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Euglycemic diabetic ketoacidosis following major vascular surgery is a new item on the differential for postoperative acidosis

New pharmacologic advances in the treatment of diabetes include SGLT-2 inhibitors, which have been demonstrated in randomized-controlled clinical trials to reduce overall and cardiac-specific mortality and slow progression of chronic kidney disease. Euglycemic diabetic ketoacidosis is a rare but life-threatening complication associated with the use of SGLT-2 inhibitors. Here we describe a case of severe euglycemic diabetic ketoacidosis after lower extremity bypass in a patient taking an SGLT-2 inhibitor. Awareness of this potential complication is essential as these novel agents are increasingly used in patients with cardiovascular disease.

Authors: Gomez-Sanchez, Clara M; Wu, Bian X; Gotts, Jeffrey E; Chang, Robert W

J Vasc Surg Cases Innov Tech. 2021 Dec;7(4):778-780. Epub 2021-10-22.

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