Sign In

Eric Jorgenson, PhD

People

Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-3473 (phone)
eric.jorgenson@kp.org
Kaiser Permanente Researcher Profiles


Eric Jorgenson, PhD, is a former research scientist at the Kaiser Permanente Northern California Division of Research. His primary research interest focused on the genetics of common, complex diseases and their treatment.  He was the principal investigator of an NIH-funded study to examine the genetic factors underlying alcohol consumption and misuse in the Research Program on Genes, Environment, and Health (RPGEH) cohort.

      Primary Research Interests:

      • Genetic Epidemiology
      • Pharmacogenomics
      • Genetic factors influencing alcohol, tobacco, and drug use
      • Genetics of vision disorders
      • Genetic and environmental influences on racial/ethnic variation in disease risk and treatment outcomes
      • Genetic determinants of cancer risk, progression, and treatment response
      • Genetics of hernia susceptibility

      Related Website(s):

      PQ3 Cutaneous Squamous Cell Carcinoma: Integrating Germline and Somatic Alterations that Underlie Tumor Progression

      The goal of this proposal is to compare tumor versus normal samples of cutaneous squamous cell carcinoma in a large cohort of approximately 77,578 Kaiser Permanente Northern California members. Our goal is to improve understanding of the mechanisms accounting for inherited susceptibility to SCC.
      Investigator: Jorgenson, Eric
      Funder: National Cancer Institute

      Alzheimer’s Disease and Related Dementias in a Diverse Cohort of Asian Americans

      This study considers the extent to which immigration history, social factors, cardiometabolic health, and genetic factors contribute to heterogeneity in dementia incidence between Asian American subgroups and between Asian Americans and whites.
      Investigator: Jorgenson, Eric
      Funder: National Institute on Aging

      Closing the Gap Between Observational Research and Randomized Trials for Prevention of Alzheimer‘s Disease and Dementia

      Observational studies should have a core role in justifying and guiding the development of randomized controlled trials, but to date observational research and trials on Alzheimer’s disease prevention are not closely aligned. Observational and randomized studies nearly always answer different questions, even when nominally addressing similar topics. Integration across heterogeneous observational data sources will be necessary to provide the sample size, diversity, and variety of measurements to provide such specificity, but currently, we do not have systematic tools to combine evidence from heterogeneous data sources to guide trial design. This proposal builds on Robins g-formula­­–based methods for counterfactual simulations and takes advantage of recent critical advances in causal methods for data integration, based on Pearls d-separation criteria for transportability.
      Investigator: Jorgenson, Eric
      Funder: National Institute on Aging

      Investigating the Effects of KIR and HLA Gene Polymorphisms on Psoriasis

      The goal of this project is to investigate the effects of genetic polymorphisms in the KIR and HLA genes on psoriasis and psoriatic arthritis.
      Investigator: Jorgenson, Eric
      Funder: University of California, Los Angeles

      Antidepressant Use and the Risk of Primary Open Angle Glaucoma

      ​The goal of this project is to address the following research question: Does the use of antidepressant treatment, specifically, selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), reduce the risk of primary open angle glaucoma?
      Investigator: Jorgenson, Eric
      Funder: Northern California Community Benefit Programs

      Genetic Etiology of Abdominal Hernia Susceptibility

      ​The objective of this project is to investigate the genetic mechanisms that drive the development of abdominal hernias. This study has three major aims: 1) to investigate the shared and individual genetic risks of different types of abdominal hernia, 2) to examine the genetic risk factors underlying recurrence of hernias in individual patients, and 3) to investigate the genetic pathways and biological mechanisms through which abdominal hernia risk loci act.
      Investigator: Choquet, Helene; Jorgenson, Eric
      Funder: National Institute of Diabetes and Digestive and Kidney Diseases

      The Role of Refractive Error in the Etiology of Glaucoma

      The specific aims of this study are to: 1) Determine whether refractive error predicts the development of glaucoma due to direct effects or shared etiology, or both, by conducting a series of genetic analyses of the two conditions; and 2) Determine the contribution of refractive error (myopia) and relevant biological pathways in the development of glaucomatous neurodegeneration.
      Investigator: Choquet, Helene; Jorgenson, Eric
      Funder: National Eye Institute

      PGRN Administration Coordination Hub

      This is the Administrative Coordination Hub for the Pharmacogenomics Research Network (PGRN). The main areas of responsibility include meetings support, communications and coordination of nascent network collaborations.
      Investigator: Jorgenson, Eric
      Funder: 

      Genetic variation in the SIM1 locus is associated with erectile dysfunction

      Author(s): Jorgenson E; Yin J; Shan J; Hoffmann TJ; Thai KK; Van Den Eeden SK; et al.

