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Cardiovascular Publications


Association of the 2020 US Presidential Election With Hospitalizations for Acute Cardiovascular Conditions

Prior studies found a higher risk of acute cardiovascular disease (CVD) around population-wide psychosocial or environmental stressors. Less is known about acute CVD risk in relation to political events. To examine acute CVD hospitalizations following the...
Author(s): Mefford MT; Sidney S; et al.

JAMA Netw Open. 2022 Apr 01;5(4):e228031. Epub 2022-04-01.

PubMed abstract

Global assessment improves risk stratification for major adverse cardiac events across a wide range of triglyceride levels: Insights from the KP REACH study

Patients with risk factors for or established atherosclerotic cardiovascular disease (ASCVD) remain at high risk for subsequent ischemic events despite statin therapy. Triglyceride (TG) levels may contribute to residual ASCVD risk, and the performance of ...
Author(s): Wagner JR; Fitzpatrick JK; Yang J; Sung SH; Allen AR; Philip S; Granowitz C; Abrahamson D; Ambrosy AP; Go AS

Am J Prev Cardiol. 2022 Mar;9:100319. Epub 2022-01-29.

PubMed abstract

Smoking and Risk of Premature Atherosclerotic Cardiovascular Disease

Author(s): Rana JS; Moffet HH; Liu JY; Nasir K; Blankstein R; Karter AJ; Sidney S

Am J Prev Med. 2022 Mar;62(3):466-468. Epub 2021-11-17.

PubMed abstract

Breast Arterial Calcification: a Novel Cardiovascular Risk Enhancer Among Postmenopausal Women

Breast arterial calcification (BAC), a common incidental finding in mammography, has been shown to be associated with angiographic coronary artery disease and cardiovascular disease (CVD) outcomes. We aimed to (1) examine the association of BAC presence a...
Author(s): Iribarren C; Chandra M; Lee C; Sanchez G; Sam DL; Azamian FF; Cho HM; Ding H; Wong ND; Molloi S

Circ Cardiovasc Imaging. 2022 Mar;15(3):e013526. Epub 2022-03-15.

PubMed abstract

Age-Adjusted Mortality Rates and Age and Risk-Associated Contributions to Change in Heart Disease and Stroke Mortality, 2011-2019 and 2019-2020

Author(s): Sidney S; Lee C; Liu J; Khan SS; Lloyd-Jones DM; Rana JS

JAMA Netw Open. 2022 Mar 01;5(3):e223872. Epub 2022-03-01.

PubMed abstract

Heart Failure with Iron Deficiency across the Left Ventricular Ejection Fraction Continuum - Need to Redefine?

Author(s): Sawicki KT; Ambrosy AP

J Card Fail. 2022 Feb 11.

PubMed abstract

Prepregnancy weight change associated with high gestational weight gain

Gestational weight gain (GWG) above recommendations is a risk factor for adverse maternal, perinatal, and long-term outcomes. This study hypothesized that prepregnancy weight gain may portend excess GWG. Among 1,126 women (51% of whom were of Black race) ...
Author(s): Catov JM; Sun B; Lewis CE; Bertolet M; Gunderson EP

Obesity (Silver Spring). 2022 Feb;30(2):524-534. Epub 2022-01-26.

PubMed abstract

Food security, diet quality, nutritional knowledge, and attitudes towards research in adults with heart failure during the COVID-19 pandemic

The impact of the novel coronavirus disease 2019 (COVID-19) pandemic on diet and nutrition among older adults with chronic medical conditions have not been well-described. We conducted a survey addressing (1) food access, (2) diet quality and composition,...
Author(s): Ambrosy AP; Malik UI; Leong TK; Allen AR; Sung SH; Go AS; Healthy Eating as a Means for Active Living in Heart Failure (HEAL-HF) Study

Clin Cardiol. 2022 Feb;45(2):180-188. Epub 2022-02-02.

PubMed abstract

Loop and thiazide diuretic use and risk of chronic kidney disease progression: a multicentre observational cohort study

To evaluate the association between diuretic use by class with chronic kidney disease (CKD) progression and onset of end-stage renal disease (ESRD). Retrospective cohort study. Large integrated healthcare delivery system in Northern California. Adults wit...
Author(s): Fitzpatrick JK; Yang J; Ambrosy AP; Cabrera C; Stefansson BV; Greasley PJ; Patel J; Tan TC; Go AS

BMJ Open. 2022 Jan 31;12(1):e048755. Epub 2022-01-31.

