Incidence of Osteoporosis and Abnormal Lipid Profiles in Women Over Age 40, Who Test Positive for a BRCA1 or BRCA2 Mutation and Have Had a Risk-Reducing Salpingo-oophorectomy

This cohort study will use DXA scans to: 1) establish the incidence of abnormal DXA scans in women post testing positive for BRCA1 or 2 mutations who have undergone risk-reducing salpingo-oophorectomy (RRSO); and 2) identify risk factors for abnormal DXA tests. The study will also examine lipid profiles to: 1) establish the incidence of abnormal lipid profiles in women post testing positive for BRCA1 or 2 mutations who have undergone RRSO; and 2) identify risk factors for abnormal lipid profiles. Secondary aims are to evaluate the incidence of adverse health outcomes in women with BRCA mutations, undergoing RRSO, including sexual dysfunction, menopausal symptoms, increase in BMI, development of hypertension, hyperlipidemia, diabetes, depression, new cancers, including BRCA-related (ovary/peritoneal, breast, melanoma) and other cancers, and identify risk factors which are associated with adverse outcomes.

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