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The Colonic Microbiome Preceding Parkinson’s Disease: A Pilot Study

Gut changes, including evidence of alpha synuclein and the microbiome, appear to differ between people with and without Parkinson’s disease. This pilot study will use colonic biospecimens from deceased patients with Parkinson’s disease and control patients to determine if we can characterize the microbiome with good resolution and demonstrate at least one signal of microbiome differences between the two groups. Early studies have been positive. The findings will be used to support an NIH R01 application to fully elucidate the temporality of microbiome changes in prodromal Parkinson’s disease. 

Investigator: Van Den Eeden, Stephen

Funder: University of California, San Francisco, Project Grant

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