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Cardiovascular Publications

 

Natriuretic peptides as a surrogate endpoint in clinical trials - a riddle wrapped in an enigma


Author(s): Hardwick AB; Ambrosy AP

Eur J Heart Fail. 2019 Mar 27.

PubMed abstract

Incident Anemia in Older Adults with Heart Failure Rate, Etiology, and Association with Outcomes

Limited data exist on the epidemiology, evaluation, and prognosis of otherwise unexplained anemia of the elderly in HF. Thus, we aimed to determine the incidence of anemia, to characterize diagnostic testing patterns for potentially reversible causes of a...
Author(s): Ambrosy AP; Tabada GH; Sung SH; Go AS; et al.

Eur Heart J Qual Care Clin Outcomes. 2019 Mar 07.

PubMed abstract

Applying data science approaches to identify frequent flyers in heart failure: rise of the machines


Author(s): Ambrosy AP; Lee KK

Eur J Heart Fail. 2019 Feb 07.

PubMed abstract

Burden of medical co-morbidities and benefit from surgical revascularization in patients with ischaemic cardiomyopathy

The landmark STICH trial found that surgical revascularization compared to medical therapy alone improved survival in patients with heart failure (HF) of ischaemic aetiology and an ejection fraction (EF) ≤ 35%. However, the interaction between the burden ...
Author(s): Ambrosy AP; Roy A; STICH Trial Investigators; et al.

Eur J Heart Fail. 2019 Jan 30.

PubMed abstract

Contrasting Causal Effects of Workplace Interventions.

Occupational exposure guidelines are ideally based on estimated effects of static interventions that assign constant exposure over a working lifetime. Static effects are difficult to estimate when follow-up extends beyond employment because their ident...
Author(s): Izano, Monika A MA; Brown, Daniel M DM; Neophytou, Andreas M AM; Garcia, Erika E; Eisen, Ellen A EA

Epidemiology (Cambridge, Mass.). 2018 07 ;29(4):542-546. Epub --.

PubMed abstract

Kidney function, proteinuria and breast arterial calcification in women without clinical cardiovascular disease: The MINERVA study

Breast arterial calcification (BAC) may be a predictor of cardiovascular events and is highly prevalent in persons with end-stage kidney disease. However, few studies to date have examined the association between mild-to-moderate kidney function and prote...
Author(s): Parikh RV; Iribarren C; Lee C; Levine-Hall T; Tan TC; Sanchez G; Ding H; Bidgoli FA; Molloi S; Go AS

PLoS ONE. 2019;14(1):e0210973. Epub 2019-01-17.

PubMed abstract

Trimethylamine N-oxide and risk of heart failure progression: marker or mediator of disease


Author(s): Chioncel O; Ambrosy AP

Eur J Heart Fail. 2019 Jan 09.

PubMed abstract

The Association of Polycystic Ovary Syndrome and Gestational Hypertensive Disorders in a Diverse Community-Based Cohort

To examine the association of polycystic ovary syndrome (PCOS) and pregnancy-induced hypertension (PIH) within a large population of pregnant women in an integrated healthcare system. This retrospective study utilized a source cohort of 1023 women with PC...
Author(s): Schneider D; Gonzalez JR; Yamamoto M; Yang J; Lo JC

J Pregnancy. 2019;2019:9847057. Epub 2019-01-01.

PubMed abstract

Is Time From Last Hospitalization for Heart Failure to Placement of a Primary Prevention Implantable Cardioverter-Defibrillator Associated With Patient Outcomes?

Landmark studies have demonstrated the safety and efficacy of implantable cardioverter-defibrillators (ICDs) in selected stable ambulatory patients with heart failure (HF) with a reduced ejection fraction receiving optimal medical therapy. It is not known...
Author(s): Ambrosy AP; Parzynski CS; Friedman DJ; Fudim M; Hernandez AF; Fonarow GC; Masoudi FA; Al-Khatib SM

Circulation. 2018 Dec 11;138(24):2787-2797.

