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Eric Jorgenson, PhD


Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-3814 (phone)
Kaiser Permanente Researcher Profiles

Eric Jorgenson, PhD, is a research scientist at the Kaiser Permanente Northern California Division of Research. His primary research interest focuses on the genetics of common, complex diseases and their treatment.  He is currently the principal investigator of an NIH-funded study to examine the genetic factors underlying alcohol consumption and misuse in the Research Program on Genes, Environment, and Health (RPGEH) cohort.

Current Position(s):

  • Research Scientist II, Division of Research, Kaiser Permanente Northern California

    Primary Research Interests:

    • Genetic Epidemiology
    • Pharmacogenomics
    • Genetic factors influencing alcohol, tobacco, and drug use
    • Genetics of vision disorders
    • Genetic and environmental influences on racial/ethnic variation in disease risk and treatment outcomes
    • Genetic determinants of cancer risk, progression, and treatment response
    • Genetics of hernia susceptibility

    Related Website(s):

    The Role of Refractive Error in the Etiology of Glaucoma

    The specific aims of this study are to: 1) Determine whether refractive error predicts the development of glaucoma due to direct effects or shared etiology, or both, by conducting a series of genetic analyses of the two conditions; and 2) Determine the contribution of refractive error (myopia) and relevant biological pathways in the development of glaucomatous neurodegeneration.
    Investigator: Jorgenson, Eric
    Funder: National Eye Institute

    Genome-Wide Association Study of Cutaneous Squamous Cell Carcinoma

    Cutaneous squamous cell carcinoma (SCC) is the second most common cancer among people of European ancestry. The primary risk factor for SCC is sun exposure, but genetics also has a substantial role. To date, no published genome-wide association studies have been performed on cutaneous SCCs. We aim to conduct a genome-wide SNP association study of 6,179 participants within the Research Program in Genes and Environmental Health (RPGEH) cohort members diagnosed with a cutaneous SCC and 101,348 controls to search for new sequence variants that confer risk of cutaneous SCC.
    Investigator: Choquet, Helene; Jorgenson, Eric
    Funder: National Cancer Institute

    PGRN Administration Coordination Hub

    This is the Administrative Coordination Hub for the Pharmacogenomics Research Network (PGRN). The main areas of responsibility include meetings support, communications and coordination of nascent network collaborations.
    Investigator: Jorgenson, Eric

    Role of ABCG2 in the Disposition and Anti-Hyperuricemic Effects of Allopurinol

    The goal of this project is to investigate the role of ABCG2 in the disposition and anti-hyperuricemic effects of allopurinol.
    Investigator: Choquet, Helene; Jorgenson, Eric
    Funder: National Institute of Diabetes and Digestive and Kidney Diseases

    Genetic Studies of Blood Cell Traits in Multi-Ethnic Cohorts

    Blood cell traits, including red blood cell count (RBC), hemoglobin, white blood cell count (WBC) and platelet count, are important intermediate clinical phenotypes for a variety of cardiovascular, hematologic, oncogenic, immunologic and infectious diseases. The goal of this project is to identify novel loci associated with these traits.
    Investigator: Jorgenson, Eric

    The Genetic Basis of Pediatric Cholestasis

    The goal of this project is to identify new genes underlying pediatric cholestasis.
    Investigator: Choquet, Helene; Jorgenson, Eric
    Funder: National Institute of Diabetes and Digestive and Kidney Diseases
    No results found matching criteria

    ​Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study

    Author(s): Jorgenson E; Thai KK; Hoffmann TJ; Sakoda LC; Kvale MN; Banda Y; Schaefer C; Risch N; Mertens J; Weisner C; Choquet H;
    PubMed abstract

    Prognostics factors and survival in acral lentiginous melanoma

    Author(s): Asgari MM; Shen L; Sokil MM; Yeh I; Jorgenson E
    PubMed abstract

    Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.

    Author(s): Hoffmann TJ; Passarelli MN; Graff RE; Emami NC; Sakoda LC; Jorgenson E; Habel LA; Shan J; Ranatunga DK; Quesenberry CP; Chao CR; Ghai NR; Aaronson D; Presti J; Nordström T; Wang Z; Berndt SI; Chanock SJ; Mosley JD; Klein RJ; Middha M; Lilja H; |Melander O; Kvale MN; Kwok PY; Schaefer C; Risch N; Van Den Eeden SK; Witte JS;
    PubMed abstract

    A GWAS of Cutaneous Squamous Cell Carcinoma-Letter

    Author(s): Whittemore AS; Wang W; Jorgenson E; Asgari MM
    PubMed abstract

    Clinical Utility of Multi-marker Genetic Risk Scores for Prediction of Incident Coronary Heart Disease; A Cohort Study among over 51 Thousand Individuals of European Ancestry

    Author(s): Iribarren C; Lu M; Jorgenson E; Martinez M; Lluis-Ganella C; Subirana I; Salas E; Elosua R
    PubMed abstract

