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Cardiovascular Publications


Cardiovascular Events after New-Onset Atrial Fibrillation in Adults with CKD: Results from the Chronic Renal Insufficiency Cohort (CRIC) Study

Atrial fibrillation (AF), the most common sustained arrhythmia in CKD, is associated with poor clinical outcomes in both patients without CKD and patients with dialysis-treated ESRD. However, less is known about AF-associated outcomes in patients with CKD...
Author(s): Bansal N; Go AS; et al.

J Am Soc Nephrol. 2018 Oct 30.

PubMed abstract

Undiagnosed dysglycemia in patients hospitalized for worsening heart failure: not so sweet after all.

Author(s): Chioncel, Ovidiu O; Ambrosy, Andrew P AP

European journal of preventive cardiology. 2018 Oct 28;():2047487318810561. Epub 2018-10-28.

PubMed abstract

Longer lactation duration is associated with decreased prevalence of non-alcoholic fatty liver disease in women

Lactation lowers blood glucose and triglycerides, and increases insulin sensitivity. We hypothesized that a longer duration of lactation would be associated with lower prevalence of non-alcoholic fatty liver disease (NAFLD), which is the leading cause of ...
Author(s): Ajmera VH; Terrault NA; VanWagner LB; Sarkar M; Lewis CE; Carr JJ; Gunderson EP

J Hepatol. 2018 Oct 24.

PubMed abstract

Association Between Bariatric Surgery and Macrovascular Disease Outcomes in Patients With Type 2 Diabetes and Severe Obesity

Macrovascular disease is a leading cause of morbidity and mortality for patients with type 2 diabetes, and medical management, including lifestyle changes, may not be successful at lowering risk. To investigate the relationship between bariatric surgery a...
Author(s): Fisher DP; Sidney S; et al.

JAMA. 2018 10 16;320(15):1570-1582.

PubMed abstract

Risk Factors for Recurrent Acute Kidney Injury in a Large Population-Based Cohort

Acute kidney injury (AKI) has numerous sequelae. Repeated episodes of AKI may be an important determinant of adverse outcomes, including chronic kidney disease and death. In a population-based cohort study, we sought to determine the incidence of and pred...
Author(s): Liu KD; Yang J; Tan TC; Glidden DV; Zheng S; Pravoverov L; Hsu CY; Go AS

Am J Kidney Dis. 2018 Oct 10.

PubMed abstract

Risk of Cardiovascular Disease Among Young Adults: Marijuana Use or the Company it Keeps

Author(s): Rana JS; Auer R; Reis JP; Sidney S

J Am Coll Cardiol. 2018 Sep 25;72(13):1559-1560.

PubMed abstract

Multimorbidity Burden and Adverse Outcomes in a Community-Based Cohort of Adults with Heart Failure

To assess multimorbidity burden and its association with clinical outcomes in adults with heart failure (HF) according to sex, age, and HF type. Retrospective cohort study. Five healthcare delivery systems across the United States. Adults with HF (N=114,5...
Author(s): Tisminetzky M; Gurwitz JH; Fan D; Reynolds K; Smith DH; Magid DJ; Sung SH; Murphy TE; Goldberg RJ; Go AS

J Am Geriatr Soc. 2018 Sep 24.

PubMed abstract

Natural History of Patients Postacute Coronary Syndrome Based on Heart Failure Status.

The natural history of patients hospitalized for acute coronary syndrome (ACS) with pre-existing versus (vs) de novo heart failure (HF) has not been previously reported over an extended duration of follow-up. The IMPROVE-IT trial enrolled 18,144 patien...
Author(s): Ambrosy, Andrew P AP; Cerbin, Lukasz P LP; Fudim, Marat M; Clare, Robert M RM; Lokhnygina, Yuliya Y; Braunwald, Eugene E; Califf, Robert M RM; Cannon, Christopher P CP; Tershakovec, Andrew M AM; Roe, Matthew T MT; Blazing, Michael A MA

The American journal of cardiology. 2018 Nov 01;122(9):1451-1458. Epub 2018-08-04.

PubMed abstract

Contemporary Burden and Correlates of Symptomatic Paroxysmal Supraventricular Tachycardia

Contemporary data about symptomatic paroxysmal supraventricular tachycardia (PSVT) epidemiology are limited. We characterized prevalence and correlates of symptomatic PSVT within a large healthcare delivery system and estimated national PSVT burden. We id...
Author(s): Go AS; Hlatky MA; Liu TI; Fan D; Garcia EA; Sung SH; Solomon MD

J Am Heart Assoc. 2018 Jul 07;7(14). Epub 2018-07-07.

