Clinically Actionable Pharmacogenetic Loci and Drug-Gene Combinations in the Multi-Ethnic KP Research Bank

This project will examine the new Kaiser Permanente Research Bank genomic data (N=300,000) on pharmacogenes, comparing results of genotyping with other sources of data, and to provide information about the prevalence of altered drug metabolization status in different ancestry groups, as well as data on the frequency of exposure to drug-gene combinations with potential clinical consequences of altered metabolization in the KP population. The results of this project will be useful to KP in considering the implications of pharmacogenetic testing, and also to researchers interested in using the data on pharmacogenes to better understand the health consequences of pharmacogenetic variation.

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