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Cardiovascular Publications


Should providers prescribe sacubitril/valsartan based on trial eligibility, approval indication, or guideline recommendations?

Author(s): Ambrosy AP; Fudim M; Chioncel O

Eur J Heart Fail. 2019 Jul 22.

PubMed abstract

Risk Estimates for Diabetes and Hypertension with Different Physical Activity Methods

To estimate risks of incident Type 2 Diabetes (T2D) and Stage 2 and greater hypertension associated with self-reported and accelerometer-determined moderate-vigorous physical activity (MVPA) separately and adjusted for each other. The sample included 2,29...
Author(s): Sternfeld B; Gabriel KP; Jiang SF; Whitaker KM; Jacobs DR; Quesenberry CP; Carnethon M; Sidney S

Med Sci Sports Exerc. 2019 Jul 03.

PubMed abstract

A Balancing Act: Preserving Renal Function and the Need for Decongestion

Author(s): Fudim M; Ambrosy AP

J Card Fail. 2019 Jun 26.

PubMed abstract

Treatment and Outcomes of Acute Pulmonary Embolism and Deep Venous Thrombosis: The Cardiovascular Research Network Venous Thromboembolism (CVRN VTE) Study

Few studies describe both inpatient and outpatient treatment and outcomes of patients with acute venous thromboembolism in the US. A multi-institutional cohort of patients diagnosed with confirmed pulmonary embolism and/or deep venous thrombosis during ye...
Author(s): Fang MC; Fan D; Sung SH; Witt DM; Schmelzer JR; Williams MS; Yale SH; Baumgartner C; Go AS

Am J Med. 2019 Jun 24.

PubMed abstract

In-hospital initiation of sacubitril/valsartan in acute decompensated heart failure: being in the right place at the right time

Author(s): Ambrosy AP; DeVore AD; Velazquez EJ

Eur J Heart Fail. 2019 Jun 19.

PubMed abstract

Using Pharmacy Data and Adherence to Define Long-Term Bisphosphonate Exposure in Women

Assigning drug exposure is a necessary first step in examining bisphosphonate (BP) treatment in observational studies using pharmacy data. To determine whether the choice of adherence level using the proportion of days covered (PDC) affected BP exposure a...
Author(s): Izano MA; Neugebauer R; Ettinger B; Hui R; Chandra M; Adams AL; Niu F; Ott SM; Lo JC

J Manag Care Spec Pharm. 2019 Jun;25(6):719-723.

PubMed abstract

Natriuretic peptides as a surrogate endpoint in clinical trials - a riddle wrapped in an enigma

Author(s): Hardwick AB; Ambrosy AP

Eur J Heart Fail. 2019 Mar 27.

PubMed abstract

Incident Anemia in Older Adults with Heart Failure Rate, Etiology, and Association with Outcomes

Limited data exist on the epidemiology, evaluation, and prognosis of otherwise unexplained anemia of the elderly in HF. Thus, we aimed to determine the incidence of anemia, to characterize diagnostic testing patterns for potentially reversible causes of a...
Author(s): Ambrosy AP; Tabada GH; Sung SH; Go AS; et al.

Eur Heart J Qual Care Clin Outcomes. 2019 Mar 07.

PubMed abstract

Applying data science approaches to identify frequent flyers in heart failure: rise of the machines

Author(s): Ambrosy AP; Lee KK

Eur J Heart Fail. 2019 Feb 07.

PubMed abstract

Burden of medical co-morbidities and benefit from surgical revascularization in patients with ischaemic cardiomyopathy

The landmark STICH trial found that surgical revascularization compared to medical therapy alone improved survival in patients with heart failure (HF) of ischaemic aetiology and an ejection fraction (EF) ≤ 35%. However, the interaction between the burden ...
Author(s): Ambrosy AP; Roy A; STICH Trial Investigators; et al.

Eur J Heart Fail. 2019 Jan 30.

