Cervical Cancer Screening After Age 65 in the Era of HPV Testing: Estimating Benefits and Harms of Screening Cessation and Continuation

Although cervical cancer screening has been successful in the United States, little is known about the optimal circumstances under which screening can safely end. This study will address this research gap by estimating cervical cancer screening benefits and harms after age 65 in a large group of women enrolled in two large integrated healthcare systems in California. Using data from 2 KP regions (KPNC, KPSC), this study aims to: 1) determine whether cervical cancer incidence and mortality in individuals over age 65 varies by historical clinical factors used in guidelines for ending cervical cancer screening; 2) estimate cervical cancer screening benefits and harms in individuals over age 65; and 3) use cost-effectiveness analyses to identify the optimal criteria for ending cervical cancer screening in women.

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