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Advancing Geriatrics Infrastructure & Network Growth (AGING) Initiative

The study will evaluate the association of comorbidity burden and specific comorbidities with health and utilization outcomes following transcatheter aortic valve replacement (TAVR) for the treatment of severe aortic stenosis. Patients who receive TAVR tend to be elderly, frail, and have multiple chronic conditions. To evaluate how comorbidities relate to TAVR outcomes, we will: 1) characterize a contemporary population of patients receiving TAVR in terms of their comorbidities, 2) evaluate the associations of comorbidity burden and key comorbidities with TAVR outcomes, and 3) develop clinical risk calculators for TAVR outcomes that incorporate comorbidity burden and the presence of key comorbidities. This pilot work will support the development of a systems-level intervention to identify high-risk TAVR patients and provide more intense follow-up care based on expected outcomes from the clinical risk calculators and the presence of comorbidities.
Investigator: Go, Alan
Funder: National Institute on Aging