      Proc Natl Acad Sci USA. 2018 Oct 23;115(43):11018-11023. Epub 2018-10-08.

      PubMed abstract

      A Large Multi-ethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci

      Author(s): Hoffmann TJ; Choquet H; Yin J; Banda Y; Kvale MN; Glymour M; Schaefer C; Risch N; Jorgenson E

      Genetics. 2018 Aug 14.

      PubMed abstract

      A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci

      Author(s): Choquet H; Thai KK; Hoffmann TJ; Yin J; Schaefer C; Risch N; Jorgenson E; et al.

      Nat Commun. 2018 Jun 11;9(1):2278. Epub 2018-06-11.

      PubMed abstract

      A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure

      Author(s): Choquet H; Thai KK; Yin J; Hoffmann TJ; Kvale MN; Banda Y; Schaefer C; Risch N; Nair KS; Melles R; Jorgenson E

      Nat Commun. 2017 Dec 13;8(1):2108. Epub 2017-12-13.

      PubMed abstract

      Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

      Author(s): Ferreira MA; Vonk JM; Baurecht H; Marenholz I; Tian C; Hoffman JD; Helmer Q; Tillander A; Ullemar V; van Dongen J; Lu Y; Rüschendorf F; Esparza-Gordillo J; Medway CW; Mountjoy E; Burrows K; Hummel O; Grosche S; Brumpton BM; Witte JS; Hottenga JJ; Willemsen G; Zheng J; Rodríguez E; Hotze M; Franke A; Revez JA; Beesley J; Matheson MC; Dharmage SC; Bain LM; Fritsche LG; Gabrielsen ME; Balliu B; 23andMe Research Team; AAGC collaborators; BIOS consortium; LifeLines Cohort Study; Nielsen JB; Zhou W; Hveem K; Langhammer A; Holmen OL; Løset M; Abecasis GR; Willer CJ; Arnold A; Homuth G; Schmidt CO; Thompson PJ; Martin NG; Duffy DL; Novak N; Schulz H; Karrasch S; Gieger C; Strauch K; Melles RB; Hinds DA; Hübner N; Weidinger S; Magnusson PKE; Jansen R; Jorgenson E; Lee YA; Boomsma DI; Almqvist C; Karlsson R; Koppelman GH; Paternoster L

      Nat Genet. 2017 Oct 30.

      PubMed abstract

      Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study

      Author(s): Jorgenson, E E; Thai, K K KK; Hoffmann, T J TJ; Sakoda, L C LC; Kvale, M N MN; Banda, Y Y; Schaefer, C C; Risch, N N; Mertens, J J; Weisner, C C; Choquet, H H

      Molecular psychiatry. 2017 Sep ;22(9):1359-1367. Epub 2017-05-09.

      PubMed abstract

      Identification of 31 loci for mammographic density phenotypes and their associations with breast cancer risk

      Author(s): Sieh W; Alexeeff SE; Sakoda LC; Jorgenson E; Schaefer C; Habel LA; et al.

      Nat Commun. 2020 10 09;11(1):5116. Epub 2020-10-09.

      PubMed abstract

      Age-of-onset information helps identify 76 genetic variants associated with allergic disease

      Author(s): Ferreira MAR; 23andMe Research Team; collaborators of the SHARE study; Jorgenson E; Koppelman GH; et al.

      PLoS Genet. 2020 Jun;16(6):e1008725. Epub 2020-06-30.

      PubMed abstract

      A multiethnic genome-wide analysis of 44,039 individuals identifies 41 new loci associated with central corneal thickness

      Author(s): Choquet H; Schaefer C; Jorgenson E; et al.

