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Cardiovascular and Metabolic Conditions Studies

 

Metabolites Preceding Progression to Type 2 Diabetes in Women after Gestational Diabetes

This study will identify biochemical markers that predict type 2 diabetes mellitus in women after a pregnancy complicated by gestational diabetes mellitus (GDM). Ultimately, the results of this study may lead to improved testing and more effective, person...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Gunderson, Erica

Advancing Geriatrics Infrastructure & Network Growth (AGING) Initiative

The study will evaluate the association of comorbidity burden and specific comorbidities with health and utilization outcomes following transcatheter aortic valve replacement (TAVR) for the treatment of severe aortic stenosis. Patients who receive TAVR te...
Funder: National Institute on Aging
Investigator: Go, Alan

Extended Window for Thrombectomy - Have we extended our resources appropriately and effectively

Study will evaluate the performance of the RAPID software interpretation of CT perfusion (CTP) studies and determination of qualifications for endovascular therapy (EST). It will include a retrospective case review of prospectively collected data on conse...
Funder: 
Investigator: Nguyen-Huynh, Mai

Lifecourse CVD Risk and Midlife Cognitive Trajectories and Brain Aging: Implications for Alzheimer's and Dementia Prevention

Determinants of cognitive ...
Funder: National Institute on Aging
Investigator: Sidney, Stephen

Gestational diabetes phenotypes, glucose tolerance transitions and lifestyle behaviors related to cardiovascular risk status

The Study of Women, Infant Feeding, and Type 2 Diabetes after GDM Pregnancy (SWIFT) is a prospective, community-based cohort of mothers aged 20-45 years of age and diagnosed with gestational diabetes mellitus (GDM) who delivered a singleton pregnancy long...
Funder: National Heart, Lung, and Blood Institute
Investigator: Gunderson, Erica

Community-based, Longitudinal Cohort of Patients with Interstitial Lung Disease (ILD) in the Kaiser Permanente Northern California (KPNC) Health System

The KPNC-ILD cohort will consist of approximately 10,000 patients with interstitial lung disease. It will be built through electronic health recordbased case identification using an algorithm that will be further developed. We anticipate optimizing the e...
Funder: Genentech, Inc.
Investigator: Iribarren, Carlos

Leveraging Multi-omics Approaches to Examine Metabolic Challenges of Obesity in Relation to Cardiovascular Diseases

This project will generate longitudinal plasma metabolomic profiles in the CARDIA study cohort to better understand underlying molecular mechanisms for cardiovascular disease (CVD). We will identify metabolites and metabolic pathways related to CVD risk f...
Funder: National Heart, Lung, and Blood Institute
Investigator: Sidney, Stephen

Healthy Eating as a Means for Active Living in Heart Failure (HEAL-HF) Study

There is an unmet clinical need to better understand the impact of lifestyle choices with respect to diet and nutrition in high-risk heart failure patients who have been recently hospitalized. We will conduct a survey-based project using a combination of ...
Funder: Northern California Community Benefit Programs
Investigator: Ambrosy, Andrew; Go, Alan

Multimorbidity and Treatment-Related Outcomes in Older Heart Failure Patients

This multicenter Cardiovascular Research Network (CVRN) collaborative project will examine the risks and benefits of targeted medical therapies used for heart failure across the spectrum of multimorbidity burden and level of left ventricular systolic func...
Funder: National Institute on Aging
Investigator: Go, Alan

Community-Based, Longitudinal cohort of Patients with Interstitial Lung Disease in the Kaiser Permanente Northern California Health System

The study aim is to optimize the Kaiser Permanente Northern California (KPNC) Interstitial Lung Disease (ILD) algorithm and establish the KPNC-ILD cohort. The KPNC-ILD cohort will consist of approximately 10,000 patients with ILD. It will be built through...
Funder: Genentech, Inc.
Investigator: Iribarren, Carlos

Disparities in Residual Risk in Patients Receiving Statins for Primary or Secondary Prevention at an Integrated Health Care Delivery System

Patients with risk factors for or established atherosclerotic cardiovascular disease (ASCVD) remain at high risk for first-time or recurrent nonfatal and fatal events, despite guideline-directed medical therapy for primary and secondary prevention. In fac...
Funder: Amarin Corporation
Investigator: Ambrosy, Andrew

MINERVA Biomarkers Substudy

The purpose of this study is to conduct assays of a selected panel of cardiac/metabolic/cancer biomarkers in blood samples already collected by the MINERVA Study (n = 4,491), currently stored at the Kaiser Permanente Research Bank. The biomarker data will...
Funder: Abbott Laboratories
Investigator: Iribarren, Carlos

