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Infectious Diseases Publications


Health System-Based Unhealthy Alcohol Use Screening and Treatment Comparing Demographically-Matched Participants With and Without HIV

Unhealthy alcohol use among persons living with HIV (PLWH) is linked to significant morbidity and use of alcohol services may differ by HIV status. Our objective was to compare unhealthy alcohol use screening and treatment by HIV status in primary care. C...
Author(s): Silverberg MJ; Alexeeff SE; Lam JO; Weisner CM; Sterling SA; Satre DD; et al.

Alcohol Clin Exp Res. 2020 Oct 17.

PubMed abstract

Shouting at each other into the void: A linguistic network analysis of vaccine hesitance and support in online discourse regarding California law SB277

In 2015, California passed Senate Bill 277 and became the third state in the United States to ban all nonmedical exemptions from school immunization requirements, effectively prohibiting religious and personal belief exemptions. This attracted grassroots ...
Author(s): DeDominicis K; Buttenheim AM; Howa AC; Delamater PL; Salmon D; Omer SB; Klein NP

Soc Sci Med. 2020 Aug 28;266:113216. Epub 2020-08-28.

PubMed abstract

Timing of Antiretroviral Therapy Initiation and Risk of Cancer among Persons Living with HIV

Persons living with HIV (PLWH) experience a high burden of cancer. It remains unknown which cancer types are reduced in PLWH with earlier initiation of antiretroviral therapy (ART). We evaluated AIDS-free, ART-naive PLWH during 1996-2014 from 22 cohorts p...
Author(s): Silverberg MJ; Neugebauer RS; North American AIDS Cohort Collaboration on Research and Design of the International Epidemiologic Databases to Evaluate AIDS; et al.

Clin Infect Dis. 2020 Aug 12.

PubMed abstract

Individual and Neighborhood Factors Associated with Failure to Vaccinate against Influenza during Pregnancy

Influenza vaccine uptake among pregnant women remains low. We investigated whether unvaccinated pregnant women cluster geographically and determined factors associated with failure to vaccinate using a spatial and multivariate logistic regression analyses...
Author(s): Zerbo O; Ray T; Zhang L; Goddard K; Fireman B; Adams A; Omer S; Kulldorff M; Klein NP

Am J Epidemiol. 2020 Jul 31.

PubMed abstract

HIV Stigma and Its Associations with Longitudinal Health Outcomes Among Persons Living with HIV with a History of Unhealthy Alcohol Use

This study examined the demographic and clinical correlates of HIV stigma and evaluated how HIV stigma was associated with physical and mental health outcomes one year later in a primary-care based cohort of persons living with HIV (PLHIV; N = 584). HIV s...
Author(s): Hojilla JC; Santiago-Rodriguez EI; Sterling S; Williams EC; Leyden W; Hare CB; Silverberg MJ; Satre DD

AIDS Behav. 2020 Jul 06.

PubMed abstract

Smoking and cessation treatment among persons with and without HIV in a U.S. integrated health system

Persons with HIV (PWH) are more likely to smoke and are more susceptible to the harmful effects of smoking than persons without HIV. We examined smoking patterns and use of cessation treatment among PWH and persons without HIV in a U.S. integrated health ...
Author(s): Lam JO; Levine-Hall T; Hood N; Alexeeff SE; Horberg MA; Young-Wolff KC; Sterling SA; Williams A; Weisner C; Satre DD; Silverberg MJ

Drug Alcohol Depend. 2020 Aug 01;213:108128. Epub 2020-06-18.

PubMed abstract

Evaluation of a Vaccine-Communication Tool for Physicians

To evaluate a Kaiser Permanente Northern California physician-training-tool entitled "Effective Communication without Confrontation" (ECC) aimed at improving communication with vaccine-hesitant parents, building trust, and alleviating physician ...
Author(s): Glanternik JR; McDonald JC; Yee AH; Howell A; Saba KN; Mellor RG; Fireman B; Klein NP

J Pediatr. 2020 Jun 06.

PubMed abstract

Early Adopters of Event-driven Human Immunodeficiency Virus Pre-exposure Prophylaxis in a Large Healthcare System in San Francisco

Among 279 patients within a large healthcare system in San Francisco, event-driven HIV pre-exposure prophylaxis using a 2-1-1 regimen was a desirable alternative to daily dosing. Problems with adherence, planning sex in advance, or side effects were infre...
Author(s): Hojilla JC; Marcus JL; Silverberg MJ; Hare CB; Herbers R; Hurley L; Satre DD; Volk JE

Clin Infect Dis. 2020 Jun 04.

