Comparing the Effects of Prenatal Depression and its Treatment on Developmental Outcomes of the Offspring

This study will test the hypothesis that the underlying prenatal depression and use of SSRIs are independent risk factors for adverse neurodevelopmental outcomes. The aims of this study are: 1) evaluate the effect of untreated prenatal depression, compared to no prenatal depression, on neurodevelopmental outcomes of the offspring, after adjustment for confounders; 2) evaluate the effect of treatment for prenatal depression with SSRIs on neurodevelopmental outcomes of the offspring; 3) on a subsample of 2,000 children, evaluate prenatal depression and its treatment in parental interviews to identify less severe neurodevelopmental outcomes.

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