Kelly-Taylor, Kendria
Research interests include reproductive health inequities among Black populations.
Long-term adverse health outcomes for women and children following SARS-CoV-2 infection during pregnancy
The study will assemble a longitudinal cohort of more than 195,000 pregnant women (>22,000 women with SARS-CoV-2 infection during pregnancy…
Moderna Cytomegalovirus Child Hearing and Autism Study (MOCCHA)
Human cytomegalovirus (CMV) is the most common infection acquired before birth. In the US, about 1 of every 150 to…
Novel approaches to examining weight changes in pregnancies affected by obesity
Current gestational weight change (GWC) recommendations for obese individuals were established with limited evidence of the pattern and timing of…
Prenatal exposure to per- and polyfluoroalkyl substances and childhood autism-related outcomes
Epidemiologic evidence linking prenatal exposure to per- and polyfluoroalkyl substances (PFAS) with altered neurodevelopment is inconclusive, and few large studies…
Prepregnancy Body Mass Index and Risk of Childhood Asthma
Growing evidence suggests that maternal obesity may affect the intrauterine environment and increase a child's risk of developing asthma. We…
Opportunities for Inclusion and Engagement in the Transition of Autistic Youth from Pediatric to Adult Healthcare: A Qualitative Study
Transitioning autistic youth from pediatric to adult healthcare requires coordination of multiple stakeholders, including youth, caregivers, and pediatric and adult…
Understanding facilitators and barriers to achieving glycemic control among a diverse population with gestational diabetes
The SUNRISE project capitalizes on our previous qualitative research that demonstrated our ability to identify facilitators and barriers that contribute…
Center for upstream prevention of adiposity and diabetes mellitus
The UPSTREAM Center conducts research on the upstream prevention of adiposity and diabetes by identifying risk factors and conducting interventions…
GEARs Combining advances in Genomics and Environmental science to accelerate Actionable Research and practice in ASD
The Autism Centers of Excellence (ACE) program is a trans-NIH initiative that supports large-scale studies on autism spectrum disorder. A…
Epigenetic changes in sperm are associated with paternal and child quantitative autistic traits in an autism-enriched cohort
There is a need to consider paternal contributions to autism spectrum disorder (ASD) more strongly. Autism etiology is complex, and…
Associations of prenatal exposure to a mixture of persistent organic pollutants with social traits and cognitive and adaptive function in early childhood: Findings from the EARLI study
Literature suggests that maternal exposure to persistent organic pollutants (POPs) may influence child neurodevelopment. Evidence linking prenatal POPs and autism…
Health Care Utilization During the COVID-19 Pandemic Among Individuals Born Preterm
Limited data exist on pediatric health care utilization during the COVID-19 pandemic among children and young adults born preterm. To…
Assessment of Psychosocial and Neonatal Risk Factors for Trajectories of Behavioral Dysregulation Among Young Children From 18 to 72 Months of Age
Emotional and behavioral dysregulation during early childhood are associated with severe psychiatric, behavioral, and cognitive disorders through adulthood. Identifying the…
The prospective association of hyperandrogenism, oligomenorrhea and polycystic ovary syndrome with incident gestational diabetes: The coronary artery risk development in young adults women’s study
In this 28-year prospective study of 455 women (mean age: 26 years), polycystic ovary syndrome (PCOS) was associated with a 2.6-fold…
NICU Versus Mother/Baby Unit Admission for Low-Acuity Infants Born at 35 Weeks’ Gestation
To estimate the effect of NICU admission of low-acuity infants born at 35 weeks' gestation versus care in a mother/baby…
Changes in Body Mass Index Among School-Aged Youths Following Implementation of the Healthy, Hunger-Free Kids Act of 2010
The prevalence of obesity among youths 2 to 19 years of age in the US from 2017 to 2018 was…
In utero metabolomic signatures of refined grains intake and risk of gestational diabetes: A metabolome-wide association study
Epidemiologic evidence has linked refined grain intake to a higher risk of gestational diabetes (GDM), but the biological underpinnings remain…
Incidence Rates of Medically Attended COVID-19 in Infants Less Than 6 Months of Age
