The Role of Bariatric Surgery in the Management of Nonalcoholic Fatty Liver Disease

This project is proposed by University of California, San Francisco (UCSF) gastroenterology fellow Suzanne Sharpton, who is also earning an M.S. in public health. She is supported by Kaiser Permanente gastroenterologist Varun Saxton and bariatric surgeon Robert Li, as well as her UCSF mentor. The project has three specific aims. The first is to examine changes in hepatic fibrosis at baseline, 6, and 12 months post-surgery among morbidly obese adults who underwent bariatric surgery and had nonalcoholic steatohepatitis on a liver biopsy at baseline. The second is to compare the change in nonalcoholic fatty liver disease fibrosis score between Roux-en-Y gastric bypass versus sleeve gastrectomy. The third aim is to compare the rate of cardiovascular morbidity after bariatric surgery in morbidly obese adults with and without histologic evidence of nonalcoholic steatohepatitis at baseline.

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