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Infectious Diseases Publications


Long-term effectiveness of zoster vaccine live for postherpetic neuralgia prevention

Postherpetic neuralgia (PHN) occurs in 5-30% of individuals with herpes zoster (HZ) and is characterized by long-lasting pain. Zoster vaccine live (ZVL) is licensed for people 50 years and older to prevent HZ and PHN. This study evaluated vaccine effectiv...
Author(s): Klein NP; Bartlett J; Fireman B; Marks MA; Hansen J; Lewis E; Aukes L; Saddier P

Vaccine. 2019 Jul 10.

PubMed abstract

Antibody persistence and booster response following MenACWY-CRM vaccination in children as assessed by two different assay methods

The quadrivalent meningococcal conjugate vaccine MenACWY-CRM has been shown to be immunogenic and well-tolerated in infants and toddlers. We evaluated antibody persistence for up to 4 years after vaccination with MenACWY-CRM in the first years of life and...
Author(s): Klein NP; Block SL; Essink B; Barbi S; Smolenov I; Keshavan P

Vaccine. 2019 Jul 26;37(32):4460-4467. Epub 2019-07-03.

PubMed abstract

Colorectal Cancer Screening in People With and Without HIV in an Integrated Health Care Setting

As people with HIV (PWH) live longer, age-appropriate colorectal cancer (CRC) screening is increasingly important. Limited data exist on CRC screening and outcomes comparing PWH and persons without HIV. Large integrated health care system. This study incl...
Author(s): Lam JO; Hurley LB; Udaltsova N; Alexeeff SE; Klein DB; Corley DA; Silverberg MJ

J Acquir Immune Defic Syndr. 2019 Jul 01;81(3):284-291.

PubMed abstract

If Influenza Vaccines Wane Can We Delay Vaccination Without Compromising Coverage?

Author(s): Klein NP; Fireman B

Clin Infect Dis. 2019 Jun 29.

PubMed abstract

Interventions to Reduce Unhealthy Alcohol Use among Primary Care Patients with HIV: the Health and Motivation Randomized Clinical Trial

Unhealthy alcohol use has adverse effects on HIV treatment. Screening, brief intervention, and referral to treatment (SBIRT) has some evidence of efficacy but may not be sufficient for those with low motivation or comorbid substance use. To examine the ef...
Author(s): Satre DD; Leibowitz AS; Leyden W; Lam JO; Weisner CM; Sterling SA; Silverberg MJ; et al.

J Gen Intern Med. 2019 Jun 11.

PubMed abstract

Acellular Pertussis Vaccine Effectiveness Over Time

To determine pertussis risk by diphtheria-tetanus-acellular pertussis (DTaP) vaccination status and time since last DTaP dose. Children born at Kaiser Permanente Northern California between 1999 and 2016 were followed from 3 months of age until they teste...
Author(s): Zerbo O; Bartlett J; Goddard K; Fireman B; Lewis E; Klein NP

Pediatrics. 2019 Jun 10.

PubMed abstract

Hepatitis C treatment uptake and response among human immunodeficiency virus/hepatitis C virus-coinfected patients in a large integrated healthcare system.

U.S. guidelines recommend that patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) be prioritized for HCV treatment with direct-acting antiviral agents (DAAs), but the high cost of DAAs may contribute to disparities ...
Author(s): Lam, Jennifer O JO; Hurley, Leo B LB; Chamberland, Scott S; Champsi, Jamila H JH; Gittleman, Laura C LC; Korn, Daniel G DG; Lai, Jennifer B JB; Quesenberry, Charles P CP; Ready, Joanna J; Saxena, Varun V; Seo, Suk I SI; Witt, David J DJ; Silverberg, Michael J MJ; Marcus, Julia L JL

International journal of STD & AIDS. 2019 Jun ;30(7):689-695. Epub 2019-05-02.

PubMed abstract

Early outcomes of a high-resolution anoscopy-based anal cancer screening program among people with HIV enrolled in an integrated healthcare system

Few studies have examined outcomes of high-resolution anoscopy (HRA)-based screening for people with HIV infection (PWH), a population at increased risk for anal cancer. SETTING00:: Large integrated healthcare system. Cohort study of 13,552 PWH, c...
Author(s): Barnell GM; Merchant M; Lam JO; Silverberg MJ

J Acquir Immune Defic Syndr. 2019 Mar 29.

PubMed abstract

Mental and Physical Quality of Life by Age Groups in People Living With HIV

Quality of life (QoL) is relevant to people living with HIV (PLWH) with increased life expectancy because of antiretroviral therapy. Our cross-sectional study examined associations between sociodemographic, HIV-related and psychological variables, and QoL...
Author(s): Jang HJ; Satre DD; Leyden W; Leibowitz A; Silverberg MJ

J Assoc Nurses AIDS Care. 2019 Mar 20.