Studies suggest infants may be at increased risk of severe coronavirus disease 2019 (COVID-19) relative to older children, but few…
Prenatal Antidepressant Exposures and Autism Spectrum Disorder or Traits: A Retrospective, Multi-Cohort Study
Prenatal antidepressant exposure has been associated with increased risk for neurodevelopmental disorders in childhood, including autism spectrum disorder (ASD). The…
Racial-Ethnic Differences in Treatment Initiation for New Diagnoses of Perinatal Depression
The adverse consequences of untreated perinatal depression highlight the need to identify populations to target in order to increase treatment…
Incidence Rates of Childhood Asthma with Recurrent Exacerbations in the U.S. Environmental influences on Child Health Outcomes (ECHO) Program
Descriptive epidemiological data on incidence rates (IRs) of asthma with recurrent exacerbations (ARE) are sparse. We hypothesized that IRs for…
The Environmental influences on Child Health Outcomes (ECHO)-wide Cohort
The Environmental influences on Child Health Outcomes (ECHO)-wide Cohort Study (EWC), a collaborative research design comprising 69 cohorts in 31…
Modifying the social responsiveness scale for adaptive administration
The social responsiveness scale (SRS) is frequently used to quantify the autism-related phenotype and is gaining use in health outcomes…
A framework for measuring the cost to families of caring for children’s health: the design, methodology, and study population of the r-Kids study
All families experience financial and time costs related to caring for their children's health. Understanding the economic burden faced by…
Rates of malignancies among patients with moderate to severe atopic dermatitis: a retrospective cohort study
Patients with atopic dermatitis (AD), also known as eczema, may be at an increased risk for malignancies compared with patients…
Impact of sedentary behavior and emotional support on prenatal psychological distress and birth outcomes during the COVID-19 pandemic
Abstract. Studies have reported mixed findings regarding the impact of the coronavirus disease 2019 (COVID-19) pandemic on pregnant women and…
Using Peer Support to Prevent Diabetes: Results of a Pragmatic RCT
High-contact structured diabetes prevention programs are effective in lowering weight and HbA1cs, yet their intensity level can create barriers to…
Associations between antidepressant use patterns during pregnancy and birth outcomes among periconception antidepressant users
Little is known about antidepressant medication use patterns during pregnancy among periconception (before and immediately following conception) users. Additionally, the…
Evaluation of the EmbrACE Intervention for Pregnant Adults with a History of Adverse Childhood Experiences
Feasibility study of a 6-week virtual intervention for pregnant women with high adverse childhood experience (ACE) exposure and moderate to…
Wellness coaching during pregnancy and maternal weight outcomes
Study to determine if individuals who participated in Wellness Coaching have lower risk of high gestational weight gain and postpartum…
Associations between Glycemic Control Trajectories among Individuals with Gestational Diabetes and Obesity Risk and Growth Trajectories in the Offspring
The study will examine the association between glycemic control trajectories among individuals with gestational diabetes (GDM) included in the GDM…
Evaluating patient engagement in “KP Connected Pregnancy Care” and its association with utilization, perinatal outcomes and patient satisfaction.
This cohort study evaluates a new prenatal care delivery pathway, KP Connected Pregnancy Care (KPCPC). KPCPC is an opt-in hybrid…
Prenatal medication exposure in autism, birth complications and developmental disabilities
Systematically investigate the effects of maternal medication use in pregnancy on offspring autism spectrum disorder (ASD) risk. Test the mechanisms…
Birth Outcomes in Relation to Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Stress in the Environmental Influences on Child Health Outcomes (ECHO) Program
Per- and polyfluoroalkyl substances (PFAS) are persistent and ubiquitous chemicals associated with risk of adverse birth outcomes. Results of previous…
Perinatal Outcomes After Bariatric Surgery Compared With a Matched Control Group
To evaluate perinatal outcomes associated with pregnancy after bariatric surgery within a large integrated health care system using propensity score…