PubMed abstract

Shake Rattle & Roll - Design and rationale for a pragmatic trial to improve blood pressure control among blacks with persistent hypertension

In Kaiser Permanente Northern California (KPNC), members had similar access to care and a very high overall rate of hypertension control. However, blacks had poorer blood pressure (BP) control than whites. The Shake Rattle & Roll (SRR) trial aimed to ...
Author(s): Nguyen-Huynh MN; Young JD; Alexeeff S; Hatfield MK; Sidney S

Contemp Clin Trials. 2019 Jan;76:85-92. Epub 2018-11-28.

PubMed abstract

Association of Breast Arterial Calcification Presence and Gradation with the Ankle-Brachial Index among Postmenopausal Women

To examine the association of breast arterial calcification (BAC) with the ankle brachial index (ABI), a sensitive metric of peripheral arterial disease (PAD), among postmenopausal women. Background: BAC is an emerging risk marker of cardiovascular di...
Author(s): Iribarren C; Sanchez G; Lu M; Bidgoli FA; Cho HM; Ding H; Molloi S

Eur J Cardiovasc Med. 2018 Nov;5(5):544-551. Epub 2018-11-16.

PubMed abstract

Cardiovascular Events after New-Onset Atrial Fibrillation in Adults with CKD: Results from the Chronic Renal Insufficiency Cohort (CRIC) Study

Atrial fibrillation (AF), the most common sustained arrhythmia in CKD, is associated with poor clinical outcomes in both patients without CKD and patients with dialysis-treated ESRD. However, less is known about AF-associated outcomes in patients with CKD...
Author(s): Bansal N; Go AS; et al.

J Am Soc Nephrol. 2018 Oct 30.

PubMed abstract

Undiagnosed dysglycemia in patients hospitalized for worsening heart failure: not so sweet after all.


Author(s): Chioncel, Ovidiu O; Ambrosy, Andrew P AP

European journal of preventive cardiology. 2018 Oct 28;():2047487318810561. Epub 2018-10-28.

PubMed abstract

Longer lactation duration is associated with decreased prevalence of non-alcoholic fatty liver disease in women

Lactation lowers blood glucose and triglycerides, and increases insulin sensitivity. We hypothesized that a longer duration of lactation would be associated with lower prevalence of non-alcoholic fatty liver disease (NAFLD), which is the leading cause of ...
Author(s): Ajmera VH; Terrault NA; VanWagner LB; Sarkar M; Lewis CE; Carr JJ; Gunderson EP

J Hepatol. 2018 Oct 24.

PubMed abstract

Association Between Bariatric Surgery and Macrovascular Disease Outcomes in Patients With Type 2 Diabetes and Severe Obesity

Macrovascular disease is a leading cause of morbidity and mortality for patients with type 2 diabetes, and medical management, including lifestyle changes, may not be successful at lowering risk. To investigate the relationship between bariatric surgery a...
Author(s): Fisher DP; Sidney S; et al.

JAMA. 2018 10 16;320(15):1570-1582.

PubMed abstract

Risk Factors for Recurrent Acute Kidney Injury in a Large Population-Based Cohort

Acute kidney injury (AKI) has numerous sequelae. Repeated episodes of AKI may be an important determinant of adverse outcomes, including chronic kidney disease and death. In a population-based cohort study, we sought to determine the incidence of and pred...
Author(s): Liu KD; Yang J; Tan TC; Glidden DV; Zheng S; Pravoverov L; Hsu CY; Go AS

Am J Kidney Dis. 2018 Oct 10.

PubMed abstract

Risk of Cardiovascular Disease Among Young Adults: Marijuana Use or the Company it Keeps


Author(s): Rana JS; Auer R; Reis JP; Sidney S

J Am Coll Cardiol. 2018 Sep 25;72(13):1559-1560.

PubMed abstract

Multimorbidity Burden and Adverse Outcomes in a Community-Based Cohort of Adults with Heart Failure

To assess multimorbidity burden and its association with clinical outcomes in adults with heart failure (HF) according to sex, age, and HF type. Retrospective cohort study. Five healthcare delivery systems across the United States. Adults with HF (N=114,5...
Author(s): Tisminetzky M; Gurwitz JH; Fan D; Reynolds K; Smith DH; Magid DJ; Sung SH; Murphy TE; Goldberg RJ; Go AS

J Am Geriatr Soc. 2018 Sep 24.

