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Cancer Studies

 

Precision Prostate Cancer Screening with Genetically Adjusted Prostate-Specific Antigen Levels

This is a project more comprehensively determine the genetic factors associated with PSA levels, and to develop and apply prediction models for PCa outcomes based on genetically-adjusted PSA levels throughout life, by executing the following specific aims...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Van Den Eeden, Stephen

Comparative Effectiveness of Pretreatment Lung Cancer Nodal Staging

The proposed project will determine whether a guideline-recommended nodal staging strategy is superior to a guideline-discordant nodal staging strategy, and whether a validated risk-based nodal staging strategy that reduces unnecessary biopsies is an equi...
Funder: National Cancer Institute
Investigator: Sakoda, Lori

Characterizing Colon Cancer Chemotoxicity Risk based on Epigenetic Age and Modification by Resistance Training Intervention

This study will investigate whether epigenetic aging — a molecular marker of biological age — at the start of chemotherapy is associated with chemotoxicity in patients receiving treatment for colon cancer. We will also look at whether chemotherapy treatme...
Funder: National Cancer Institute
Investigator: Caan, Bette

NRG Oncology NCORP Research Base - NRG-CC005 FORTE (supplement)

In the initial phase of this study, we will manually review patients for eligibility for initial contact; complete a patient identification and tracking database; and develop and submit supplemental electronic IRB/email consent documents.
Funder: National Cancer Institute
Investigator: Corley, Douglas

Influence of Comorbidities and Inflammatory Biomarkers in Disparities in Ovarian Cancer Treatment, Treatment Response, and Survival

This project examines racial and ethnic disparities in ovarian cancer patients diagnosed and treated in KPNC from 2000 to 2023. It is an ancillary study to an NCI-funded research project (R01 CA243188) led by MPIs Kushi, Doherty (University of Utah), Band...
Funder: 
Investigator: Kushi, Lawrence

Treatment Patterns and Clinical Outcomes in Patients with HR+/HER2- and HR+/HER2+ Metastatic Breast Cancer in an Integrated Health Care System

This is an observational, retrospective cohort study of patients diagnosed with HR+/HER2 - and HR+/HER2+ metastatic breast cancer (mBC) who initiated first-line systemic therapy in the metastatic setting. Study aims are: 1) Among HR+/HER2- mBC patients di...
Funder: Pfizer Inc.
Investigator: Kwan, Marilyn

Rates and Risk Factors of Post-Colonoscopy Colorectal Cancer in a Large, United States Population-based Cohort Study

Colorectal cancer (CRC) is the third leading cause of cancer death in the United States. Colonoscopy can reduce CRC incidence and deaths through removal of precancerous adenomatous polyps (adenomas) and detection of cancer at an earlier, more treatable st...
Funder: Northern California Community Benefit Programs
Investigator: Lee, Jeffrey

Comparative Effectiveness Trial of Non-invasive vs. Invasive Strategies (FIT vs Colonoscopy) for Older Adults with a History of Pre-neoplastic Colon Polyps

This comparative effectiveness trial will evaluate detection of significant neoplasia between the strategies of low threshold annual FIT vs. colonoscopy for older adults with a history of colon polyps. We will investigate whether the FIT strategy is non-i...
Funder: Patient-Centered Outcomes Research Institute
Investigator: Levin, Theodore

A Prospective Study to Establish a New Onset Diabetes (NOD) Cohort

In this study we are estimating the risk of pancreatic ductal adenocarcinoma among individuals NOD (New Onset Diabetes) Protocol defined hyperglycemia by study status (enrolled, not enrolled, not recruited). We will also participate in a national multi-si...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Van Den Eeden, Stephen

Pyroaeromycoses: fundamental discovery and modeling in an unexplored phenomenon

We are examining the risk from the pyroaeromyobiome from a public health perspective. In particular, our goals are to determine: the association between exposure to wildfire smoke and mycoses diagnose; the mechanisms of fungal biota acquisition, maintenan...
Funder: 
Investigator: Van Den Eeden, Stephen

Radiomic and genomic predictors of breast cancer risk

Improving breast cancer risk prediction models could enable more personalized screening. This would enhance the benefits of screening while limiting the harms. This study will evaluate the performance of multi-feature image risk score models in a large po...
Funder: National Cancer Institute
Investigator: Habel, Laurel

Developing a TPMG Pathway for Selective Oncotype DX Testing in Early Breast Cancer

The goal of this project is to determine whether Ki-67 testing, using newer methods, could be used as a replacement for Oncotype DX testing in selected patients with HR+/HER2- breast cancer.
Funder: TPMG Delivery Science Projects Program
Investigator: Habel, Laurel

Improved Selection of BRCA-negative High-Risk Women for Breast MRI Screening through Validation of IBIS Risk Model Variants

