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Cardiovascular Publications


Rationale and Design of the Pragmatic Randomized Trial of Icosapent Ethyl for High Cardiovascular Risk Adults (MITIGATE)

The MITIGATE study aims to evaluate the real-world clinical effectiveness of pre-treatment with icosapent ethyl (IPE), compared with usual care, on laboratory-confirmed viral upper respiratory infection (URI)-related morbidity and mortality in adults with...
Author(s): Ambrosy AP; Skarbinski J; Go AS; et al.

Am Heart J. 2021 Jan 28.

PubMed abstract

No Association Between Bone Mineral Density and Breast Arterial Calcification Among Postmenopausal Women

The association between bone mineral density (BMD) and breast arterial calcification (BAC) remains poorly understood and controversial. The objective of this article is to examine the association between BMD and BAC in a large cohort of postmenopausal wom...
Author(s): Iribarren C; Chandra M; Molloi S; Sam D; Sanchez G; Bidgoli FA; Cho HM; Ding H; Lo JC

J Endocr Soc. 2020 Feb 01;4(2):bvz026. Epub 2019-11-27.

PubMed abstract

Implication of Trends in Timing of Dialysis Initiation for Incidence of End-stage Kidney Disease

In the last 2 decades, there have been notable changes in the level of estimated glomerular filtration rate (eGFR) at which patients initiate long-term dialysis in the US and around the world. How changes over time in the likelihood of dialysis initiation...
Author(s): Hsu CY; Parikh RV; Pravoverov LN; Zheng S; Glidden DV; Tan TC; Go AS

JAMA Intern Med. 2020 Oct 12.

PubMed abstract

Bone Mineral Density in Older U.S. Filipino, Chinese, Japanese, and White Women

Bone mineral density (BMD) reference data exist for U.S. White, Black, and Hispanic (Mexican American) populations but not for U.S. Asians. Few studies have compared BMD findings among different U.S. Asian ethnicities. Retrospective observational study. L...
Author(s): Lo JC; Chandra M; Lee C; Darbinian JA; Ramaswamy M; Ettinger B

J Am Geriatr Soc. 2020 Oct 12.

PubMed abstract

The Heart Failure Readmission Intervention by Variable Early Follow-up (THRIVE) Study: A Pragmatic Randomized Trial

In-person clinic follow-up within 7 days after discharge from a heart failure hospitalization is associated with lower 30-day readmission. However, health systems and patients may find it difficult to complete an early postdischarge clinic visit, especial...
Author(s): Lee KK; Thomas RC; Tan TC; Leong TK; Steimle A; Go AS

Circ Cardiovasc Qual Outcomes. 2020 Sep 24:CIRCOUTCOMES120006553.

PubMed abstract

Kidney Function and Potassium Monitoring After Initiation of Renin-Angiotensin-Aldosterone System Blockade Therapy and Outcomes in 2 North American Populations

Clinical practice guidelines recommend routine kidney function and serum potassium testing within 30 days of initiating ACE (angiotensin-converting enzyme) inhibitor or angiotensin II receptor blocker therapy. However, evidence is lacking about whether fo...
Author(s): Parikh RV; Go AS; et al.

Circ Cardiovasc Qual Outcomes. 2020 Sep;13(9):e006415. Epub 2020-09-02.

PubMed abstract

Angiotensin Receptor-Neprilysin Inhibition Based on History of Heart Failure and Use of Renin-Angiotensin System Antagonists

The PIONEER-HF (comParIson Of sacubitril/valsartaN versus Enalapril on Effect on nt-pRo-bnp in patients stabilized from an acute Heart Failure episode) trial demonstrated the efficacy and safety of sacubitril/valsartan (S/V) in stabilized patients with ac...
Author(s): Ambrosy AP; Braunwald E; Morrow DA; DeVore AD; McCague K; Meng X; Duffy CI; Rocha R; Velazquez EJ; PIONEER-HF Investigators

J Am Coll Cardiol. 2020 Sep 01;76(9):1034-1048.

