Identification of DNA Methylation Markers for Risk of Metastasis in Localized Prostate Cancer

The overarching goal of this study is to develop DNA methylation marker-based prediction algorithms that will pave the way for individualized management strategies for men with localized PCa. To achieve this goal, we propose a nested case-control study based on over 6,500 untreated men to evaluate the prognostic utility of DNA methylation markers measurable from diagnostic PCa biopsy specimens, and to develop and validate a prediction model for 10-year risk of metastasis in localized PCa. This is a study of KPSC and KPNC men with prostate cancer.

0