The goal of this project is to identify the optimal IBIS model that maximizes screening benefits and minimizes harms. We hypothesize that the “full” model (with all breast cancer risk factors) has better calibration/discrimination compared to a reduced mo...
Funder: TPMG Delivery Science Projects Program
Investigator: Habel, Laurel

Genomic and Transcriptomic Analysis of Mammographic Density

This study will combine functional data from gene expression and co-expression networks with GWAS data to elucidate the genetic determinants of mammographic density, an important risk factor for breast cancer.
Funder: National Cancer Institute
Investigator: Habel, Laurel

NCI Community Oncology Research Program (NCORP) – KP Community Site

The overarching goal of the KP NCORP Community Site is to bring the benefits of medical advances to our racially and ethnically diverse membership and to the community at large by increasing clinical trial access/accrual and by conducting cancer care deli...
Funder: National Cancer Institute
Investigator: Habel, Laurel

Multi-panel Gene Mutation Testing and Targeted Therapy -STRATA Program

Identify KPNC patients with metastatic/incurable cancer for testing of tumors by next generation sequencing (NGS). NGS screening protocol is aligned to a portfolio of pharma-sponsored therapeutic protocols open now or theoretically open in the future, in...
Funder: The Permanente Medical Group
Investigator: Habel, Laurel

Long-term effectiveness of BPH/LUTS pharmacological therapies and using machine learning based predictive analytics to tailor treatment.

This career development award project will compare the effectiveness of pharmacological therapy for lower urinary tract symptoms secondary to benign prostatic hyperplasia in preventing long-term disease progression; and develop and validate predictive mod...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Langston, Marvin

Disparities in REsults of Immune Checkpoint Inhibitor Treatment (DiRECT): A Prospective Cohort Study of Cancer Survivors Treated with anti-PD-1/anti-PD-L1 in a Community Oncology Setting

This project will establish a prospective cohort of white and Black cancer patients treated with immune checkpoint inhibitors, leveraging the NCI Community Oncology Research Program network infrastructure, to investigate racial differences in immune-relat...
Funder: National Cancer Institute
Investigator: Sakoda, Lori

Leveraging Diversity in Cancer Epidemiology Cohorts and Novel Methods to Improve Polygenic Risk Scores

Inadequate representation of diverse racial/ethnic populations in genetic studies is hindering the translational potential of polygenic risk scores (PRS) in cancer risk prediction. To address this shortcoming, we aim to construct and evaluate PRS for canc...
Funder: National Cancer Institute
Investigator: Sakoda, Lori

mHealth Mindfulness Intervention for Pregnant Black and Latina Women at Risk of Postpartum Depression

This randomized controlled trial of an mHealth mindfulness intervention designed for Black and Latinx pregnant women at risk of developing postpartum depression will compare outcomes (depression, stress, sleep) of participants in the intervention with tho...
Funder: National Institute of Mental Health
Investigator: Avalos, Lyndsay; Kubo, Ai

De-Implementation of Outdated Colonoscopy Surveillance Interval Recommendations among Patients with Low-Risk Adenomas (DESIRE)

Recent guidelines have extended surveillance intervals for patients with low-risk adenomas from 5 years to 10. However, it remains unclear how to implement this change. In a pragmatic randomized 2-arm study of 1,000 patients with a history of low-risk ade...
Funder: TPMG Delivery Science Projects Program
Investigator: Lee, Jeffrey

Evaluating Acceptance and Screening Yield for Early Colorectal Cancer Screening: (EASY Early CRC)

Three national guideline groups now recommend that all adults start colorectal cancer (CRC) screening at age 45. Before 2018, some guideline groups only recommended African Americans begin CRC screening at age 45. There is currently no empirical evidence ...
Funder: Garfield Memorial Fund
Investigator: Levin, Theodore

Bipolar Disease and Parkinson's Disease

This study, being done with a parallel effort at UCSF, will focus on how bipolar disease is related to Parkinson's disease. We will look within the KPNC membership data, as well as focusing on a specific KP study population of bipolar disease.
Funder: Michael J. Fox Foundation
Investigator: Schaefer, Catherine; Van Den Eeden, Stephen

Racial/Ethnic Disparities in Ovarian Cancer Treatment and Survival: An Integrative Approach

We reported previously that African American and Hispanic women have worse survival after ovarian cancer diagnosis than white women, and Asian women have similar survival. We will investigate reasons for these disparities, focusing on tumor subtypes, hea...
Funder: National Cancer Institute
Investigator: Kushi, Lawrence

Energy Balance, mTOR Pathway Signaling, and Breast Cancer Prognosis: The Pathways Study

This application will use the Pathways Study resource to investigate genetic and non-genetic factors in the interplay of energy balance, mTOR signaling, and breast cancer prognosis. mTOR expression will be determined in tumor tissue from tissue microarra...
Funder: National Cancer Institute
Investigator: Kwan, Marilyn
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