Brain pathologies, reserve, and cognition in aging and dementia

This study is examining racial/ethnic group similarities and differences in brain mechanisms underlying cognitive reserve and functional reserve, and their life course determinants, by conducting secondary data analysis and harmonization of existing data from 4 ongoing longitudinal studies: Alzheimer’s Disease Center cohort at UCD, KHANDLE at DOR/UCD, STAR at DOR/UCD, and LA 90 at DOR/UCD. The combined data from these 4 studies will be used to examine MRI derived brain imaging variables associated with cognitive and functional decline; develop measures of functional reserve; examine potentially modifiable factors measured in mid-life that can build cognitive and functional reserve and promote cognitive health and functional independence.

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