This study aims to improve breast cancer risk prediction models that could enable more personalized screening to enhance its benefits and limit the harms. It will: evaluate the performance of multi-feature image risk score models in a large population-bas...
Funder: National Cancer Institute
Investigator: Habel, Laurel
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This career development award project will compare the effectiveness of pharmacological therapy for lower urinary tract symptoms secondary to benign prostatic hyperplasia in preventing long-term disease progression; and develop and validate predictive mod...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Langston, Marvin
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This project will establish a prospective cohort of white and Black cancer patients treated with immune checkpoint inhibitors, leveraging the NCI Community Oncology Research Program network infrastructure, to investigate racial differences in immune-relat...
Funder: National Cancer Institute
Investigator: Sakoda, Lori
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Inadequate representation of diverse racial/ethnic populations in genetic studies is hindering the translational potential of polygenic risk scores (PRS) in cancer risk prediction. To address this shortcoming, we aim to construct and evaluate PRS for canc...
Funder: National Cancer Institute
Investigator: Sakoda, Lori
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This randomized controlled trial of an mHealth mindfulness intervention designed for Black and Latinx pregnant women at risk of developing postpartum depression will compare outcomes (depression, stress, sleep) of participants in the intervention with tho...
Funder: National Institute of Mental Health
Investigator: Kubo, Ai
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Recent guidelines have extended surveillance intervals for patients with low-risk adenomas from 5 years to 10. However, it remains unclear how to implement this change. In a pragmatic randomized 2-arm study of 1,000 patients with a history of low-risk ade...
Funder: TPMG Delivery Science Projects Program
Investigator: Lee, Jeffrey
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Three national guideline groups now recommend that all adults start colorectal cancer (CRC) screening at age 45. Before 2018, some guideline groups only recommended African Americans begin CRC screening at age 45. There is currently no empirical evidence ...
Funder: Garfield Memorial Fund
Investigator: Levin, Theodore
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This study, being done with a parallel effort at UCSF, will focus on how bipolar disease is related to Parkinson's disease. We will look within the KPNC membership data, as well as focusing on a specific KP study population of bipolar disease.
Funder: Michael J. Fox Foundation
Investigator: Schaefer, Catherine; Van Den Eeden, Stephen
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We reported previously that African American and Hispanic women have worse survival after ovarian cancer diagnosis than white women, and Asian women have similar survival. We will investigate reasons for these disparities, focusing on tumor subtypes, hea...
Funder: National Cancer Institute
Investigator: Kushi, Lawrence
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This application will use the Pathways Study resource to investigate genetic and non-genetic factors in the interplay of energy balance, mTOR signaling, and breast cancer prognosis. mTOR expression will be determined in tumor tissue from tissue microarra...
Funder: National Cancer Institute
Investigator: Kwan, Marilyn
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The primary objectives of this study are to determine the sensitivity and specificity of Freenome's test for colorectal adenocarcinoma, using screening CS with histopathology as the reference method.
Funder: Freenome Holdings, Inc
Investigator: Levin, Theodore
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This multiple institution effort will assemble the largest set of pancreatic cases and controls to examine in detail the genetic influences on the risk and progression of pancreatic cancer and perform exome sequencing of minorities with pancreatic cancer.
Funder: National Cancer Institute
Investigator: Van Den Eeden, Stephen
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An effort to more comprehensively determine the genetic factors associated with prostate-specific antigen (PSA) levels, and to develop and apply prediction models for prostate cancer outcomes based on genetically-adjusted PSA levels throughout life.
Funder: National Cancer Institute
Investigator: Van Den Eeden, Stephen
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This study will investigate the incremental yield of using radiology imaging report information to diagnose non-alcoholic fatty liver disease (NAFLD) compared to International Classification of Disease, Ninth/Tenth Revision, Clinical Modification diagnose...
Funder: Northern California Community Benefit Programs
Investigator: Levin, Theodore
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Postoperative urinary retention (POUR) is the inability to void despite a full bladder following a surgical procedure. POUR can result in painful catherization, increased patient distress, increased postoperative hospital stay, urinary tract infections, d...
Funder: Northern California Community Benefit Programs
Investigator: Langston, Marvin
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The goal of this project is to evaluate the impact of the COVID pandemic on colorectal cancer screening and surveillance activities, and the impact on outcomes such as colorectal cancer incidence and stage.
Funder: Garfield Memorial Fund
Investigator: Levin, Theodore
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Goals of the project are to: 1) Identify terms from content in the EHR, based on theory and prior literature, and informed by clinical stakeholders in BC care, that measure structural and/or functional social support, have been associated with BC treatmen...
Funder: National Cancer Institute
Investigator: Kroenke, Candyce
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Patient frailty increases the risk for surgical complications, which are common, costly, and deadly, especially for older Americans. To improve surgical care for older adults, we will investigate whether electronic measures of frailty can help reduce comp...
Funder: National Institute on Aging
Investigator: Feliciano, Elizabeth
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This study proposes to understand patterns and multilevel determinants of racial/ethnic disparities in Lung Cancer Screening utilization from 2017 onward at KPNC.
Funder: Northern California Community Benefit Programs
Investigator: Sakoda, Lori
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Gut changes, including evidence of alpha synuclein and the microbiome, appear to differ between people with and without Parkinson's disease. This pilot study will use colonic biospecimens from deceased patients with Parkinson's disease and control patient...
Funder: University of California, San Francisco, Project Grant
Investigator: Van Den Eeden, Stephen
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This study, along with a parallel effort at the University of California, San Francisco, will focus on the relationship between bipolar disease and Parkinson's disease.
Funder: Michael J. Fox Foundation
Investigator: Van Den Eeden, Stephen
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We will assess the incidence and severity of breast white adipose tissue (B-WAT) inflammation in mastectomy specimens from approximately 1,900 Pathways Study participants to examine associations of various factors with B-WAT inflammation incidence and sev...
Funder: National Cancer Institute
Investigator: Kushi, Lawrence
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We previously found that one third of nonmetastatic breast cancer patients had sarcopenia (age-related loss of muscle tissue) at the time of their diagnosis and that having sarcopenia and obesity was associated with an 89% increased risk of death. This st...
Funder: National Cancer Institute
Investigator: Feliciano, Elizabeth
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This study will comprehensively assess the clinical course of intermediate risk non-muscle invasive bladder cancer (NMIBC) in 291 patients diagnosed at Kaiser Permanente Northern California who are enrolled in the Be-Well Study. Intermediate risk NMIBC is...
Funder: UroGen Pharma, Inc.
Investigator: Kwan, Marilyn
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This is a non-inferiority trial design comparing colorectal cancer incidence in trial participants with 1-2 non-advanced adenomas randomized to recommendation for a 5- and 10-year surveillance colonoscopy exam vs. a 10-year surveillance colonoscopy exam.
Funder: National Cancer Institute
Investigator: Corley, Douglas
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