NUDGE-FLU was a nationwide, pragmatic, registry-based, cluster-randomized implementation trial during the 2022-23 influenza season in Denmark. NUDGE FLU randomized >960,000 Danish citizens aged 65 years or older to usual care or 9 different behaviorally i...
Funder: Sanofi Pasteur S.A.
Investigator: Bhatt, Ankeet
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IDENTIFY-WHF is a prospective, virtual, parallel-group, randomized, quality improvement intervention of EHR-based alerts for worsening heart failure (WHF) to improve the adoption of guideline-directed medical therapy (GDMT) within an integrated and learni...
Funder: TPMG Delivery Science Projects Program
Investigator: Ambrosy, Andrew
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This initiative evaluates strategies (including technology-based decision support, referral to a virtual guideline-directed medical therapy team, and general educational tools/resources for clinicians and patients) to improve use of guideline-directed the...
Funder: American College of Cardiology Foundation
Investigator: Bhatt, Ankeet
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Study has 3 aims: Identify and characterize common and rare genetic variants and environmental factors underlying untreated LDL-cholesterol, HDL-cholesterol, triglycerides and total cholesterol in each of four race/ethnicity groups; identify common and ...
Funder: University of California, San Francisco, Project Grant
Investigator: Iribarren, Carlos
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This study will use the GERA cohort to develop a polygenic risk score-guided precision medicine tool for statin treatment decisions. It will develop an algorithm that predicts baseline atherosclerotic cardiovascular disease (ASCVD) and statin-induced ASCV...
Funder: National Heart, Lung, and Blood Institute
Investigator: Iribarren, Carlos
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This study examines hip fracture risk and outcome in older Black women using data from Kaiser Permanente Northern California. The study will examine the predictors of hip fracture, fracture risk prediction, and morbidity and mortality following hip fractu...
Funder: KP National Office of Community Health
Investigator: Lo, Joan
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This study will apply a targeted metabolomics approach to the prediction of gestational diabetes mellitus (GDM) from a single blood sample collected in the first trimester of pregnancy and stored for the Research Program on Genes, Environment and Health (...
Funder: University of Toronto
Investigator: Gunderson, Erica
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CREST-2 is a multicenter randomized trial of intensive medical management with or without revascularization in patients with asymptomatic high-grade carotid stenosis.This study is a long-term observational extension of participants in the CREST-2 randomiz...
Funder: National Institute of Neurological Disorders and Stroke
Investigator: Nguyen-Huynh, Mai
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Despite the wide availability of bisphosphonate drugs that reduce fracture risk, treatment rates have fallen, attributable to concerns for atypical femoral fractures and osteonecrosis of the jaw. While risk/benefit ratios of bisphosphonate treatment for o...
Funder: National Institute on Aging
Investigator: Lo, Joan
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The primary objective of the TREAT-WHF study is to leverage a diverse and contemporary heart failure cohort with rigorously adjudicated worsening heart failure events to describe the crude rate of all-cause and cause-specific health care utilization and t...
Funder: Lexicon Pharmaceuticals, Inc.
Investigator: Ambrosy, Andrew
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This landmark 35-year study describes the distribution of coronary heart disease risk factors in a biracial cohort of men and women aged 18 to 30 years at entry; and identifies habits, behaviors and lifestyles that are associated with initial levels of ri...
Funder: National Heart, Lung, and Blood Institute
Investigator: Bhatt, Ankeet
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The NHLBI NGHS enrolled 871 girls (50% Black and 50% white) in 1987 at age 9 or 10 and examined them up to 17 times, to age 27. This resulted in 7 echocardiogram reports from ages 20-27, multiple saved samples, and reproductive history questionnaires. We ...
Funder: National Heart, Lung, and Blood Institute
Investigator: Gunderson, Erica
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The overall objective of the Cholesterol Lowering via Bempedoic Acid/Ezetimibe, an ACL-Inhibiting Regimen in Acute Coronary Syndrome ACS (CLEAR ACS) study is to determine the efficacy, safety, and tolerability of bempedoic acid/ezetimibe (BA/E) in a conte...
