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Characterization of Statin Low-Density Lipoprotein Cholesterol Dose-Response Using Electronic Health Records in a Large Population-Based Cohort

Author(s): Oni-Orisan A; Hoffmann TJ; Ranatunga D; Medina MW; Jorgenson E; Schaefer C; Krauss RM; Iribarren C; Risch N

Circ Genom Precis Med. 2018 Sep;11(9):e002043.

PubMed abstract

A Large Multi-ethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci

Author(s): Hoffmann TJ; Choquet H; Yin J; Banda Y; Kvale MN; Glymour M; Schaefer C; Risch N; Jorgenson E

Genetics. 2018 Aug 14.

PubMed abstract

Incorporating machine learning approaches to assess putative environmental risk factors for multiple sclerosis

Author(s): Mowry EM; Schaefer CA; Bellesis KH; Barcellos LF; et al.

Mult Scler Relat Disord. 2018 Jun 23;24:135-141. Epub 2018-06-23.

PubMed abstract

A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci

Author(s): Choquet H; Thai KK; Hoffmann TJ; Yin J; Schaefer C; Risch N; Jorgenson E; et al.

Nat Commun. 2018 Jun 11;9(1):2278. Epub 2018-06-11.

PubMed abstract

Genetic variants in the HLA class II region associated with risk of cutaneous squamous cell carcinoma

Author(s): Wang W; Ollila HM; Whittemore AS; Demehri S; Ioannidis NM; Jorgenson E; Mignot E; Asgari MM

Cancer Immunol Immunother. 2018 May 12.

PubMed abstract

Age at menarche and late adolescent adiposity associated with mammographic density on processed digital mammograms in 24,840 women

Author(s): Alexeeff SE; Odo N; Lipson JA; Achacoso N; Rothstein JH; Yaffe MJ; Liang RY; Acton L; McGuire V; Whitmore AS; Rubin DL; Sieh W; Habel LA

Cancer Epidemiol Biomarkers Prev. 2017 Jul 11.

PubMed abstract

A Genetic Marker Associated with Shoulder Dislocation

Author(s): Kim S; Kleimeyer JP; Ahmed MA; Avins AL; Fredericson M; Dragoo JL; Ioannidis JPA

Int J Sports Med. 2017 May 18.

PubMed abstract

Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study

Author(s): Jorgenson, E E; Thai, K K KK; Hoffmann, T J TJ; Sakoda, L C LC; Kvale, M N MN; Banda, Y Y; Schaefer, C C; Risch, N N; Mertens, J J; Weisner, C C; Choquet, H H

Molecular psychiatry. 2017 Sep ;22(9):1359-1367. Epub 2017-05-09.

PubMed abstract

Two Genetic Loci associated with Medial Collateral Ligament Injury

Author(s): Roos AK; Avins AL; Ahmed MA; Kleimeyer JP; Roos TR; Fredericson M; Ioannidis JPA; Dragoo JL; Kim S

Int J Sports Med. 2017 May 08.

PubMed abstract

​Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS

Author(s): Gianfrancesco MA; Stridh P; Rhead B; Shao X; Xu E; Graves JS; Chitnis T; Waldman A; Lotze T; Schreiner T; Belman A; Greenberg B; Weinstock-Guttman B; Aaen G; Tillema JM; Hart J; Caillier S; Ness J; Harris Y; Rubin J; Candee M; Krupp L; Gorman M; Benson L; Rodriguez M; Mar S; Kahn I; Rose J; Roalstad S; Casper TC; Shen L; Quach H; Quach D; Hillert J; Bäärnhielm M; Hedstrom A; Olsson T; Kockum I; Alfredsson L; Metayer C; Schaefer C; Barcellos LF; Waubant E; Network of Pediatric Multiple Sclerosis Centers

​Neurology. 2017 Apr 25;88(17):1623-1629. doi: 10.1212/WNL.0000000000003849. Epub 2017 Mar 29.