PubMed abstract

Contrasting Causal Effects of Workplace Interventions.

Occupational exposure guidelines are ideally based on estimated effects of static interventions that assign constant exposure over a working lifetime. Static effects are difficult to estimate when follow-up extends beyond employment because their ident...
Author(s): Izano, Monika A MA; Brown, Daniel M DM; Neophytou, Andreas M AM; Garcia, Erika E; Eisen, Ellen A EA

Epidemiology (Cambridge, Mass.). 2018 07 ;29(4):542-546. Epub --.

PubMed abstract

Kidney function, proteinuria and breast arterial calcification in women without clinical cardiovascular disease: The MINERVA study

Breast arterial calcification (BAC) may be a predictor of cardiovascular events and is highly prevalent in persons with end-stage kidney disease. However, few studies to date have examined the association between mild-to-moderate kidney function and prote...
Author(s): Parikh RV; Iribarren C; Lee C; Levine-Hall T; Tan TC; Sanchez G; Ding H; Bidgoli FA; Molloi S; Go AS

PLoS ONE. 2019;14(1):e0210973. Epub 2019-01-17.

PubMed abstract

Trimethylamine N-oxide and risk of heart failure progression: marker or mediator of disease

Author(s): Chioncel O; Ambrosy AP

Eur J Heart Fail. 2019 Jan 09.

PubMed abstract

The Association of Polycystic Ovary Syndrome and Gestational Hypertensive Disorders in a Diverse Community-Based Cohort

To examine the association of polycystic ovary syndrome (PCOS) and pregnancy-induced hypertension (PIH) within a large population of pregnant women in an integrated healthcare system. This retrospective study utilized a source cohort of 1023 women with PC...
Author(s): Schneider D; Gonzalez JR; Yamamoto M; Yang J; Lo JC

J Pregnancy. 2019;2019:9847057. Epub 2019-01-01.

PubMed abstract

Is Time From Last Hospitalization for Heart Failure to Placement of a Primary Prevention Implantable Cardioverter-Defibrillator Associated With Patient Outcomes?

Landmark studies have demonstrated the safety and efficacy of implantable cardioverter-defibrillators (ICDs) in selected stable ambulatory patients with heart failure (HF) with a reduced ejection fraction receiving optimal medical therapy. It is not known...
Author(s): Ambrosy AP; Parzynski CS; Friedman DJ; Fudim M; Hernandez AF; Fonarow GC; Masoudi FA; Al-Khatib SM

Circulation. 2018 Dec 11;138(24):2787-2797.

PubMed abstract

Shake Rattle & Roll - Design and rationale for a pragmatic trial to improve blood pressure control among blacks with persistent hypertension

In Kaiser Permanente Northern California (KPNC), members had similar access to care and a very high overall rate of hypertension control. However, blacks had poorer blood pressure (BP) control than whites. The Shake Rattle & Roll (SRR) trial aimed to ...
Author(s): Nguyen-Huynh MN; Young JD; Alexeeff S; Hatfield MK; Sidney S

Contemp Clin Trials. 2019 Jan;76:85-92. Epub 2018-11-28.

PubMed abstract

Association of Breast Arterial Calcification Presence and Gradation with the Ankle-Brachial Index among Postmenopausal Women

To examine the association of breast arterial calcification (BAC) with the ankle brachial index (ABI), a sensitive metric of peripheral arterial disease (PAD), among postmenopausal women. Background: BAC is an emerging risk marker of cardiovascular di...
Author(s): Iribarren C; Sanchez G; Lu M; Bidgoli FA; Cho HM; Ding H; Molloi S

Eur J Cardiovasc Med. 2018 Nov;5(5):544-551. Epub 2018-11-16.