Optimizing Atrial Fibrillation Management in Chronic Kidney Disease

As an extension of the ATRIA-CVRN collaboration in Kaiser Permanente Northern California and Southern California, we will examine the recent use and associated outcomes of different management strategies for atrial fibrillation in adults with and without ...
Funder: National Heart, Lung, and Blood Institute
Investigator: Go, Alan

Sleep Disordered Breathing and Outcomes in Chronic Kidney Disease

The overall objective of this ancillary study to the ongoing NIH-sponsored Chronic Renal Insufficiency Cohort (CRIC) study is to evaluate sleep-disordered breathing (assessed by home sleep-monitoring using the WatchPAT200 device) as a potential predictor ...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Go, Alan

Prenatal Blood Pressure Patterns to Predict Pregnancy-Related Hypertension and Later-Life Cardiovascular Risk

This study utilizes clinical prenatal-care blood pressure measurements and other clinical and biochemical variables to develop models for the early prediction of hypertensive disorders of pregnancy, and evaluates the relationship of pregnancy blood-pressu...
Funder: National Heart, Lung, and Blood Institute
Investigator: Gunderson, Erica

Nor-Cal-CSC for Northern California Regional Coordinating Center

The Northern California Regional Coordinating Stroke Center (NorCal-CSC) is a joint effort between U.C. San Francisco and selected medical center(s) within Kaiser Permanente as part of the National Institute of Neurological Disorders and Stroke (NINDS) St...
Funder: National Institute of Neurological Disorders and Stroke
Investigator: Nguyen-Huynh, Mai

Acute Kidney Injury among Patients with Chronic Kidney Disease

This ancillary project to the multicenter Chronic Renal Insufficiency Cohort (CRIC) Study will examine the incidence and associated predictors of episodes of acute kidney injury among a prospective cohort of adults with underlying chronic kidney disease, ...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Go, Alan

Chronic Renal Insufficiency Cohort Study IV (CRIC-4)

This is a renewal of the Chronic Renal Insufficiency Cohort (CRIC) Study Clinical Center at Kaiser Permanente Northern California and UCSF, which will continue long-term follow-up of existing participants with chronic kidney. The overall goals are to exam...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Go, Alan

Population-Based Pharmacogenomic Assessment of QT Prolongation

​Cardiotoxicity of commonly prescribed medications, typically assessed by electrocardiographic features such as prolongation of the QT interval, has regulatory effects and is associated with potentially fatal outcomes. This project aims to advance unde...
Funder: National Heart, Lung, and Blood Institute
Investigator: Iribarren, Carlos

TRANSFORM-HF (ToRsemide compArisoN with furoSemide FOR Management of Heart Failure) Study

Patients with heart failure will be randomized 1:1 to either oral torsemide or oral furosemide prior to hospital discharge. The primary endpoint will be all-cause mortality over the follow-up period. Secondary endpoints are hospitalizations, quality o...
Funder: National Heart, Lung, and Blood Institute
Investigator: Ambrosy, Andrew

How Fast is Fast Enough? Assessing Door-to-Needle Times and Outcomes of Stroke Patients Receiving Acute Thrombolysis Therapy Under the Kaiser Permanente Northern California Stroke EXPRESS Program

With stroke treatment, there is a general belief that "time is brain." However, there has been no published data examining specifically the association between door-to-needle times for acute treatment with intravenous alteplase in stroke patient...
Funder: The Permanente Medical Group
Investigator: Nguyen-Huynh, Mai

Network and Infrastructure Support for Development of Interdisciplinary Aging Research

For adults aged 40 to 75 years, randomized trials provide conclusive evidence that statins reduce the risk of initial and secondary cardiovascular disease (CVD) events. However, there is limited evidence that statins reduce CVD events in individuals over ...
Funder: National Institute on Aging
Investigator: Go, Alan

Predicting Readmission After Stroke Study (PRESS)

Hospital readmissions are a tremendous burden on patients, their families, and the health care system. In 2008, the Centers for Medicare and Medicaid Services began publicly reporting hospital-level, risk-standardized, 30-day readmission and mortality rat...
Funder: National Institute of Neurological Disorders and Stroke
Investigator: Nguyen-Huynh, Mai

Hispanic Chronic Renal Insufficiency Cohort (HCRIC) Study

This is a renewal of an ongoing ancillary study to the Chronic Renal Insufficiency Cohort (CRIC) Study to examine whether rates of loss of kidney function and subclinical and clinical cardiovascular disease varies among Hispanics versus other race/ethnic ...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Go, Alan

Multiple Chronic Conditions and Adverse Outcomes in Older Adults with Heart Failure

This ancillary pilot study to the Cardiovascular Research Network Heart Failure Consortium will evaluate the frequency and association of multiple chronic condition burden with clinical outcomes in adults who have diagnosed heart failure.
Funder: National Institute on Aging
Investigator: Go, Alan
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