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Cardiovascular and Metabolic Conditions Studies

 

Acute Emergency Care and Outcomes for Stroke, Myocardial Infarction, and Surgery During the COVID-19 Pandemic in Kaiser Permanente Northern California: Implications for Care Delivery During COVID-19 Recovery Phase and Future Surges

The decreased trend in patients seeking care for acute stroke, acute MI, and acute surgical presentations during the COVID-19 pandemic is concerning for potential long-term morbidity, mortality, rehabilitation costs, and preventable downstream health care...
Funder: Garfield Memorial Fund
Investigator: Nguyen-Huynh, Mai

Outpatient Worsening Heart Failure in an Integrated Health Care Delivery System: An Innovative Approach to Characterizing a Novel Clinical Entity

While the Affordable Care Act-mandated Hospital Readmission Reduction Program launched in 2012 has modestly reduced readmissions, an unintended consequence has been the shift of a significant fraction of heart failure (HF)-related care to the outpatient s...
Funder: National Heart, Lung, and Blood Institute
Investigator: Ambrosy, Andrew

Fetal and Early Postnatal Influences on Child Metabolic Health After Gestational Diabetes

This 5-year RO1 study will determine the independent contribution of fetal exposures and early postnatal lifestyle factors on subsequent development of child adiposity and metabolic health among youth (ages 9 to 13 ) exposed to gestational diabetes in ute...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Gunderson, Erica

KP NOURISH: Evaluation of the Clinical Utility of Medically-Tailored Meals in Adults with Chronic Conditions

This pragmatic randomized clinical trial funded through National and NCAL Community Health/Benefits is testing the impact of medically-tailored meals and enhanced nutritional counseling compared to usual care on clinical and patient-centered outcomes in h...
Funder: Kaiser Permanente Program Office
Investigator: Go, Alan; Ambrosy, Andrew

A Multi-center, Multi-country Retrospective Cohort Study to Evaluate the Clinical Outcomes in Adults with Severe COVID-19

This multi-center, multi-country retrospective cohort study will assess the clinical course and outcome of adults with severe COVID-19 not treated with remdesivir using a 7-point ordinal scale for clinical outcomes on Day 14 and all-cause mortality at Day...
Funder: Gilead Sciences, Inc.
Investigator: Go, Alan; Ambrosy, Andrew

Transcatheter Mitral-Valve Repair in Patients with Heart Failure and Functional Mitral Regurgitation - Potential Scope and Clinical Benefit of Early Adoption at an Integrated Healthcare Delivery System

This study will look at the clinical benefit of early adoption of the MitraClip device in patients with heart failure in a real-world setting. Previous research showed patients who have the MitraClip procedure have 50% fewer hospitalizations for heart fai...
Funder: Abbott Laboratories
Investigator: Ambrosy, Andrew

Evaluating Inpatient and OutpatIent Encounters Within a Learning and Integrated Health Care Delivery Organization Due to Worsening Heart Failure (UTILIZE-WHF)

This study will assess the inpatient and outpatient health care utilization and mortality of patients with heart failure and how it relates to their degree of systolic dysfunction.
Funder: Novartis International AG
Investigator: Ambrosy, Andrew

Pragmatic RandomIzed Trial of Icosapent Ethyl for High-Cadiovascular Risk Adults (MITIGATE)

The MITIGATE Study will evaluate the real-world clinical effectiveness of icosapent ethyl (Vascepa®) compared to usual care in patients with established atherosclerotic cardiovascular disease. The study will evaluate whether the drug, which is used to red...
Funder: Amarin Corporation
Investigator: Ambrosy, Andrew

Metabolites Preceding Progression to Type 2 Diabetes in Women after Gestational Diabetes

This study will identify biochemical markers that predict type 2 diabetes mellitus in women after a pregnancy complicated by gestational diabetes mellitus (GDM). Ultimately, the results of this study may lead to improved testing and more effective, person...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Gunderson, Erica

Advancing Geriatrics Infrastructure & Network Growth (AGING) Initiative

The study will evaluate the association of comorbidity burden and specific comorbidities with health and utilization outcomes following transcatheter aortic valve replacement (TAVR) for the treatment of severe aortic stenosis. Patients who receive TAVR te...
Funder: National Institute on Aging
Investigator: Go, Alan

Extended Window for Thrombectomy - Have we extended our resources appropriately and effectively

Study will evaluate the performance of the RAPID software interpretation of CT perfusion (CTP) studies and determination of qualifications for endovascular therapy (EST). It will include a retrospective case review of prospectively collected data on conse...
Funder: 
Investigator: Nguyen-Huynh, Mai

Lifecourse CVD Risk and Midlife Cognitive Trajectories and Brain Aging: Implications for Alzheimer's and Dementia Prevention

Determinants of cognitive aging may begin decades prior to the development of pathological brain changes, but it is unknown whether risk factors such as hypertension and diabetes exert their influence as early as young adulthood. In this CARDIA Ye...
Funder: National Institute on Aging
Investigator: Sidney, Stephen

Gestational diabetes phenotypes, glucose tolerance transitions and lifestyle behaviors related to cardiovascular risk status

