Tina R. Raine-Bennett, MD, MPH

People

Kaiser Permanente Division of Research
2000 Broadway
Oakland, CA 94612

(510) 891-5930 (phone)
tina.r.raine-bennett@kp.org
Kaiser Permanente Researcher Profiles

Dr. Raine-Bennett is a senior research scientist at the Kaiser Permanente Northern California Division of Research and a senior staff physician in the Oakland Medical Center. She received her medical training at the University of California, San Diego, and residency training and MPH at the University of Washington in Seattle, where she also completed a Robert Wood Johnson Clinical Scholars Fellowship. She is a Board Certified Obstetrician-Gynecologist with special interest in contraception and reproductive health.

Dr. Raine-Bennett focuses on expanding research on women's health and translating women's health research into clinical practice within the Obstetrics and Gynecology departments in Northern California. In addition to research on contraception, she conducts research on cervical cancer screening and hysterectomy trends. Dr. Raine-Bennett has been a Principal Investigator on NIH Grants to assess hormonal contraceptive use in high-risk women and develop interventions to improve contraceptive use. Her past research on emergency contraception focused on the safety of making emergency contraception more accessible and available to teens without a prescription.

Dr. Raine-Bennett is also currently a volunteer clinical faculty member at the University of California, San Francisco, where she was formerly a Professor and the Medical Director of the New Generation Health Center, a UCSF affiliate site that seeks to help teens and young women avoid unintended pregnancy.

She is the author of numerous scientific papers in major peer-reviewed journals. She served on the editorial board of Obstetrics and Gynecology and is currently a reviewer for the journal. She has served as an examiner for the American Board of Obstetrics and Gynecology as well as on national committees for the American College of Obstetrics and Gynecology and the National Medical Board of Planned Parenthood Federation of America. She is currently on the Board of Directors and the Treasurer of the Society of Family Planning and Society of Family Planning Research Fund.

Current Position(s):

Research Scientist III, Division of Research, Kaiser Permanente Northern California
Staff Physician, Kaiser Permanente Medical Center, Oakland, California
Volunteer Clinical Professor of Obstetrics Gynecology and Reproductive Sciences, UCSF
Research Director, Women's Health Research Institute

Section Affiliations:

Women's and Children's Health

Primary Research Interests:

Interventions to reduce adolescent and unintended pregnancy
Disparities in reproductive health
Primary prevention in women's health
Comparative effectiveness of procedures to treat gynecologic problems

Studies

Cervical Cancer Screening Follow-up

This study will use follow-up data on women with cervical specimens collected in the KPNC/NCI HPV biorepository and women in the cervical cancer screening program to investigate novel biomarkers of cervical pre-cancer and epidemiology of disease progression from HPV infection to cancer.
Investigator: Raine-Bennett, Tina
Funder: National Cancer Institute

Incidence and Trend of Ectopic Pregnancy and Contraceptive Use

Incidence and management of ectopic pregnancy have undergone significant changes in recent decades. There is a general consensus that available effective contraceptive methods reduce the absolute risk of ectopic pregnancy. Ectopic pregnancy incidence rate has not been well-documented in the last decade, and the mix of methods of contraceptives used has changed significantly over this time period. The goal of this project is to assess the feasibility of and generate data using electronic health records on ectopic pregnancy incidence, risk factors, and management trends in the general population and in women using select contraceptive methods, particularly intrauterine devices.
Investigator: Raine-Bennett, Tina
Funder: Bayer AG

Incidence of Osteoporosis and Abnormal Lipid Profiles in Women Over Age 40, Who Test Positive for a BRCA1 or BRCA2 Mutation and Have Had a Risk-Reducing Salpingo-oophorectomy

