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Cardiovascular Publications


Renin-Angiotensin System Blockade after Acute Kidney Injury (AKI) and Risk of Recurrent AKI

How to best medically manage patients who survived hospitalized AKI is unclear. Use of renin-angiotensin system blockers in this setting may increase risk of recurrent AKI. This is a cohort study of 10,242 members of an integrated health care delivery sys...
Author(s): Hsu CY; Liu KD; Yang J; Glidden DV; Tan TC; Pravoverov L; Zheng S; Go AS

Clin J Am Soc Nephrol. 2019 Dec 16.

PubMed abstract

Non-cardiac-related morbidity, mobility limitation, and outcomes in older adults with heart failure

To examine the individual and combined associations of non-cardiac-related conditions and mobility limitation with morbidity and mortality in adults with heart failure (HF). We conducted a retrospective cohort study in a large, diverse group of adults wit...
Author(s): Tisminetzky M; Gurwitz JH; Fan D; Reynolds K; Smith DH; Fouayzi H; Sung SH; Goldberg R; Go AS

J Gerontol A Biol Sci Med Sci. 2019 Dec 09.

PubMed abstract

Research Needs and Priorities for Catheter Ablation of Atrial Fibrillation: A Report from a National Heart, Lung, and Blood Institute Virtual Workshop

Catheter ablation has brought major advances in the management of patients with atrial fibrillation (AF). As evidenced by multiple randomized trials, AF catheter ablation can reduce the risk of recurrent AF and improve quality of life. In some studies, AF...
Author(s): Al-Khatib SM; Go AS; et al.

Circulation. 2019 Nov 20.

PubMed abstract

Comparison of Long-Term Adverse Outcomes in Patients With Atrial Fibrillation Having Ablation Versus Antiarrhythmic Medications

The impact of atrial fibrillation (AF) catheter ablation versus chronic antiarrhythmic therapy alone on clinical outcomes such as death and stroke remains unclear. We compared adverse outcomes for AF ablation versus chronic antiarrhythmic therapy in 1,070...
Author(s): Freeman JV; Tabada GH; Reynolds K; Sung SH; Singer DE; Wang PJ; Liu TI; Gupta N; Hlatky MA; Go AS

Am J Cardiol. 2019 Nov 19.

PubMed abstract

Statin Therapy and Risk of Incident Diabetes Mellitus in Adults With Cardiovascular Risk Factors

The association between statins and diabetes mellitus (DM) remains controversial. The Kaiser Permanente CHAMP Study identified adults without DM who had cardiovascular (CV) risk factors and no previous lipid lowering therapy (LLT) between 2008 and 2010. T...
Author(s): Go AS; Ambrosy AP; Kheder K; Fan D; Sung SH; Inveiss AI; Romo-LeTourneau V; Thomas SM; Koren A; Lo JC; Kaiser Permanente Cholesterol-Lowering Therapy in High-Risk Adults: Management and Patient Risks (KP CHAMP) Study

Am J Cardiol. 2019 Nov 19.

PubMed abstract

Hyperglycemia and outcomes in acute heart failure - A bittersweet relationship

Author(s): Chioncel O; Ambrosy AP

Int J Cardiol. 2019 Nov 18.

PubMed abstract

Association Between Aging of the US Population and Heart Disease Mortality From 2011 to 2017

A deceleration in the rate of decrease of heart disease (HD) mortality between 2011 and 2014 has been reported. In the context of the rapid increase in the population of adults aged 65 years and older, extending the examination of HD mortality through 201...
Author(s): Sidney S; Go AS; Jaffe MG; Solomon MD; Ambrosy AP; Rana JS

JAMA Cardiol. 2019 Oct 30.

PubMed abstract

Atypical femur fracture incidence in women increases with duration of bisphosphonate exposure

In a northern California population of older women who were treated with oral bisphosphonate drugs, the incidence of atypical femur fracture, a rare complication of treatment, increased with longer duration of bisphosphonate exposure. These findings align...
Author(s): Lo JC; Grimsrud CD; Ott SM; Chandra M; Hui RL; Ettinger B

Osteoporos Int. 2019 Sep 25.

PubMed abstract

Trends Associated With Large-scale Expansion of Peritoneal Dialysis Within an Integrated Care Delivery Model

Despite favorable national trends in the incidence of end-stage renal disease (ESRD) from 2008 to 2011, ESRD incidence has been increasing recently, and less than 10% of patients with ESRD start renal replacement therapy with peritoneal dialysis (PD) in t...
Author(s): Pravoverov LV; Zheng S; Parikh R; Tan TC; Bhalla N; Reddy C; Mroz J; Jonelis TY; Go AS

JAMA Intern Med. 2019 Sep 09.

PubMed abstract

Depot Medroxyprogesterone Acetate, Oral Contraceptive, Intrauterine Device Use, and Fracture Risk

To assess fracture risk among women with depot medroxyprogesterone acetate (DMPA), oral contraceptive pill (OCP), and intrauterine device (IUD) use. A retrospective cohort study of 308,876 women age 12-45 years who initiated DMPA, combined or progestin-on...
Author(s): Raine-Bennett T; Chandra M; Armstrong MA; Alexeeff S; Lo JC

Obstet Gynecol. 2019 Sep;134(3):581-589.

PubMed abstract

Links Between Childhood Obesity, Gestational Diabetes, and Infant Temperament-Reply

Author(s): Faith MS; Hittner JB; Gunderson EP

JAMA Pediatr. 2019 Aug 26.

