastatic setting. Study aims are: 1) Among HR+/HER2- mBC patients di...
Funder: Pfizer Inc.
Investigator: Kwan, Marilyn
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Colorectal cancer (CRC) is the third leading cause of cancer death in the United States. Colonoscopy can reduce CRC incidence and deaths through removal of precancerous adenomatous polyps (adenomas) and detection of cancer at an earlier, more treatable st...
Funder: Northern California Community Benefit Programs
Investigator: Lee, Jeffrey
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This comparative effectiveness trial will evaluate detection of significant neoplasia between the strategies of low threshold annual FIT vs. colonoscopy for older adults with a history of colon polyps. We will investigate whether the FIT strategy is non-i...
Funder: Patient-Centered Outcomes Research Institute
Investigator: Levin, Theodore
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In this study we are estimating the risk of pancreatic ductal adenocarcinoma among individuals NOD (New Onset Diabetes) Protocol defined hyperglycemia by study status (enrolled, not enrolled, not recruited). We will also participate in a national multi-si...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Van Den Eeden, Stephen
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We are examining the risk from the pyroaeromyobiome from a public health perspective. In particular, our goals are to determine: the association between exposure to wildfire smoke and mycoses diagnose; the mechanisms of fungal biota acquisition, maintenan...
Funder:
Investigator: Van Den Eeden, Stephen
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Improving breast cancer risk prediction models could enable more personalized screening. This would enhance the benefits of screening while limiting the harms. This study will evaluate the performance of multi-feature image risk score models in a large po...
Funder: National Cancer Institute
Investigator: Habel, Laurel
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The goal of this project is to determine whether Ki-67 testing, using newer methods, could be used as a replacement for Oncotype DX testing in selected patients with HR+/HER2- breast cancer.
Funder: TPMG Delivery Science Projects Program
Investigator: Habel, Laurel
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The goal of this project is to identify the optimal IBIS model that maximizes screening benefits and minimizes harms. We hypothesize that the “full” model (with all breast cancer risk factors) has better calibration/discrimination compared to a reduced mo...
Funder: TPMG Delivery Science Projects Program
Investigator: Habel, Laurel
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This study will combine functional data from gene expression and co-expression networks with GWAS data to elucidate the genetic determinants of mammographic density, an important risk factor for breast cancer.
Funder: National Cancer Institute
Investigator: Habel, Laurel
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The overarching goal of the KP NCORP Community Site is to bring the benefits of medical advances to our racially and ethnically diverse membership and to the community at large by increasing clinical trial access/accrual and by conducting cancer care deli...
Funder: National Cancer Institute
Investigator: Habel, Laurel
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Identify KPNC patients with metastatic/incurable cancer for testing of tumors by next generation sequencing (NGS). NGS screening protocol is aligned to a portfolio of pharma-sponsored therapeutic protocols open now or theoretically open in the future, in...
Funder: The Permanente Medical Group
Investigator: Habel, Laurel
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