    The Association of Refractive Error with Glaucoma in a Multiethnic Population

    Author(s): Shen L; Melles RB; Metlapally R; Barcellos L; Schaefer C; Risch N; Herrinton LJ; Wildsoet C; Jorgenson E
    PubMed abstract

    Identification of Susceptibility Loci for Cutaneous Squamous Cell Carcinoma

    Author(s): Asgari MM; Wang W; Ioannidis NM; Itnyre J; Hoffmann T; Jorgenson E; Whittemore AS
    PubMed abstract

    Common coding variants in the HLA-DQB1 region confer susceptibility to age-related macular degeneration

    Author(s): Jorgenson E; Melles RB; Hoffmann TJ; Jia X; Sakoda LC; Kvale MN; Banda Y; Schaefer C; Risch N; Shen L
    PubMed abstract

    A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia

    Author(s): Jorgenson E; Makki N; Shen L; Chen DC; Tian C; Eckalbar WL; Hinds D; Ahituv N; Avins A
    PubMed abstract

    Diabetes Pathology and Risk of Primary Open-Angle Glaucoma: Evaluating Causal Mechanisms by Using Genetic Information

    Author(s): Shen L; Walter S; Melles RB; Glymour MM; Jorgenson E
    PubMed abstract

    Genotyping Informatics and Quality Control for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

    Author(s): Kvale MN; Hesselson S; Hoffmann TJ; Cao Y; Chan D; Connell S; Croen LA; Dispensa BP; Eshragh J; Finn A; Gollub J; Iribarren C; Jorgenson E; Kushi LH; Lao R; Lu Y; Ludwig D; Mathauda GK; McGuire WB; Mei G; Miles S; Mittman M; Patil M; Quesenberry CP Jr; Ranatunga D; Rowell S; Sadler M; Sakoda LC; Shapero M; Shen L; Shenoy T; Smethurst D; Somkin CP; Van Den Eeden SK; Walter L; Wan E; Webster T; Whitmer RA; Wong S; Zau C; Zhan Y; Schaefer C; Kwok PY; Risch N;
    PubMed abstract

    Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

    Author(s): Lapham K; Kvale MN; Lin J; Connell S; Croen LA; Dispensa BP; Fang L; Hesselson S; Hoffmann TJ; Iribarren C; Jorgenson E; Kushi LH; Ludwig D; Matsuguchi T; McGuire WB; Miles S; Quesenberry CP Jr; Rowell S; Sadler M; Sakoda LC; Smethurst D; Somkin CP; Van Den Eeden SK; Walter L; Whitmer RA; Kwok PY; Risch N; Schaefer C; Blackburn EH;
    PubMed abstract

    Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

    Author(s): Banda Y; Kvale MN; Hoffmann TJ; Hesselson SE; Ranatunga D; Tang H; Sabatti C; Croen LA; Dispensa BP; Henderson M; Iribarren C; Jorgenson E; Kushi LH; Ludwig D; Olberg D; Quesenberry CP Jr; Rowell S; Sadler M; Sakoda LC; Sciortino S; Shen L; Smethurst D; Somkin CP; Van Den Eeden SK; Walter L; Whitmer RA; Kwok PY; Schaefer C; Risch N;
    PubMed abstract

    Differences in the Genetic Susceptibility to Age-Related Macular Degeneration Clinical Subtypes

    Author(s): Shen L; Hoffmann TJ; Melles RB; Sakoda LC; Kvale MN; Banda Y; Schaefer C; Risch N; Jorgenson E
    PubMed abstract

    A large multi-ethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences

    Author(s): Hoffmann TJ; Van Den Eeden SK; Sakoda LC; Jorgenson E; Habel LA; Graff RE; Passarelli MN; Cario CL; Emami NC; Chao CR; Ghai NR; Shan J; Ranatunga DK; Quesenberry CP; Aaronson D; Presti J; Zhaoming W; Berndt SI; Chanock SJ; McDonnell SK; French AJ; Schaid DJ; Thibodeau SN; Li Q; Freedman ML; Penney KL; Mucci LA; Haiman CA; Henderson BE; Seminara D; Kvale MN; Kwok PY; Schaefer C; Risch N; Witte JS
    PubMed abstract

    Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response

    Author(s): Wen CC; Yee SW; Liang X; Hoffmann TJ; Kvale MN; Banda Y; Jorgenson E; Schaefer C; Risch N; Giacomini KM
    PubMed abstract

    Imputation of the Rare HOXB13 G84E Mutation and Cancer Risk in a Large Population-Based Cohort

    Author(s): Hoffmann TJ; Sakoda LC; Shen L; Jorgenson E; Habel LA; Liu J; Kvale MN; Asgari MM; Banda Y; Corley D; Kushi LH; Quesenberry CP; Schaefer C; Van Den Eeden SK; Risch N; Witte JS
    PubMed abstract

    Association between alcohol and cardiovascular disease; Mendelian randomisation analysis based on individual participant data