The Study of Women, Infant Feeding, and Type 2 Diabetes after GDM Pregnancy (SWIFT) is a prospective, community-based cohort of mothers aged 20-45 years of age and diagnosed with gestational diabetes mellitus (GDM) who delivered a singleton pregnancy long...
Funder: National Heart, Lung, and Blood Institute
Investigator: Gunderson, Erica

Community-based, Longitudinal Cohort of Patients with Interstitial Lung Disease (ILD) in the Kaiser Permanente Northern California (KPNC) Health System

The KPNC-ILD cohort will consist of approximately 10,000 patients with interstitial lung disease. It will be built through electronic health recordbased case identification using an algorithm that will be further developed. We anticipate optimizing the e...
Funder: Genentech, Inc.
Investigator: Iribarren, Carlos

Leveraging Multi-omics Approaches to Examine Metabolic Challenges of Obesity in Relation to Cardiovascular Diseases

This project will generate longitudinal plasma metabolomic profiles in the CARDIA study cohort to better understand underlying molecular mechanisms for cardiovascular disease (CVD). We will identify metabolites and metabolic pathways related to CVD risk f...
Funder: National Heart, Lung, and Blood Institute
Investigator: Sidney, Stephen

Multimorbidity and Treatment-Related Outcomes in Older Heart Failure Patients

This multicenter Cardiovascular Research Network (CVRN) collaborative project will examine the risks and benefits of targeted medical therapies used for heart failure across the spectrum of multimorbidity burden and level of left ventricular systolic func...
Funder: National Institute on Aging
Investigator: Go, Alan

Healthy Eating as a Means for Active Living in Heart Failure (HEAL-HF) Study

There is an unmet clinical need to better understand the impact of lifestyle choices with respect to diet and nutrition in high-risk heart failure patients who have been recently hospitalized. We will conduct a survey-based project using a combination of ...
Funder: Northern California Community Benefit Programs
Investigator: Ambrosy, Andrew; Go, Alan; Gordon, Nancy

Community-Based, Longitudinal cohort of Patients with Interstitial Lung Disease in the Kaiser Permanente Northern California Health System

The study aim is to optimize the Kaiser Permanente Northern California (KPNC) Interstitial Lung Disease (ILD) algorithm and establish the KPNC-ILD cohort. The KPNC-ILD cohort will consist of approximately 10,000 patients with ILD. It will be built through...
Funder: Genentech, Inc.
Investigator: Iribarren, Carlos

Disparities in Residual Risk in Patients Receiving Statins for Primary or Secondary Prevention at an Integrated Health Care Delivery System

Patients with risk factors for or established atherosclerotic cardiovascular disease (ASCVD) remain at high risk for first-time or recurrent nonfatal and fatal events, despite guideline-directed medical therapy for primary and secondary prevention. In fac...
Funder: Amarin Corporation
Investigator: Ambrosy, Andrew

MINERVA Biomarkers Substudy

We will conduct assays of a selected panel of cardiac, metabolic, and cancer biomarkers in 3,000 blood samples collected by the MINERVA (MultIethNic Study of BrEast ARterial Calcium Gradation and CardioVAscular Disease) Study and stored at the Kaiser Biob...
Funder: Abbott Laboratories
Investigator: Iribarren, Carlos

Optimizing Atrial Fibrillation Management in Chronic Kidney Disease

As an extension of the ATRIA-CVRN collaboration in Kaiser Permanente Northern California and Southern California, we will examine the recent use and associated outcomes of different management strategies for atrial fibrillation in adults with and without ...
Funder: National Heart, Lung, and Blood Institute
Investigator: Go, Alan

Sleep Disordered Breathing and Outcomes in Chronic Kidney Disease

The overall objective of this ancillary study to the ongoing NIH-sponsored Chronic Renal Insufficiency Cohort (CRIC) study is to evaluate sleep-disordered breathing (assessed by home sleep-monitoring using the WatchPAT200 device) as a potential predictor ...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Go, Alan

Prenatal Blood Pressure Patterns to Predict Pregnancy-Related Hypertension and Later-Life Cardiovascular Risk

This study utilizes clinical prenatal-care blood pressure measurements and other clinical and biochemical variables to develop models for the early prediction of hypertensive disorders of pregnancy, and evaluates the relationship of pregnancy blood-pressu...
Funder: National Heart, Lung, and Blood Institute
Investigator: Gunderson, Erica

Nor-Cal-CSC for Northern California Regional Coordinating Center

The Northern California Regional Coordinating Stroke Center (NorCal-CSC) is a joint effort between U.C. San Francisco and selected medical center(s) within Kaiser Permanente as part of the National Institute of Neurological Disorders and Stroke (NINDS) St...
Funder: National Institute of Neurological Disorders and Stroke
Investigator: Nguyen-Huynh, Mai

Acute Kidney Injury among Patients with Chronic Kidney Disease

This ancillary project to the multicenter Chronic Renal Insufficiency Cohort (CRIC) Study will examine the incidence and associated predictors of episodes of acute kidney injury among a prospective cohort of adults with underlying chronic kidney disease, ...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Go, Alan
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