This network participates in PCORI’s Clinical Data Research Network (CDRN) program to enhance the nation’s capacity to conduct comparative effectiveness research by creating a national electronic data infrastructure. This program promotes the development of data networks and engages patients, clinicians, and health care systems in the research process. Kaiser Permanente’s 7 regions have joined together with Group Health Cooperative, HealthPartners (Minnesota), and Denver Health to form the PORTAL Network. We are developing governance and data infrastructure approaches, conducting patient engagement activities, and developing innovative new methods to support patient engagement in research. Cohorts of patients that are formed around three conditions — colorectal cancer, congenital heart disease, and obesity — will be surveyed to establish priorities for patient-centered research.