Defining a Comprehensive Reference Profile of Circulating Human Extracellular RNA: A CARDIA Ancillary Study

Blood and other body fluids harbor abundant and stable extracellular RNAs (exRNA) which are increasingly recognized as novel potential biomarkers of disease. This study has the main objective of generating reference profiles of both short and long non-coding regulatory exRNA, including environmentally-derived exRNA, from 720 plasma samples collected at the 10-year CARDIA visit. These healthy subjects will be stratified as follows: 180 subjects in each of the following 4 groups: male Caucasian, female Caucasian, male African American, female African American.

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