      Commun Biol. 2020 Jun 11;3(1):301. Epub 2020-06-11.

      PubMed abstract

      Genetic and environmental factors underlying keratinocyte carcinoma risk

      Author(s): Choquet H; Ashrafzadeh S; Kim Y; Asgari MM; Jorgenson E

      JCI Insight. 2020 May 21;5(10). Epub 2020-05-21.

      PubMed abstract

      Developing a risk prediction model for keratinocyte carcinoma in patients with actinic keratosis

      Author(s): Kim Y; Jorgenson E; Asgari MM

      Br J Dermatol. 2020 May 10.

      PubMed abstract

      Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia

      Author(s): Hysi PG†; Choquet H†; Consortium for Refractive Error and Myopia; UK Eye and Vision Consortium; 23andMe Inc.; Jorgenson E; Hammond CJ; et al.
      † These authors jointly led this work.

      Nat Genet. 2020 Apr;52(4):401-407. Epub 2020-03-30.

      PubMed abstract

      Genome-wide meta-analysis identifies eight new susceptibility loci for cutaneous squamous cell carcinoma

      Author(s): Sarin KY; Wu W; Asgari MM; Han J; et al.

      Nat Commun. 2020 Feb 10;11(1):820. Epub 2020-02-10.

      PubMed abstract

      Functional validity, role, and implications of heavy alcohol consumption genetic loci

      Author(s): Thompson A; Cook J; Choquet H; Jorgenson E; Yin J; Kinnunen T; Barclay J; Morris AP; Pirmohamed M

      Sci Adv. 2020 Jan;6(3):eaay5034. Epub 2020-01-15.

      PubMed abstract

      Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

      Author(s): Kowalski MH; Choquet H; Jorgenson E; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; TOPMed Hematology & Hemostasis Working Group; Li Y; et al.

      PLoS Genet. 2019 Dec 23;15(12):e1008500. Epub 2019-12-23.

      PubMed abstract

      Genetic ancestry does not explain increased atopic dermatitis susceptibility or worse disease control among African American subjects in 2 large US cohorts

      Author(s): Abuabara K; You Y; Margolis DJ; Hoffmann TJ; Risch N; Jorgenson E

      J Allergy Clin Immunol. 2019 Jul 29.

      PubMed abstract

      Genome-wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol

      Author(s): Brackman DJ; Ranatunga D; Jorgenson E; Giacomini KM; et al.

      Clin Pharmacol Ther. 2019 Mar 28.

      PubMed abstract

      Reply to Liu et al.: Tissue specificity of SIM1 gene expression and erectile dysfunction

      Author(s): Jorgenson E; Yin J; Shan J; Hoffmann TJ; Thai KK; Van Den Eeden SK; et al.

      Proc Natl Acad Sci USA. 2019 Feb 26;116(9):3349-3350. Epub 2019-02-12.

      PubMed abstract

      Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.

      Author(s): Liu M; 23andMe Research Team; HUNT All-In Psychiatry; Choquet H; Zhao W; Thai KK; Weisner C; Yin J; Jorgenson E; Vrieze S; et al.

      Nature genetics. 2019 Feb ;51(2):237-244. Epub 2019-01-14.

      PubMed abstract

      Large-scale, multi-ethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults

      Author(s): Dahlin A; Iribarren C; Lu M; Jorgenson E; Wu AC; et al.

      J Allergy Clin Immunol. 2018 Dec 19.

      PubMed abstract

      Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma.

      Author(s): Ioannidis, Nilah M NM; Wang, Wei W; Furlotte, Nicholas A NA; Hinds, David A DA; ; Bustamante, Carlos D CD; Jorgenson, Eric E; Asgari, Maryam M MM; Whittemore, Alice S AS

      Nature communications. 2018 Oct 15;9(1):4264. Epub 2018-10-15.

      PubMed abstract

      Genetic variation in the SIM1 locus is associated with erectile dysfunction

      Author(s): Jorgenson E; Yin J; Shan J; Hoffmann TJ; Thai KK; Van Den Eeden SK; et al.

