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Study

Understanding and Informing Early Hospital Antibiotic Prescribing for Potential Infection

The goals of this study are to (1) examine temporal trends in early hospital antibiotic prescribing patterns over the past 5 years, to assess for unintended consequences associated with earlier antibiotics in severe sepsis/septic shock; (2) quantify the patient-level harm associated with receipt of unnecessary antibiotics; and (3) identify subsets of patients, discernable in real-time with high certainty, who benefit from immediate antibiotics, versus the subsets of patients for whom it is safe to delay antibiotics by 3 hours (thereby allowing time for rapid diagnostics, such as procalcitonin).
Investigator: Liu, Vincent
Funder: Agency for Healthcare Research and Quality