Breast White Adipose Tissue Inflammation and Breast Cancer Outcomes

We will assess the incidence and severity of breast white adipose tissue (B-WAT) inflammation in mastectomy specimens from approximately 1,900 Pathways Study participants to examine associations of various factors with B-WAT inflammation incidence and severity at the time of breast cancer surgery, and to examine whether B-WAT inflammation impacts breast cancer recurrence, second primary breast cancer, and breast cancer progression-free survival. We will also investigate the associations of inflammatory blood biomarkers, body composition, and lifestyle factors such as diet and physical activity with B-WAT inflammation and severity. This collaborative project includes investigators at the Fred Hutchinson Cancer Research Center, Memorial Sloan Kettering Cancer Center, Roswell Park Comprehensive Cancer Center, and Weill Cornell Medical College, where Dr. Andrew Dannenberg, who co-leads this project, is located. 

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