      Proc Natl Acad Sci USA. 2018 Oct 23;115(43):11018-11023. Epub 2018-10-08.

      PubMed abstract

      Characterization of Statin Low-Density Lipoprotein Cholesterol Dose-Response Using Electronic Health Records in a Large Population-Based Cohort

      Author(s): Oni-Orisan A; Hoffmann TJ; Ranatunga D; Medina MW; Jorgenson E; Schaefer C; Krauss RM; Iribarren C; Risch N

      Circ Genom Precis Med. 2018 Sep;11(9):e002043.

      PubMed abstract

      A Large Multi-ethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci

      Author(s): Hoffmann TJ; Choquet H; Yin J; Banda Y; Kvale MN; Glymour M; Schaefer C; Risch N; Jorgenson E

      Genetics. 2018 Aug 14.

      PubMed abstract

      A Prediction Tool to Facilitate Risk-Stratified Screening for Squamous Cell Skin Cancer

      Author(s): Wang W; Jorgenson E; Ioannidis NM; Asgari MM; Whittemore AS

      J Invest Dermatol. 2018 Dec;138(12):2589-2594. Epub 2018-07-02.

      PubMed abstract

      A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci

      Author(s): Choquet H; Thai KK; Hoffmann TJ; Yin J; Schaefer C; Risch N; Jorgenson E; et al.

      Nat Commun. 2018 Jun 11;9(1):2278. Epub 2018-06-11.

      PubMed abstract

      Genetic variants in the HLA class II region associated with risk of cutaneous squamous cell carcinoma

      Author(s): Wang W; Ollila HM; Whittemore AS; Demehri S; Ioannidis NM; Jorgenson E; Mignot E; Asgari MM

      Cancer Immunol Immunother. 2018 May 12.

      PubMed abstract

      Weighted Multi-marker Genetic Risk Scores for Incident Coronary Heart Disease among Individuals of African, Latino and East-Asian Ancestry

      Author(s): Iribarren C; Lu M; Jorgenson E; Martínez M; Lluis-Ganella C; Subirana I; Salas E; Elosua R

      Sci Rep. 2018 May 01;8(1):6853. Epub 2018-05-01.

      PubMed abstract

      Common mitochondrial haplogroups and cutaneous squamous cell carcinoma risk

      Author(s): Jorgenson E; Choquet H; Yin J; Asgari M

      Cancer Epidemiol Biomarkers Prev. 2018 Apr 25.

      PubMed abstract

      Eleven loci with new reproducible genetic associations with allergic disease risk

      Author(s): Ferreira MA; Lu Y; 23andMe Research Team; collaborators of the SHARE study; Jorgenson E; Paternoster L; et al.

      J Allergy Clin Immunol. 2018 Apr 18.

      PubMed abstract

      A large electronic-health-record-based genome-wide study of serum lipids

      Author(s): Hoffmann TJ; Theusch E; Haldar T; Ranatunga DK; Jorgenson E; Medina MW; Kvale MN; Kwok PY; Schaefer C; Krauss RM; Iribarren C; Risch N

      Nat Genet. 2018 Mar;50(3):401-413. Epub 2018-03-05.

      PubMed abstract

      The relationship between non-steroidal anti-inflammatory drug use and age-related macular degeneration

      Author(s): Modjtahedi BS; Fong DS; Jorgenson E; Van Den Eeden SK; Quinn V; Slezak JS

      Am J Ophthalmol. 2018 Jan 19.

      PubMed abstract

      A functional splicing variant associated with decreased asthma risk abolishes the ability of gasdermin B (GSMDB) to induce epithelial cell pyroptosis

      Author(s): Panganiban RA; Iribarren C; Jorgenson E; Lu Q; et al

      J Allergy Clin Immunol. 2018 Jan 09.

      PubMed abstract

      Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma

      Author(s): Asai Y; Jorgensen E; Daley D; et al

      J Allergy Clin Immunol. 2018 Jan 08.

      PubMed abstract

      A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure

      Author(s): Choquet H; Thai KK; Yin J; Hoffmann TJ; Kvale MN; Banda Y; Schaefer C; Risch N; Nair KS; Melles R; Jorgenson E

      Nat Commun. 2017 Dec 13;8(1):2108. Epub 2017-12-13.