PubMed abstract

Genome-wide association screens for Achilles tendon and ACL tears and tendinopathy

Author(s): Kim SK; Roos TR; Roos AK; Kleimeyer JP; Ahmed MA; Goodlin GT; Fredericson M; Ioannidis JP; Avins AL; Dragoo JL

PLoS ONE. 2017;12(3):e0170422. Epub 2017-03-30.

PubMed abstract

Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.

Author(s): Hoffmann TJ; Passarelli MN; Graff RE; Emami NC; Sakoda LC; Jorgenson E; Habel LA; Shan J; Ranatunga DK; Quesenberry CP; Chao CR; Ghai NR; Aaronson D; Presti J; Nordström T; Wang Z; Berndt SI; Chanock SJ; Mosley JD; Klein RJ; Middha M; Lilja H; |Melander O; Kvale MN; Kwok PY; Schaefer C; Risch N; Van Den Eeden SK; Witte JS;

​Nat Commun. 2017 Jan 31;8:14248. doi: 10.1038/ncomms14248.

PubMed abstract

Causal Effect of Genetic Variants Associated With Body Mass Index on Multiple Sclerosis Susceptibility

Author(s): Gianfrancesco MA; Glymour MM; Walter S; Rhead B; Shao X; Shen L; Quach H; Hubbard A; Jónsdóttir I; Stefánsson K; Strid P; Hillert J; Hedström A; Olsson T; Kockum I; Schaefer C; Alfredsson L; Barcellos LF;

Am J Epidemiol. 2017 Jan 09.

PubMed abstract

Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease

Author(s): Brant SR; Herrinton LJ; Kugathasan S; et al.

Gastroenterology. 2017 01;152(1):206-217.e2. Epub 2016-09-28.

PubMed abstract

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

Author(s): Barban N; Jansen R; de Vlaming R; Vaez A; Mandemakers JJ; Tropf FC; Shen X; Wilson JF; Chasman DI; Nolte IM; Tragante V; van der Laan SW; Perry JR; Kong A; BIOS Consortium, Ahluwalia TS; Albrecht E; Yerges-Armstrong L; Atzmon G; Auro K; Ayers K; Bakshi A; Ben-Avraham D; Berger K; Bergman A; Bertram L; Bielak LF; Bjornsdottir G; Bonder MJ; Broer L; Bui M; Barbieri C; Cavadino A; Chavarro JE; Turman C; Concas MP; Cordell HJ; Davies G; Eibich P; Eriksson N; Esko T; Eriksson J; Falahi F; Felix JF; Fontana MA; Franke L; Gandin I; Gaskins AJ; Gieger C; Gunderson EP; Guo X; Hayward C; He C; Hofer E; Huang H; Joshi PK; Kanoni S; Karlsson R; Kiechl S; Kifley A; Kluttig A; Kraft P; Lagou V; Lecoeur C; Lahti J; Li-Gao R; Lind PA; Liu T; Makalic E; Mamasoula C; Matteson L; Mbarek H; McArdle PF; McMahon G; Meddens SF; Mihailov E; Miller M; Missmer SA; Monnereau C; van der Most PJ; Myhre R; Nalls MA; Nutile T; Kalafati IP; Porcu E; Prokopenko I; Rajan KB; Rich-Edwards J; Rietveld CA; Robino A; Rose LM; Rueedi R; Ryan KA; Saba Y; Schmidt D; Smith JA; Stolk L; Streeten E; Tönjes A; Thorleifsson G; Ulivi S; Wedenoja J; Wellmann J; Willeit P; Yao J; Yengo L; Zhao JH; Zhao W; Zhernakova DV; Amin N; Andrews H; Balkau B; Barzilai N; Bergmann S; Biino G; Bisgaard H; Bønnelykke K; Boomsma DI; Buring JE; Campbell H; Cappellani S; Ciullo M; Cox SR; Cucca F; Toniolo D; Davey-Smith G; Deary IJ; Dedoussis G; Deloukas P; van Duijn CM; de Geus EJ; Eriksson JG; Evans DA; Faul JD; Sala CF; Froguel P; Gasparini P; Girotto G; Grabe HJ; Greiser KH; Groenen PJ; de Haan HG; Haerting J; Harris TB; Heath AC; Heikkilä K; Hofman A; Homuth G; Holliday EG; Hopper J; Hyppönen E; Jacobsson B; Jaddoe VW; Johannesson M; Jugessur A; Kähönen M; Kajantie E; Kardia SL; Keavney B; Kolcic I; Koponen P; Kovacs P; Kronenberg F; Kutalik Z; La Bianca M; Lachance G; Iacono WG; Lai S; Lehtimäki T; Liewald DC; ; LifeLines Cohort Study; Lindgren CM; Liu Y; Luben R; Lucht M; Luoto R; Magnus P; Magnusson PK; Martin NG; McGue M; McQuillan R; Medland SE; Meisinger C; Mellström D; Metspalu A; Traglia M; Milani L; Mitchell P; Montgomery GW; Mook-Kanamori D; de Mutsert R; Nohr EA; Ohlsson C; Olsen J; Ong KK; Paternoster L; Pattie A; Penninx BW; Perola M; Peyser PA; Pirastu M; Polasek O; Power C; Kaprio J; Raffel LJ; Räikkönen K; Raitakari O; Ridker PM; Ring SM; Roll K; Rudan I; Ruggiero D; Rujescu D; Salomaa V; Schlessinger D; Schmidt H; Schmidt R; Schupf N; Smit J; Sorice R; Spector TD; Starr JM; Stöckl D; Strauch K; Stumvoll M; Swertz MA; Thorsteinsdottir U; Thurik AR; Timpson NJ; Tung JY; Uitterlinden AG; Vaccargiu S; Viikari J; Vitart V; Völzke H; Vollenweider P; Vuckovic D; Waage J; Wagner GG; Wang JJ; Wareham NJ; Weir DR; Willemsen G; Willeit J; Wright AF; Zondervan KT; Stefansson K; Krueger RF; Lee JJ; Benjamin DJ; Cesarini D; Koellinger PD; den Hoed M; Snieder H; Mills MC;