Metabolomic biomarkers of the mediterranean diet in pregnant individuals: A prospective study
Metabolomic profiling is a systematic approach to identifying biomarkers for dietary patterns. Yet, metabolomic markers for dietary patterns in pregnant…
Intergenerational transmission of the effects of maternal exposure to childhood maltreatment in the USA: a retrospective cohort study
Childhood maltreatment is associated with adverse health outcomes and this risk can be transmitted to the next generation. We aimed…
The impact of autism spectrum disorder on parent employment: Results from the r-Kids study
Parents of children with autism spectrum disorder (ASD) and other chronic health conditions often face exceptional caregiving demands that can…
Accuracy of diagnostic codes for prenatal opioid exposure and neonatal opioid withdrawal syndrome
Determine the accuracy of diagnostic codes in identifying Prenatal Opioid Exposure (POE) and Neonatal Opioid Withdrawal Syndrome (NOWS). A cross-sectional…
Healthcare transition outcomes among autistic youth at KPNC
The study follows a cohort of autistic and non-autistic youth longitudinally to examine several transition indicators measurable in the EHR…
Maternal and neonatal outcomes associated with treating hypertension in pregnancy at different thresholds
In the United States, there has been controversy over whether treatment of mild-to-moderate hypertension during pregnancy conveys more benefit than…
Perinatal Outcomes During vs. Prior to the COVID-19 Pandemic and the Role of Maternal Depression and Perceived Stress: A Report from the ECHO Program
We sought to evaluate the impact of the COVID-19 pandemic on perinatal outcomes while accounting for maternal depression or perceived…
SARS-CoV-2 testing and detection during peripartum hospitalizations among a multi-center cohort of pregnant persons, March 2020-February 2021
Identifying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections during peripartum hospitalizations is important to guide care, implement prevention measures,…
Dietary Quality Indices in Early Pregnancy and Rate of Gestational Weight Gain among a Prospective Multi-Racial and Ethnic Cohort
Meeting the Institute of Medicine (IOM) gestational weight gain (GWG) guidelines is associated with a reduced risk of adverse perinatal…
Association of the COVID-19 Pandemic With Unstable and/or Unsafe Living Situations and Intimate Partner Violence Among Pregnant Individuals
The social, behavioral, and economic consequences of the COVID-19 pandemic may be associated with unstable and/or unsafe living situations and…
Trends in Screen Time Use Among Children During the COVID-19 Pandemic, July 2019 Through August 2021
The COVID-19 pandemic led to widespread lockdowns and school closures that may have affected screen time among children. Although restrictions…
Daytime napping and nighttime sleep in pregnant individuals with insomnia disorder
Examine bidirectional associations between daytime napping and nighttime sleep among pregnant individuals with insomnia disorder. We used baseline data from…
Association of cannabis use during pregnancy with severe acute respiratory syndrome coronavirus 2 infection: a retrospective cohort study
Cannabis use is increasingly common among pregnant individuals and might be a risk factor for severe acute respiratory syndrome coronavirus…
Impact of the COVID-19 pandemic on children’s sleep habits: an ECHO study
Sleep in childhood is affected by behavioral, environmental, and parental factors. We propose that these factors were altered during the…
Placental Histopathologic Findings of a Large Cohort of Patients With SARS-CoV-2 Infection During Pregnancy
Pregnant individuals with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are at a higher risk for adverse pregnancy outcomes. Previous…
Ambient air pollutants are associated with morning serum cortisol in overweight and obese Latino youth in Los Angeles.
BACKGROUND: Hypothalamic-pituitary-adrenal (HPA)-axis dysfunction has been associated with a variety of mental health and cardio-metabolic disorders. While causal models of…
Prenatal Maternal Cortisol Levels and Infant Birth Weight in a Predominately Low-Income Hispanic Cohort.
Infant birth weight influences numerous health outcomes throughout the life course including childhood obesity and metabolic morbidities. Maternal experience of…
Third trimester cortisol is positively associated with gestational weight gain in pregnant women with class one obesity.
