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HPV16 Sublineage Associations With Histology-Specific Cancer Risk Using HPV Whole-Genome Sequences in 3200 Women

HPV16 is a common sexually transmitted infection although few infections lead to cervical precancer/cancer; we cannot distinguish nor mechanistically explain why only certain infections progress. HPV16 can be classified into four main evolutionary-derived variant lineages (A, B, C, D) that have been previously suggested to have varying disease risks. We used a high-throughput HPV16 whole-genome sequencing assay to investigate variant lineage risk among 3215 HPV16-infected women. Using sublineages A1/A2 as the reference, we assessed all variant lineage associations with infection outcome over three or more years of follow-up: 1107 control subjects (

Authors: Mirabello L; Yeager M; Cullen M; Boland JF; Chen Z; Wentzensen N; Zhang X; Yu K; Yang Q; Mitchell J; Roberson D; Bass S; Xiao Y; Burdett L; Raine-Bennett T; Lorey T; Castle PE; Burk RD; Schiffman M

J Natl Cancer Inst. 2016 Sep;108(9). Epub 2016-04-29.

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