We aim to develop and extend methods of probabilistic modeling of temporal electronic health record (EHR) data, using non-stationary Gaussian processes, hidden Markov models, and composite mixture models, to identify opportunities to conduct clinical bios...
Funder:
Investigator: Liu, Vincent
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Prediction models have the potential to transform targeted prevention strategies for suicide, a leading cause of death in the U.S. The work of our partners in the Mental Health Research Network demonstrated that predictive machine learning algorithms for ...
Funder: Northern California Community Benefit Programs
Investigator: Papini, Santiago
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This 3-arm randomized pragmatic clinical trial will test the efficacy of patient-focused continuous glucose monitoring (Arm 1 - "patient-only CGM") and patient/provider-focused continuous glucose monitoring (Arm 2 - "patient + provider CGM") intervention ...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Grant, Richard
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This study explores whether using a Hypoglycemia Champion to target high-risk patients with type 2 diabetes is a feasible and effective model of care to reduce hypoglycemia risk in this population. We will develop an evidence-based, expert consensus clini...
Funder: TPMG Delivery Science Projects Program
Investigator: Grant, Richard
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The major goal of this project is to generate robust evidence on the impact of the COVID-induced shift to telemedicine on dementia care. Specifically, during the COVID-19 pandemic, we seek to characterize disparities in use of ambulatory telemedicine for ...
Funder: National Institute on Aging
Investigator: Reed, Mary
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Older adults with poorly controlled type 2 diabetes (T2D) have a higher risk of infection than patients with good glycemic control. However tight glycemic control (e.g., A1C under 7%) in older adults has other risks. In a longitudinal cohort of T2D patien...
Funder: National Institute on Aging
Investigator: Karter, Andrew
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Safely administering insulin to manage blood glucose is challenging for people with type 1 diabetes (T1D). Artificial pancreas or automated insulin delivery (AID) systems mimic pancreatic function by measuring blood glucose (using real-time continuous glu...
Funder: The Leona M. and Harry B. Helmsley Charitable Trust
Investigator: Karter, Andrew
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Using quasi-experimental research methods, this study is assessing the extent to which disparities in type 2 diabetes prevention and outcomes were exacerbated during the coronavirus disease 2019 (COVID-19) pandemic between the Medi-Cal and commercially-in...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Rodriguez, Luis
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This study will establish a cohort of adult KPNC members with prior SARS-CoV-2 infection and identify those with a confirmed diagnosis of post-acute sequelae of SARS-CoV-2 infection to examine predictors, clinical care characteristics, and associated diag...
Funder: TPMG Delivery Science Projects Program
Investigator: Reed, Mary
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Limited English proficiency may be an important social determinant of health and health care access. This study will use electronic health record data to describe and compare health risks, chronic health conditions, quality metrics, and health care use by...
Funder: KP National Office of Community Health
Investigator: Gordon, Nancy
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This study addresses predicting risk of post-traumatic stress disorder and other mental health conditions following hospitalization for life-threatening conditions.
We will use an existing, retrospective cohort of 408,377 patients hospitalized with sever...
Funder: Section Pilot Grants
Investigator: Papini, Santiago
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This project will assess the potential impact of algorithmic bias on the allocation of preventive care for suicide and compare the performance of methods designed to mitigate algorithmic bias.
Funder: Section Pilot Grants
Investigator: Papini, Santiago
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Social Needs Network for Evaluation and Translation (SONNET) is a national network of applied researchers who help design, evaluate, and implement effective social health interventions to improve member health across Kaiser Permanente. The SONNET Evaluat...
Funder: Kaiser Permanente Program Office
Investigator: Grant, Richard
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Kaiser Permanente has set a national goal to increase social health screening among members. Dr. Grant and his DOR Complex Care Team will work with KP National Office of Community Health in a consultative role to address barriers and facilitators to socia...
Funder: KP National Office of Community Health
Investigator: Grant, Richard
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Our goal is to evaluate the effectiveness of a proactive, tailored care intervention in improving early outcomes for Latinx individuals with younger-onset type 2 diabetes. We will also conduct post-intervention interviews with study participants to identi...
Funder: American Diabetes Association
Investigator: Gopalan, Anjali
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Our DOR Complex Care Team is working with Dr. Anand Shah and his team in a consultative role to address barriers and facilitators to social health screening. This work focuses on evaluating and implementing novel informatics-based strategies to guide memb...
Funder: Kaiser Permanente Program Office
Investigator: Grant, Richard
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This study will characterize patients selected by their providers for intermittently-scanned, continuous glucose monitor (isCGM) initiation and estimate the effect of isCGM initiation (relative to non-initiators) on clinical outcomes. We hypothesize that ...
Funder: TPMG Delivery Science Projects Program
Investigator: Karter, Andrew
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Physicians rely on hemoglobin A1c (A1C), an integrated measure of glycemia (blood glucose), to make treatment decisions for patients with diabetes. There is evidence that, given comparable glycemia, A1C results in African Americans can be significantly hi...
Funder: Northern California Community Benefit Programs
Investigator: Karter, Andrew
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We intend to determine the epidemiology of pre-sepsis, including ambulatory and prehospital care settings, to identify modifiable care delays, opportunities for primary sepsis prevention, and to improve early sepsis care for vulnerable populations. The ob...
Funder: Gordon and Betty Moore Foundation
Investigator: Liu, Vincent
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We previously developed an automated electronic health record-based risk stratification tool, called the Comorbidity Assessment and Surgical Triage (CAST) score, which we implemented in KP HealthConnect to improve triage of elective surgical patients to p...
Funder: TPMG Delivery Science Projects Program
Investigator: Liu, Vincent
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We will evaluate a culturally responsive community health worker (CHW) intervention targeting younger-onset Latinx individuals with a new type 2 diabetes (T2D) diagnosis (AURORA [Active Outreach to Younger Latinx]). The AURORA strategy centers on a CHW wh...
Funder: Garfield Memorial Fund
Investigator: Gopalan, Anjali
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We propose to survey White, Black, Latina, Filipina, Chinese, South Asian, Vietnamese, and Japanese women aged 35-79 to characterize and compare these racial/ethnic groups on behaviors and risks related to 7 lifestyle medicine domains (diet, physical acti...
Funder: Northern California Community Benefit Programs
Investigator: Gordon, Nancy
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This study will evaluate TracFone/CareLink program within Kaiser Permanente (KP) Digital Health Equity portfolio. It will involve engaging local leaders, end users, and KP members in the planning, implementation, and initial assessment of barriers and fac...
Funder: Northern California Community Benefit Programs
Investigator: Grant, Richard
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The Diabetes Research for Equity through Advanced Multilevel Science Center for Diabetes Translational Research(DREAMS-CDTR) supports diabetes translational research through mentoring and supporting junior faculty, and by fostering collaborations between ...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Schmittdiel, Julie
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In a population of adults newly diagnosed with type 2 diabetes (T2D) from 2010-2015 and followed for 5 years this study will use machine learning-based predictive analytic methods to develop and validate predictive models using EHR-derived patient data av...
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Investigator: Gopalan, Anjali
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