SAN FRANCISCO — Coffee drinkers may be less likely to be hospitalized for heart rhythm disturbances, according to a new study by the Kaiser Permanente Division of Research in Oakland, Calif. The researchers, who note the findings may be surprising because patients frequently report palpitations after drinking coffee, are presenting the study at the American Heart Association’s 50th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in San Francisco on March 5, 2010.
While it has been established that very large doses of caffeine, the
most active ingredient in coffee, can produce rhythm disturbances, there
has been limited epidemiologic research about the caffeine doses people
take. Previous data from a population study in Denmark compared heavy
to light coffee drinkers with respect to risk of atrial fibrillation,
the most common major rhythm disturbance, and found no statistically
significant difference. This research presentation is believed to be the
first large, multiethnic population study to look at all major types of
heart rhythm disturbance, the researchers said.
The researchers followed 130,054 men and women and found that those who
reported drinking four or more cups of coffee each day had an 18 percent
lower risk of hospitalization for heart rhythm disturbances. Those who
reported drinking one to three cups each day had a 7 percent reduction
in risk, according to Arthur Klatsky, MD, the study’s lead investigator and
a senior consultant in cardiology at Kaiser Permanente Division of
Research in Oakland, Calif.
“Coffee drinking is related to lower risk of hospitalization for rhythm
problems, but the association does not prove cause and effect, or that
coffee has a protective effect,” Klasky said. Other explanations for the
association might include other traits of coffee drinkers such as
exercise or dietary habits. Additionally, some people with heart rhythm
problems often are not hospitalized.
“However, these data might be reassuring to people who drink moderate
amounts of coffee that their habit is not likely to cause a majorrhythm
disturbance,” Klatsky said. While this report is not sufficient evidence
to say that people should drink coffee to prevent rhythm problems, it
supports the idea that people who are at risk for rhythm problems, or
who have rhythm problems, do not necessarily need to abstain from
coffee, emphasized Klatsky.
The long-term observational study involved 130,054 men and women, 18 to
90 years old, with the majority less than 50 years old. About 2 percent
(3,317) were hospitalized for rhythm disturbances; 50 percent of those
were for atrial fibrillation, the most common heart rhythm problem. The
18 percent reduction in risk was consistent among men and women,
different ethnic groups, smokers and nonsmokers. It also was similar for
various rhythm problems such as paroxysmal supraventricular
tachycardia, atrial flutter, and atrial fibrillation.
In the study, 14 percent reported drinking less than one cup of coffee a
day; 42 percent reported drinking one to three cups; and 17 percent
reported drinking four cups or more each day. Only 27 percent were not
While emphasizing that these observational data do not establish
causality and a protective mechanism is unclear, researchers speculate
that moderate doses of caffeine may affect rhythm disturbances by
antagonism of adenosine, a nucleoside compound widely distributed in the
body. In the heart adenosine has several effects on conduction of
electrical impulses, muscle cell energetics, and heart muscle cell
recovery that might predispose to rhythm problems. Caffeine antagonizes
adenosine effects by blocking its chemical sites of action.
The researchers examined hospitalization data by elapsed time after the
initial examination. For hospitalization within 10 years, the reduction
in hospitalizations for people who consumed four cups of coffee or more
each day reached 28 percent.
The researchers also studied persons in the group with or without
symptoms or history of heart and respiratory disease. For both groups,
consuming four cups of coffee daily appeared to be associated with fewer
hospitalizations for rhythm disturbances.
Co-authors are: Amatul Hasan, MD; Cynthia Morton, MD; Mary Anne
Armstrong, MA, biostatistician; and Natalia Udaltsova, PhD, programmer.
Author disclosures are on the abstract. This study was supported by a
grant from the Kaiser Foundation Research Institute and the Robert Wood