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Colorectal Cancer Screening and Outcomes in HIV-Positive and HIV-Negative Individuals

With increasing age of HIV patients, HIV care is increasingly directed towards prevention of chronic disease, including cancer. With the exception of our recent study, prior research has not noted a higher risk of colorectal cancer in HIV patients. However, few studies have evaluated colorectal screening practices and precancerous outcomes in HIV patients, which is essential now that HIV-positive patients have reached screening age. We will conduct a cohort study of 6,000 HIV-positive and 1:1 matched HIV-negative individuals, ages 50-75 years, during 2000-2015 from Kaiser Permanente. We will evaluate, by HIV status, screening rates, modality of screening, and screening outcomes, including adenoma and cancer. We will then explore HIV-specific factors associated with outcomes, such as current and nadir CD4, current viral load, duration of known HIV and antiretroviral therapy class.

Investigator: Silverberg, Michael

Funder: Northern California Community Benefit Programs

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