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Infectious Diseases Publications


Incidence of Guillain-Barré Syndrome After COVID-19 Vaccination in the Vaccine Safety Datalink

Postauthorization monitoring of vaccines in a large population may detect rare adverse events not identified in clinical trials such as Guillain-Barré syndrome (GBS), which has a background rate of 1 to 2 per 100 000 person-years. To describe cases and in...
Author(s): Hanson KE; Fireman B; Klein NP; et al.

JAMA Netw Open. 2022 Apr 01;5(4):e228879. Epub 2022-04-01.

PubMed abstract

Added Benefit of Covid-19 Vaccination after Previous Infection

Author(s): Klein NP

N Engl J Med. 2022 Mar 31;386(13):1278-1279.

PubMed abstract

Safety of measles and pertussis-containing vaccines in children with autism spectrum disorders

To determine whether children aged 4-7 years with a diagnosis of autism spectrum disorders (ASD) were at increased risk of fever, febrile seizures, or emergency department (ED) visits following measles- or pertussis-containing vaccines compared with child...
Author(s): Zerbo O; Fireman B; Klein NP; et al.

Vaccine. 2022 Mar 18.

PubMed abstract

Effectiveness of COVID-19 Pfizer-BioNTech BNT162b2 mRNA Vaccination in Preventing COVID-19-Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Nonimmunocompromised Children and Adolescents Aged 5-17 Years - VISION Network, 10 States, April 2021-January 2022

The efficacy of the BNT162b2 (Pfizer-BioNTech) vaccine against laboratory-confirmed COVID-19 exceeded 90% in clinical trials that included children and adolescents aged 5-11, 12-15, and 16-17 years (1-3). Limited real-world data on 2-dose mRNA vaccine eff...
Author(s): Klein NP; Fireman B; Zerbo O; Verani JR; et al.

MMWR Morb Mortal Wkly Rep. 2022 Mar 04;71(9):352-358. Epub 2022-03-04.

PubMed abstract

Incidence and Estimated Vaccine Effectiveness Against Hospitalizations for All-Cause Pneumonia Among Older US Adults Who Were Vaccinated and Not Vaccinated With 13-Valent Pneumococcal Conjugate Vaccine

Following routine use of 13-valent pneumococcal conjugate vaccine (PCV13) in children in 2010, invasive pneumococcal disease rates have decreased substantially in children and adults. In 2014, the Advisory Committee for Immunization Practices recommended ...
Author(s): Hsiao A; Hansen J; Timbol J; Lewis N; Isturiz R; Alexander-Parrish R; McLaughlin JM; Gessner BD; Klein NP

JAMA Netw Open. 2022 Mar 01;5(3):e221111. Epub 2022-03-01.

PubMed abstract

Safety of recombinant quadrivalent influenza vaccine compared to inactivated influenza vaccine in Chinese adults: An observational study

Recombinant influenza vaccine (RIV) has been in use in US adults since 2013. This study evaluated the safety of quadrivalent recombinant influenza vaccine (RIV4, Flublok® Quadrivalent, Sanofi Pasteur) compared with standard-dose quadrivalent inactivated i...
Author(s): Hsiao A; Hansen J; Nunley KV; Lewis N; Selmani A; Inamdar A; Mallett-Moore T; Izikson R; Rudin D; Klein NP

Vaccine. 2022 01 31;40(5):774-779. Epub 2022-01-06.

PubMed abstract

Human Immunodeficiency Virus Infection and Variation in Heart Failure Risk by Age, Sex, and Ethnicity: The HIV HEART Study

To evaluate the risk of heart failure (HF) linked to human immunodeficiency virus (HIV) infection, how risk varies by demographic characteristics, and whether it is explained by atherosclerotic disease or risk factor treatment. We performed a retrospectiv...
Author(s): Go AS; Silverberg MJ; et al.

Mayo Clin Proc. 2021 Dec 11.

PubMed abstract

Comparison of dementia incidence and prevalence between individuals with and without HIV infection in primary care from 2000 to 2016

To compare dementia incidence and prevalence after age 50 by HIV status. Observational cohort, 2000 to 2016. People with HIV (PWH) on antiretroviral therapy (ART) and demographically-similar people without HIV (PWoH), all aged 50 years and older, were ide...
Author(s): Lam JO; Lee C; Gilsanz P; Hou CE; Leyden WA; Satre DD; Flamm JA; Towner WJ; Horberg MA; Silverberg MJ

AIDS. 2021 Nov 24.

