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Cardiovascular Publications


Virtual Care Team-Guided Therapeutic Optimization During Hospitalization in Patients with Heart Failure: The IMPLEMENT-HF Study.

BACKGROUND: Scalable and safe approaches for heart failure GDMT optimization are needed. OBJECTIVE: We assessed the safety and effectiveness of a virtual care team-guided strategy on GDMT use in hospitalized patients with HFrEF. METHODS: In a multicenter ...
Author(s): Bhatt, Ankeet S; Vaduganathan, Muthiah; et al.

J Am Coll Cardiol. 2023 Feb 21:S0735-1097(23)04471-6. doi: 10.1016/j.jacc.2023.02.029.

PubMed abstract

Strategic transformations in academic clinical medicine.

Author(s): Bhatt, Ankeet S; Deckers, Peter J

Conn Med. 2014 Jun-Jul;78(6):357-61.

PubMed abstract

Interaction of Body Mass Index on the Association Between N-Terminal-Pro-b-Type Natriuretic Peptide and Morbidity and Mortality in Patients With Acute Heart Failure: Findings From ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure).

BACKGROUND: Higher body mass index (BMI) is associated with lower circulating levels of N-terminal-pro-b-type natriuretic peptide (NT-proBNP). The Interaction between BMI and NT-proBNP with respect to clinical outcomes is not well characterized in patient...
Author(s): Bhatt, Ankeet S; Cooper, Lauren B; Ambrosy, Andrew P; Clare, Robert M; Coles, Adrian; Joyce, Emer; Krishnamoorthy, Arun; Butler, Javed; Felker, G Michael; Ezekowitz, Justin A; Armstrong, Paul W; Hernandez, Adrian F; O'Connor, Christopher M; Mentz, Robert J

J Am Heart Assoc. 2018 Feb 3;7(3). pii: JAHA.117.006740. doi: 10.1161/JAHA.117.006740.

PubMed abstract

Adverse Remodeling and Reverse Remodeling After Myocardial Infarction.

PURPOSE OF REVIEW: The purpose of this review it to summarize the current literature on remodeling after myocardial infarction, inclusive of pathophysiological considerations, imaging modalities, treatment strategies, and future directions. RECENT FINDING...
Author(s): Bhatt, Ankeet S; Ambrosy, Andrew P; Velazquez, Eric J

Curr Cardiol Rep. 2017 Aug;19(8):71. doi: 10.1007/s11886-017-0876-4.

PubMed abstract

Achieving a Maximally Tolerated beta-Blocker Dose in Heart Failure Patients: Is There Room for Improvement?

Heart failure (HF) is associated with significant morbidity and mortality. Although initially thought to be harmful in HF, beta-adrenergic blockers (beta-blockers) have consistently been shown to reduce mortality and HF hospitalization in chronic HF with ...
Author(s): Bhatt, Ankeet S; DeVore, Adam D; DeWald, Tracy A; Swedberg, Karl; Mentz, Robert J

J Am Coll Cardiol. 2017 May 23;69(20):2542-2550. doi: 10.1016/j.jacc.2017.03.563.

PubMed abstract

Can Vaccinations Improve Heart Failure Outcomes?: Contemporary Data and Future Directions.

Heart failure (HF) is a chronic syndrome characterized by acute exacerbations. There is significant overlap between respiratory infections and exacerbation of underlying HF. Vaccination against respiratory infections in patients with HF could serve as a p...
Author(s): Bhatt, Ankeet S; DeVore, Adam D; Hernandez, Adrian F; Mentz, Robert J

JACC Heart Fail. 2017 Mar;5(3):194-203. doi: 10.1016/j.jchf.2016.12.007. Epub 2017 Feb 1.

PubMed abstract

Curious Crosses: Injection-Induced Lesions.

Author(s): Bhatt, Ankeet S; Perkins, Scott; McKinnon, Elizabeth; Perfect, John R

Am J Med. 2017 Jan;130(1):31-33. doi: 10.1016/j.amjmed.2016.08.023. Epub 2016 Sep 9.

PubMed abstract

Improving operating room turnover time: a systems based approach.

Operating room (OR) turnover time (TT) has a broad and significant impact on hospital administrators, providers, staff and patients. Our objective was to identify current problems in TT management and implement a consistent, reproducible process to reduce...
Author(s): Bhatt, Ankeet S; Carlson, Grant W; Deckers, Peter J

J Med Syst. 2014 Dec;38(12):148. doi: 10.1007/s10916-014-0148-4. Epub 2014 Nov 8.

PubMed abstract

Fewer Hospitalizations for Acute Cardiovascular Conditions During the COVID-19 Pandemic.