This cohort study will use DXA scans to: 1) establish the incidence of abnormal DXA scans in women post testing positive for BRCA1 or 2 mutations who have undergone risk-reducing salpingo-oophorectomy (RRSO); and 2) identify risk factors for abnormal DXA tests. The study will also examine lipid profiles to: 1) establish the incidence of abnormal lipid profiles in women post testing positive for BRCA1 or 2 mutations who have undergone RRSO; and 2) identify risk factors for abnormal lipid profiles. Secondary aims are to evaluate the incidence of adverse health outcomes in women with BRCA mutations, undergoing RRSO, including sexual dysfunction, menopausal symptoms, increase in BMI, development of hypertension, hyperlipidemia, diabetes, depression, new cancers, including BRCA-related (ovary/peritoneal, breast, melanoma) and other cancers, and identify risk factors which are associated with adverse outcomes.
Investigator: Raine-Bennett, Tina
Funder: Kaiser Permanente Institutional Planned Giving

Contraceptive Clinical Trials Network

The NICHD Contraceptive Clinical Trials Network (CCTN) will consist of up to 16 sites capable of performing female contraceptive clinical trials. Each site will work with the CCTN Statistical and Clinical Coordinating Center and NICHD to rapidly develop protocols and initiate clinical trials. The CCTN sites contractors will evaluate systematically the safety and efficacy of new female contraceptive drugs and devices as well as drug treatments of gynecologic conditions.
Investigator: Raine-Bennett, Tina
Funder: National Institute of Child Health and Human Development

Highlighted Publications

Occult Uterine Sarcoma and Leiomyosarcoma: Incidence of and Survival Associated With Morcellation

Author(s): Raine-Bennett T; Axtell A; Lentz SE; et al.

Obstet Gynecol. 2016 Jan;127(1):29-39.

Current Position(s):

Section Affiliations:

Primary Research Interests:

Studies

Cervical Cancer Screening Follow-up

Incidence and Trend of Ectopic Pregnancy and Contraceptive Use

Incidence of Osteoporosis and Abnormal Lipid Profiles in Women Over Age 40, Who Test Positive for a BRCA1 or BRCA2 Mutation and Have Had a Risk-Reducing Salpingo-oophorectomy

Contraceptive Clinical Trials Network

Highlighted Publications

Occult Uterine Sarcoma and Leiomyosarcoma: Incidence of and Survival Associated With Morcellation

Reproductive health outcomes of insured adolescent and adult women who access oral levonorgestrel emergency contraception

An Over-the-Counter Simulation Study of a Single-Tablet Emergency Contraceptive in Young Females

Publications

Pharmacists' knowledge, perspectives, and experiences with mifepristone dispensing for medication abortion

Genetic and Epigenetic Variations of HPV52 in Cervical Precancer

Design of the Association of Uterine Perforation and Expulsion of IUD (APEX-IUD) Study: A Multisite Retrospective Cohort Study

Identifying Ectopic Pregnancy in a Large Integrated Health Care Delivery System: Algorithm Validation

Breast cancer risk after hysterectomy with and without salpingo-oophorectomy for benign indications

Association of HPV35 with cervical carcinogenesis among women of African ancestry: Evidence of viral-host interaction with implications for disease intervention

Prediction of Occult Uterine Sarcoma prior to Hysterectomy for Women with Leiomyoma or Abnormal Bleeding

A study of type-specific HPV natural history and implications for contemporary cervical cancer screening programs

A Study of Partial Human Papillomavirus Genotyping in Support of the 2019 ASCCP Risk-Based Management Consensus Guidelines

Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance

Sexual function, menopausal symptoms, depression and cancer worry in women with BRCA mutations

Outcomes of Robotic Hysterectomy for Treatment of Benign Conditions: Influence of Patient Complexity

Racial Disparities in Route of Hysterectomy for Benign Indications Within an Integrated Health Care System

Depot Medroxyprogesterone Acetate, Oral Contraceptive, Intrauterine Device Use, and Fracture Risk

Scientific abstracts: Featured research at the 2019 Society of Family Planning Annual Meeting

Viral coinfection analysis using a MinHash toolkit

Human papillomavirus 16 sub-lineage dispersal and cervical cancer risk worldwide: Whole viral genome sequences from 7116 HPV16-positive women

