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HIV Status and Incidence and Outcomes of Heart Failure

Antiretroviral therapy (ART) has prolonged the lifespan of HIV-infected patients, resulting in a growing number of individuals aging with HIV infection. As this population ages, comorbidities, such as cardiovascular disease have increasingly contributed to excess morbidity and mortality. Unlike acute myocardial infarction, heart failure incidence is increasing in the general population, with associated serious morbidity and excess mortality, but has received less attention in the HIV population. Leveraging the Cardiovascular Research Network’s Heart Failure consortium, our study goals are: 1) To characterize the association of HIV status with the incidence of heart failure; 2) Among HIV-infected patients, to evaluate the effect of ART use, CD4 and HIV viral replication on the incidence of heart failure; and 3) To examine the influence of HIV status on heart failure-related treatment patterns, hospitalizations and death among incident heart failure patients.

Investigator: Silverberg, Michael

Funder: National Heart, Lung, and Blood Institute

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