Nat Genet. 2016 Dec;48(12):1462-1472. Epub 2016-10-31.

PubMed abstract

The Kaiser Permanente Northern California research program on genes, environment, and health (RPGEH) pregnancy cohort; study design, methodology and baseline characteristics.

Author(s): Hedderson MM; Ferrara A; Avalos LA; Van den Eeden SK; Gunderson EP; Li DK; Altschuler A; Woo S; Rowell S; Choudhary V; Xu F; Flanagan T; Schaefer C; Croen LA;

​BMC Pregnancy Childbirth. 2016 Nov 29;16(1):381.

PubMed abstract

Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation

Author(s): Hoffmann TJ; Ehret GB; Nandakumar P; Ranatunga D; Schaefer C; Kwok PY; Iribarren C; Chakravarti A; Risch N

Nat Genet. 2016 Nov 14.

PubMed abstract

Variants in Pharmacokinetic Transporters and Glycaemic Response to Metformin: A MetGen Meta-Analysis

Author(s): Dujic T; Zhou K; Yee SW; van Leeuwen N; de Keyser CE; Javorský M; Goswami S; Zaharenko L; Hougaard Christensen MM; Out M; Tavendale R; Kubo M; Hedderson MM; van der Heijden AA; Klimčáková L; Pirags V; Kooy A; Brøsen K; Klovins J; Semiz S; Tkáč I; Stricker BH; Palmer C; 't Hart LM; Giacomini KM; Pearson ER;

Clin Pharmacol Ther. 2016 Nov 10.

PubMed abstract

Clinical Utility of Multi-marker Genetic Risk Scores for Prediction of Incident Coronary Heart Disease; A Cohort Study among over 51 Thousand Individuals of European Ancestry

Author(s): Iribarren C; Lu M; Jorgenson E; Martinez M; Lluis-Ganella C; Subirana I; Salas E; Elosua R

Circ Cardiovasc Genet. 2016 Oct 25.