PubMed abstract

Community-Based Epidemiology of Hospitalized Acute Kidney Injury

Acute kidney injury (AKI) may lead to short- and long-term consequences in children, but its epidemiology has not been well described at a population level and outside of ICU settings. In a large, diverse pediatric population receiving care within an inte...
Author(s): Parikh RV; Tan TC; Salyer AS; Auron A; Kim PS; Ku E; Go AS

Pediatrics. 2020 Sep;146(3). Epub 2020-08-11.

PubMed abstract

Acute Stroke Presentation, Care, and Outcomes in Community Hospitals in Northern California During the COVID-19 Pandemic

Shelter-in-place (SIP) orders implemented to mitigate severe acute respiratory syndrome coronavirus 2 spread may inadvertently discourage patient care-seeking behavior for critical conditions like acute ischemic stroke. We aimed to compare temporal trends...
Author(s): Nguyen-Huynh MN; Tang XN; Vinson DR; Flint AC; Alexander JG; Meighan M; Burnett M; Sidney S; Klingman JG

Stroke. 2020 Aug 07:STROKEAHA120031099.

PubMed abstract

Risk of Distal Embolization From tPA (Tissue-Type Plasminogen Activator) Administration Prior to Endovascular Stroke Treatment

In large artery occlusion stroke, both intravenous (IV) tPA (tissue-type plasminogen activator) and endovascular stroke treatment (EST) are standard-of-care. It is unknown how often tPA causes distal embolization, in which a procedurally accessible large ...
Author(s): Flint AC; Avins AL; Nguyen-Huynh MN; et al.

Stroke. 2020 Sep;51(9):2697-2704. Epub 2020-08-06.

PubMed abstract

Changes in Mortality in Top 10 Causes of Death from 2011 to 2018

Author(s): Rana JS; Khan SS; Lloyd-Jones DM; Sidney S

J Gen Intern Med. 2020 Jul 23.

PubMed abstract

Changes in Cardiometabolic Risk Factors Before and After Gestational Diabetes: A Prospective Life-Course Analysis in CARDIA Women

This study hypothesized that both preconception and postchildbearing patterns of cardiometabolic risk factors may be different for women with gestational diabetes mellitus (GDM) compared with women without GDM. Among 1,302 (51% black) women in the Coronar...
Author(s): Catov JM; Sun B; Bertolet M; Snyder GG; Lewis CE; Allen NB; Shikany JM; Ingram KH; Appiah D; Gunderson EP

Obesity (Silver Spring). 2020 Jul 06.

PubMed abstract

Hospitalizations for heart failure during the COVID-19 pandemic: making sense of the known knowns, known unknowns, and unknown unknowns

Author(s): Ambrosy AP; Fitzpatrick JK; Fudim M

Eur J Heart Fail. 2020 Jul 02.

PubMed abstract

Improving Physical Activity and Exercise Capacity in Heart Failure Taking the First Step is Always the Hardest

Author(s): Ambrosy AP; Chioncel O

Eur J Heart Fail. 2020 Jun 13.

PubMed abstract

Advancing Research on the Complex Interrelations Between Atrial Fibrillation and Heart Failure: A Report From a US National Heart, Lung, and Blood Institute Virtual Workshop

The interrelationships between atrial fibrillation (AF) and heart failure (HF) are complex and poorly understood, yet the number of patients with AF and HF continues to increase worldwide. Thus, there is a need for initiatives that prioritize research on ...
Author(s): Al-Khatib SM; Go AS; et al.

Circulation. 2020 Jun 09;141(23):1915-1926. Epub 2020-06-08.

PubMed abstract

The Covid-19 Pandemic and the Incidence of Acute Myocardial Infarction

Author(s): Solomon MD; McNulty EJ; Rana JS; Leong TK; Lee C; Sung SH; Ambrosy AP; Sidney S; Go AS

N Engl J Med. 2020 May 19.

PubMed abstract

Pregnancy and Subsequent Glucose Intolerance in Women of Childbearing Age: Heeding the Early Warning Signs for Primary Prevention of Cardiovascular Disease in Women.

