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Resistance Training to Reduce Chemotoxicity in Colon Cancer

The goal of this study is to test a randomized intervention of up to six months of home-based resistance training and protein supplementation versus a waitlist control. The intervention will begin during the first month of chemotherapy and continue through completion of treatment. The study will examine differences in chemotherapy outcomes, including reductions in dosing, treatment delays, and early discontinuation of treatment; differences in total combined number of moderate and severe grade 3 and 4 toxicities; and pre and post intervention differences in the pharmacokinetics of FOLFOX (colon cancer chemotherapy regimen), changes in body composition, functional status, and strength. If improving muscle mass through resistance training leads to a reduced risk of chemotoxicities, CT scans routinely performed for clinical diagnosis could be used to identify high-risk patients who will benefit from tailored exercise guidelines.

Investigator: Caan, Bette

Funder: National Cancer Institute

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