PubMed abstract

A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records.

Author(s): Hoffmann TJ; Keats BJ; Yoshikawa N; Schaefer C; Risch N; Lustig LR;

PLoS Genet. 2016 Oct 20;12(10):e1006371. doi: 10.1371/journal.pgen.1006371. eCollection 2016 Oct.

PubMed abstract

Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk

Author(s): Rhead B; Bäärnhielm M; Gianfrancesco M; Mok A; Shao X; Quach H; Shen L; Schaefer C; Link J; Gyllenberg A; Hedström AK; Olsson T; Hillert J; Kockum I; Glymour MM; Alfredsson L; Barcellos LF;

Neurol Genet. 2016 Oct;2(5):e97. Epub 2016-09-13.

PubMed abstract

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

Author(s): Zhou K; Yee SW; Seiser EL; van Leeuwen N; Tavendale R; Bennett AJ; Groves CJ; Coleman RL; van der Heijden AA; Beulens JW; de Keyser CE; Zaharenko L; Rotroff DM; Out M; Jablonski KA; Chen L; Javorsk? M; ?idzik J; Levin AM; Williams LK; Dujic T; Semiz S; Kubo M; Chien HC; Maeda S; Witte JS; Wu L; Tk?? I; Kooy A; van Schaik RH; Stehouwer CD; Logie L; MetGen Investigators; DPP Investigators; ACCORD Investigators; Sutherland C; Klovins J; Pirags V; Hofman A; Stricker BH; Motsinger-Reif AA; Wagner MJ; Innocenti F; Hart LM; Holman RR; McCarthy MI; Hedderson MM; Palmer CN; Florez JC; Giacomini KM; Pearson ER

Nat Genet. 2016 Sep;48(9):1055-9. Epub 2016-08-08.

PubMed abstract

The Association of Refractive Error with Glaucoma in a Multiethnic Population

Author(s): Shen L; Melles RB; Metlapally R; Barcellos L; Schaefer C; Risch N; Herrinton LJ; Wildsoet C; Jorgenson E

Ophthalmology. 2015 Aug 7.

PubMed abstract

Impact of type 2 diabetes on lower urinary tract symptoms in men: a cohort study

Author(s): Van Den Eeden SK; Ferrara A; Shan J; Jacobsen SJ; Quinn VP; Haque R; Quesenberry CP

BMC Urol. 2013 Feb 20;13:12.

PubMed abstract

A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin

Author(s): Goswami S; Yee SW; Xu F; Sridhar SB; Mosley JJ; Takahashi A; Kubo M; Maeda S; Davis RL; Roden DM; Hedderson MM; Giacomini KM; Savic RM

Clin Pharmacol Ther. 2016 Jul 14.

PubMed abstract

Case-control study of mammographic density and breast cancer risk using processed digital mammograms

Author(s): Habel LA; Lipson JA; Achacoso N; Rothstein JH; Yaffe MJ; Liang RY; Acton L; McGuire V; Whittemore AS; Rubin DL; Sieh W

Breast Cancer Res. 2016;18(1):53. Epub 2016-05-21.

PubMed abstract

Identification of Susceptibility Loci for Cutaneous Squamous Cell Carcinoma

Author(s): Asgari MM; Wang W; Ioannidis NM; Itnyre J; Hoffmann T; Jorgenson E; Whittemore AS

J Invest Dermatol. 2016 Jan 29.

PubMed abstract

Common coding variants in the HLA-DQB1 region confer susceptibility to age-related macular degeneration

Author(s): Jorgenson E; Melles RB; Hoffmann TJ; Jia X; Sakoda LC; Kvale MN; Banda Y; Schaefer C; Risch N; Shen L

Eur J Hum Genet. 2016 Jan 6.

