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Future Directions for Cardiovascular Disease Comparative Effectiveness Research: Report of a Workshop Sponsored by the National Heart, Lung, and Blood Institute

Comparative effectiveness research (CER) aims to provide decision makers with the evidence needed to evaluate the benefits and harms of alternative clinical management strategies. CER has become a national priority, with considerable new research funding allocated. Cardiovascular disease is a priority area for CER. This workshop report provides an overview of CER methods, with an emphasis on practical clinical trials and observational treatment comparisons. The report also details recommendations to the National Heart, Lung, and Blood Institute for a new framework for evidence development to foster cardiovascular CER, and specific studies to address 8 clinical issues identified by the Institute of Medicine as high priorities for cardiovascular CER.

Authors: Hlatky MA; Douglas PS; Cook NL; Wells B; Benjamin EJ; Dickersin K; Goff DC; Hirsch AT; Hylek EM; Peterson ED; Roger VL; Selby JV; Udelson JE; Lauer MS

J Am Coll Cardiol. 2012 Aug 14;60(7):569-80. Epub 2012 Jul 11.

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