Eric Jorgenson, PhD

People

Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-3473 (phone)
eric.jorgenson@kp.org
Kaiser Permanente Researcher Profiles

Eric Jorgenson, PhD, is a former research scientist at the Kaiser Permanente Northern California Division of Research. His primary research interest focused on the genetics of common, complex diseases and their treatment. He was the principal investigator of an NIH-funded study to examine the genetic factors underlying alcohol consumption and misuse in the Research Program on Genes, Environment, and Health (RPGEH) cohort.

Primary Research Interests:

Genetic Epidemiology
Pharmacogenomics
Genetic factors influencing alcohol, tobacco, and drug use
Genetics of vision disorders
Genetic and environmental influences on racial/ethnic variation in disease risk and treatment outcomes
Genetic determinants of cancer risk, progression, and treatment response
Genetics of hernia susceptibility

Related Website(s):

Research Program on Genes, Environment and Health

Studies

PQ3 Cutaneous Squamous Cell Carcinoma: Integrating Germline and Somatic Alterations that Underlie Tumor Progression

The goal of this proposal is to compare tumor versus normal samples of cutaneous squamous cell carcinoma in a large cohort of approximately 77,578 Kaiser Permanente Northern California members. Our goal is to improve understanding of the mechanisms accounting for inherited susceptibility to SCC.
Investigator: Jorgenson, Eric
Funder: National Cancer Institute

Alzheimer’s Disease and Related Dementias in a Diverse Cohort of Asian Americans

This study considers the extent to which immigration history, social factors, cardiometabolic health, and genetic factors contribute to heterogeneity in dementia incidence between Asian American subgroups and between Asian Americans and whites.
Investigator: Jorgenson, Eric
Funder: National Institute on Aging

Closing the Gap Between Observational Research and Randomized Trials for Prevention of Alzheimer‘s Disease and Dementia

Observational studies should have a core role in justifying and guiding the development of randomized controlled trials, but to date observational research and trials on Alzheimer’s disease prevention are not closely aligned. Observational and randomized studies nearly always answer different questions, even when nominally addressing similar topics. Integration across heterogeneous observational data sources will be necessary to provide the sample size, diversity, and variety of measurements to provide such specificity, but currently, we do not have systematic tools to combine evidence from heterogeneous data sources to guide trial design. This proposal builds on Robins g-formula–based methods for counterfactual simulations and takes advantage of recent critical advances in causal methods for data integration, based on Pearls d-separation criteria for transportability.
Investigator: Jorgenson, Eric
Funder: National Institute on Aging

Investigating the Effects of KIR and HLA Gene Polymorphisms on Psoriasis

The goal of this project is to investigate the effects of genetic polymorphisms in the KIR and HLA genes on psoriasis and psoriatic arthritis.
Investigator: Jorgenson, Eric
Funder: University of California, Los Angeles

Antidepressant Use and the Risk of Primary Open Angle Glaucoma

The goal of this project is to address the following research question: Does the use of antidepressant treatment, specifically, selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), reduce the risk of primary open angle glaucoma?
Investigator: Jorgenson, Eric
Funder: Northern California Community Benefit Programs

PGRN Administration Coordination Hub

This is the Administrative Coordination Hub for the Pharmacogenomics Research Network (PGRN). The main areas of responsibility include meetings support, communications and coordination of nascent network collaborations.
Investigator: Jorgenson, Eric
Funder:

Highlighted Publications

Genetic variation in the SIM1 locus is associated with erectile dysfunction

Author(s): Jorgenson E; Yin J; Shan J; Hoffmann TJ; Thai KK; Van Den Eeden SK; et al.

Proc Natl Acad Sci USA. 2018 Oct 23;115(43):11018-11023. Epub 2018-10-08.