PubMed abstract

Immunogenicity and Safety of a Measles-Mumps-Rubella Vaccine Administered as a First Dose to Children Aged 12 to 15 Months: A Phase III, Randomized, Noninferiority, Lot-to-Lot Consistency Study

MMR II (M-M-R II [Merck & Co, Inc.]) is currently the only measles, mumps, and rubella (MMR) vaccine licensed in the United States. A second MMR vaccine would mitigate the potential risk of vaccine supply shortage or delay. In this study, we assessed ...
Author(s): Klein NP; Henry O; et al.

J Pediatric Infect Dis Soc. 2019 Mar 08.

PubMed abstract

Long term risk of developing type 1 diabetes after HPV vaccination in males and females

Despite minimal evidence, public concerns that the human papillomavirus (HPV) vaccine can cause autoimmune diseases (AD) persist. We evaluated whether HPV vaccine is associated with a long-term increased risk of diabetes mellitus type 1 (DM1). This was a ...
Author(s): Klein NP; Goddard K; Lewis E; Ross P; Gee J; DeStefano F; Baxter R

Vaccine. 2019 Mar 28;37(14):1938-1944. Epub 2019-03-01.

PubMed abstract

Immunogenicity and safety following primary and booster vaccination with a hexavalent diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated poliovirus and Haemophilus influenzae type b vaccine: a randomized trial in the United States

Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliomyelitis and Haemophilus influenzae type b vaccine (DTaP-HBV-IPV/Hib) can further reduce the number of injections in pediatric immunization schedules of countries curr...
Author(s): Klein NP; Abu-Elyazeed R; Cheuvart B; Janssens W; Mesaros N

Hum Vaccin Immunother. 2018 Nov 16.

PubMed abstract

Impact of Alternative Encounter Types on HIV Viral Suppression Rates in an Integrated Health System

Kaiser Permanente Mid-Atlantic States (KPMAS) members are increasingly utilizing electronic encounter types, such as telephone appointments and secure messaging for healthcare purposes, although their impact on health outcomes is unknown. We evaluated whe...
Author(s): Horberg MA; Blank JG; Rubenstein KB; Certa JM; Hurley LB; Kadlecik PM; Klein DB; Silverberg MJ

AIDS Patient Care STDS. 2018 Nov;32(11):425-431.

PubMed abstract

A framework for research on vaccine effectiveness

The need for a systematic approach to research on vaccine effectiveness (VE) is increasing with growing numbers of vaccines and complexity of immunization programs. The diverse scientific fields that investigate how vaccines work and why they fail continu...
Author(s): Crowcroft NS; Klein NP

Vaccine. 2018 Nov 19;36(48):7286-7293. Epub 2018-10-26.

PubMed abstract

Immunogenicity and safety of the Haemophilus influenzae type b and Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine co-administered with human rotavirus, hepatitis A and 13-valent pneumococcal conjugate vaccines: results from a phase III, randomized, multicenter study in infants

This phase III, open-label, randomized study (NCT01978093) evaluated the immunogenicity and safety of co-administered Haemophilus influenzae type b-Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine (Hib-MenCY-TT) with human rotavi...
Author(s): Klein NP; Abu-Elyazeed R; Baine Y; Cheuvart B; Silerova M; Mesaros N

Hum Vaccin Immunother. 2018 Sep 25.

PubMed abstract

Recurrence after hospitalization for acute coronary syndrome among HIV-infected and HIV-uninfected individuals

We evaluated the association of HIV infection and immunodeficiency with acute coronary syndrome (ACS) recurrence, and with all-cause mortality as a secondary outcome, after hospitalization for ACS among HIV-infected and HIV-uninfected individuals. We cond...
Author(s): Marcus JL; Hurley LB; Prasad A; Zaroff J; Klein DB; Horberg MA; Go AS; DeLorenze GN; Quesenberry CP; Sidney S; Lo JC; Silverberg MJ

HIV Med. 2018 Sep 04.

PubMed abstract

Effectiveness of catch-up human papillomavirus vaccination on incident cervical neoplasia in a US health-care setting: a population-based case-control study

The population effectiveness of human papillomavirus (HPV) catch-up vaccination, defined in the USA as first vaccination at ages 13-26 years, has not been studied extensively. We aimed to assess the risk of cervical intraepithelial neoplasia (CIN) 2, CIN3...
Author(s): Silverberg MJ; Leyden WA; Lam JO; Gregorich SE; Huchko MJ; Kulasingam S; Kuppermann M; Smith-McCune KK; Sawaya GF

Lancet Child Adolesc Health. 2018 Oct;2(10):707-714. Epub 2018-08-08.