PubMed abstract

Response to Brandt, Bednarz-Knoll, Kleinheinz et al

Author(s): Chaturvedi AK; Udaltsova N; Engels EA; Katzel JA; Yanik EL; Katki HA; Lingen MW; Silverberg MJ

J Natl Cancer Inst. 2020 Jun 01.

PubMed abstract

Comparison of Overall and Comorbidity-Free Life Expectancy Between Insured Adults With and Without HIV Infection, 2000-2016

Antiretroviral therapy (ART) has improved life expectancy for individuals with HIV infection, but recent data comparing life span and comorbidity-free years by HIV status are lacking. To quantify the gap in life span and comorbidity-free years by HIV stat...
Author(s): Marcus JL; Leyden WA; Alexeeff SE; Anderson AN; Hechter RC; Hu H; Lam JO; Towner WJ; Yuan Q; Horberg MA; Silverberg MJ

JAMA Netw Open. 2020 Jun 01;3(6):e207954. Epub 2020-06-01.

PubMed abstract

Effectiveness of 'catch-up' human papillomavirus vaccination to prevent cervical neoplasia in immunosuppressed and non-immunosuppressed women

It is unknown whether the HPV vaccine is effective in immunocompromised women during catch-up ages. We performed a case-control study of 4,357 women with incident CIN2+ (cases) and 5:1 age-matched, incidence-density selected controls (N = 21,773) enrolled...
Author(s): Silverberg MJ; Leyden WA; Lam JO; Chao CR; Gregorich SE; Huchko MJ; Kulasingam S; Kuppermann M; Smith-McCune KK; Sawaya GF

Vaccine. 2020 Jun 15;38(29):4520-4523. Epub 2020-05-20.

PubMed abstract

Identification and description of mumps cases in a non-outbreak setting and evaluation of the effectiveness of mumps-containing vaccines over time

Mumps outbreaks among previously vaccinated young adults raise concerns regarding waning vaccine immunity. This study identified, described and assessed the changing incidence of mumps cases following mumps-containing vaccination (MMR/MMRV) in a non-mumps...
Author(s): Zerbo O; Modaressi S; Glanternik JR; Goddard K; Ross P; Lewis N; Klein NP

Hum Vaccin Immunother. 2020 May 13:1-5.

PubMed abstract

Vaccine effectiveness of cell-culture relative to egg-based inactivated influenza vaccine during the 2017-18 influenza season

There is concern that influenza vaccine effectiveness (VE) may be attenuated by passage in eggs during manufacture. We compared quadrivalent cell-culture vaccine with egg-based vaccines, most of which were trivalent, against influenza A and B during 2017-...
Author(s): Klein NP; Fireman B; Goddard K; Zerbo O; Asher J; Zhou J; King J; Lewis N

PLoS ONE. 2020;15(2):e0229279. Epub 2020-02-26.

PubMed abstract

Retrospective study of the use of an influenza disease two-tiered classification system to characterize clinical severity in US children

In children 39°C, acute otitis media, lower respiratory tract infection (LRTI), or extra-pulmonary complications; otherwise, they were classified as mild. We used multivariable log-binomial models to assess whether M-S influenza disease was associated wit...
Author(s): Hsiao A; Buck PO; Yee A; Hansen J; Lewis EM; Aukes LL; Yanni E; Bekkat-Berkani R; Schuind A; Klein NP

Hum Vaccin Immunother. 2020 Feb 20:1-9.

PubMed abstract

Oral leukoplakia and risk of progression to oral cancer: A population-based cohort study

The optimal clinical management of oral precancer remains uncertain. We investigated the natural-history of oral leukoplakia, the most common oral precancerous lesion, to estimate the relative and absolute risks of progression to cancer, the predictive ac...
Author(s): Chaturvedi AK; Udaltsova N; Engels EA; Katzel JA; Yanik EL; Katki HA; Lingen MW; Silverberg MJ

J Natl Cancer Inst. 2019 Dec 20.

PubMed abstract

Changes in Days of Unhealthy Alcohol Use and Antiretroviral Therapy Adherence, HIV RNA Levels, and Condomless Sex: A Secondary Analysis of Clinical Trial Data

In a sample of people with HIV (PWH) enrolled in an alcohol intervention trial and followed for 12 months, we examined the association of changes in days (i.e., decrease, increase, no change [reference]) of unhealthy drinking (consuming ≥ 4/≥ 5 drinks for...
Author(s): Satre DD; Sarovar V; Leyden W; Hare CB; Catz SL; Bryant KJ; Williams EC; Hojilla JC; Horberg MA; Silverberg MJ

AIDS Behav. 2019 Nov 26.

