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Early Identification and Prognosis in Neurodegenerative Parkinsonism

The goals of this study are to develop an efficient method for identification of people destined to develop a neurodegenerative synucleinopathy, develop an efficient method for early stratification of persons with neurodegenerative parkinsonism to identify expected final diagnosis (e.g., Parkinson’s disease, dementia with Lewy bodies, progressive supranuclear palsy, corticobasal degeneration, or multiple system atrophy) and, within Parkinson’s disease, to predict rate of progression to malignant syndromes (e.g., Parkinson’s disease dementia, dyskinesiasm), and to use existing genotype data to calculate a polygenic risk score. This study is a collaboration with Dr. Caroline Tanner (co-principal investigator) at UCSF.

Investigator: Van Den Eeden, Stephen

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