BACKGROUND: Although patients with cardiovascular disease face excess risks of severe illness with coronavirus disease-2019 (COVID-19), there may be indirect consequences of the pandemic on this high-risk patient segment. OBJECTIVES: This study sought to ...
Author(s): Bhatt, Ankeet S; Moscone, Alea; McElrath, Erin E; Varshney, Anubodh S; Claggett, Brian L; Bhatt, Deepak L; Januzzi, James L; Butler, Javed; Adler, Dale S; Solomon, Scott D; Vaduganathan, Muthiah

J Am Coll Cardiol. 2020 Jul 21;76(3):280-288. doi: 10.1016/j.jacc.2020.05.038. Epub 2020 May 26.

PubMed abstract

Post-discharge haemodilution, congestion, and clinical outcomes among patients hospitalized for heart failure with reduced ejection fraction: results from the EVEREST trial.

Author(s): Bhatt, Ankeet S; Vaduganathan, Muthiah; Patel, Ravi B; Fonarow, Gregg C; Subacius, Haris P; Konstam, Marvin A; Zannad, Faiez; Butler, Javed; Greene, Stephen J

Eur J Heart Fail. 2020 Jan;22(1):164-167. doi: 10.1002/ejhf.1651. Epub 2019 Dec 3.

PubMed abstract

International variation in characteristics and clinical outcomes of patients with type 2 diabetes and heart failure: Insights from TECOS.

International differences in management/outcomes among patients with type 2 diabetes and heart failure (HF) are not well characterized. We sought to evaluate geographic variation in treatment and outcomes among these patients. METHODS AND RESULTS: Among 1...
Author(s): Bhatt, Ankeet S; Luo, Nancy; Solomon, Nicole; Pagidipati, Neha J; Ambrosio, Giuseppe; Green, Jennifer B; McGuire, Darren K; Standl, Eberhard; Cornel, Jan H; Halvorsen, Sigrun; Lopes, Renato D; White, Harvey D; Holman, Rury R; Peterson, Eric D; Mentz, Robert J

Am Heart J. 2019 Dec;218:57-65. doi: 10.1016/j.ahj.2019.08.016. Epub 2019 Aug 28.

PubMed abstract

Reply: Vaccination in Patients With Heart Failure: An Established Recommendation in Patients With Chronic Heart Disease.

Author(s): Bhatt, Ankeet S; DeVore, Adam D; Hernandez, Adrian F

JACC Heart Fail. 2019 Jan;7(1):85. doi: 10.1016/j.jchf.2018.11.015.

PubMed abstract

Vaccination Trends in Patients With Heart Failure: Insights From Get With The Guidelines-Heart Failure.

OBJECTIVES: This study sought to evaluate and contribute to the limited data on U.S. hospital practice patterns with respect to respiratory vaccination in patients hospitalized with heart failure (HF). BACKGROUND: Respiratory infection is a major driver o...
Author(s): Bhatt, Ankeet S; Liang, Li; DeVore, Adam D; Fonarow, Gregg C; Solomon, Scott D; Vardeny, Orly; Yancy, Clyde W; Mentz, Robert J; Khariton, Yevgeniy; Chan, Paul S; Matsouaka, Roland; Lytle, Barbara L; Pina, Ileana L; Hernandez, Adrian F

JACC Heart Fail. 2018 Oct;6(10):844-855. doi: 10.1016/j.jchf.2018.04.012. Epub 2018 Aug 8.

PubMed abstract

Discovery and care innovation amidst a pandemic.

Author(s): Bhatt, Ankeet S; Vaduganathan, Muthiah

Eur J Heart Fail. 2020 Dec;22(12):2202-2204. doi: 10.1002/ejhf.2070. Epub 2020 Dec 14.

PubMed abstract

A Man in His 30s With a New Continuous Murmur and Fever.

Author(s): Li, Selena; Bhatt, Ankeet S; O'Gara, Patrick T

JAMA Cardiol. 2020 Aug 1;5(8):e203255. doi: 10.1001/jamacardio.2020.3255. Epub 2020 Aug 19.

PubMed abstract

Growing Mismatch Between Evidence Generation and Implementation in Heart Failure.

Author(s): Bhatt, Ankeet S; Vaduganathan, Muthiah; Butler, Javed

Am J Med. 2020 May;133(5):525-527. doi: 10.1016/j.amjmed.2019.11.032. Epub 2020 Jan 17.

PubMed abstract

Angiotensin-neprilysin inhibition in de novo heart failure - starting off strong.

Author(s): Bhatt, Ankeet S; Vaduganathan, Muthiah; Butler, Javed

Eur J Heart Fail. 2020 Feb;22(2):313-314. doi: 10.1002/ejhf.1675. Epub 2019 Dec 16.

PubMed abstract

Clinical Outcomes in Patients With Heart Failure Hospitalized With COVID-19.

