The NOD (New-Onset Diabetes) Cohort Study is part of a multisite effort to create a cohort with strictly defined new-onset diabetes. Kaiser Permanente Northern California is also receiving funding from the National Cancer Institute Community Oncology Research Program (NCORP). The full study is designed to recruit 10,000 participants with new-onset diabetes from across the nation and follow them closely with questionnaire data for at least a 3-year period. Biospecimens will also be obtained at regular intervals. The primary goals of the study are to: 1) estimate the risk of pancreatic and other cancers within a 3-year period after new-onset diabetes; 2) create a biospecimen resource for the development of biomarkers for pancreatic cancer; and 3) serve as a validation set for externally developed biomarkers.