PubMed abstract

Cardiovascular Events after New-Onset Atrial Fibrillation in Adults with CKD: Results from the Chronic Renal Insufficiency Cohort (CRIC) Study

Atrial fibrillation (AF), the most common sustained arrhythmia in CKD, is associated with poor clinical outcomes in both patients without CKD and patients with dialysis-treated ESRD. However, less is known about AF-associated outcomes in patients with CKD...
Author(s): Bansal N; Go AS; et al.

J Am Soc Nephrol. 2018 Oct 30.

PubMed abstract

Undiagnosed dysglycemia in patients hospitalized for worsening heart failure: not so sweet after all.

Author(s): Chioncel, Ovidiu O; Ambrosy, Andrew P AP

European journal of preventive cardiology. 2018 Oct 28;():2047487318810561. Epub 2018-10-28.

PubMed abstract

Longer lactation duration is associated with decreased prevalence of non-alcoholic fatty liver disease in women

Lactation lowers blood glucose and triglycerides, and increases insulin sensitivity. We hypothesized that a longer duration of lactation would be associated with lower prevalence of non-alcoholic fatty liver disease (NAFLD), which is the leading cause of ...
Author(s): Ajmera VH; Terrault NA; VanWagner LB; Sarkar M; Lewis CE; Carr JJ; Gunderson EP

J Hepatol. 2018 Oct 24.

PubMed abstract

Association Between Bariatric Surgery and Macrovascular Disease Outcomes in Patients With Type 2 Diabetes and Severe Obesity

Macrovascular disease is a leading cause of morbidity and mortality for patients with type 2 diabetes, and medical management, including lifestyle changes, may not be successful at lowering risk. To investigate the relationship between bariatric surgery a...
Author(s): Fisher DP; Sidney S; et al.

JAMA. 2018 10 16;320(15):1570-1582.

PubMed abstract

Risk Factors for Recurrent Acute Kidney Injury in a Large Population-Based Cohort

Acute kidney injury (AKI) has numerous sequelae. Repeated episodes of AKI may be an important determinant of adverse outcomes, including chronic kidney disease and death. In a population-based cohort study, we sought to determine the incidence of and pred...
Author(s): Liu KD; Yang J; Tan TC; Glidden DV; Zheng S; Pravoverov L; Hsu CY; Go AS

Am J Kidney Dis. 2018 Oct 10.

PubMed abstract

Risk of Cardiovascular Disease Among Young Adults: Marijuana Use or the Company it Keeps

Author(s): Rana JS; Auer R; Reis JP; Sidney S

J Am Coll Cardiol. 2018 Sep 25;72(13):1559-1560.

PubMed abstract

Multimorbidity Burden and Adverse Outcomes in a Community-Based Cohort of Adults with Heart Failure

To assess multimorbidity burden and its association with clinical outcomes in adults with heart failure (HF) according to sex, age, and HF type. Retrospective cohort study. Five healthcare delivery systems across the United States. Adults with HF (N=114,5...
Author(s): Tisminetzky M; Gurwitz JH; Fan D; Reynolds K; Smith DH; Magid DJ; Sung SH; Murphy TE; Goldberg RJ; Go AS

J Am Geriatr Soc. 2018 Sep 24.

PubMed abstract

Natural History of Patients Postacute Coronary Syndrome Based on Heart Failure Status.

The natural history of patients hospitalized for acute coronary syndrome (ACS) with pre-existing versus (vs) de novo heart failure (HF) has not been previously reported over an extended duration of follow-up. The IMPROVE-IT trial enrolled 18,144 patien...
Author(s): Ambrosy, Andrew P AP; Cerbin, Lukasz P LP; Fudim, Marat M; Clare, Robert M RM; Lokhnygina, Yuliya Y; Braunwald, Eugene E; Califf, Robert M RM; Cannon, Christopher P CP; Tershakovec, Andrew M AM; Roe, Matthew T MT; Blazing, Michael A MA

The American journal of cardiology. 2018 Nov 01;122(9):1451-1458. Epub 2018-08-04.

PubMed abstract