OBJECTIVES: The purpose of this study was to evaluate in-hospital outcomes among patients with a history of heart failure (HF) hospitalized with coronavirus disease-2019 (COVID-19). BACKGROUND: Cardiometabolic comorbidities are common in patients with sev...
Author(s): Bhatt, Ankeet S; Jering, Karola S; Vaduganathan, Muthiah; Claggett, Brian L; Cunningham, Jonathan W; Rosenthal, Ning; Signorovitch, James; Thune, Jens J; Vardeny, Orly; Solomon, Scott D

JACC Heart Fail. 2021 Jan;9(1):65-73. doi: 10.1016/j.jchf.2020.11.003.

PubMed abstract

Treatment of HF in an Era of Multiple Therapies: Statement From the HF Collaboratory.

The treatment of heart failure with reduced ejection fraction (HFrEF) has changed considerably over time, particularly with the sequential development of therapies aimed at antagonism of maladaptive biologic pathways, including inhibition of the sympathet...
Author(s): Bhatt, Ankeet S; Abraham, William T; Lindenfeld, JoAnn; Bristow, Michael; Carson, Peter E; Felker, G Michael; Fonarow, Gregg C; Greene, Stephen J; Psotka, Mitchell A; Solomon, Scott D; Stockbridge, Norman; Teerlink, John R; Vaduganathan, Muthiah; Wittes, Janet; Fiuzat, Mona; O'Connor, Christopher M; Butler, Javed

JACC Heart Fail. 2021 Jan;9(1):1-12. doi: 10.1016/j.jchf.2020.10.014. Epub 2020 Dec 9.

PubMed abstract

Reply: Are We Missing Something in the Management of Acute Coronary Syndromes in COVID-19-Negative Patients?

Author(s): Bhatt, Ankeet S; Vaduganathan, Muthiah

J Am Coll Cardiol. 2020 Nov 24;76(21):2574-2575. doi: 10.1016/j.jacc.2020.09.548.

PubMed abstract

Accuracy of ICD-10 Diagnostic Codes to Identify COVID-19 Among Hospitalized Patients.

Author(s): Bhatt, Ankeet S; McElrath, Erin E; Claggett, Brian L; Bhatt, Deepak L; Adler, Dale S; Solomon, Scott D; Vaduganathan, Muthiah

J Gen Intern Med. 2021 Aug;36(8):2532-2535. doi: 10.1007/s11606-021-06936-w. Epub 2021 Jun 7.

PubMed abstract

Virtual optimization of guideline-directed medical therapy in hospitalized patients with heart failure with reduced ejection fraction: the IMPLEMENT-HF pilot study.

AIMS: Implementation of guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) remains incomplete. Non-cardiovascular hospitalization may present opportunities for GDMT optimization. We assessed the efficacy and...
Author(s): Bhatt, Ankeet S; Varshney, Anubodh S; Nekoui, Mahan; Moscone, Alea; Cunningham, Jonathan W; Jering, Karola S; Patel, Parth N; Sinnenberg, Lauren E; Bernier, Thomas D; Buckley, Leo F; Cook, Bryan M; Dempsey, Jillian; Kelly, Julie; Knowles, Danielle M; Lupi, Kenneth; Malloy, Rhynn; Matta, Lina S; Rhoten, Megan N; Sharma, Krishan; Snyder, Caroline A; Ting, Clara; McElrath, Erin E; Amato, Mary G; Alobaidly, Maryam; Ulbricht, Catherine E; Choudhry, Niteesh K; Adler, Dale S; Vaduganathan, Muthiah

Eur J Heart Fail. 2021 Jul;23(7):1191-1201. doi: 10.1002/ejhf.2163. Epub 2021 Apr 13.

PubMed abstract

Influenza vaccination: a 'shot' at INVESTing in cardiovascular health.

The link between viral respiratory infection and non-pulmonary organ-specific injury, including cardiac injury, has become increasingly appreciated during the current coronavirus disease 2019 (COVID-19) pandemic. Even prior to the pandemic, however, the a...
Author(s): Bhatt, Ankeet S; Vardeny, Orly; Udell, Jacob A; Joseph, Jacob; Kim, KyungMann; Solomon, Scott D

Eur Heart J. 2021 May 21;42(20):2015-2018. doi: 10.1093/eurheartj/ehab133.

PubMed abstract

For vaptans, as for life, balance is better.

Author(s): Bhatt, Ankeet S; Yanamandala, Mounica; Konstam, Marvin A

Eur J Heart Fail. 2021 May;23(5):751-753. doi: 10.1002/ejhf.2042. Epub 2020 Nov 18.

PubMed abstract

Reply: Improving Heart Failure Therapeutics: Thinking Outside the Pillbox?

Author(s): Bhatt, Ankeet S; Fiuzat, Mona; Lindenfeld, JoAnn; O'Connor, Christopher M; Butler, Javed

JACC Heart Fail. 2021 Apr;9(4):320-321. doi: 10.1016/j.jchf.2021.01.005.

PubMed abstract