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Health Care Delivery Publications


Automated Identification of Adults at Risk for In-Hospital Clinical Deterioration

Hospitalized adults whose condition deteriorates while they are in wards (outside the intensive care unit [ICU]) have considerable morbidity and mortality. Early identification of patients at risk for clinical deterioration has relied on manually calculat...
Author(s): Escobar GJ; Liu VX; Schuler A; Lawson B; Greene JD; Kipnis P

N Engl J Med. 2020 11 12;383(20):1951-1960.

PubMed abstract

Expanding Post-discharge Readmission Metrics in Patients with Chronic Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease (COPD) is a common and costly reason for hospitalization and rehospitalization. The Hospital Readmissions Reduction Program penalizes hospitals for excess, non-elective, all-cause 30-day, inpatient rehospitalizations ...
Author(s): Myers LC; Camargo C; Escobar G; Liu VX

Chronic Obstr Pulm Dis. 2020 Nov 06.

PubMed abstract

Racial-ethnic differences in prevalence of social determinants of health and social risks among middle-aged and older adults in a Northern California health plan

Social determinants of health (SDoHs) and social risks (SRs) have been associated with adverse health and healthcare utilization and racial/ethnic disparities. However, there is limited information about the prevalence of SRs in non-"safety net" adult pop...
Author(s): Gordon NP; Banegas MP; Tucker-Seeley RD

PLoS One. 2020;15(11):e0240822. Epub 2020-11-04.

PubMed abstract


Increasing numbers of delivering women experience major morbidity and mortality. Limited work has been done on automated predictive models that could be used for prevention. Using only routinely collected obstetric data, we aimed to develop a predictive m...
Author(s): Escobar GJ; Soltesz L; Schuler A; Niki H; Malenica I; Lee C

Am J Obstet Gynecol. 2020 Oct 21.

PubMed abstract

Intraocular Pressure Reduction After Phacoemulsification: A Matched Cohort Study

Phacoemulsification has been linked to lowered intraocular pressure (IOP) in patients with glaucoma, ocular hypertension, anatomic narrow angles, and in glaucoma suspects (henceforth, "glaucoma"), but the reported magnitude of change has varied. Retrospec...
Author(s): Carolan JA; Liu L; Alexeeff SE; Amsden LB; Shorstein NH; Herrinton LJ

Ophthalmol Glaucoma. 2020 Oct 09.

PubMed abstract

Understanding the Uptake of Digital Technologies for Health-Related Purposes in Frail Older Adults

Author(s): Lee DR; Lo JC; Ramalingam N; Gordon NP

J Am Geriatr Soc. 2020 Oct 03.

PubMed abstract

Assessment of Value of Neighborhood Socioeconomic Status in Models That Use Electronic Health Record Data to Predict Health Care Use Rates and Mortality

Prediction models are widely used in health care as a way of risk stratifying populations for targeted intervention. Most risk stratification has been done using a small number of predictors from insurance claims. However, the utility of diverse nonclinic...
Author(s): Schuler A; O'Súilleabháin L; Rinetti-Vargas G; Kipnis P; Barreda F; Liu VX; Sofrygin O; Escobar GJ

JAMA Netw Open. 2020 Oct 01;3(10):e2017109. Epub 2020-10-01.

PubMed abstract

Estimates of Workload Associated With Suicide Risk Alerts After Implementation of Risk-Prediction Model

Author(s): Kline-Simon AH; Sterling S; Young-Wolff K; Simon G; Lu Y; Does M; Liu V

JAMA Netw Open. 2020 Oct 01;3(10):e2021189. Epub 2020-10-01.

PubMed abstract

A Randomized Encouragement Trial to Increase Mail Order Pharmacy Use and Medication Adherence in Patients with Diabetes

Mail order pharmacy (MOP) use has been linked to improved medication adherence and health outcomes among patients with diabetes. However, no large-scale intervention studies have assessed the effect of encouraging MOP use on medication adherence. To asses...
Author(s): Ramachandran B; Neugebauer RS; Karter AJ; Schmittdiel JA; et al.

