Impact of Low IL-10 Levels at Birth and Leukemia Risk

The objectives of this retrospective cohort study of an established case-control study of childhood leukemia are to understand the relationships among immune status at birth, infectious exposures during childhood, and leukemogenesis, and to use this understanding to decrease the incidence of childhood acute lymphoblastic leukemia (ALL). The aims are to: 1) Assess whether a low interleukin-10 level at birth is associated with an increased incidence of early infections characterized by severe clinical symptoms from medical records and self-report; and 2) Determine whether decreased interleukin-10 can contribute to increased ALL in the setting of immune system activation.

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