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Cardiovascular and Metabolic Conditions Studies

 

TRANSFORM-HF (ToRsemide compArisoN with furoSemide FOR Management of Heart Failure) Study

Patients with heart failure will be randomized 1:1 to either oral torsemide or oral furosemide prior to hospital discharge. The primary endpoint will be all-cause mortality over the follow-up period. Secondary endpoints are hospitalizations, quality o...
Funder: 
Investigator: Ambrosy, Andrew

ATRIA-CKD: Optimizing Atrial Fibrillation Management in Chronic Kidney Disease

As an extension of the ATRIA-CVRN collaboration in Kaiser Permanente Northern California and Southern California, we will examine the recent use and associated effectiveness and safety of different management strategies for atrial fibrillation in a large,...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Go, Alan

Community-based, Longitudinal Cohort of Patients with Interstitial Lung Disease (ILD) in the Kaiser Permanente Northern California (KPNC) Health System

The KPNC-ILD cohort will consist of approximately 10,000 patients with interstitial lung disease. It will be built through electronic health recordbased case identification using an algorithm that will be further developed. We anticipate optimizing the e...
Funder: Genentech, Inc.
Investigator: Iribarren, Carlos

Leveraging Multi-omics Approaches to Examine Metabolic Challenges of Obesity in Relation to Cardiovascular Diseases

This project will generate longitudinal plasma metabolomic profiles in the CARDIA study cohort to better understand underlying molecular mechanisms for cardiovascular disease (CVD). We will identify metabolites and metabolic pathways related to CVD risk f...
Funder: National Heart, Lung, and Blood Institute
Investigator: Sidney, Stephen

Shared Antecedents to Preterm Birth and Cardiovascular Disease in Women

We will conduct secondary data analysis of women in the CARDIA study that leverages existing data (biomarkers assays funded by Dr. Gunderson’s ancillary study R01 to CARDIA) to evaluate the relation of pre-pregnancy inflammation to the occurrenc...
Funder: National Heart, Lung, and Blood Institute
Investigator: Gunderson, Erica

Prenatal Blood Pressure Patterns to Predict Pregnancy-Related Hypertension and Later-Life Cardiovascular Risk

This study utilizes clinical prenatal-care blood pressure measurements and other clinical and biochemical variables to develop models for the early prediction of hypertensive disorders of pregnancy, and evaluates the relationship of pregnancy blood-pressu...
Funder: National Heart, Lung, and Blood Institute
Investigator: Gunderson, Erica

Nor-Cal-CSC for Northern California Regional Coordinating Center

The Northern California Regional Coordinating Stroke Center (NorCal-CSC) is a joint effort between U.C. San Francisco and selected medical center(s) within Kaiser Permanente as part of the National Institute of Neurological Disorders and Stroke (NINDS) St...
Funder: National Institute of Neurological Disorders and Stroke
Investigator: Nguyen-Huynh, Mai

Acute Kidney Injury among Patients with Chronic Kidney Disease

This ancillary project to the multicenter Chronic Renal Insufficiency Cohort (CRIC) Study will examine the incidence and associated predictors of episodes of acute kidney injury among a prospective cohort of adults with underlying chronic kidney disease, ...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Go, Alan

Chronic Renal Insufficiency Cohort Study IV (CRIC-4)

This is a renewal of the Chronic Renal Insufficiency Cohort (CRIC) Study Clinical Center at Kaiser Permanente Northern California and UCSF, which will continue long-term follow-up of existing participants with chronic kidney. The overall goals are to exam...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Go, Alan

Population-Based Pharmacogenomic Assessment of QT Prolongation

​Cardiotoxicity of commonly prescribed medications, typically assessed by electrocardiographic features such as prolongation of the QT interval, has regulatory effects and is associated with potentially fatal outcomes. This project aims to advance unde...
Funder: National Heart, Lung, and Blood Institute
Investigator: Iribarren, Carlos

How Fast is Fast Enough? Assessing Door-to-Needle Times and Outcomes of Stroke Patients Receiving Acute Thrombolysis Therapy Under the Kaiser Permanente Northern California Stroke EXPRESS Program

With stroke treatment, there is a general belief that "time is brain." However, there has been no published data examining specifically the association between door-to-needle times for acute treatment with intravenous alteplase in stroke patient...
Funder: The Permanente Medical Group
Investigator: Nguyen-Huynh, Mai

Network and Infrastructure Support for Development of Interdisciplinary Aging Research

For adults aged 40 to 75 years, randomized trials provide conclusive evidence that statins reduce the risk of initial and secondary cardiovascular disease (CVD) events. However, there is limited evidence that statins reduce CVD events in individuals over ...
Funder: National Institute on Aging
Investigator: Go, Alan