Identification and validation of uterine perforation, intrauterine device expulsion, and breastfeeding in four health care systems with electronic health records

Risk of cardiovascular disease in women with BRCA1 and BRCA2 mutations

Contraception after Abortion and Risk of Repeated Unintended Pregnancy among Health Plan Members

Scientific abstracts featured research at the 2018 North American Forum on Family Planning

The Relationship Between Prescription Copayments and Contraceptive Adherence in a New-user Cohort

Recent Intrauterine device use and the risk of precancerous cervical lesions and cervical cancer

Automated Cervical Screening and Triage, Based on HPV Testing and Computer-Interpreted Cytology

Exploring young women's decisional needs for contraceptive method choice: A qualitative study

Bone loss in women with BRCA1 and BRCA2 mutations

Validation of an HPV DNA cervical screening test that provides expanded HPV typing

Human Papillomavirus DNA methylation as a biomarker for cervical precancer: Consistency across 12 genotypes and potential impact on management of HPV-positive women

Adjuvant gemcitabine-docetaxel chemotherapy for stage I uterine leiomyosarcoma: Trends and survival outcomes

HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis

Scientific abstracts featured research at the 2017 North American Forum on Family Planning

Minimally Invasive Hysterectomy and Power Morcellation Trends in a West Coast Integrated Health System

Over-the-Counter Access to Oral Contraceptives for Adolescents

Patient perceptions of a decision support tool to assist with young women's contraceptive choice

Deep sequencing of HPV16 genomes: A new high-throughput tool for exploring the carcinogenicity and natural history of HPV16 infection

HPV16 Sublineage Associations With Histology-Specific Cancer Risk Using HPV Whole-Genome Sequences in 3200 Women

Experience With Opportunistic Salpingectomy in a Large, Community-Based Health System in the United States

Featured research at the 2015 North American Forum on Family Planning

The role of human papillomavirus (HPV) genotyping in cervical cancer screening: A large-scale evaluation of the cobas HPV test

Development of a Brief Questionnaire to Assess Contraceptive Intent

Improved Perinatal Depression Screening, Treatment, and Outcomes With a Universal Obstetric Program

HPV16 methyl-haplotypes determined by a novel next-generation sequencing method are associated with cervical precancer

Occult Uterine Sarcoma and Leiomyosarcoma: Incidence of and Survival Associated With Morcellation

A study of HPV typing for the management of HPV-positive ASC-US cervical cytologic results

Reproductive health outcomes of insured adolescent and adult women who access oral levonorgestrel emergency contraception

A STUDY OF GENOTYPING FOR THE MANAGEMENT OF HUMAN PAPILLOMAVIRUS-POSITIVE, CYTOLOGY-NEGATIVE CERVICAL SCREENING RESULTS

Risk management options elected by women after testing positive for a BRCA mutation

Counseling and provision of long-acting reversible contraception in the US: National survey of nurse practitioners

Evaluation of e-mail contact to conduct follow-up among adolescent women participating in a longitudinal cohort study of contraceptive use

Five-year risks of CIN 2+ and CIN 3+ among women with HPV-positive and HPV-negative LSIL Pap results

Benchmarking CIN 3+ risk as the basis for incorporating HPV and Pap cotesting into cervical screening and management guidelines

Five-year risks of CIN 3+ and cervical cancer among women with HPV testing of ASC-US Pap results

Five-year risk of CIN 3+ to guide the management of women aged 21 to 24 years

Five-year risk of recurrence after treatment of CIN 2, CIN 3, or AIS: performance of HPV and Pap cotesting in posttreatment management

Follow-up testing after colposcopy: five-year risk of CIN 2+ after a colposcopic diagnosis of CIN 1 or less

Five-year risks of CIN 3+ and cervical cancer among women with HPV-positive and HPV-negative high-grade Pap results

'Do ask, do provide' contraception for women in the u.s. Military

With pills, patches, rings, and shots: who still uses condoms? A longitudinal cohort study

An Over-the-Counter Simulation Study of a Single-Tablet Emergency Contraceptive in Young Females