J Gen Intern Med. 2020 Oct 01.

PubMed abstract

Inpatient-outpatient shared electronic health records: telemedicine and laboratory follow-up after hospital discharge

Continuity of patient information across settings can improve transitions after hospital discharge, but outpatient clinicians often have limited access to complete information from recent hospitalizations. We examined whether providers' timely access to c...
Author(s): Reed M; Huang J; Brand R; Graetz I; Jaffe MG; Ballard D; Neugebauer R; Fireman B; Hsu J

Am J Manag Care. 2020 Oct 01;26(10):e327-e332. Epub 2020-10-01.

PubMed abstract

Examining if the relationship between BMI and incident type 2 diabetes among middle-older aged adults varies by race/ethnicity: evidence from the Multi-Ethnic Study of Atherosclerosis (MESA).

AIMS: Disparities persist on the prevalence of undiagnosed type 2 diabetes in racial/ethnic minorities in the USA. This study evaluated the association between BMI and incident type 2 diabetes risk by racial/ethnic group, to determine whether BMI and pres...
Author(s): Rodriguez LA; Bradshaw PT; Shiboski SC; Fernandez A; Vittinghoff E; Herrington D; Ding J; Kanaya AM

Diabet Med. 2020 Aug 4:e14377. doi: 10.1111/dme.14377.

PubMed abstract

Endometrial Cancer Detection During the Coronavirus Disease 2019 (COVID-19) Pandemic

Author(s): Suh-Burgmann EJ; Alavi M; Schmittdiel J

Obstet Gynecol. 2020 Jul 21.

PubMed abstract

Diabetes and cardiovascular disease mortality among a population-based cohort of women with and without breast cancer.

PURPOSE: We investigated whether the relationship between diabetes and all-cause and CVD-related mortality differed between women with and without breast cancer among a cohort drawn from the same source population. METHODS: We interviewed 1,363 women newl...
Author(s): Rodriguez LA; Bradshaw PT; Parada H; Khankari NK; Wang T; Cleveland RJ; Teitelbaum SL; Neugut AI; Gammon MD

Cancer Causes Control. 2020 May;31(5):517-524. doi: 10.1007/s10552-020-01292-2. Epub 2020 Mar 7.

PubMed abstract

Design of a cluster-randomized trial of the effectiveness and cost-effectiveness of metformin on prevention of type 2 diabetes among prediabetic Mexican adults (the PRuDENTE initiative of Mexico City).

INTRODUCTION: Type 2 diabetes (T2D) is a global epidemic, and nations are struggling to implement effective healthcare strategies to reduce the burden. While efficacy studies demonstrate that metformin can reduce incident T2D by half among younger, obese ...
Author(s): Rodriguez LA; Schillinger D; et al.

Contemp Clin Trials. 2020 Aug;95:106067. doi: 10.1016/j.cct.2020.106067. Epub 2020 Jun 21.

PubMed abstract

Study protocol: Using peer support to aid in prevention and treatment in prediabetes (UPSTART)

There is an urgent need to develop and evaluate effective and scalable interventions to prevent or delay the onset of type 2 diabetes mellitus (T2DM). In this randomized controlled pragmatic trial, 296 adults with prediabetes will be randomized to either ...
Author(s): Heisler M; Adams A; Hedderson M; Schmittdiel JA; et al.

Contemp Clin Trials. 2020 Jun 01;95:106048. Epub 2020-06-01.

PubMed abstract

Patient Characteristics Associated With Choosing a Telemedicine Visit vs Office Visit With the Same Primary Care Clinicians

Video or telephone telemedicine can offer patients access to a clinician without arranging for transportation or spending time in a waiting room, but little is known about patient characteristics associated with choosing between telemedicine or office vis...
Author(s): Reed ME; Huang J; Graetz I; Lee C; Muelly E; Kennedy C; Kim E

JAMA Netw Open. 2020 Jun 01;3(6):e205873. Epub 2020-06-01.

