Polygenic Risk Scores for Advancing CVD Risk Stratification among Asymptomatic Adults

Leveraging the GERA Cohort to evaluate the performance of a 12-SNP PRS for CVD against the Pool Cohorts Equation across ethnic groups; validate MEGASTROKE Consortium PRS_32 for ischemic stroke; and assess the interplay between genetic background and lifestyle factors. We will evaluate the independent and joint contributions of PRS_12, smoking status, Mediterranean diet pattern and meeting physical activity recommendations to risk of CVD. Separate analyses for each ethnic group.

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