PubMed abstract

Cancer in people with and without hepatitis C virus infection: comparison of risk before and after introduction of direct-acting antivirals

Chronic hepatitis C virus (HCV) infection is a leading cause of liver cancer. The association of HCV infection with extrahepatic cancers, and the impact of direct-acting antiviral (DAA) treatment on these cancers, is less well known. We conducted a cohort...
Author(s): Lam JO; Quesenberry CP; Silverberg MJ; et al.

Cancer Epidemiol Biomarkers Prev. 2021 Sep 28.

PubMed abstract

Lessons from a mature acellular pertussis vaccination program and strategies to overcome suboptimal vaccine effectiveness

Despite high vaccination coverage among children and adolescents, pertussis remains a public health problem, with large outbreaks occurring periodically in the US and other developed countries. We examined lessons learned more than 20 years after implemen...
Author(s): Zerbo O; Fireman B; Klein NP

Expert Rev Vaccines. 2021 Sep 24.

PubMed abstract

Effectiveness of Covid-19 Vaccines in Ambulatory and Inpatient Care Settings

There are limited data on the effectiveness of the vaccines against symptomatic coronavirus disease 2019 (Covid-19) currently authorized in the United States with respect to hospitalization, admission to an intensive care unit (ICU), or ambulatory care in...
Author(s): Thompson MG; Fireman B; Zerbo O; Klein NP; et al.

N Engl J Med. 2021 Sep 08.

PubMed abstract

Surveillance for Adverse Events After COVID-19 mRNA Vaccination

Safety surveillance of vaccines against COVID-19 is critical to ensure safety, maintain trust, and inform policy. To monitor 23 serious outcomes weekly, using comprehensive health records on a diverse population. This study represents an interim analysis ...
Author(s): Klein NP; Fireman B; Zerbo O; Weintraub ES; et al.

JAMA. 2021 Sep 03.

PubMed abstract

Population-based assessment of risks for severe COVID-19 disease outcomes

Among approximately 4.6 million members of Kaiser Permanente Northern California, we examined associations of severe COVID-19 with demographic factors and comorbidities. As of July 23, 2021, 16 182 had been hospitalized, 2416 admitted to an ICU, and 1525 ...
Author(s): Zerbo O; Lewis N; Fireman B; Goddard K; Skarbinski J; Sejvar JJ; Azziz-Baumgartner E; Klein NP

Influenza Other Respir Viruses. 2021 Aug 25.

PubMed abstract

A phase 3, randomized, double-blind study to evaluate the immunogenicity and safety of 3 lots of 20-valent pneumococcal conjugate vaccine in pneumococcal vaccine-naive adults 18 through 49 years of age

Introduction of pneumococcal conjugate vaccines (PCVs), including the 13-valent PCV (PCV13), has considerably reduced pneumococcal disease burden. However, additional serotypes not in PCV13 continue to present a substantial disease burden. The 20-valent P...
Author(s): Klein NP; Peyrani P; Yacisin K; Caldwell N; Xu X; Scully IL; Scott DA; Jansen KU; Gruber WC; Watson W

Vaccine. 2021 Jul 24.

PubMed abstract

A Risk Score to Predict Clostridioides difficile Infection

Clostridioides difficile infection (CDI) is a major cause of severe diarrhea. In this retrospective study, we identified CDI risk factors by comparing demographic and clinical characteristics for Kaiser Permanente Northern California members ≥18 years old...
Author(s): Aukes L; Fireman B; Lewis E; Timbol J; Hansen J; Yu H; Cai B; Gonzalez E; Lawrence J; Klein NP

Open Forum Infect Dis. 2021 Mar;8(3):ofab052. Epub 2021-02-04.

PubMed abstract

The relationship of smoking and unhealthy alcohol use to the HIV care continuum among people with HIV in an integrated health care system

Smoking tobacco and unhealthy alcohol use may negatively influence HIV care continuum outcomes but have not been examined in combination. Participants were people with HIV (PWH) in Kaiser Permanente Northern California. Predictors included smoking status ...
Author(s): Satre DD; Sterling SA; Young-Wolff KC; Lam JO; Alexeeff S; Hojilla JC; Weisner C; Silverberg MJ; et al.

Drug Alcohol Depend. 2021 Feb 01;219:108481. Epub 2021-01-08.

PubMed abstract

Comparison of dementia risk after age 50 between individuals with and without HIV infection

To compare risk of dementia after age 50 by HIV status among individuals in a primary care setting. Observational cohort study; participants were identified from 2013-2017 and followed through 2019. Participants were people with HIV (PWH) on antiretrovira...
Author(s): Lam JO; Hou CE; Hojilla JC; Anderson AN; Gilsanz P; Alexeeff SE; Levine-Hall T; Hood N; Lee C; Satre DD; Silverberg MJ

AIDS. 2020 Dec 30.