Primary Research Interests:

Related Website(s):

Studies

PQ3 Cutaneous Squamous Cell Carcinoma: Integrating Germline and Somatic Alterations that Underlie Tumor Progression

Alzheimer’s Disease and Related Dementias in a Diverse Cohort of Asian Americans

Closing the Gap Between Observational Research and Randomized Trials for Prevention of Alzheimer‘s Disease and Dementia

Investigating the Effects of KIR and HLA Gene Polymorphisms on Psoriasis

Antidepressant Use and the Risk of Primary Open Angle Glaucoma

PGRN Administration Coordination Hub

Highlighted Publications

Genetic variation in the SIM1 locus is associated with erectile dysfunction

A Large Multi-ethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci

A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci

A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study

Publications

A large-scale association study detects novel rare variants, risk genes, functional elements, and polygenic architecture of prostate cancer susceptibility

A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts

Cigarette smoking behaviors and the importance of ethnicity and genetic ancestry

Genetic ancestry, skin pigmentation, and the risk of cutaneous squamous cell carcinoma in Hispanic/Latino and non-Hispanic white populations

Identification of 31 loci for mammographic density phenotypes and their associations with breast cancer risk

Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts

The Polygenic and Monogenic Basis of Blood Traits and Diseases

Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations

Association of genetic risk for Alzheimer disease and hearing impairment

Age-of-onset information helps identify 76 genetic variants associated with allergic disease

A multiethnic genome-wide analysis of 44,039 individuals identifies 41 new loci associated with central corneal thickness

Genetic and environmental factors underlying keratinocyte carcinoma risk

Developing a risk prediction model for keratinocyte carcinoma in patients with actinic keratosis

Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia

Genome-wide meta-analysis identifies eight new susceptibility loci for cutaneous squamous cell carcinoma

Functional validity, role, and implications of heavy alcohol consumption genetic loci

Genetic ancestry does not explain increased atopic dermatitis susceptibility or worse disease control among African American subjects in 2 large US cohorts

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

Telomere length and socioeconomic status at neighborhood and individual levels among 80,000 adults in the Genetic Epidemiology Research on Adult Health and Aging cohort

Large-scale, multi-ethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults

Genome-wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol

Reply to Liu et al.: Tissue specificity of SIM1 gene expression and erectile dysfunction

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

A Prediction Tool to Facilitate Risk-Stratified Screening for Squamous Cell Skin Cancer

A functional splicing variant associated with decreased asthma risk abolishes the ability of gasdermin B (GSMDB) to induce epithelial cell pyroptosis

Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma.

Genetic variation in the SIM1 locus is associated with erectile dysfunction

A Large Multi-ethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci

Characterization of Statin Low-Density Lipoprotein Cholesterol Dose-Response Using Electronic Health Records in a Large Population-Based Cohort

Common mitochondrial haplogroups and cutaneous squamous cell carcinoma risk

A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci

Genetic variants in the HLA class II region associated with risk of cutaneous squamous cell carcinoma

Weighted Multi-marker Genetic Risk Scores for Incident Coronary Heart Disease among Individuals of African, Latino and East-Asian Ancestry

Eleven loci with new reproducible genetic associations with allergic disease risk

The relationship between non-steroidal anti-inflammatory drug use and age-related macular degeneration

Susceptibility loci associated cutaneous squamous cell carcinoma invasiveness

A large electronic-health-record-based genome-wide study of serum lipids

Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma

A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes c11orf30/EMSY as a genetic risk factor for food allergy

Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study

Prognostics factors and survival in acral lentiginous melanoma

Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer

Clinical Utility of Multi-marker Genetic Risk Scores for Prediction of Incident Coronary Heart Disease: A Cohort Study among over 51 Thousand Individuals of European Ancestry

A GWAS of Cutaneous Squamous Cell Carcinoma-Letter

The Association of Refractive Error with Glaucoma in a Multiethnic Population

Common coding variants in the HLA-DQB1 region confer susceptibility to age-related macular degeneration

Identification of Susceptibility Loci for Cutaneous Squamous Cell Carcinoma

Diabetes Pathology and Risk of Primary Open-Angle Glaucoma: Evaluating Causal Mechanisms by Using Genetic Information

A large multi-ethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences

Genotyping Informatics and Quality Control for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

Differences in the Genetic Susceptibility to Age-Related Macular Degeneration Clinical Subtypes

Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response

Imputation of the Rare HOXB13 G84E Mutation and Cancer Risk in a Large Population-Based Cohort

A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia

Association between alcohol and cardiovascular disease; Mendelian randomisation analysis based on individual participant data

Examination of rare missense variants in the CHRNA5-A3-B4 gene cluster to level of response to alcohol in the San Diego Sibling Pair study

The impact of improved microarray coverage and larger sample sizes on future genome-wide association studies

Genetic analysis of a population heavy drinking phenotype identifies risk variants in whites