Determinants
of cognitive ...
Funder: National Institute on Aging
Investigator: Sidney, Stephen
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The KPNC-ILD cohort will consist of approximately 10,000 patients with interstitial lung disease. It will be built through electronic health recordbased case identification using an algorithm that will be further developed. We anticipate optimizing the e...
Funder: Genentech, Inc.
Investigator: Iribarren, Carlos
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This project will generate longitudinal plasma metabolomic profiles in the CARDIA study cohort to better understand underlying molecular mechanisms for cardiovascular disease (CVD). We will identify metabolites and metabolic pathways related to CVD risk f...
Funder: National Heart, Lung, and Blood Institute
Investigator: Sidney, Stephen
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There is an unmet clinical need to better understand the impact of lifestyle choices with respect to diet and nutrition in high-risk heart failure patients who have been recently hospitalized. We will conduct a survey-based project using a combination of ...
Funder: Northern California Community Benefit Programs
Investigator: Ambrosy, Andrew; Go, Alan
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This multicenter Cardiovascular Research Network (CVRN) collaborative project will examine the risks and benefits of targeted medical therapies used for heart failure across the spectrum of multimorbidity burden and level of left ventricular systolic func...
Funder: National Institute on Aging
Investigator: Go, Alan
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The study aim is to optimize the Kaiser Permanente Northern California (KPNC) Interstitial Lung Disease (ILD) algorithm and establish the KPNC-ILD cohort. The KPNC-ILD cohort will consist of approximately 10,000 patients with ILD. It will be built through...
Funder: Genentech, Inc.
Investigator: Iribarren, Carlos
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Patients with risk factors for or established atherosclerotic cardiovascular disease (ASCVD) remain at high risk for first-time or recurrent nonfatal and fatal events, despite guideline-directed medical therapy for primary and secondary prevention. In fac...
Funder: Amarin Corporation
Investigator: Ambrosy, Andrew
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The purpose of this study is to conduct assays of a selected panel of cardiac/metabolic/cancer biomarkers in blood samples already collected by the MINERVA Study (n = 4,491), currently stored at the Kaiser Permanente Research Bank. The biomarker data will...
Funder: Abbott Laboratories
Investigator: Iribarren, Carlos
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As an extension of the ATRIA-CVRN collaboration in Kaiser Permanente Northern California and Southern California, we will examine the recent use and associated outcomes of different management strategies for atrial fibrillation in adults with and without ...
Funder: National Heart, Lung, and Blood Institute
Investigator: Go, Alan
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The overall objective of this ancillary study to the ongoing NIH-sponsored Chronic Renal Insufficiency Cohort (CRIC) study is to evaluate sleep-disordered breathing (assessed by home sleep-monitoring using the WatchPAT200 device) as a potential predictor ...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Go, Alan
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This study will conduct a secondary data analysis of CARDIA women that leverages existing data to evaluate the relation of pre-pregnancy inflammation to the occurrence of pre-term birth and to determine whether the inflammatory profile is exacerbated foll...
Funder: National Heart, Lung, and Blood Institute
Investigator: Gunderson, Erica
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This study utilizes clinical prenatal-care blood pressure measurements and other clinical and biochemical variables to develop models for the early prediction of hypertensive disorders of pregnancy, and evaluates the relationship of pregnancy blood-pressu...
Funder: National Heart, Lung, and Blood Institute
Investigator: Gunderson, Erica
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The Northern California Regional Coordinating Stroke Center (NorCal-CSC) is a joint effort between U.C. San Francisco and selected medical center(s) within Kaiser Permanente as part of the National Institute of Neurological Disorders and Stroke (NINDS) St...
Funder: National Institute of Neurological Disorders and Stroke
Investigator: Nguyen-Huynh, Mai
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This ancillary project to the multicenter Chronic Renal Insufficiency Cohort (CRIC) Study will examine the incidence and associated predictors of episodes of acute kidney injury among a prospective cohort of adults with underlying chronic kidney disease, ...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Go, Alan
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This is a renewal of the Chronic Renal Insufficiency Cohort (CRIC) Study Clinical Center at Kaiser Permanente Northern California and UCSF, which will continue long-term follow-up of existing participants with chronic kidney. The overall goals are to exam...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Go, Alan
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Cardiotoxicity of commonly prescribed medications, typically assessed by electrocardiographic features such as prolongation of the QT interval, has regulatory effects and is associated with potentially fatal outcomes. This project aims to advance unde...
Funder: National Heart, Lung, and Blood Institute
Investigator: Iribarren, Carlos
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Patients with heart failure will be randomized 1:1 to either oral torsemide or oral furosemide prior to hospital discharge. The primary endpoint will be all-cause mortality over the follow-up period. Secondary endpoints are hospitalizations, quality o...
Funder: National Heart, Lung, and Blood Institute
Investigator: Ambrosy, Andrew
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With stroke treatment, there is a general belief that "time is brain." However, there has been no published data examining specifically the association between door-to-needle times for acute treatment with intravenous alteplase in stroke patient...
Funder: The Permanente Medical Group
Investigator: Nguyen-Huynh, Mai
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For adults aged 40 to 75 years, randomized trials provide conclusive evidence that statins reduce the risk of initial and secondary cardiovascular disease (CVD) events. However, there is limited evidence that statins reduce CVD events in individuals over ...
Funder: National Institute on Aging
Investigator: Go, Alan
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Hospital readmissions are a tremendous burden on patients, their families, and the health care system. In 2008, the Centers for Medicare and Medicaid Services began publicly reporting hospital-level, risk-standardized, 30-day readmission and mortality rat...
Funder: National Institute of Neurological Disorders and Stroke
Investigator: Nguyen-Huynh, Mai
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This is a renewal of an ongoing ancillary study to the Chronic Renal Insufficiency Cohort (CRIC) Study to examine whether rates of loss of kidney function and subclinical and clinical cardiovascular disease varies among Hispanics versus other race/ethnic ...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Go, Alan
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The goal of this study is to develop a simple biomarker signature that can predict future type 2 diabetes with excellent specificity, sensitivity and precision.
Funder: Janssen Pharmaceuticals, Inc.
Investigator: Gunderson, Erica
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This ancillary pilot study to the Cardiovascular Research Network Heart Failure Consortium will evaluate the frequency and association of multiple chronic condition burden with clinical outcomes in adults who have diagnosed heart failure.
Funder: National Institute on Aging
Investigator: Go, Alan
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