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Leveraging Multi-omics Approaches to Examine Metabolic Challenges of Obesity in Relation to Cardiovascular Diseases

This project will generate longitudinal plasma metabolomic profiles in the CARDIA study cohort to better understand underlying molecular mechanisms for cardiovascular disease (CVD). We will identify metabolites and metabolic pathways related to CVD risk factors and CVD incidence; identify specific metabolites that mediate pathways from genomic CVD-susceptibility to CVD risk factors and incidence; identify metabolites and major metabolic pathways to CVD risk factors and incidence that are modified by obesity; and test most-promising metabolic pathways for CVD etiology using targeted metabolic profiling.
Investigator: Sidney, Stephen
Funder: National Heart, Lung, and Blood Institute