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Leveraging Genetic and Electronic Health Records Data to Identify Novel Targets and Drugs for Treating Alcohol Use Disorder

This pharmacoepidemiologic study conducted in collaboration with Dr. Joshua Gray at the Uniformed Services University of the Health Sciences will examine L-type calcium channel blockers (e.g., nifedipine, felodipine) as a potential novel therapeutic target for treatment of alcohol use disorder. Dr. Gray and others have shown that L-type calcium channels are genetically supported targets with theoretical and preclinical support for repurposing for treating alcohol use disorder. This study will use electronic health records data from Kaiser Permanente Northern California to examine whether patients treated with L-type calcium channel blockers have significantly greater reductions in alcohol use compared to a control group of patients.

Investigator: Sterling, Stacy

Funder: National Institute on Alcohol Abuse and Alcoholism

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