PubMed abstract

A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia

Author(s): Jorgenson E; Makki N; Shen L; Chen DC; Tian C; Eckalbar WL; Hinds D; Ahituv N; Avins A

Nat Commun. 2015;6:10130. Epub 2015-12-21.

PubMed abstract

Diabetes Pathology and Risk of Primary Open-Angle Glaucoma: Evaluating Causal Mechanisms by Using Genetic Information

Author(s): Shen L; Walter S; Melles RB; Glymour MM; Jorgenson E

Am J Epidemiol. 2015 Nov 25.

PubMed abstract

Polymorphisms In HLA Class II Genes Are Associated With Susceptibility To Staphylococcus aureus Infection In A Caucasian Population

Author(s): DeLorenze GN; Nelson CL; Scott WK; Allen AS; Ray GT; Tsai AL; Quesenberry CP; Fowler VG

J Infect Dis. 2015 Oct 8.

PubMed abstract

Genotyping Informatics and Quality Control for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

Author(s): Kvale MN; Hesselson S; Hoffmann TJ; Cao Y; Chan D; Connell S; Croen LA; Dispensa BP; Eshragh J; Finn A; Gollub J; Iribarren C; Jorgenson E; Kushi LH; Lao R; Lu Y; Ludwig D; Mathauda GK; McGuire WB; Mei G; Miles S; Mittman M; Patil M; Quesenberry CP Jr; Ranatunga D; Rowell S; Sadler M; Sakoda LC; Shapero M; Shen L; Shenoy T; Smethurst D; Somkin CP; Van Den Eeden SK; Walter L; Wan E; Webster T; Whitmer RA; Wong S; Zau C; Zhan Y; Schaefer C; Kwok PY; Risch N;

​​Genetics. 2015 Aug;200(4):1051-60. doi: 10.1534/genetics.115.178905. Epub 2015 Jun 19.

PubMed abstract

Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

Author(s): Lapham K; Kvale MN; Lin J; Connell S; Croen LA; Dispensa BP; Fang L; Hesselson S; Hoffmann TJ; Iribarren C; Jorgenson E; Kushi LH; Ludwig D; Matsuguchi T; McGuire WB; Miles S; Quesenberry CP Jr; Rowell S; Sadler M; Sakoda LC; Smethurst D; Somkin CP; Van Den Eeden SK; Walter L; Whitmer RA; Kwok PY; Risch N; Schaefer C; Blackburn EH;

​Genetics. 2015 Aug;200(4):1061-72. doi: 10.1534/genetics.115.178624. Epub 2015 Jun 19.

PubMed abstract

Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

Author(s): Banda Y; Kvale MN; Hoffmann TJ; Hesselson SE; Ranatunga D; Tang H; Sabatti C; Croen LA; Dispensa BP; Henderson M; Iribarren C; Jorgenson E; Kushi LH; Ludwig D; Olberg D; Quesenberry CP Jr; Rowell S; Sadler M; Sakoda LC; Sciortino S; Shen L; Smethurst D; Somkin CP; Van Den Eeden SK; Walter L; Whitmer RA; Kwok PY; Schaefer C; Risch N;

​Genetics. 2015 Aug;200(4):1285-95. doi: 10.1534/genetics.115.178616. Epub 2015 Jun 19.

PubMed abstract

Differences in the Genetic Susceptibility to Age-Related Macular Degeneration Clinical Subtypes

Author(s): Shen L; Hoffmann TJ; Melles RB; Sakoda LC; Kvale MN; Banda Y; Schaefer C; Risch N; Jorgenson E

Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4290-9.

PubMed abstract

A large multi-ethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences

Author(s): Hoffmann TJ; Van Den Eeden SK; Sakoda LC; Jorgenson E; Habel LA; Graff RE; Passarelli MN; Cario CL; Emami NC; Chao CR; Ghai NR; Shan J; Ranatunga DK; Quesenberry CP; Aaronson D; Presti J; Zhaoming W; Berndt SI; Chanock SJ; McDonnell SK; French AJ; Schaid DJ; Thibodeau SN; Li Q; Freedman ML; Penney KL; Mucci LA; Haiman CA; Henderson BE; Seminara D; Kvale MN; Kwok PY; Schaefer C; Risch N; Witte JS

Cancer Discov. 2015 Jun 1.