BACKGROUND/OBJECTIVE: Prevalence of pre-pregnancy obesity and excessive gestational weight gain (GWG) are higher among women of color with low SES.…
Effects of COVID-19 Financial and Social Hardships on Infants’ and Toddlers’ Development in the ECHO Program
The financial hardships and social isolation experienced during the COVID-19 pandemic have been found to adversely affect children's developmental outcomes.…
Indoor and outdoor air pollution and couple fecundability: a systematic review
Air pollution is both a sensory blight and a threat to human health. Inhaled environmental pollutants can be naturally occurring…
Pregnancy post-bariatric surgery: Improved outcomes with telephonic nutritional management program
Pregnancies post-bariatric surgery are increasingly common. It is important to understand how to manage prenatal care in this high-risk population…
Prenatal Opioid Exposure and Neurodevelopmental Outcomes
The opioid epidemic in the United States has resulted in a significant increase in opioid use disorder among pregnant women…
Perinatal Anesthesia Exposure and Autism Spectrum Disorders
Epidural analgesia is frequently used during labor among pregnant people in the United States. Different factors have been associated with…
Changes in COVID-19 Vaccine Intent Among a Diverse Population of Older Adults, June 2021-February 2022
Introduction COVID-19 vaccination rates remain suboptimal in the United States. Clinicians and policymakers need to better understand how likely vaccine-hesitant…
Habitual coffee consumption and subsequent risk of type 2 diabetes in individuals with a history of gestational diabetes – a prospective study
Females with a history of gestational diabetes mellitus (GDM) are at higher risk of developing type 2 diabetes mellitus (T2D)…
Physical activity and individual plasma phospholipid saturated fatty acids in pregnancy, a longitudinal study among a multiracial/multiethnic cohort in the United States
Circulating individual SFAs in pregnant females are critical for maternal and fetal health. However, research on identifying their modifiable factors…
Examining shortened versions of the Social Responsiveness Scale for use in autism spectrum disorder prediction and as a quantitative trait measure: Results from a validation study of 3-5 year old children
The Social Responsiveness Scale (SRS) is a 65-item measure yielding a continuous score capturing autism-related traits. Scores based on SRS…
Racial/Ethnic Differences in Psychiatric and Medical Diagnoses Among Autistic Adults
Racial/ethnic disparities in access to diagnostic services are pervasive for autistic children. However, a few studies have examined racial/ethnic health…
Associations of Neighborhood Opportunity and Social Vulnerability With Trajectories of Childhood Body Mass Index and Obesity Among US Children
Physical and social neighborhood attributes may have implications for children's growth and development patterns. The extent to which these attributes…
COVID-19 Pandemic Experiences and Symptoms of Pandemic-Associated Traumatic Stress Among Mothers in the US
The primary outcomes of the COVID-19 pandemic on the mental health of women with children remain largely unknown. To identify…
Changes in 24-Hour Movement Behaviors From Early to Late Pregnancy in Individuals With Prepregnancy Overweight or Obesity
Understanding how sleep, sedentary behavior (SED), and physical activity (PA) (24-h movement profile) changes across pregnancy in individuals with prepregnancy…
Plasma Phospholipids Monounsaturated Fatty Acids and Gestational Diabetes Mellitus: a Longitudinal Study in the NICHD Fetal Growth Studies-Singleton Cohort
Fatty acids (FAs) have been implicated in the development of gestational diabetes mellitus (GDM), but the role of monounsaturated FAs…
Associations between accelerated parental biologic age, autism spectrum disorder, social traits, and developmental and cognitive outcomes in their children
Parental age is a known risk factor for autism spectrum disorder (ASD), however, studies to identify the biologic changes underpinning…
Urinary Phenols in Early to Mid-Pregnancy and Risk of Gestational Diabetes: A Longitudinal Study in a Multiracial Cohort
Environmental phenols are ubiquitous endocrine disruptors and putatively diabetogenic. However, data during pregnancy are scant. We investigated the prospective associations…
The clinical burden of extremely preterm birth in a large medical records database in the United States: complications, medication use, and healthcare resource utilization
Approximately 5% of global preterm births are extremely premature (EP), defined as occurring at less than 28?weeks gestational age. Advances…
Efficacious lifestyle interventions for appropriate gestational weight gain in women with overweight or obesity set in the health care system: a scoping review
Purpose: Health care systems offer opportunities to scale up interventions for appropriate gestational weight gain (GWG); however, GWG interventions in…
Antepartum and intrapartum stillbirth rates across gestation: a cross-sectional study using the revised foetal death reporting system in the U.S
There is a renewed call to address preventable foetal deaths in high-income countries, especially where progress has been slow. The…
Sujan, Ayesha
Ayesha Sujan, PhD, is a postdoctoral research fellow in the Kaiser Permanente Division of Research specializing in maternal mental health…
Chehab, Rana
Research interests include maternal and child health and health across the life course.
Mitro, Susanna
Research interests include women’s cardiometabolic health and environmental chemical exposures.
Peterson, Alicia
Research interests include perinatal epidemiology and health disparities.
Badon, Sylvia
Research interests include perinatal epidemiology, specializing in maternal lifestyle during pregnancy.
Ames, Jennifer
Research interests include chronic pain and opioid use.
