The goal of this project is to establish a multiregional partnership to study cognitive impairment and dementia in people with HIV infection. We will launch this collaborative effort by constructing a research cohort for predictive modeling of dementia in the HIV setting, with data pooled from multiple Kaiser Permanente regions to increase diversity and ensure research findings accurately represent dementia risk across population subgroups. Our long-term vision is that this cohort will facilitate ongoing research on care delivery and outcomes related to dementia and aging in the growing population of older people with HIV infection.