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Cancer Studies

 

mHealth Mindfulness Intervention for Pregnant Black and Latina Women at Risk of Postpartum Depression

This randomized controlled trial of an mHealth mindfulness intervention designed for Black and Latinx pregnant women at risk of developing postpartum depression will compare outcomes (depression, stress, sleep) of participants in the intervention with tho...
Funder: National Institute of Mental Health
Investigator: Kubo, Ai

De-Implementation of Outdated Colonoscopy Surveillance Interval Recommendations among Patients with Low-Risk Adenomas (DESIRE)

Recent guidelines have extended surveillance intervals for patients with low-risk adenomas from 5 years to 10. However, it remains unclear how to implement this change. In a pragmatic randomized 2-arm study of 1,000 patients with a history of low-risk ade...
Funder: TPMG Delivery Science Projects Program
Investigator: Lee, Jeffrey

Evaluating Acceptance and Screening Yield for Early Colorectal Cancer Screening: (EASY Early CRC)

Three national guideline groups now recommend that all adults start colorectal cancer (CRC) screening at age 45. Before 2018, some guideline groups only recommended African Americans begin CRC screening at age 45. There is currently no empirical evidence ...
Funder: Garfield Memorial Fund
Investigator: Levin, Theodore

Bipolar Disease and Parkinson's Disease

This study, being done with a parallel effort at UCSF, will focus on how bipolar disease is related to Parkinson's disease. We will look within the KPNC membership data, as well as focusing on a specific KP study population of bipolar disease.
Funder: Michael J. Fox Foundation
Investigator: Schaefer, Catherine; Van Den Eeden, Stephen

Racial/Ethnic Disparities in Ovarian Cancer Treatment and Survival: An Integrative Approach

We reported previously that African American and Hispanic women have worse survival after ovarian cancer diagnosis than white women, and Asian women have similar survival. We will investigate reasons for these disparities, focusing on tumor subtypes, hea...
Funder: National Cancer Institute
Investigator: Kushi, Lawrence

Energy Balance, mTOR Pathway Signaling, and Breast Cancer Prognosis: The Pathways Study

This application will use the Pathways Study resource to investigate genetic and non-genetic factors in the interplay of energy balance, mTOR signaling, and breast cancer prognosis. mTOR expression will be determined in tumor tissue from tissue microarra...
Funder: National Cancer Institute
Investigator: Kwan, Marilyn

PREEMPT CRC: Prevention of Colorectal Cancer Through Multiomics Blood Testing

The primary objectives of this study are to determine the sensitivity and specificity of Freenome's test for colorectal adenocarcinoma, using screening CS with histopathology as the reference method.
Funder: Freenome Holdings, Inc
Investigator: Levin, Theodore

Multi-Ancestry Mapping of Pancreatic Cancer Susceptibility Loci

This multiple institution effort will assemble the largest set of pancreatic cases and controls to examine in detail the genetic influences on the risk and progression of pancreatic cancer and perform exome sequencing of minorities with pancreatic cancer.
Funder: National Cancer Institute
Investigator: Van Den Eeden, Stephen

Precision Prostate Cancer Screening with Genetically Adjusted Prostate-Specific Antigen Levels

An effort to more comprehensively determine the genetic factors associated with prostate-specific antigen (PSA) levels, and to develop and apply prediction models for prostate cancer outcomes based on genetically-adjusted PSA levels throughout life.
Funder: National Cancer Institute
Investigator: Van Den Eeden, Stephen

Non-alcoholic Fatty Liver Disease Prevalence and Associated Mortality (NAFLD PAM)

This study will investigate the incremental yield of using radiology imaging report information to diagnose non-alcoholic fatty liver disease (NAFLD) compared to International Classification of Disease, Ninth/Tenth Revision, Clinical Modification diagnose...
Funder: Northern California Community Benefit Programs
Investigator: Levin, Theodore

Prediction of Postoperative Urinary Retention in a Large Integrated Health System

Postoperative urinary retention (POUR) is the inability to void despite a full bladder following a surgical procedure. POUR can result in painful catherization, increased patient distress, increased postoperative hospital stay, urinary tract infections, d...
Funder: Northern California Community Benefit Programs
Investigator: Langston, Marvin

COVID-19 Pandemic: Impact on Colorectal Cancer Screening and Adenoma Surveillance Outcomes (PICASO)

The goal of this project is to evaluate the impact of the COVID pandemic on colorectal cancer screening and surveillance activities, and the impact on outcomes such as colorectal cancer incidence and stage.
Funder: Garfield Memorial Fund
Investigator: Levin, Theodore