      PubMed abstract

      Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

      Author(s): Ferreira MA; Vonk JM; Baurecht H; Marenholz I; Tian C; Hoffman JD; Helmer Q; Tillander A; Ullemar V; van Dongen J; Lu Y; Rüschendorf F; Esparza-Gordillo J; Medway CW; Mountjoy E; Burrows K; Hummel O; Grosche S; Brumpton BM; Witte JS; Hottenga JJ; Willemsen G; Zheng J; Rodríguez E; Hotze M; Franke A; Revez JA; Beesley J; Matheson MC; Dharmage SC; Bain LM; Fritsche LG; Gabrielsen ME; Balliu B; 23andMe Research Team; AAGC collaborators; BIOS consortium; LifeLines Cohort Study; Nielsen JB; Zhou W; Hveem K; Langhammer A; Holmen OL; Løset M; Abecasis GR; Willer CJ; Arnold A; Homuth G; Schmidt CO; Thompson PJ; Martin NG; Duffy DL; Novak N; Schulz H; Karrasch S; Gieger C; Strauch K; Melles RB; Hinds DA; Hübner N; Weidinger S; Magnusson PKE; Jansen R; Jorgenson E; Lee YA; Boomsma DI; Almqvist C; Karlsson R; Koppelman GH; Paternoster L

      Nat Genet. 2017 Oct 30.

      PubMed abstract

      Susceptibility loci associated cutaneous squamous cell carcinoma invasiveness

      Author(s): Wang W; Jorgenson E; Whittemore AS; Asgari MM

      J Invest Dermatol. 2017 Oct 17.

      PubMed abstract

      Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes c11orf30/EMSY as a genetic risk factor for food allergy

      Author(s): Asai Y; Eslami A; van Ginkel CD; Akhabir L; Wan M; Ellis G; Ben-Shoshan M; Martino D; Ferreira MA; Allen K; Mazer B; de Groot H; de Jong NW; Gerth van Wijk RN; Dubois AEJ; Chin R; Cheuk S; Hoffman J; Jorgensen E; Witte JS; Melles RB; Hong X; Wang X; Hui J; Musk AWB; Hunter M; James AL; Koppelman GH; Sandford AJ; Clarke AE; Daley D

      J Allergy Clin Immunol. 2017 Oct 10.

      PubMed abstract

      Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study

      Author(s): Jorgenson, E E; Thai, K K KK; Hoffmann, T J TJ; Sakoda, L C LC; Kvale, M N MN; Banda, Y Y; Schaefer, C C; Risch, N N; Mertens, J J; Weisner, C C; Choquet, H H

      Molecular psychiatry. 2017 Sep ;22(9):1359-1367. Epub 2017-05-09.

      PubMed abstract

      Prognostics factors and survival in acral lentiginous melanoma

      Author(s): Asgari MM; Shen L; Sokil MM; Yeh I; Jorgenson E

      Br J Dermatol. 2017 Apr 22.

      PubMed abstract

      Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.

      Author(s): Hoffmann TJ; Passarelli MN; Graff RE; Emami NC; Sakoda LC; Jorgenson E; Habel LA; Shan J; Ranatunga DK; Quesenberry CP; Chao CR; Ghai NR; Aaronson D; Presti J; Nordström T; Wang Z; Berndt SI; Chanock SJ; Mosley JD; Klein RJ; Middha M; Lilja H; |Melander O; Kvale MN; Kwok PY; Schaefer C; Risch N; Van Den Eeden SK; Witte JS;

      ​Nat Commun. 2017 Jan 31;8:14248. doi: 10.1038/ncomms14248.

      PubMed abstract

      A GWAS of Cutaneous Squamous Cell Carcinoma-Letter

      Author(s): Whittemore AS; Wang W; Jorgenson E; Asgari MM

      Cancer Epidemiol Biomarkers Prev. 2016 Nov;25(11):1534.

