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Duration and stability of metabolically healthy obesity over 30 years

Obese adults who are free from metabolic risk factors may develop risk factors over time. Our objective was to characterize development of obesity and duration of metabolically healthy obese (MHO) over 30 years. Participants in CARDIA who developed obesity (BMI???30?kg/m2) at follow-up exams during years 7, 10, 15, 20, 25, and 30 were analyzed. MHO was defined as obese and having 0 or 1 risk factor: ?SBP/DBP 130/85?mmHg; fasting glucose ?100?mg/dL/5.55?mmol/L; fasting triglycerides (?150?mg/dL/1.69?mmol/L); and HDL-C (men <40?mg/dL/1.036?mmol/L, women <50?mg/dL/1.295?mmol/L) or on any medication(s) for these conditions. MHO duration (years) and obesity duration (years) were estimated for each subsequent time-point; and an overall cumulative duration was also calculated over available follow-up. MHO duration (%) was approximated as MHO duration?÷?obesity duration. Stable MHO was defined as 100% MHO duration over follow-up, while transient MHO was defined as <1-99%. Chi-squared tests were used to compare proportions by sex and race across obesity phenotypes. Multivariable-adjusted ANCOVA, adjusting for baseline BMI, age, race, and sex, was used to analyze obesity duration in all individuals who developed obesity, and also compare MHO duration (%) across race and sex in transient MHO individuals. Of the 987 eligible participants who developed obesity, 51% were African American (AA), 56% were women. Higher percentages of AA were classified as transient MHO, and higher proportions of females were MHO (both p?

Authors: Camhi SM; Must A; Gona PN; Hankinson A; Odegaard A; Reis J; Gunderson EP; Jacobs DR; Carnethon MR

Int J Obes (Lond). 2019 09;43(9):1803-1810. Epub 2018-08-29.

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