An Electronic Health Record-Based Tool to Identify Newly Diagnosed Breast Cancer Patients at Risk of Low Social Support

Goals of the project are to: 1) Identify terms from content in the EHR, based on theory and prior literature, and informed by clinical stakeholders in BC care, that measure structural and/or functional social support, have been associated with BC treatmen...
Funder: National Cancer Institute
Investigator: Kroenke, Candyce

Informatics approaches to assessing patient frailty in surgical care

Patient frailty increases the risk for surgical complications, which are common, costly, and deadly, especially for older Americans. To improve surgical care for older adults, we will investigate whether electronic measures of frailty can help reduce comp...
Funder: National Institute on Aging
Investigator: Feliciano, Elizabeth

Understanding Racial/Ethnic Disparities in Lung Cancer Screening Utilization

This study proposes to understand patterns and multilevel determinants of racial/ethnic disparities in Lung Cancer Screening utilization from 2017 onward at KPNC.
Funder: Northern California Community Benefit Programs
Investigator: Sakoda, Lori

The Colonic Microbiome Preceding Parkinson's Disease: A Pilot Study

Gut changes, including evidence of alpha synuclein and the microbiome, appear to differ between people with and without Parkinson's disease. This pilot study will use colonic biospecimens from deceased patients with Parkinson's disease and control patient...
Funder: University of California, San Francisco, Project Grant
Investigator: Van Den Eeden, Stephen

Bipolar Disease and Parkinson's Disease

This study, along with a parallel effort at the University of California, San Francisco, will focus on the relationship between bipolar disease and Parkinson's disease.
Funder: Michael J. Fox Foundation
Investigator: Van Den Eeden, Stephen

Breast White Adipose Tissue Inflammation and Breast Cancer Outcomes

We will assess the incidence and severity of breast white adipose tissue (B-WAT) inflammation in mastectomy specimens from approximately 1,900 Pathways Study participants to examine associations of various factors with B-WAT inflammation incidence and sev...
Funder: National Cancer Institute
Investigator: Kushi, Lawrence

Body Composition and Breast Cancer Survival: Immune and Metabolic Biomarkers in Breast Tumors

We previously found that one third of nonmetastatic breast cancer patients had sarcopenia (age-related loss of muscle tissue) at the time of their diagnosis and that having sarcopenia and obesity was associated with an 89% increased risk of death. This st...
Funder: National Cancer Institute
Investigator: Feliciano, Elizabeth

Recurrence, Treatment, and Complication Patterns of Intermediate Risk Non-muscle Invasive Bladder Cancer

This study will comprehensively assess the clinical course of intermediate risk non-muscle invasive bladder cancer (NMIBC) in 291 patients diagnosed at Kaiser Permanente Northern California who are enrolled in the Be-Well Study. Intermediate risk NMIBC is...
Funder: UroGen Pharma, Inc.
Investigator: Kwan, Marilyn

NRG Oncology NCORP Research Base

This is a non-inferiority trial design comparing colorectal cancer incidence in trial participants with 1-2 non-advanced adenomas randomized to recommendation for a 5- and 10-year surveillance colonoscopy exam vs. a 10-year surveillance colonoscopy exam.
Funder: National Cancer Institute
Investigator: Corley, Douglas

Kaiser Permanente Interregional Cancer Statistics Project

A Kaiser Permanente interregional cancer statistics report will be developed to include incidence and 5-year relative survival rates for breast, colorectal, and lung cancer. The development of new mortality measures will be explored, along with improved r...
Funder: Center for Effectiveness and Safety Research
Investigator: Kushi, Lawrence

PREDICT PCCC: PREDICTing Post Colonoscopy Colorectal Cancer

We are using post-polypectomy surveillance, an increasingly common indication for colonoscopy in clinical practice at TPMG and across the United States, as a model for how we might risk-stratify patients for care. Patients and physicians desire more preci...
Funder: The Permanente Medical Group
Investigator: Levin, Theodore

D3-creatine dilution to assess skeletal muscle mass in colon cancer patients

Among colon cancer patients participating in a resistance training intervention during chemotherapy, this study will examine whether a new method to evaluate skeletal muscle mass (d3-creatine dilution) is associated with the key cancer outcomes of strengt...
Funder: National Cancer Institute
Investigator: Feliciano, Elizabeth

Pediatric obstructive sleep apnea: predictive modeling to streamline care

To prioritize pediatric attended polysomnography and treatment for children most in need while reducing the unnecessary use of overnight sleep studies, we propose to build and rigorously evaluate a clinical risk prediction model. We will combine data from...
Funder: The Permanente Medical Group
Investigator: Feliciano, Elizabeth
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