      PubMed abstract

      Clinical Utility of Multi-marker Genetic Risk Scores for Prediction of Incident Coronary Heart Disease; A Cohort Study among over 51 Thousand Individuals of European Ancestry

      Author(s): Iribarren C; Lu M; Jorgenson E; Martinez M; Lluis-Ganella C; Subirana I; Salas E; Elosua R

      Circ Cardiovasc Genet. 2016 Oct 25.

      PubMed abstract

      The Association of Refractive Error with Glaucoma in a Multiethnic Population

      Author(s): Shen L; Melles RB; Metlapally R; Barcellos L; Schaefer C; Risch N; Herrinton LJ; Wildsoet C; Jorgenson E

      Ophthalmology. 2015 Aug 7.

      PubMed abstract

      Identification of Susceptibility Loci for Cutaneous Squamous Cell Carcinoma

      Author(s): Asgari MM; Wang W; Ioannidis NM; Itnyre J; Hoffmann T; Jorgenson E; Whittemore AS

      J Invest Dermatol. 2016 Jan 29.

      PubMed abstract

      Common coding variants in the HLA-DQB1 region confer susceptibility to age-related macular degeneration

      Author(s): Jorgenson E; Melles RB; Hoffmann TJ; Jia X; Sakoda LC; Kvale MN; Banda Y; Schaefer C; Risch N; Shen L

      Eur J Hum Genet. 2016 Jan 6.

      PubMed abstract

      A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia

      Author(s): Jorgenson E; Makki N; Shen L; Chen DC; Tian C; Eckalbar WL; Hinds D; Ahituv N; Avins A

      Nat Commun. 2015;6:10130. Epub 2015-12-21.

      PubMed abstract

      Diabetes Pathology and Risk of Primary Open-Angle Glaucoma: Evaluating Causal Mechanisms by Using Genetic Information

      Author(s): Shen L; Walter S; Melles RB; Glymour MM; Jorgenson E

      Am J Epidemiol. 2015 Nov 25.

      PubMed abstract

      Genotyping Informatics and Quality Control for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

      Author(s): Kvale MN; Hesselson S; Hoffmann TJ; Cao Y; Chan D; Connell S; Croen LA; Dispensa BP; Eshragh J; Finn A; Gollub J; Iribarren C; Jorgenson E; Kushi LH; Lao R; Lu Y; Ludwig D; Mathauda GK; McGuire WB; Mei G; Miles S; Mittman M; Patil M; Quesenberry CP Jr; Ranatunga D; Rowell S; Sadler M; Sakoda LC; Shapero M; Shen L; Shenoy T; Smethurst D; Somkin CP; Van Den Eeden SK; Walter L; Wan E; Webster T; Whitmer RA; Wong S; Zau C; Zhan Y; Schaefer C; Kwok PY; Risch N;

      ​​Genetics. 2015 Aug;200(4):1051-60. doi: 10.1534/genetics.115.178905. Epub 2015 Jun 19.

      PubMed abstract

      Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

      Author(s): Lapham K; Kvale MN; Lin J; Connell S; Croen LA; Dispensa BP; Fang L; Hesselson S; Hoffmann TJ; Iribarren C; Jorgenson E; Kushi LH; Ludwig D; Matsuguchi T; McGuire WB; Miles S; Quesenberry CP Jr; Rowell S; Sadler M; Sakoda LC; Smethurst D; Somkin CP; Van Den Eeden SK; Walter L; Whitmer RA; Kwok PY; Risch N; Schaefer C; Blackburn EH;

      ​Genetics. 2015 Aug;200(4):1061-72. doi: 10.1534/genetics.115.178624. Epub 2015 Jun 19.

      PubMed abstract

      Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

      Author(s): Banda Y; Kvale MN; Hoffmann TJ; Hesselson SE; Ranatunga D; Tang H; Sabatti C; Croen LA; Dispensa BP; Henderson M; Iribarren C; Jorgenson E; Kushi LH; Ludwig D; Olberg D; Quesenberry CP Jr; Rowell S; Sadler M; Sakoda LC; Sciortino S; Shen L; Smethurst D; Somkin CP; Van Den Eeden SK; Walter L; Whitmer RA; Kwok PY; Schaefer C; Risch N;

      ​Genetics. 2015 Aug;200(4):1285-95. doi: 10.1534/genetics.115.178616. Epub 2015 Jun 19.

