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Studies

Germline and Tumor Genomic Analyses of Breast Cancer in Latinas

​This project expands a consortium of studies examining germline genetic mutations in breast cancer risk in Latinas. It builds on a study that will include approximately 550 Latina women with breast cancer in the Pathways Study; genetic data from Latina women without breast cancer will be contributed from Kaiser Permanente Northern California’s Research Program on Genes, Environment and Health. Led by Susan Neuhausen, PhD, of City of Hope, and Elad Ziv, MD, of UC San Francisco, this project further incorporates Latina cases and controls from studies led by Dr. Neuhausen. While this project includes investigation of tumor DNA, Pathways Study and Kaiser Permanente Northern California participants will not be included in that aspect.


Investigator: Kushi, Lawrence
Funder: National Cancer Institute

Infrastructure for Pathways, a Prospective Study of Breast Cancer Survivorship

This grant provides core infrastructure support for the Pathways Study (Kushi, PI), a prospective cohort study of breast cancer survivorship and prognosis. Since 2006, the study enrolled 4,505 women diagnosed with invasive breast cancer in KPNC. Activities (Ambrosone, Christine, Roswell Park Cancer Institute, Co-PI) include ongoing follow-up of participants, active and passive ascertainment of outcomes, collection of tumor specimens, linkage to KPNC electronic records, enhancement of area-level data from contextual databases through virtual neighborhood audits, provision of genotypic data from genome-wide assays, and establishment of a community and participant advisory board. These activities enhance the Pathways Study to make it an unparalleled, outstanding resource for studies of breast cancer prognosis.
Investigator: Kushi, Lawrence
Funder: National Cancer Institute