PubMed abstract

Dialysis therapy and mortality in older adults with heart failure and advanced chronic kidney disease: A high-dimensional propensity-matched cohort study

Heart failure (HF) and chronic kidney disease (CKD) frequently coexist, and the combination is linked to poor outcomes, but limited data exist to guide optimal management. We evaluated the outcome of dialysis therapy in older patients with HF and advanced...
Author(s): Zheng S; Yang J; Tan TC; Belani S; Law D; Pravoverov LV; Kim SS; Go AS

PLoS One. 2022;17(1):e0262706. Epub 2022-01-21.

PubMed abstract

Early Pregnancy Blood Pressure Patterns Identify Risk of Hypertensive Disorders of Pregnancy Among Racial and Ethnic Groups

Hypertensive disorders of pregnancy are a leading cause of severe maternal morbidity and mortality and 4-fold higher perinatal mortality in Black women. Early pregnancy blood pressure patterns may differentiate risk of hypertensive disorders of pregnancy....
Author(s): Gunderson EP; Greenberg M; Nguyen-Huynh MN; Tierney C; Roberts JM; Go AS; Tao W; Alexeeff SE

Hypertension. 2021 Dec 29:HYPERTENSIONAHA12118568.

PubMed abstract

Management of Adults with Newly Diagnosed Atrial Fibrillation With and Without Chronic Kidney Disease

Background: Atrial fibrillation (AF) is highly prevalent in chronic kidney disease (CKD) and is associated with worse cardiovascular and kidney outcomes. Limited data exist on use of AF pharmacotherapies and AF-related procedures by CKD status. We examine...
Author(s): Bansal N; Zelnick L; Reynolds K; Harrison T; Lee MS; Singer D; Sung SH; Fan D; Go A

J Am Soc Nephrol. 2021 Dec 17.

PubMed abstract

Human Immunodeficiency Virus Infection and Variation in Heart Failure Risk by Age, Sex, and Ethnicity: The HIV HEART Study

To evaluate the risk of heart failure (HF) linked to human immunodeficiency virus (HIV) infection, how risk varies by demographic characteristics, and whether it is explained by atherosclerotic disease or risk factor treatment. We performed a retrospectiv...
Author(s): Go AS; Silverberg MJ; et al.

Mayo Clin Proc. 2021 Dec 11.

PubMed abstract

A Natural Language Processing-Based Approach for Identifying Hospitalizations for Worsening Heart Failure Within an Integrated Health Care Delivery System

The current understanding of epidemiological mechanisms and temporal trends in hospitalizations for worsening heart failure (WHF) is based on claims and national reporting databases. However, these data sources are inherently limited by the accuracy and c...
Author(s): Ambrosy AP; Go AS; et al.

JAMA Netw Open. 2021 Nov 01;4(11):e2135152. Epub 2021-11-01.

PubMed abstract

Description of Major Osteoporotic Fractures in Women with Invasive Breast Cancer Who Received Endocrine Therapy

Author(s): Lo JC; Laurent CA; Roh JM; Lee J; Chandra M; Yao S; Kwan ML

JAMA Netw Open. 2021 Nov 01;4(11):e2133861. Epub 2021-11-01.

PubMed abstract

Population-based identification and temporal trend of children with primary nephrotic syndrome: The Kaiser Permanente nephrotic syndrome study

Limited population-based data exist about children with primary nephrotic syndrome (NS). We identified a cohort of children with primary NS receiving care in Kaiser Permanente Northern California, an integrated healthcare delivery system caring for >750,0...
Author(s): Parikh RV; Go AS; et al.

PLoS One. 2021;16(10):e0257674. Epub 2021-10-14.

PubMed abstract

Triglyceride Levels and Residual Risk of Atherosclerotic Cardiovascular Disease Events and Death in Adults Receiving Statin Therapy for Primary or Secondary Prevention: Insights From the KP REACH Study

Background Patients with risk factors or established atherosclerotic cardiovascular disease remain at high-risk for ischemic events. Triglyceride levels may play a causal role. Methods and Results We performed a retrospective study of adults aged ≥45 year...
Author(s): Ambrosy AP; Yang J; Sung SH; Allen AR; Fitzpatrick JK; Rana JS; Wagner J; Philip S; Abrahamson D; Granowitz C; Go AS

J Am Heart Assoc. 2021 Oct 19;10(20):e020377. Epub 2021-10-08.