      PubMed abstract

      Differences in the Genetic Susceptibility to Age-Related Macular Degeneration Clinical Subtypes

      Author(s): Shen L; Hoffmann TJ; Melles RB; Sakoda LC; Kvale MN; Banda Y; Schaefer C; Risch N; Jorgenson E

      Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4290-9.

      PubMed abstract

      A large multi-ethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences

      Author(s): Hoffmann TJ; Van Den Eeden SK; Sakoda LC; Jorgenson E; Habel LA; Graff RE; Passarelli MN; Cario CL; Emami NC; Chao CR; Ghai NR; Shan J; Ranatunga DK; Quesenberry CP; Aaronson D; Presti J; Zhaoming W; Berndt SI; Chanock SJ; McDonnell SK; French AJ; Schaid DJ; Thibodeau SN; Li Q; Freedman ML; Penney KL; Mucci LA; Haiman CA; Henderson BE; Seminara D; Kvale MN; Kwok PY; Schaefer C; Risch N; Witte JS

      Cancer Discov. 2015 Jun 1.

      PubMed abstract

      Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response

      Author(s): Wen CC; Yee SW; Liang X; Hoffmann TJ; Kvale MN; Banda Y; Jorgenson E; Schaefer C; Risch N; Giacomini KM

      Clin Pharmacol Ther. 2015 May;97(5):518-25. Epub 2015-04-06.

      PubMed abstract

      Imputation of the Rare HOXB13 G84E Mutation and Cancer Risk in a Large Population-Based Cohort

      Author(s): Hoffmann TJ; Sakoda LC; Shen L; Jorgenson E; Habel LA; Liu J; Kvale MN; Asgari MM; Banda Y; Corley D; Kushi LH; Quesenberry CP; Schaefer C; Van Den Eeden SK; Risch N; Witte JS

      PLoS Genet. 2015 Jan;11(1):e1004930. Epub 2015-01-28.

      PubMed abstract

      Association between alcohol and cardiovascular disease; Mendelian randomisation analysis based on individual participant data

      Author(s): Holmes MV; Dale CE; Zuccolo L; Silverwood RJ; Guo Y; Ye Z; Prieto-Merino D; Dehghan A; Trompet S; Wong A; Cavadino A; Drogan D; Padmanabhan S; Li S; Yesupriya A; Leusink M; Sundstrom J; Hubacek JA; Pikhart H; Swerdlow DI; Panayiotou AG; Borinskaya SA; Finan C; Shah S; Kuchenbaecker KB; Shah T; Engmann J; Folkersen L; Eriksson P; Ricceri F; Melander O; Sacerdote C; Gamble DM; Rayaprolu S; Ross OA; McLachlan S; Vikhireva O; Sluijs I; Scott RA; Adamkova V; Flicker L; Bockxmeer FM; Power C; Marques-Vidal P; Meade T; Marmot MG; Ferro JM; Paulos-Pinheiro S; Humphries SE; Talmud PJ; Mateo Leach I; Verweij N; Linneberg A; Skaaby T; Doevendans PA; Cramer MJ; van der Harst P; Klungel OH; Dowling NF; Dominiczak AF; Kumari M; Nicolaides AN; Weikert C; Boeing H; Ebrahim S; Gaunt TR; Price JF; Lannfelt L; Peasey A; Kubinova R; Pajak A; Malyutina S; Voevoda MI; Tamosiunas A; Maitland-van der Zee AH; Norman PE; Hankey GJ; Bergmann MM; Hofman A; Franco OH; Cooper J; Palmen J; Spiering W; de Jong PA; Kuh D; Hardy R; Uitterlinden AG; Ikram MA; Ford I; Hyppönen E; Almeida OP; Wareham NJ; Khaw KT; Hamsten A; Husemoen LL; Tjønneland A; Tolstrup JS; Rimm E; Beulens JW; Verschuren WM; Onland-Moret NC; Hofker MH; Wannamethee SG; Whincup PH; Morris R; Vicente AM; Watkins H; Farrall M; Jukema JW; Meschia J; Cupples LA; Sharp SJ; Fornage M; Kooperberg C; LaCroix AZ; Dai JY; Lanktree MB; Siscovick DS; Jorgenson E; Spring B; Coresh J; Li YR; Buxbaum SG; Schreiner PJ; Ellison RC; Tsai MY; Patel SR; Redline S; Johnson AD; Hoogeveen RC; Hakonarson H; Rotter JI; Boerwinkle E; de Bakker PI; Kivimaki M; Asselbergs FW; Sattar N; Lawlor DA; Whittaker J; Davey Smith G; Mukamal K; Psaty BM; Wilson JG; Lange LA; Hamidovic A; Hingorani AD; Nordestgaard BG; Bobak M; Leon DA; Langenberg C; Palmer TM; Reiner AP; Keating BJ; Dudbridge F; Casas JP; InterAct Consortium