PubMed abstract

Parental Risk Factors for Fever in their Children 7-10 Days After the First Dose of Measles-Containing Vaccines

We evaluated whether parental clinical conditions were associated with fever after a first dose of MCV in the child in a cohort study including 244125 children born in Kaiser Permanente Northern California between 2009 - 2016 who received MCV between ages...
Author(s): Zerbo O; Modaressi S; Goddard K; Lewis E; Bok K; Gans H; Klein NP

Hum Vaccin Immunother. 2019 Oct 04.

PubMed abstract

Alcohol and drug use, partner PrEP use and STI prevalence among people with HIV

People with HIV (PWH) have a high burden of bacterial sexually transmitted infections (STIs). We examined the relationship of alcohol and drug use and partner pre-exposure prophylaxis (PrEP) use to STI prevalence in a cohort of PWH with a history of unhea...
Author(s): Hojilla JC; Marcus J; Volk JE; Leyden W; Hare CB; Hechter RC; Edelman EJ; Silverberg M; Satre DD

Sex Transm Infect. 2019 Aug 23.

PubMed abstract

Implementing electronic substance use disorder and depression and anxiety screening and behavioral interventions in primary care clinics serving people with HIV: Protocol for the Promoting Access to Care Engagement (PACE) trial

Substance use disorders (SUDs) and psychiatric disorders are common among people with HIV (PWH) and lead to poor outcomes. Yet these conditions often go unrecognized and untreated in primary care. The Promoting Access to Care Engagement (PACE) trial curre...
Author(s): Satre DD; Anderson AN; Leibowitz AS; Levine-Hall T; Weisner CM; Silverberg MJ; et al.

Contemp Clin Trials. 2019 Sep;84:105833. Epub 2019-08-22.

PubMed abstract

Long-term effectiveness of zoster vaccine live for postherpetic neuralgia prevention

Postherpetic neuralgia (PHN) occurs in 5-30% of individuals with herpes zoster (HZ) and is characterized by long-lasting pain. Zoster vaccine live (ZVL) is licensed for people 50 years and older to prevent HZ and PHN. This study evaluated vaccine effectiv...
Author(s): Klein NP; Bartlett J; Fireman B; Marks MA; Hansen J; Lewis E; Aukes L; Saddier P

Vaccine. 2019 Jul 10.

PubMed abstract

Antibody persistence and booster response following MenACWY-CRM vaccination in children as assessed by two different assay methods

The quadrivalent meningococcal conjugate vaccine MenACWY-CRM has been shown to be immunogenic and well-tolerated in infants and toddlers. We evaluated antibody persistence for up to 4 years after vaccination with MenACWY-CRM in the first years of life and...
Author(s): Klein NP; Block SL; Essink B; Barbi S; Smolenov I; Keshavan P

Vaccine. 2019 Jul 26;37(32):4460-4467. Epub 2019-07-03.

PubMed abstract

Colorectal Cancer Screening in People With and Without HIV in an Integrated Health Care Setting

As people with HIV (PWH) live longer, age-appropriate colorectal cancer (CRC) screening is increasingly important. Limited data exist on CRC screening and outcomes comparing PWH and persons without HIV. Large integrated health care system. This study incl...
Author(s): Lam JO; Hurley LB; Udaltsova N; Alexeeff SE; Klein DB; Corley DA; Silverberg MJ

J Acquir Immune Defic Syndr. 2019 Jul 01;81(3):284-291.

PubMed abstract

If Influenza Vaccines Wane Can We Delay Vaccination Without Compromising Coverage?

Author(s): Klein NP; Fireman B

Clin Infect Dis. 2019 Jun 29.

PubMed abstract

Interventions to Reduce Unhealthy Alcohol Use among Primary Care Patients with HIV: the Health and Motivation Randomized Clinical Trial

Unhealthy alcohol use has adverse effects on HIV treatment. Screening, brief intervention, and referral to treatment (SBIRT) has some evidence of efficacy but may not be sufficient for those with low motivation or comorbid substance use. To examine the ef...
Author(s): Satre DD; Leibowitz AS; Leyden W; Lam JO; Weisner CM; Sterling SA; Silverberg MJ; et al.

J Gen Intern Med. 2019 Jun 11.

PubMed abstract

Acellular Pertussis Vaccine Effectiveness Over Time

To determine pertussis risk by diphtheria-tetanus-acellular pertussis (DTaP) vaccination status and time since last DTaP dose. Children born at Kaiser Permanente Northern California between 1999 and 2016 were followed from 3 months of age until they teste...
Author(s): Zerbo O; Bartlett J; Goddard K; Fireman B; Lewis E; Klein NP

Pediatrics. 2019 Jun 10.

PubMed abstract