Funder: Esperion Therapeutics, Inc.
Investigator: Ambrosy, Andrew
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Leveraging the GERA Cohort to evaluate the performance of a 12-SNP PRS for CVD against the Pool Cohorts Equation across ethnic groups; validate MEGASTROKE Consortium PRS_32 for ischemic stroke; and assess the interplay between genetic background and lifes...
Funder: GENinCode PLC
Investigator: Iribarren, Carlos
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The prevalence of aortic stenosis (AS), currently estimated to be 4% among adults 70 years of age and over is projected to double by 2040 and triple by 2060. However, the prevalence, clinical characteristics, and outcomes of the condition have not been we...
Funder: Edwards Lifesciences LLC
Investigator: Ambrosy, Andrew
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The burden of osteoporosis has increased as the US population over age 65 years has increased. Ethnic diversity in the U.S. has also increased. This is the first large scale US study of fracture outcomes among Asians and ethnic subgroups that will inform ...
Funder: National Institute on Aging
Investigator: Lo, Joan
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This CARDIA ancillary study will examine the longitudinal relations of 35-year changes in reported physical activity from young adulthood to late midlife with indicators of subclinical heart failure collected at late midlife, and evaluate interaction in t...
Funder: National Heart, Lung, and Blood Institute
Investigator: Sidney, Stephen
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To determine if one-time screening for atrial fibrillation using the 14-day Zio XT patch leads to a reduced risk of stroke compared with usual care among adults aged 70 years or older without prior known atrial fibrillation or atrial flutter.
Funder: Bristol-Myers Squibb Company
Investigator: Go, Alan; Ambrosy, Andrew
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The goal of this study is to obtain COVID-19 surveillance study (questionnaire and serology) in 6 cohort studies funded by NHLBI including the CARDIA study. A surveillance questionnaire will be administered 3 times at approximately 6 month intervals and ...
Funder: National Heart, Lung, and Blood Institute
Investigator: Sidney, Stephen
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In CARDIA Year 35 exam: Assess whether sexual minority and gender minority (SGM) individuals in CARDIA have increased odds of objectively-determined traditional cardiovascular disease (CVD) risk factors and poorer CVD outcomes compared to their non-SGM co...
Funder: National Heart, Lung, and Blood Institute
Investigator: Sidney, Stephen
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Determine the independent and joint contributions of behavioral, psychosocial and clinical characteristics over 35 years of CARDIA participation on sleep and circadian characteristics in middle-aged adults. Identify the relationship of sleep and circadian...
Funder: National Heart, Lung, and Blood Institute
Investigator: Sidney, Stephen
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This study will assess the accuracy of using a natural language processing-based approach to retrospectively identify episodes of outpatient worsening heart failure in unstructured electronic health record data within an integrated health care delivery sy...
Funder: Northern California Community Benefit Programs
Investigator: Ambrosy, Andrew
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This virtual, pragmatic randomized clinical trial will evaluate whether rivaroxaban reduces the risk of a composite endpoint of major venous and arterial thrombotic events, all-cause hospitalization, and all-cause mortality compared with placebo in outpat...
Funder: Janssen AIzheimer Immunotherapy R＆D
Investigator: Go, Alan; Ambrosy, Andrew
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The decreased trend in patients seeking care for acute stroke, acute MI, and acute surgical presentations during the COVID-19 pandemic is concerning for potential long-term morbidity, mortality, rehabilitation costs, and preventable downstream health care...
Funder: Garfield Memorial Fund
Investigator: Nguyen-Huynh, Mai
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While the Affordable Care Act-mandated Hospital Readmission Reduction Program launched in 2012 has modestly reduced readmissions, an unintended consequence has been the shift of a significant fraction of heart failure (HF)-related care to the outpatient s...
Funder: National Heart, Lung, and Blood Institute
Investigator: Ambrosy, Andrew
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