The burden of osteoporosis has increased with the growing US population over age 65 years, and ethnic diversity has also increased. This study addresses an important knowledge gap by conducting the first large scale U.S. study of fracture outcomes among A...
Funder: National Institute on Aging
Investigator: Lo, Joan
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This CARDIA ancillary study will examine the longitudinal relations of 35-year changes in reported physical activity from young adulthood to late midlife with indicators of subclinical heart failure collected at late midlife, and evaluate interaction in t...
Funder: National Heart, Lung, and Blood Institute
Investigator: Sidney, Stephen
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To determine if one-time screening for atrial fibrillation using the 14-day Zio XT patch leads to a reduced risk of stroke compared with usual care among adults aged 70 years or older without prior known atrial fibrillation or atrial flutter.
Funder: Bristol-Myers Squibb Company
Investigator: Go, Alan; Ambrosy, Andrew
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The goal of this study is to obtain COVID-19 surveillance study (questionnaire and serology) in 6 cohort studies funded by NHLBI including the CARDIA study. A surveillance questionnaire will be administered 3 times at approximately 6 month intervals and ...
Funder: National Heart, Lung, and Blood Institute
Investigator: Sidney, Stephen
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In CARDIA Year 35 exam: Assess whether sexual minority and gender minority (SGM) individuals in CARDIA have increased odds of objectively-determined traditional cardiovascular disease (CVD) risk factors and poorer CVD outcomes compared to their non-SGM co...
Funder: National Heart, Lung, and Blood Institute
Investigator: Sidney, Stephen
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Determine the independent and joint contributions of behavioral, psychosocial and clinical characteristics over 35 years of CARDIA participation on sleep and circadian characteristics in middle-aged adults. Identify the relationship of sleep and circadian...
Funder: National Heart, Lung, and Blood Institute
Investigator: Sidney, Stephen
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This study will assess the accuracy of using a natural language processing-based approach to retrospectively identify episodes of outpatient worsening heart failure in unstructured electronic health record data within an integrated health care delivery sy...
Funder: Northern California Community Benefit Programs
Investigator: Ambrosy, Andrew
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This virtual, pragmatic randomized clinical trial will evaluate whether rivaroxaban reduces the risk of a composite endpoint of major venous and arterial thrombotic events, all-cause hospitalization, and all-cause mortality compared with placebo in outpat...
Funder: Janssen AIzheimer Immunotherapy R＆D
Investigator: Go, Alan; Ambrosy, Andrew
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The decreased trend in patients seeking care for acute stroke, acute MI, and acute surgical presentations during the COVID-19 pandemic is concerning for potential long-term morbidity, mortality, rehabilitation costs, and preventable downstream health care...
Funder: Garfield Memorial Fund
Investigator: Nguyen-Huynh, Mai
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While the Affordable Care Act-mandated Hospital Readmission Reduction Program launched in 2012 has modestly reduced readmissions, an unintended consequence has been the shift of a significant fraction of heart failure (HF)-related care to the outpatient s...
Funder: National Heart, Lung, and Blood Institute
Investigator: Ambrosy, Andrew
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This 5-year RO1 study will determine the independent contribution of fetal exposures and early postnatal lifestyle factors on subsequent development of child adiposity and metabolic health among youth (ages 9 to 13 ) exposed to gestational diabetes in ute...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Gunderson, Erica
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This pragmatic randomized clinical trial funded through National and NCAL Community Health/Benefits is testing the impact of medically-tailored meals and enhanced nutritional counseling compared to usual care on clinical and patient-centered outcomes in h...
Funder: Kaiser Permanente Program Offices
Investigator: Go, Alan; Ambrosy, Andrew
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This multi-center, multi-country retrospective cohort study will assess the clinical course and outcome of adults with severe COVID-19 not treated with remdesivir using a 7-point ordinal scale for clinical outcomes on Day 14 and all-cause mortality at Day...
Funder: Gilead Sciences, Inc.
Investigator: Go, Alan; Ambrosy, Andrew
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This study will look at the clinical benefit of early adoption of the MitraClip device in patients with heart failure in a real-world setting. Previous research showed patients who have the MitraClip procedure have 50% fewer hospitalizations for heart fai...
Funder: Abbott Laboratories
Investigator: Ambrosy, Andrew
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This study will assess the inpatient and outpatient health care utilization and mortality of patients with heart failure and how it relates to their degree of systolic dysfunction.
Funder: Novartis International AG
Investigator: Ambrosy, Andrew
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The MITIGATE Study will evaluate the real-world clinical effectiveness of icosapent ethyl (Vascepa®) compared to usual care in patients with established atherosclerotic cardiovascular disease. The study will evaluate whether the drug, which is used to red...
Funder: Amarin Corporation
Investigator: Ambrosy, Andrew
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This study will identify biochemical markers that predict type 2 diabetes mellitus in women after a pregnancy complicated by gestational diabetes mellitus (GDM). Ultimately, the results of this study may lead to improved testing and more effective, person...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Gunderson, Erica
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Study will evaluate the performance of the RAPID software interpretation of CT perfusion (CTP) studies and determination of qualifications for endovascular therapy (EST). It will include a retrospective case review of prospectively collected data on conse...
Funder:
Investigator: Nguyen-Huynh, Mai
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Determinants
of cognitive aging may begin decades prior to the development of pathological
brain changes, but it is unknown whether risk factors such as hypertension
and diabetes exert their influence as early as young adulthood. In this
CARDIA Ye...
Funder: National Institute on Aging
Investigator: Sidney, Stephen
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The Study of Women, Infant Feeding, and Type 2 Diabetes after GDM Pregnancy (SWIFT) is a prospective, community-based cohort of mothers aged 20-45 years of age and diagnosed with gestational diabetes mellitus (GDM) who delivered a singleton pregnancy long...
Funder: National Heart, Lung, and Blood Institute
Investigator: Gunderson, Erica
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The KPNC-ILD cohort will consist of approximately 10,000 patients with interstitial lung disease. It will be built through electronic health recordbased case identification using an algorithm that will be further developed. We anticipate optimizing the e...
Funder: Genentech, Inc.
Investigator: Iribarren, Carlos
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This project will generate longitudinal plasma metabolomic profiles in the CARDIA study cohort to better understand underlying molecular mechanisms for cardiovascular disease (CVD). We will identify metabolites and metabolic pathways related to CVD risk f...
Funder: National Heart, Lung, and Blood Institute
Investigator: Sidney, Stephen
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This multicenter Cardiovascular Research Network (CVRN) collaborative project will examine the risks and benefits of targeted medical therapies used for heart failure across the spectrum of multimorbidity burden and level of left ventricular systolic func...
Funder: National Institute on Aging
Investigator: Go, Alan
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There is an unmet clinical need to better understand the impact of lifestyle choices with respect to diet and nutrition in high-risk heart failure patients who have been recently hospitalized. We will conduct a survey-based project using a combination of ...
Funder: Northern California Community Benefit Programs
Investigator: Go, Alan; Ambrosy, Andrew; Gordon, Nancy
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The study aim is to optimize the Kaiser Permanente Northern California (KPNC) Interstitial Lung Disease (ILD) algorithm and establish the KPNC-ILD cohort. The KPNC-ILD cohort will consist of approximately 10,000 patients with ILD. It will be built through...
Funder: Genentech, Inc.
Investigator: Iribarren, Carlos
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