The overarching objective of this proposal is to discover genetic and social determinants of drug safety and efficacy in previously-understudied populations using electronic health record (EHR)-linked biobanks. Aims include determining the impact of social factors on drug effects, identifying genome-wide polymorphisms predictive of drug effects in historically-excluded populations, and discovering eQTL determinants of drug response.
Genetic and social determinants of pharmacological health outcomes in ancestrally diverse populations
Investigator: Iribarren, Carlos
Funder: National Human Genome Research Institute