PubMed abstract

Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response

Author(s): Wen CC; Yee SW; Liang X; Hoffmann TJ; Kvale MN; Banda Y; Jorgenson E; Schaefer C; Risch N; Giacomini KM

Clin Pharmacol Ther. 2015 May;97(5):518-25. Epub 2015-04-06.

PubMed abstract

Imputation of the Rare HOXB13 G84E Mutation and Cancer Risk in a Large Population-Based Cohort

Author(s): Hoffmann TJ; Sakoda LC; Shen L; Jorgenson E; Habel LA; Liu J; Kvale MN; Asgari MM; Banda Y; Corley D; Kushi LH; Quesenberry CP; Schaefer C; Van Den Eeden SK; Risch N; Witte JS

PLoS Genet. 2015 Jan;11(1):e1004930. Epub 2015-01-28.

PubMed abstract

Estimating genotype error rates from high-coverage next-generation sequence data

Author(s): Wall JD; Tang LF; Zerbe B; Kvale MN; Kwok PY; Schaefer C; Risch N

Genome Res. 2014 Nov;24(11):1734-9. Epub 2014-10-10.

PubMed abstract

Evaluating Racial/Ethnic Disparities in Lower Urinary Tract Symptoms in Men

Author(s): Van Den Eeden SK; Shan J; Jacobsen SJ; Aaronsen D; Haque R; Quinn VP; Quesenberry CP Jr; Urologic Diseases in America Project

J Urol. 2012 Jan;187(1):185-9. Epub 2011 Nov 17.

PubMed abstract

Design and coverage of high throughput genotyping arrays optimized for individuals of East Asian, African American, and Latino race/ethnicity using imputation and a novel hybrid SNP selection algorithm

Author(s): Hoffmann TJ; Zhan Y; Kvale MN; Hesselson SE; Gollub J; Iribarren C; Lu Y; Mei G; Purdy MM; Quesenberry C; Rowell S; Shapero MH; Smethurst D; Somkin CP; Van den Eeden SK; Walter L; Webster T; Whitmer RA; Finn A; Schaefer C; Kwok PY; Risch N

Genomics. 2011 Dec;98(6):422-30. Epub 2011 Aug 28.

PubMed abstract

​Is rigorous retrospective harmonization possible? Application of the DataSHaPER approach across 53 large studies.

Author(s): Fortier I; Doiron D; Little J; Ferretti V; L'Heureux F; Stolk RP; Knoppers BM; Hudson TJ; Burton PR; International Harmonization Initiative;

​Int J Epidemiol. 2011 Oct;40(5):1314-28. doi: 10.1093/ije/dyr106. Epub 2011 Jul 30.

PubMed abstract

Next generation genome-wide association tool: design and coverage of a high-throughput European-optimized SNP array.

Author(s): Hoffmann TJ; Kvale MN; Hesselson SE; Zhan Y; Aquino C; Cao Y; Cawley S; Chung E; Connell S; Eshragh J; Ewing M; Gollub J; Henderson M; Hubbell E; Iribarren C; Kaufman J; Lao RZ; Lu Y; Ludwig D; Mathauda GK; McGuire W; Mei G; Miles S; Purdy MM; Quesenberry C; Ranatunga D; Rowell S; Sadler M; Shapero MH; Shen L; Shenoy TR; Smethurst D; Van den Eeden SK; Walter L; Wan E; Wearley R; Webster T; Wen CC; Weng L; Whitmer RA; Williams A; Wong SC; Zau C; Finn A; Schaefer C; Kwok PY; Risch N.;

​​Genomics. 2011 Aug;98(2):79-89. doi: 10.1016/j.ygeno.2011.04.005. Epub 2011 Apr 30.

PubMed abstract