      BMJ. 2014;349:g4164. Epub 2014-07-10.

      PubMed abstract

      Examination of rare missense variants in the CHRNA5-A3-B4 gene cluster to level of response to alcohol in the San Diego Sibling Pair study

      Author(s): Choquet H; Joslyn G; Lee A; Kasberger J; Robertson M; Brush G; Schuckit MA; White R; Jorgenson E

      Alcohol Clin Exp Res. 2013 Aug;37(8):1311-6. doi: 10.1111/acer.12099. Epub 2013 Mar 4.

      PubMed abstract

      The impact of improved microarray coverage and larger sample sizes on future genome-wide association studies

      Author(s): Lindquist KJ; Jorgenson E; Hoffmann TJ; Witte JS

      Genet Epidemiol. 2013 May;37(4):383-92.

      PubMed abstract

      ALDH1A3 loss of function causes bilateral anophthalmia/microphthalmia and hypoplasia of the optic nerve and optic chiasm

      Author(s): Yahyavi M; Abouzeid H; Gawdat G; de Preux AS; Xiao T; Bardakjian T; Schneider A; Choi A; Jorgenson E; Baier H; El Sada M; Schorderet DF; Slavotinek AM

      Hum Mol Genet. 2013 Aug 15;22(16):3250-8. Epub 2013-04-15.

      PubMed abstract

      Turning of COGS moves forward findings for hormonally mediated cancers

      Author(s): Sakoda LC; Jorgenson E; Witte JS

      Nat Genet. 2013 Apr;45(4):345-8.

      PubMed abstract

      ​Genetic analysis of a population heavy drinking phenotype identifies risk variants in whites

      Author(s): Hamidovic A; Goodloe RJ; Young TR; Styn MA; Mukamal KJ; Choquet H; Kasberger JL; Buxbaum SG; Papanicolaou GJ; White W; Volcik K; Spring B; Hitsman B; Levy D; Jorgenson E.;

      ​J Clin Psychopharmacol. 2013 Apr;33(2):206-10. doi: 10.1097/JCP.0b013e318287009a.

      PubMed abstract

      Contribution of common PCSK1 genetic variants to obesity in 8,359 subjects from multi-ethnic American population

      Author(s): Choquet H; Kasberger J; Hamidovic A; Jorgenson E

      PLoS One. 2013;8(2):e57857. doi: 10.1371/journal.pone.0057857. Epub 2013 Feb 25.

      PubMed abstract

      Gene-centric analysis of serum cotinine levels in African and European American populations

      Author(s): Hamidovic A; Goodloe RJ; Bergen AW; Benowitz NL; Styn MA; Kasberger JL; Choquet H; Young TR; Meng Y; Palmer C; Pletcher M; Kertesz S; Hitsman B; Spring B; Jorgenson E

      Neuropsychopharmacology. 2012 Mar;37(4):968-74. doi: 10.1038/npp.2011.280. Epub 2011 Nov 16.

      PubMed abstract

      Human genetic variation recognizes functional elements in noncoding sequence

      Author(s): Lomelin D; Jorgenson E; Risch N

      Genome Res. 2010 Mar;20(3):311-9. Epub 2009 Dec 23.

      PubMed abstract