PubMed abstract

Renal Function and Exercise Training in AmbulatoryHeart Failure Patients With a Reduced Ejection Fraction.

Patients with chronic kidney disease (CKD) and/or end-stage renal disease are less active and experience significant functional limitations. The impact of a structured aerobic exercise intervention on outcomes in ambulatory heart failure (HF) patients ...
Author(s): Ambrosy, Andrew P AP; Mulder, Hillary H; Coles, Adrian A; Krauss, William E WE; Lam, Carolyn S P CSP; McCullough, Peter A PA; Pina, Ileana I; Tromp, Jasper J; Whellan, David J DJ; O'Connor, Christopher M CM; Mentz, Robert J RJ

The American journal of cardiology. 2018 Sep 15;122(6):999-1007. Epub 2018-06-23.

PubMed abstract

Combination drug therapy in heart failure: greater than the sum of its parts.

Author(s): Ambrosy, Andrew P AP; Chioncel, Ovidiu O

European journal of heart failure. 2018 Sep 17;20(9):1323-1325. Epub 2018-06-22.

PubMed abstract

Contemporary rates and predictors of fast progression of chronic kidney disease in adults with and without diabetes mellitus

Chronic kidney disease (CKD) is highly prevalent but identification of patients at high risk for fast CKD progression before reaching end-stage renal disease in the short-term has been challenging. Whether factors associated with fast progression vary by ...
Author(s): Go AS; Yang J; Tan TC; Cabrera CS; Stefansson BV; Greasley PJ; Ordonez JD; Kaiser Permanente Northern California CKD Outcomes Study

BMC Nephrol. 2018 Jun 22;19(1):146. Epub 2018-06-22.

PubMed abstract

Long-Term Outcomes of Adults With Heart Failure by Left Ventricular Systolic Function Status

Patients with heart failure (HF) and preserved (HFpEF) or borderline preserved ejection fraction (HFbEF) outnumber patients with HF and reduced ejection fraction (HFrEF), but limited data exist on outcomes in community-based populations of these patients....
Author(s): Avula HR; Leong TK; Lee KK; Sung SH; Go AS

Am J Cardiol. 2018 Jun 21.

PubMed abstract

Non-recovery from dialysis-requiring acute kidney injury and short-term mortality and cardiovascular risk: a cohort study

The high mortality and cardiovascular disease (CVD) burden in patients with end-stage renal disease (ESRD) is well-documented. Recent literature suggests that acute kidney injury is also associated with CVD. It is unknown whether patients with incident ES...
Author(s): Lee BJ; Hsu CY; Parikh RV; Leong TK; Tan TC; Walia S; Liu KD; Hsu RK; Go AS

BMC Nephrol. 2018 Jun 11;19(1):134. Epub 2018-06-11.

PubMed abstract

Association of Pulse Wave Velocity With Chronic Kidney Disease Progression and Mortality: Findings From the CRIC Study (Chronic Renal Insufficiency Cohort)

Patients with chronic kidney diseases (CKDs) are at risk for further loss of kidney function and death, which occur despite reasonable blood pressure treatment. To determine whether arterial stiffness influences CKD progression and death, independent of b...
Author(s): Townsend RR; CRIC Study Investigators; et al.

Hypertension. 2018 Jun;71(6):1101-1107. Epub 2018-04-30.

PubMed abstract

Breastfeeding and Future Maternal Health-No Causal Evidence-Reply

In Reply Velle-Forbord and colleagues raise concerns about reverse causation and differences in metabolic parameters among lactation groups. The longitudinal design in our study� (up to 7 examinations in 30 years) addressed reverse causation by measuring ...
Author(s): Gunderson EP; Lewis CE

JAMA Intern Med. 2018 Jun 01;178(6):871-872.

PubMed abstract

Blood Pressure Patterns and Subsequent Coronary Artery Calcification in Women Who Delivered Preterm Births

Women who delivered preterm infants have excess cardiovascular disease, but vascular pathways linking these conditions are not understood. We considered that higher blood pressure over 25 years among women with preterm delivery may be associated with coro...
Author(s): Catov JM; Snyder GG; Fraser A; Lewis CE; Liu K; Althouse AD; Bertolet M; Gunderson EP

Hypertension. 2018 May 23.