PubMed abstract

Natural History of Patients Postacute Coronary Syndrome Based on Heart Failure Status.

The natural history of patients hospitalized for acute coronary syndrome (ACS) with pre-existing versus (vs) de novo heart failure (HF) has not been previously reported over an extended duration of follow-up. The IMPROVE-IT trial enrolled 18,144 patien...
Author(s): Ambrosy, Andrew P AP; Cerbin, Lukasz P LP; Fudim, Marat M; Clare, Robert M RM; Lokhnygina, Yuliya Y; Braunwald, Eugene E; Califf, Robert M RM; Cannon, Christopher P CP; Tershakovec, Andrew M AM; Roe, Matthew T MT; Blazing, Michael A MA

The American journal of cardiology. 2018 Nov 01;122(9):1451-1458. Epub 2018-08-04.

PubMed abstract

Contemporary Burden and Correlates of Symptomatic Paroxysmal Supraventricular Tachycardia

Contemporary data about symptomatic paroxysmal supraventricular tachycardia (PSVT) epidemiology are limited. We characterized prevalence and correlates of symptomatic PSVT within a large healthcare delivery system and estimated national PSVT burden. We id...
Author(s): Go AS; Hlatky MA; Liu TI; Fan D; Garcia EA; Sung SH; Solomon MD

J Am Heart Assoc. 2018 Jul 07;7(14). Epub 2018-07-07.

PubMed abstract

Renal Function and Exercise Training in AmbulatoryHeart Failure Patients With a Reduced Ejection Fraction.

Patients with chronic kidney disease (CKD) and/or end-stage renal disease are less active and experience significant functional limitations. The impact of a structured aerobic exercise intervention on outcomes in ambulatory heart failure (HF) patients ...
Author(s): Ambrosy, Andrew P AP; Mulder, Hillary H; Coles, Adrian A; Krauss, William E WE; Lam, Carolyn S P CSP; McCullough, Peter A PA; Pina, Ileana I; Tromp, Jasper J; Whellan, David J DJ; O'Connor, Christopher M CM; Mentz, Robert J RJ

The American journal of cardiology. 2018 Sep 15;122(6):999-1007. Epub 2018-06-23.

PubMed abstract

Combination drug therapy in heart failure: greater than the sum of its parts.


Author(s): Ambrosy, Andrew P AP; Chioncel, Ovidiu O

European journal of heart failure. 2018 Sep 17;20(9):1323-1325. Epub 2018-06-22.

PubMed abstract

Contemporary rates and predictors of fast progression of chronic kidney disease in adults with and without diabetes mellitus

Chronic kidney disease (CKD) is highly prevalent but identification of patients at high risk for fast CKD progression before reaching end-stage renal disease in the short-term has been challenging. Whether factors associated with fast progression vary by ...
Author(s): Go AS; Yang J; Tan TC; Cabrera CS; Stefansson BV; Greasley PJ; Ordonez JD; Kaiser Permanente Northern California CKD Outcomes Study

BMC Nephrol. 2018 Jun 22;19(1):146. Epub 2018-06-22.

PubMed abstract

Long-Term Outcomes of Adults With Heart Failure by Left Ventricular Systolic Function Status

Patients with heart failure (HF) and preserved (HFpEF) or borderline preserved ejection fraction (HFbEF) outnumber patients with HF and reduced ejection fraction (HFrEF), but limited data exist on outcomes in community-based populations of these patients....
Author(s): Avula HR; Leong TK; Lee KK; Sung SH; Go AS

Am J Cardiol. 2018 Jun 21.

PubMed abstract

Non-recovery from dialysis-requiring acute kidney injury and short-term mortality and cardiovascular risk: a cohort study

The high mortality and cardiovascular disease (CVD) burden in patients with end-stage renal disease (ESRD) is well-documented. Recent literature suggests that acute kidney injury is also associated with CVD. It is unknown whether patients with incident ES...
Author(s): Lee BJ; Hsu CY; Parikh RV; Leong TK; Tan TC; Walia S; Liu KD; Hsu RK; Go AS

BMC Nephrol. 2018 Jun 11;19(1):134. Epub 2018-06-11.

PubMed abstract
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