Predicting Readmission After Stroke Study (PRESS)

Hospital readmissions are a tremendous burden on patients, their families, and the health care system. In 2008, the Centers for Medicare and Medicaid Services began publicly reporting hospital-level, risk-standardized, 30-day readmission and mortality rat...
Funder: National Institute of Neurological Disorders and Stroke
Investigator: Nguyen-Huynh, Mai

MINERVA Biomarkers Substudy

The purpose of this research study is to conduct assays of a selected panel of cardiac, metabolic, and cancer biomarkers in blood samples already collected by the Multiethnic Study of Breast Arterial Calcium Gradation and Cardiovascular Disease (MINERVA) ...
Funder: Abbott Laboratories
Investigator: Iribarren, Carlos

Hispanic Chronic Renal Insufficiency Cohort (HCRIC) Study

This is a renewal of an ongoing ancillary study to the Chronic Renal Insufficiency Cohort (CRIC) Study to examine whether rates of loss of kidney function and subclinical and clinical cardiovascular disease varies among Hispanics versus other race/ethnic ...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Go, Alan

Biomarkers to Predict Type 2 Diabetes

The goal of this study is to develop a simple biomarker signature that can predict future type 2 diabetes with excellent specificity, sensitivity and precision.
Funder: Janssen Pharmaceuticals, Inc.
Investigator: Gunderson, Erica

Multiple Chronic Conditions and Adverse Outcomes in Older Adults with Heart Failure

This ancillary pilot study to the Cardiovascular Research Network Heart Failure Consortium will evaluate the frequency and association of multiple chronic condition burden with clinical outcomes in adults who have diagnosed heart failure.
Funder: National Institute on Aging
Investigator: Go, Alan

Anticoagulation Length of ThErapy and Risk of New Adverse evenTs In Venous thromboEmbolism (ALTERNATIVE) Study

This observational study involves a collaboration between KPNC, KPSC and UCSF that will examine clinical and patient-centered outcomes (recurrent VTE, hemorrhage, treatment satisfaction, and quality of life) associated with different lengths of anticoagul...
Funder: Patient-Centered Outcomes Research Institute
Investigator: Go, Alan

Multiethnic Study of Breast Arterial Calcium Gradation and CVD

Specific study aims are: 1) To establish a multi-ethnic cohort between the ages of 60 and 79 years with equal representation of white, African-American, Asian and Hispanic/Latina women. All participants will be recruited at the time of their regular s...
Funder: National Heart, Lung, and Blood Institute
Investigator: Iribarren, Carlos

A Randomized, Double-Blind, Multinational Study to Prevent Major Vascular Events with Ticagrelor Compared to Aspirin in Patients with Acute Ischemic Stroke

The primary objective of the trial is to compare the effect of 90-day treatment with ticagrelor (180 mg [two 90 mg tablets] loading dose on Day 1 followed by 90 mg twice daily maintenance dose for the remainder of the study) vs acetylsalicylic acid (ASA)-...
Funder: AstraZeneca PLC
Investigator: Nguyen-Huynh, Mai

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2)

Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multi-center, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic ...
Funder: National Institute of Neurological Disorders and Stroke
Investigator: Avins, Andrew; Chang, Robert; Nguyen-Huynh, Mai

Identifying Modifiable Biomarkers/Mediators for Disease Progression and Cardiovascular Risk in Chronic Kidney Disease

This ancillary study to the multi-center Chronic Renal Insufficiency Cohort (CRIC) aims to leverage newer proteomic techniquest to identify novel pathways associated with cardiovascular complications in the setting of impaired kidney function.
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Go, Alan

Tubular Secretion in Chronic Kidney Disease

This ancillary study to the ongoing prospective Chronic Renal Insufficiency Cohort (CRIC) aims to examine the predictive value of different markers of tubular secretion compared with estimated and measured glomerular filtration for progression of chronic ...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Go, Alan

Partnership for Anemia: Clinical and Translational Trials in the Elderly (PACTTE)

Within the CVRN-HF Network, and in collaboration with NIA-sponsored PACTTE consortium investigators, we will examine the following among a large, multi-center cohort of elderly patients with heart failure with reduced or preserved left ventricular systoli...
Funder: National Institute on Aging
Investigator: Ambrosy, Andrew; Go, Alan

Pregnancy-Related Risk Factors and Glucose Intolerance in Women during Midlife

This is an ancillary study to the CARDIA Study, a multi-center longitudinal study of 5,115 black and white women and men (18-30) enrolled in 1985-1986, and followed at in-person exams serially through 2011. The study will evaluate pregnancy-related change...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Gunderson, Erica
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