PubMed abstract

Evolution of Echocardiographic Measures of Cardiac Disease From CKD to ESRD and Risk of All-Cause Mortality: Findings From the CRIC Study

Abnormal cardiac structure and function are common in chronic kidney disease (CKD) and end-stage renal disease (ESRD) and linked with mortality and heart failure. We examined changes in echocardiographic measures during the transition from CKD to ESRD and...
Author(s): Bansal N; Chen HY; Go AS; CRIC Study Investigators; et al.

Am J Kidney Dis. 2018 May 18.

PubMed abstract

Association of Burden of Atrial Fibrillation With Risk of Ischemic Stroke in Adults With Paroxysmal Atrial Fibrillation: The KP-RHYTHM Study

Atrial fibrillation is a potent risk factor for stroke, but whether the burden of atrial fibrillation in patients with paroxysmal atrial fibrillation independently influences the risk of thromboembolism remains controversial. To determine if the burden of...
Author(s): Go AS; Reynolds K; Yang J; Gupta N; Lenane J; Sung SH; Harrison TN; Liu TI; Solomon MD

JAMA Cardiol. 2018 May 16.

PubMed abstract

Cognitive Impairment in Non-Dialysis-Dependent CKD and the Transition to Dialysis: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study

Advanced chronic kidney disease is associated with elevated risk for cognitive impairment. However, it is not known whether and how cognitive impairment is associated with planning and preparation for end-stage renal disease. Retrospective observational s...
Author(s): Harhay MN; Go AS; CRIC Study Investigators; et al.

Am J Kidney Dis. 2018 May 02.

PubMed abstract

Weighted Multi-marker Genetic Risk Scores for Incident Coronary Heart Disease among Individuals of African, Latino and East-Asian Ancestry

We examined the clinical utility of two multi-locus genetic risk scores (GRSs) previously validated in Europeans among persons of African (AFR; n = 2,089), Latino (LAT; n = 4,349) and East-Asian (EA; n = 4,804) ancestry. We used data from the GERA cohort ...
Author(s): Iribarren C; Lu M; Jorgenson E; Martínez M; Lluis-Ganella C; Subirana I; Salas E; Elosua R

Sci Rep. 2018 May 01;8(1):6853. Epub 2018-05-01.

PubMed abstract

Breastfeeding and growth during infancy among offspring of mothers with gestational diabetes mellitus: a prospective cohort study

Breastfeeding (BF) may protect against obesity and type 2 diabetes mellitus in children exposed to maternal diabetes in utero, but its effects on infant growth among this high-risk group have rarely been evaluated. The objective of this study was to evalu...
Author(s): Gunderson EP; Greenspan LC; Faith MS; Hurston SR; Quesenberry CP; SWIFT Offspring Study Investigators

Pediatr Obes. 2018 Apr 24.

PubMed abstract

Anxiety, Depression, and Adverse Clinical Outcomes in Patients With Atrial Fibrillation Starting Warfarin: Cardiovascular Research Network WAVE Study

Anxiety and depression are associated with worse outcomes in several cardiovascular conditions, but it is unclear whether they affect outcomes in atrial fibrillation (AF). In a large diverse population of adults with AF, we evaluated the association of di...
Author(s): Baumgartner C; Fan D; Sung SH; Go AS; et al.

J Am Heart Assoc. 2018 Apr 14;7(8). Epub 2018-04-14.

PubMed abstract

Comparative Trends in Heart Disease, Stroke, and All-Cause Mortality in the United States and a Large Integrated Healthcare Delivery System

Heart disease and stroke remain among the leading causes of death nationally. We examined whether differences in recent trends in heart disease, stroke, and total mortality exist in the United States and Kaiser Permanente Northern California (KPNC), a lar...
Author(s): Sidney S; Sorel ME; Quesenberry CP; Jaffe MG; Solomon MD; Nguyen-Huynh MN; Go AS; Rana JS

Am J Med. 2018 Apr 02.

PubMed abstract

Pre-Pregnancy Fitness and Risk of Gestational Diabetes: A Longitudinal Analysis.

PURPOSE: To assess the associations of pre-pregnancy cardiorespiratory fitness, moderate-to vigorous-intensity physical activity (MVPA), and time spent watching television with subsequent development of gestational diabete...
Author(s): Whitaker, Kara M KM; Ingram, Katherine H KH; Appiah, Duke D; Nicholson, Wanda K WK; Bennett, Wendy L WL; Lewis, Cora E CE; Reis, Jared P JP; Schreiner, Pamela J PJ; Gunderson, Erica P EP

Medicine and science in sports and exercise. 2018 Mar 08;():. Epub 2018-03-08.

PubMed abstract