    Author(s): Holmes MV; Dale CE; Zuccolo L; Silverwood RJ; Guo Y; Ye Z; Prieto-Merino D; Dehghan A; Trompet S; Wong A; Cavadino A; Drogan D; Padmanabhan S; Li S; Yesupriya A; Leusink M; Sundstrom J; Hubacek JA; Pikhart H; Swerdlow DI; Panayiotou AG; Borinskaya SA; Finan C; Shah S; Kuchenbaecker KB; Shah T; Engmann J; Folkersen L; Eriksson P; Ricceri F; Melander O; Sacerdote C; Gamble DM; Rayaprolu S; Ross OA; McLachlan S; Vikhireva O; Sluijs I; Scott RA; Adamkova V; Flicker L; Bockxmeer FM; Power C; Marques-Vidal P; Meade T; Marmot MG; Ferro JM; Paulos-Pinheiro S; Humphries SE; Talmud PJ; Mateo Leach I; Verweij N; Linneberg A; Skaaby T; Doevendans PA; Cramer MJ; van der Harst P; Klungel OH; Dowling NF; Dominiczak AF; Kumari M; Nicolaides AN; Weikert C; Boeing H; Ebrahim S; Gaunt TR; Price JF; Lannfelt L; Peasey A; Kubinova R; Pajak A; Malyutina S; Voevoda MI; Tamosiunas A; Maitland-van der Zee AH; Norman PE; Hankey GJ; Bergmann MM; Hofman A; Franco OH; Cooper J; Palmen J; Spiering W; de Jong PA; Kuh D; Hardy R; Uitterlinden AG; Ikram MA; Ford I; Hyppönen E; Almeida OP; Wareham NJ; Khaw KT; Hamsten A; Husemoen LL; Tjønneland A; Tolstrup JS; Rimm E; Beulens JW; Verschuren WM; Onland-Moret NC; Hofker MH; Wannamethee SG; Whincup PH; Morris R; Vicente AM; Watkins H; Farrall M; Jukema JW; Meschia J; Cupples LA; Sharp SJ; Fornage M; Kooperberg C; LaCroix AZ; Dai JY; Lanktree MB; Siscovick DS; Jorgenson E; Spring B; Coresh J; Li YR; Buxbaum SG; Schreiner PJ; Ellison RC; Tsai MY; Patel SR; Redline S; Johnson AD; Hoogeveen RC; Hakonarson H; Rotter JI; Boerwinkle E; de Bakker PI; Kivimaki M; Asselbergs FW; Sattar N; Lawlor DA; Whittaker J; Davey Smith G; Mukamal K; Psaty BM; Wilson JG; Lange LA; Hamidovic A; Hingorani AD; Nordestgaard BG; Bobak M; Leon DA; Langenberg C; Palmer TM; Reiner AP; Keating BJ; Dudbridge F; Casas JP; InterAct Consortium
    PubMed abstract

    Examination of rare missense variants in the CHRNA5-A3-B4 gene cluster to level of response to alcohol in the San Diego Sibling Pair study

    Author(s): Choquet H; Joslyn G; Lee A; Kasberger J; Robertson M; Brush G; Schuckit MA; White R; Jorgenson E
    PubMed abstract

    The impact of improved microarray coverage and larger sample sizes on future genome-wide association studies

    Author(s): Lindquist KJ; Jorgenson E; Hoffmann TJ; Witte JS
    PubMed abstract

    ALDH1A3 loss of function causes bilateral anophthalmia/microphthalmia and hypoplasia of the optic nerve and optic chiasm

    Author(s): Yahyavi M; Abouzeid H; Gawdat G; de Preux AS; Xiao T; Bardakjian T; Schneider A; Choi A; Jorgenson E; Baier H; El Sada M; Schorderet DF; Slavotinek AM
    PubMed abstract

    Turning of COGS moves forward findings for hormonally mediated cancers

    Author(s): Sakoda LC; Jorgenson E; Witte JS
    PubMed abstract

    ​Genetic analysis of a population heavy drinking phenotype identifies risk variants in whites

    Author(s): Hamidovic A; Goodloe RJ; Young TR; Styn MA; Mukamal KJ; Choquet H; Kasberger JL; Buxbaum SG; Papanicolaou GJ; White W; Volcik K; Spring B; Hitsman B; Levy D; Jorgenson E.;
    PubMed abstract

    Contribution of common PCSK1 genetic variants to obesity in 8,359 subjects from multi-ethnic American population

    Author(s): Choquet H; Kasberger J; Hamidovic A; Jorgenson E
    PubMed abstract

    Gene-centric analysis of serum cotinine levels in African and European American populations

    Author(s): Hamidovic A; Goodloe RJ; Bergen AW; Benowitz NL; Styn MA; Kasberger JL; Choquet H; Young TR; Meng Y; Palmer C; Pletcher M; Kertesz S; Hitsman B; Spring B; Jorgenson E
    PubMed abstract

    Human genetic variation recognizes functional elements in noncoding sequence

    Author(s): Lomelin D; Jorgenson E; Risch N
    PubMed abstract