PubMed abstract

Genetic associations with a fever after measles-containing vaccines

Children have elevated fever risk 1 to 2 weeks after the first dose of a measles-containing vaccine (MCV), which is likely affected by genetic, immunologic, and clinical factors. Fever after MCV is associated with febrile seizures, though may also be asso...
Author(s): Klein NP; Zerbo O; Goddard K; Wang W; Fohner AE; Wiesner A; Shokoohi V; Coller J; Bok K; Gans HA

Hum Vaccin Immunother. 2020 Dec 22:1-7.

PubMed abstract

Beyond the HIV Care Continuum and Viral Suppression: Broadening the Scope of Quality Metrics for Total HIV Patient Care

Assessing quality care for people with HIV (PWH) should not be limited to reporting on HIV Care Continuum benchmarks, particularly viral suppression rates. At Kaiser Permanente Mid-Atlantic States (KPMAS), an integrated health system providing HIV care in...
Author(s): Horberg MA; Certa JM; Rubenstein KB; Hurley LB; Satre DD; Kadlecik PM; Silverberg MJ

AIDS Patient Care STDS. 2020 Nov;34(11):461-469.

PubMed abstract

Health System-Based Unhealthy Alcohol Use Screening and Treatment Comparing Demographically-Matched Participants With and Without HIV

Unhealthy alcohol use among persons living with HIV (PLWH) is linked to significant morbidity and use of alcohol services may differ by HIV status. Our objective was to compare unhealthy alcohol use screening and treatment by HIV status in primary care. C...
Author(s): Silverberg MJ; Alexeeff SE; Lam JO; Weisner CM; Sterling SA; Satre DD; et al.

Alcohol Clin Exp Res. 2020 Oct 17.

PubMed abstract

Association of Mortality and Years of Potential Life Lost With Active Tuberculosis in the United States

Active tuberculosis (TB) disease leads to substantial mortality but is preventable through screening and treatment for latent TB infection. Early mortality after TB diagnosis (≤1 year) is well described, but delayed mortality (>1 year) among patients with...
Author(s): Lee-Rodriguez C; Wada PY; Hung YY; Skarbinski J

JAMA Netw Open. 2020 Sep 01;3(9):e2014481. Epub 2020-09-01.

PubMed abstract

Shouting at each other into the void: A linguistic network analysis of vaccine hesitance and support in online discourse regarding California law SB277

In 2015, California passed Senate Bill 277 and became the third state in the United States to ban all nonmedical exemptions from school immunization requirements, effectively prohibiting religious and personal belief exemptions. This attracted grassroots ...
Author(s): DeDominicis K; Buttenheim AM; Howa AC; Delamater PL; Salmon D; Omer SB; Klein NP

Soc Sci Med. 2020 Aug 28;266:113216. Epub 2020-08-28.

PubMed abstract

Timing of Antiretroviral Therapy Initiation and Risk of Cancer among Persons Living with HIV

Persons living with HIV (PLWH) experience a high burden of cancer. It remains unknown which cancer types are reduced in PLWH with earlier initiation of antiretroviral therapy (ART). We evaluated AIDS-free, ART-naive PLWH during 1996-2014 from 22 cohorts p...
Author(s): Silverberg MJ; Neugebauer RS; North American AIDS Cohort Collaboration on Research and Design of the International Epidemiologic Databases to Evaluate AIDS; et al.

Clin Infect Dis. 2020 Aug 12.

PubMed abstract

Individual and Neighborhood Factors Associated with Failure to Vaccinate against Influenza during Pregnancy

Influenza vaccine uptake among pregnant women remains low. We investigated whether unvaccinated pregnant women cluster geographically and determined factors associated with failure to vaccinate using a spatial and multivariate logistic regression analyses...
Author(s): Zerbo O; Ray T; Zhang L; Goddard K; Fireman B; Adams A; Omer S; Kulldorff M; Klein NP

Am J Epidemiol. 2020 Jul 31.

PubMed abstract

Smoking and cessation treatment among persons with and without HIV in a U.S. integrated health system

Persons with HIV (PWH) are more likely to smoke and are more susceptible to the harmful effects of smoking than persons without HIV. We examined smoking patterns and use of cessation treatment among PWH and persons without HIV in a U.S. integrated health ...
Author(s): Lam JO; Levine-Hall T; Hood N; Alexeeff SE; Horberg MA; Young-Wolff KC; Sterling SA; Williams A; Weisner C; Satre DD; Silverberg MJ

Drug Alcohol Depend. 2020 Aug 01;213:108128. Epub 2020-06-18.

PubMed abstract