Author(s): Gunderson, Erica P EP; Jaffe, Marc G MG

JAMA internal medicine. 2017 12 01;177(12):1742-1744. Epub --.

PubMed abstract

How Should We Counsel Asian Americans about Fracture Risk?

Author(s): Lo JC; Ettinger B

J Am Geriatr Soc. 2020 May 06.

PubMed abstract

A reduced transferrin saturation is independently associated with excess morbidity and mortality in older adults with heart failure and incident anemia

Low transferrin saturation (TSAT) or reduced serum ferritin level are suggestive of iron deficiency but the relationship between iron parameters and outcomes has not been systematically evaluated in older adults with heart failure (HF) and anemia. We iden...
Author(s): Ambrosy AP; Go AS; RBC HEART Investigators/PACTTE Consortium; et al.

Int J Cardiol. 2020 Mar 12.

PubMed abstract

Cumulative Adherence to Secondary Prevention Guidelines and Mortality After Acute Myocardial Infarction

Background The survival benefit associated with cumulative adherence to multiple clinical and lifestyle-related guideline recommendations for secondary prevention after acute myocardial infarction (AMI) is not well established. Methods and Results We exam...
Author(s): Solomon MD; Leong TK; Levin E; Rana JS; Jaffe MG; Sidney S; Sung SH; Lee C; DeMaria A; Go AS

J Am Heart Assoc. 2020 Mar 17;9(6):e014415. Epub 2020-03-05.

PubMed abstract

The Epidemiology of Metatarsal Fractures Among Older Females With Bisphosphonate Exposure

Bisphosphonates (BP) are used to treat osteoporosis, although rare atypical femur fractures have occurred with long-term exposure, especially among Asians. Metatarsal fractures have also been reported with atypical femur fracture. We examined the epidemio...
Author(s): West TA; Pollard JD; Chandra M; Hui RL; Weintraub MR; King CM; Grimsrud CD; Lo JC

J Foot Ankle Surg. 2020 Mar - Apr;59(2):269-273.

PubMed abstract

Cardiac valvular abnormalities associated with use and cumulative exposure of cabergoline for hyperprolactinemia: the CATCH study

Whether lower dose cabergoline therapy for hyperprolactinemia increases risk of valvular dysfunction remains controversial. We examined valvular abnormalities among asymptomatic adults with hyperprolactinemia treated with dopamine agonists. This cross-sec...
Author(s): Budayr A; Tan TC; Lo JC; Zaroff JG; Tabada GH; Yang J; Go AS

BMC Endocr Disord. 2020 Feb 19;20(1):25. Epub 2020-02-19.

PubMed abstract

A longitudinal study of pre-pregnancy antioxidant levels and subsequent perinatal outcomes in black and white women: The CARDIA Study

Although protective associations between dietary antioxidants and pregnancy outcomes have been reported, randomized controlled trials of supplementation have been almost uniformly negative. A possible explanation is that supplementation during pregnancy m...
Author(s): Harville EW; Lewis CE; Catov JM; Jacobs DR; Gross MD; Gunderson EP

PLoS ONE. 2020;15(2):e0229002. Epub 2020-02-14.

PubMed abstract

Risk of atherosclerotic cardiovascular disease by cardiovascular health metric categories in approximately 1 million patients

Author(s): Rana JS; Liu JY; Moffet HH; Karter AJ; Nasir K; Solomon MD; Jaffe MG; Ambrosy AP; Go AS; Sidney S

Eur J Prev Cardiol. 2020 Feb 10:2047487320905025.

PubMed abstract

Renin-Angiotensin System Blockade after Acute Kidney Injury (AKI) and Risk of Recurrent AKI

How to best medically manage patients who survived hospitalized AKI is unclear. Use of renin-angiotensin system blockers in this setting may increase risk of recurrent AKI. This is a cohort study of 10,242 members of an integrated health care delivery sys...
Author(s): Hsu CY; Liu KD; Yang J; Glidden DV; Tan TC; Pravoverov L; Zheng S; Go AS

Clin J Am Soc Nephrol. 2019 Dec 16.

PubMed abstract