PubMed abstract

Acceptability of high-resolution anoscopy for anal cancer screening in HIV-infected patients

HIV-infected individuals are at increased risk of anal cancer. Screening for anal cancer precursors using high-resolution anoscopy (HRA) may be clinically beneficial. In this study, we examined patient tolerability of this procedure. The acceptability of ...
Author(s): Lam JO; Barnell GM; Merchant M; Ellis CG; Silverberg MJ

HIV Med. 2018 Aug 06.

PubMed abstract

Factors Affecting Vaccination in Children and Their Siblings After Autism Spectrum Disorder Diagnosis-Reply

In Reply: We appreciate the comments presented by Qin et al about our study entitled �Vaccination Patterns in Children After Autism Spectrum Disorder Diagnosis and in Their Younger Siblings.�1 The objectives of our study were to (1) determine whether ...
Author(s): Zerbo O; Klein NP

JAMA Pediatr. 2018 Aug 06.

PubMed abstract

Factors associated with hazardous alcohol use and motivation to reduce drinking among HIV primary care patients: Baseline findings from the Health & Motivation study

Limited primary care-based research has examined hazardous drinking risk factors and motivation to reduce use in persons with HIV (PWH). We computed prevalence ratios (PR) for factors associated with recent (5) included: moderate/severe depression (PR...
Author(s): Silverberg MJ; Leibowitz A; Jang HJ; Sterling S; Parthasarathy S; Satre DD; et al.

Addict Behav. 2018 Mar 31;84:110-117. Epub 2018-03-31.

PubMed abstract

Vaccination Patterns in Children After Autism Spectrum Disorder Diagnosis and in Their Younger Siblings

In recent years, rates of vaccination have been declining. Whether this phenomenon disproportionately affects children with autism spectrum disorder (ASD) or their younger siblings is unknown. To investigate if children after receiving an ASD diagnosis ob...
Author(s): Zerbo O; Modaressi S; Goddard K; Lewis E; Fireman BH; Klein NP; et al.

JAMA Pediatr. 2018 Mar 26.

PubMed abstract

Immunogenicity and safety of the quadrivalent meningococcal ACWY-tetanus toxoid conjugate vaccine (MenACWY-TT) in splenectomized or hyposplenic children and adolescents: Results of a phase III, open, non-randomized study

Individuals with functional or anatomic asplenia are at high risk for meningococcal disease. We evaluated the immunogenicity and safety of 1 and 2 doses of the quadrivalent meningococcal serogroups A, C, W, Y tetanus toxoid-conjugate vaccine (MenACWY-TT) ...
Author(s): Klein NP; Habanec T; Kosina P; Shah NR; Kolhe D; Miller JM; Hezareh M; Van der Wielen M

Vaccine. 2018 Mar 22.

PubMed abstract

Post-licensure safety surveillance study of routine use of quadrivalent meningococcal diphtheria toxoid conjugate vaccine (MenACWY-D) in infants and children

Menactra® vaccine (MenACWY-D) was licensed in the United States in 2005 for persons 11-55 years of age, in 2007 for children 2-10 years of age, and in 2011 for infants/toddlers 9-23 months of age. We conducted two studies at Kaiser Permanente Northern Cal...
Author(s): Hansen J; Zhang L; Eaton A; Baxter R; Robertson CA; Decker MD; Greenberg DP; Bassily E; Klein NP

Vaccine. 2018 Apr 12;36(16):2133-2138. Epub 2018-03-14.

PubMed abstract

Association Between Estimated Cumulative Vaccine Antigen Exposure Through the First 23 Months of Life and Non-Vaccine-Targeted Infections From 24 Through 47 Months of Age

Some parents are concerned that multiple vaccines in early childhood could weaken their child's immune system. Biological data suggest that increased vaccine antigen exposure could increase the risk for infections not targeted by vaccines. To examine esti...
Author(s): Glanz JM; Newcomer SR; Daley MF; DeStefano F; Groom HC; Jackson ML; Lewin BJ; McCarthy NL; McClure DL; Narwaney KJ; Nordin JD; Zerbo O

JAMA. 2018 03 06;319(9):906-913.

PubMed abstract

Disparities in Initiation of Direct-Acting Antiviral Agents for Hepatitis C Virus Infection in an Insured Population.

OBJECTIVES: The cost of direct-acting antiviral agents (DAAs) for hepatitis C virus (HCV) infection may contribute to treatment disparities. However, few data exist on factors associated with DAA initiation. METHODS: We conducted a retrospective c...
Author(s): Marcus JL; Lam JO; Quesenberry CP; Silverberg MJ; et al.

Public health reports (Washington, D.C. : 1974). 2018 Jan 01;():33354918772059. Epub 2018-01-01.

PubMed abstract