PubMed abstract

Vitamin D Status Among Older Women Initiating Osteoporosis Therapy

Author(s): Li CF; Ettinger B; Chandra M; Lo JC

J Am Geriatr Soc. 2019 Aug 23.

PubMed abstract

Transition From Heart Disease to Cancer as the Leading Cause of Death in the United States

Author(s): Sidney S; Go AS; Rana JS

Ann Intern Med. 2019 Aug 06;171(3):225.

PubMed abstract

Should providers prescribe sacubitril/valsartan based on trial eligibility, approval indication, or guideline recommendations?

Author(s): Ambrosy AP; Fudim M; Chioncel O

Eur J Heart Fail. 2019 Jul 22.

PubMed abstract

Risk Estimates for Diabetes and Hypertension with Different Physical Activity Methods

To estimate risks of incident Type 2 Diabetes (T2D) and Stage 2 and greater hypertension associated with self-reported and accelerometer-determined moderate-vigorous physical activity (MVPA) separately and adjusted for each other. The sample included 2,29...
Author(s): Sternfeld B; Gabriel KP; Jiang SF; Whitaker KM; Jacobs DR; Quesenberry CP; Carnethon M; Sidney S

Med Sci Sports Exerc. 2019 Jul 03.

PubMed abstract

A Balancing Act: Preserving Renal Function and the Need for Decongestion

Author(s): Fudim M; Ambrosy AP

J Card Fail. 2019 Jun 26.

PubMed abstract

Treatment and Outcomes of Acute Pulmonary Embolism and Deep Venous Thrombosis: The Cardiovascular Research Network Venous Thromboembolism (CVRN VTE) Study

Few studies describe both inpatient and outpatient treatment and outcomes of patients with acute venous thromboembolism in the US. A multi-institutional cohort of patients diagnosed with confirmed pulmonary embolism and/or deep venous thrombosis during ye...
Author(s): Fang MC; Fan D; Sung SH; Witt DM; Schmelzer JR; Williams MS; Yale SH; Baumgartner C; Go AS

Am J Med. 2019 Jun 24.

PubMed abstract

In-hospital initiation of sacubitril/valsartan in acute decompensated heart failure: being in the right place at the right time

Author(s): Ambrosy AP; DeVore AD; Velazquez EJ

Eur J Heart Fail. 2019 Jun 19.

PubMed abstract

Using Pharmacy Data and Adherence to Define Long-Term Bisphosphonate Exposure in Women

Assigning drug exposure is a necessary first step in examining bisphosphonate (BP) treatment in observational studies using pharmacy data. To determine whether the choice of adherence level using the proportion of days covered (PDC) affected BP exposure a...
Author(s): Izano MA; Neugebauer R; Ettinger B; Hui R; Chandra M; Adams AL; Niu F; Ott SM; Lo JC

J Manag Care Spec Pharm. 2019 Jun;25(6):719-723.

PubMed abstract

Natriuretic peptides as a surrogate endpoint in clinical trials - a riddle wrapped in an enigma

Author(s): Hardwick AB; Ambrosy AP

Eur J Heart Fail. 2019 Mar 27.

PubMed abstract

Incident Anemia in Older Adults with Heart Failure Rate, Etiology, and Association with Outcomes

Limited data exist on the epidemiology, evaluation, and prognosis of otherwise unexplained anemia of the elderly in HF. Thus, we aimed to determine the incidence of anemia, to characterize diagnostic testing patterns for potentially reversible causes of a...
Author(s): Ambrosy AP; Tabada GH; Sung SH; Go AS; et al.

Eur Heart J Qual Care Clin Outcomes. 2019 Mar 07.

PubMed abstract

Applying data science approaches to identify frequent flyers in heart failure: rise of the machines

Author(s): Ambrosy AP; Lee KK

Eur J Heart Fail. 2019 Feb 07.

PubMed abstract

Burden of medical co-morbidities and benefit from surgical revascularization in patients with ischaemic cardiomyopathy

The landmark STICH trial found that surgical revascularization compared to medical therapy alone improved survival in patients with heart failure (HF) of ischaemic aetiology and an ejection fraction (EF) ≤ 35%. However, the interaction between the burden ...
Author(s): Ambrosy AP; Roy A; STICH Trial Investigators; et al.

Eur J Heart Fail. 2019 Jan 30.

PubMed abstract

Contrasting Causal Effects of Workplace Interventions.

Occupational exposure guidelines are ideally based on estimated effects of static interventions that assign constant exposure over a working lifetime. Static effects are difficult to estimate when follow-up extends beyond employment because their ident...
Author(s): Izano, Monika A MA; Brown, Daniel M DM; Neophytou, Andreas M AM; Garcia, Erika E; Eisen, Ellen A EA

Epidemiology (Cambridge, Mass.). 2018 07 ;29(4):542-546. Epub --.

PubMed abstract

Kidney function, proteinuria and breast arterial calcification in women without clinical cardiovascular disease: The MINERVA study

Breast arterial calcification (BAC) may be a predictor of cardiovascular events and is highly prevalent in persons with end-stage kidney disease. However, few studies to date have examined the association between mild-to-moderate kidney function and prote...
Author(s): Parikh RV; Iribarren C; Lee C; Levine-Hall T; Tan TC; Sanchez G; Ding H; Bidgoli FA; Molloi S; Go AS

PLoS ONE. 2019;14(1):e0210973. Epub 2019-01-17.

PubMed abstract