Biomarker of Pancreatic B-cell Loss Predicting Progression to Type 2 Diabetes After Gestational Diabetes

The goal of this study is to identify unmethylated INS DNA reflecting higher type 2 diabetes risk in women after gestational diabetes pregnancy and to evaluate unmethylated INS DNA as a potential mediator of the lactation duration and intensity association with up to 50% lower relative risk of progression to type 2 diabetes in women after gestational diabetes. The study combines the two largest collections worldwide of longitudinal biospecimens from serial annual 2-h 75 g research OGTTs and in-person research visits in 1,033 women with gestational diabetes followed prospectively since early postpartum (6-9 wks) through 2 years post-delivery, and up to 12 years via electronic health records for type 2 diabetes testing in the KPNC Study of Women, Infant Feeding and Type 2 Diabetes After Gestational Diabetes (SWIFT) funded by NICHD and NIDDK (Gunderson, PI), and women enrolled from 12 weeks to 1 year postpartum and followed through 4 years post-delivery in Tianjin GDM Observational study (TGDM-O) funded by the European Foundation for the Study of Diabetes (Hu, PI

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