Brown, Susan
Research interests include behavioral interventions for weight management, physical activity, and dietary change.
Zhu, Yeyi
Interests include developmental origins of childhood obesity and fetal growth
Kubo, Ai
Research interests focus on lifestyle factors and risks of chronic diseases.
Kuzniewicz, Michael W
Research interests include perinatal health services research and perinatal clinical epidemiology
Li, De-Kun
Research interests include pregnancy outcomes and sudden infant death syndrome.
Lieu, Tracy A.
Research interest include child health services research; effectiveness and delivery of primary care; and decision sciences, including decision analysis
Hedderson, Monique M.
Research interests include perinatal epidemiology.
Avalos, Lyndsay
Interests include reproductive and perinatal epidemiology and perinatal depression.
Croen, Lisa A.
Research interests include the epidemiology of autism and other neurodevelopmental disorders.
Ehrlich, Samantha F.
Research interests include epidemiology of gestational diabetes, diabetes and obesity prevention exercise and women's health
Ferrara, Assiamira
Research interests include the epidemiology of diabetes and gestational diabetes.
Association between Quality of Maternal Prenatal Food Source and Preparation and Breastfeeding Duration in the Environmental Influences on Child Health Outcome (ECHO) Program
This study examined the relationship between maternal food source and preparation during pregnancy and the duration of breastfeeding among 751…
Association of serum folate levels during pregnancy and prenatal depression
To evaluate the association between serum folate levels during pregnancy and prenatal depression and the extent to which obesity may…
SEED Follow-Up Study
SEED is a case-control study comparing children aged 2-5 years with autism spectrum disorder to children with other developmental disabilities.…
Medically Attended Influenza During Pregnancy in the 2019-2020 and 2020-2021 Influenza Seasons
Influenza testing and case-confirmation rates in pregnant populations have not been reported during the coronavirus disease 2019 (COVID-19) pandemic. Using…
Geographic Accessibility of Retail Cannabis in Northern California and Prenatal Cannabis Use During the COVID-19 Pandemic
Prenatal cannabis use is associated with health risks for mothers and their children. Prior research suggests that rates of prenatal…
Time to positivity of blood cultures in neonatal late-onset bacteraemia
To determine the time to positivity (TTP) of blood cultures among infants with late-onset bacteraemia and predictors of TTP >36 hours.…
Peri-Pregnancy Cannabis Use and Autism Spectrum Disorder in the Offspring: Findings from the Study to Explore Early Development
The association of autism spectrum disorder (ASD) with self-reported maternal cannabis use from 3 months pre-conception to delivery ("peri-pregnancy") was assessed…
Patterns of Substance Use During Early Pregnancy and Associations With Behavioral Health Characteristics
The aims of the study are to identify patterns of early pregnancy substance use and to examine how these patterns…
Reconciling Between Medication Orders and Medication Fills for Lupus in Pregnancy
Most studies consider either medications ordered or filled, but not both. Medication underuse based on filling data cannot necessarily be…
Gestational diabetes mellitus, prenatal maternal depression, and risk for postpartum depression: an Environmental influences on Child Health Outcomes (ECHO) Study
Prior research has demonstrated bidirectional associations between gestational diabetes mellitus (GDM) and perinatal maternal depression. However, the association between GDM,…
Development and validation of prediction models for gestational diabetes treatment modality using supervised machine learning: a population-based cohort study
Gestational diabetes (GDM) is prevalent and benefits from timely and effective treatment, given the short window to impact glycemic control.…
Strategies Facilitating Video Visit Implementation by a Medical Group Serving a Diverse Population
IntroductionVideo visits have created new opportunities to enhance access to care, but limited information exists on strategies medical groups can…
Racial/ethnic disparities in subjective sleep duration, sleep quality, and sleep disturbances during pregnancy: an ECHO study
In the United States, racial/ethnic minoritized groups experience worse sleep than non-Hispanic Whites (nHW), but less is known about pregnant…
Glycemic Control Trajectories and Risk of Perinatal Complications Among Individuals With Gestational Diabetes
Glycemic control is the cornerstone of gestational diabetes management. Glycemic control trajectories account for differences in longitudinal patterns throughout pregnancy;…
Changes in BMI During the COVID-19 Pandemic
Experts hypothesized increased weight gain in children associated with the coronavirus disease 2019 (COVID-19) pandemic. Our objective was to evaluate…
Maternal autoantibody profiles as biomarkers for ASD and ASD with co-occurring intellectual disability
Maternal autoantibody-related ASD (MAR ASD) is a subtype of autism in which pathogenic maternal autoantibodies (IgG) cross the placenta, access…
Ovarian Cystadenomas: Growth Rate and Reliability of Imaging Measurements
To evaluate the growth rate of benign ovarian cystadenomas and the degree of variability in ultrasound measurements. Two independent retrospective…
Adverse short- and long-term outcomes among infants with mild neonatal encephalopathy
Studies in newborns with mild neonatal encephalopathy (mNE) demonstrated normal outcomes, but recent literature suggests otherwise. This retrospective cohort study…
Examining the Factors for the Rapid Rise of Colorectal Cancer in Young Adults: Does Increased Medical Use of Radiation and Imaging Technology Contribute to the Rise?
