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The Association of Abdominal Adiposity with Mortality in Patients with Stage I-III Colorectal Cancer

The quantity and distribution of adipose tissue may be prognostic measures of mortality in colorectal cancer patients, and such associations may vary by patient sex. This cohort included 3262 stage I-III colorectal cancer patients. Visceral and subcutaneous adipose tissues were quantified using computed tomography. The primary endpoint was all-cause mortality. Restricted cubic splines estimated statistical associations with two-sided P values. Visceral adipose tissue was prognostic of mortality in a reverse L-shaped pattern (nonlinear P?=?.02); risk was flat to a threshold (?260 cm2) then increased linearly. Subcutaneous adipose tissue was prognostic of mortality in a J-shaped pattern (nonlinear P?50 to ?560 cm2). Patient sex modified the prognostic associations between visceral adipose tissue (Pinteraction = .049) and subcutaneous adipose tissue (Pinteraction = .04) with mortality. Among men, visceral adiposity was associated with mortality in a J-shaped pattern (nonlinear P?=?.003), whereas among women, visceral adiposity was associated with mortality in a linear pattern (linear P?=?.008). Among men, subcutaneous adiposity was associated with mortality in an L-shaped pattern (nonlinear P?=?.01), whereas among women, subcutaneous adiposity was associated with mortality in a J-shaped pattern (nonlinear P?

Authors: Brown JC; Caan BJ; Prado CM; Cespedes Feliciano EM; Xiao J; Kroenke CH; Meyerhardt JA

J Natl Cancer Inst. 2020 04 01;112(4):377-383.

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