PubMed abstract

QT Interval Dynamics and Cardiovascular Outcomes: A Cohort Study in an Integrated Health Care Delivery System

Background Long QT has been associated with ventricular dysrhythmias, cardiovascular disease (CVD) mortality, and sudden cardiac death. However, no studies to date have investigated the dynamics of within-person QT change over time in relation to risk of ...
Author(s): Mantri N; Lu M; Zaroff JG; Risch N; Hoffmann T; Oni-Orisan A; Lee C; Jorgenson E; Iribarren C

J Am Heart Assoc. 2021 Sep 28:e018513.

PubMed abstract

The Prevalence of Elevated Alanine Aminotransferase Levels Meeting Clinical Action Thresholds in Children with Obesity in Primary Care Practice

Author(s): Wu SJ; Darbinian JA; Schwimmer JB; Yu EL; Ramalingam ND; Greenspan LC; Lo JC

J Pediatr. 2021 Sep 22.

PubMed abstract

Torsade de pointes: A nested case-control study in an integrated healthcare delivery system

TdP is a form of polymorphic ventricular tachycardia which develops in the setting of a prolonged QT interval. There are limited data describing risk factors, treatment, and outcomes of this potentially fatal arrhythmia. Our goals were as follows: (1) to ...
Author(s): Mantri N; Lu M; Zaroff JG; Risch N; Hoffmann T; Oni-Orisan A; Lee C; Iribarren C

Ann Noninvasive Electrocardiol. 2021 Sep 21:e12888.

PubMed abstract

Timing of AKI after urgent percutaneous coronary intervention and clinical outcomes: a high-dimensional propensity score analysis

Acute kidney injury is a common complication of percutaneous coronary intervention and has been associated with an increased risk of death and progressive chronic kidney disease. However, whether the timing of acute kidney injury after urgent percutaneous...
Author(s): Go AS; Tan TC; Parikh RV; Ambrosy AP; Pravoverov LV; Zheng S; Leong TK

BMC Nephrol. 2021 Sep 06;22(1):300. Epub 2021-09-06.

PubMed abstract

Research Priorities in the Secondary Prevention of Atrial Fibrillation: A National Heart, Lung, and Blood Institute Virtual Workshop Report

There has been sustained focus on the secondary prevention of coronary heart disease and heart failure; yet, apart from stroke prevention, the evidence base for the secondary prevention of atrial fibrillation (AF) recurrence, AF progression, and AF-relate...
Author(s): Benjamin EJ; Go AS; et al.

J Am Heart Assoc. 2021 Aug 17;10(16):e021566. Epub 2021-08-05.

PubMed abstract

Covid-19 and Risk of Venous Thromboembolism in Ethnically Diverse Populations

Limited existing data suggest the novel coronavirus disease 2019 (Covid-19) may increase risk for venous thromboembolism (VTE) but information from large, ethnically diverse populations with appropriate controls are lacking. Does the rate of VTE among adu...
Author(s): Go AS; Reynolds K; Tabada GH; Prasad PA; Sung SH; Garcia E; Portugal C; Fan D; Pai AP; Fang MC

Chest. 2021 Jul 19.

PubMed abstract

Relative-Intensity Physical Activity and Its Association With Cardiometabolic Disease

Author(s): Siddique J; Welch WA; Aaby D; Sternfeld B; Pettee Gabriel K; Carnethon MR; Rana JS; Sidney S

J Am Heart Assoc. 2021 Jul 20;10(14):e019174. Epub 2021-07-14.

PubMed abstract

Establishing a Carotid Artery Stenosis Disease Cohort for Comparative Effectiveness Research Using Natural Language Processing

Investigation of asymptomatic carotid stenosis treatment is hindered by the lack of a contemporary population-based disease cohort. We describe the use of natural language processing (NLP) to identify stenosis in patients undergoing carotid imaging. Adult...
Author(s): Chang RW; Tucker LY; Rothenberg KA; Lancaster EM; Avins AL; Kuang HC; Faruqi RM; Nguyen-Huynh MN

J Vasc Surg. 2021 Jun 25.

PubMed abstract