PubMed abstract

Differences in Diet Quality among Multiple US Racial/Ethnic Groups from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study and the Multi-Ethnic Study of Atherosclerosis (MESA).

BACKGROUND: Diet quality is an important risk factor for type 2 diabetes (T2D) and cardiovascular disease (CVD). Little is known about the diet quality of South Asians in the United States, a group with higher rates of T2D and CVD compared with other raci...
Author(s): Rodriguez LA; Jin Y; Talegawkar SA; Otto MCO; Kandula NR; Herrington DM; Kanaya AM

J Nutr. 2020 Jun 1;150(6):1509-1515. doi: 10.1093/jn/nxaa050.

PubMed abstract

Racial and Ethnic Disparities in Diabetes Care Quality among Women of Reproductive Age in an Integrated Delivery System

Diabetes is increasingly prevalent among women of reproductive age, yet little is known about quality of diabetes care for this population at increased risk of diabetes complications and poor maternal and infant health outcomes. Previous studies have iden...
Author(s): Marshall CJ; Rodriguez HP; Dyer W; Schmittdiel JA

Womens Health Issues. 2020 Apr 24.

PubMed abstract

Validation of Postpartum Hemorrhage Admission Risk Factor Stratification in a Large Obstetrics Population

This study aimed to evaluate the performance of the California Maternal Quality Care Collaborative (CMQCC) admission risk criteria for stratifying postpartum hemorrhage risk in a large obstetrics population.  Using detailed electronic health record data, ...
Author(s): Ruppel H; Liu VX; Gupta NR; Soltesz L; Escobar GJ

Am J Perinatol. 2020 May 26.

PubMed abstract

The Impact of Step-Down Unit Care on Patient Outcomes After ICU Discharge

To examine whether and how step-down unit admission after ICU discharge affects patient outcomes. Retrospective study using an instrumental variable approach to remove potential biases from unobserved differences in illness severity for patients admitted ...
Author(s): Lekwijit S; Chan CW; Green LV; Liu VX; Escobar GJ

Crit Care Explor. 2020 May;2(5):e0114. Epub 2020-05-06.

PubMed abstract

Comparison of Early Warning Scoring Systems for Hospitalized Patients With and Without Infection at Risk for In-Hospital Mortality and Transfer to the Intensive Care Unit

Risk scores used in early warning systems exist for general inpatients and patients with suspected infection outside the intensive care unit (ICU), but their relative performance is incompletely characterized. To compare the performance of tools used to d...
Author(s): Liu VX; Escobar GJ; Churpek MM; et al.

JAMA Netw Open. 2020 May 01;3(5):e205191. Epub 2020-05-01.

PubMed abstract

Characteristics of Hospitalized Adults With COVID-19 in an Integrated Health Care System in California

Author(s): Myers LC; Parodi SM; Escobar GJ; Liu VX

JAMA. 2020 Apr 24.

PubMed abstract

Increased Risk of Colorectal Cancer in Individuals With a History of Serrated Polyps

Serrated polyp (SPs) are precursors to 20%-30% cases of colorectal tumors, but patients' long-term risk after removal of SPs is poorly understood. We investigated the risk of colorectal cancer (CRC) in individuals with a history of SPs. We performed a ret...
Author(s): Li D; Liu L; Fevrier HB; Alexeeff SE; Doherty AR; Menaka LR; Amsden LB; Lee JK; Levin TR; Corley DA; Herrinton LJ

Gastroenterology. 2020 Apr 08.

PubMed abstract

From Containment to Mitigation of COVID-19 in the US

Author(s): Parodi SM; Liu VX

JAMA. 2020 Mar 13.

PubMed abstract

Continuation of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in the Face of Kidney Disease Progression-Safe and Possibly Life Saving

Author(s): DeJong C; Grant RW

JAMA Intern Med. 2020 Mar 09.

PubMed abstract