This study is examining whether the secular increase in use of medical radiation therapy and diagnostic imaging technology is associated…
Prenatal vitamin intake in first month of pregnancy and DNA methylation in cord blood and placenta in two prospective cohorts
Prenatal vitamin use is recommended before and during pregnancies for normal fetal development. Prenatal vitamins do not have a standard…
In-utero cannabis exposure and long-term psychiatric and neurodevelopmental outcomes: The limitations of existing literature and recommendations for future research
Given increases in cannabis use in pregnancy and animal model research showing effects of in-utero cannabis exposure, high-quality information on…
The clinical burden of extremely preterm birth in a large medical records database in the United States: Mortality and survival associated with selected complications
Preterm birth is a leading cause of infant mortality, particularly for those born extremely prematurely (EP;
Predictive Metabolomic Markers in Early to Mid-Pregnancy for Gestational Diabetes: A Prospective Test and Validation Study
Gestational diabetes mellitus (GDM) predisposes pregnant individuals to perinatal complications and long-term diabetes and cardiovascular diseases. We developed and validated…
Health Behavior Changes during the COVID-19 Pandemic: A Longitudinal Analysis among Children
This longitudinal study compared children's health behaviors before the COVID-19 pandemic versus during the pandemic. This analysis examined the association…
Cardiometabolic Pregnancy Complications in Association with Autism-Related Traits as Measured by the Social Responsiveness Scale in ECHO
Prior work has examined associations between cardiometabolic pregnancy complications and autism spectrum disorder (ASD) but not how these complications may…
Sociodemographic Variation in Children’s Health Behaviors During the COVID-19 Pandemic
Background: Societal changes during the COVID-19 pandemic may affect children's health behaviors and exacerbate disparities. This study aimed to describe…
Reach, acceptability, and perceived success of a telehealth diabetes prevention program among racially and ethnically diverse patients with gestational diabetes: the GEM cluster-randomized trial
Patients with gestational diabetes mellitus and from racial/ethnic minority groups face disproportionate risk for type 2 diabetes. Lifestyle interventions, if…
Coping strategies for COVID-19 pandemic-related stress and mental health during pregnancy
Increased stress has likely contributed to the observed high prevalence of depression and anxiety in pregnant individuals during the COVID-19…
Multi-Chain Semi-Markov Analysis of Intrapartum Cardiotocography
Visual assessment of the evolution of fetal heart rate (FHR) and uterine pressure (UP) patterns is the standard of care…
Associations between combined exposure to environmental hazards and social stressors at the neighborhood level and individual perinatal outcomes in the ECHO-wide cohort
Limited studies examine how prenatal environmental and social exposures jointly impact perinatal health. Here we investigated relationships between a neighborhood-level…
Association Between Prenatal Cannabis Use and Psychotropic Medication Use in Pregnant Patients With Depression and Anxiety
This cross-sectional study examined associations between prenatal cannabis use and prescribed psychotropic medication use among pregnant patients with depression or…
Prevalence of Depression and Anxiety Disorders Following Mild Traumatic Brain Injury
Previous studies have identified an association between traumatic brain injuries and the development of psychiatric disorders in general. However, these…
Maternal Dietary Patterns during Pregnancy and Child Autism-Related Traits: Results from Two US Cohorts
We examined the relationship between maternal intake of established dietary patterns and child autism-related outcomes in two prospective cohorts in…
Placental morphology in association with autism-related traits in the EARLI study
In prior work we observed differences in morphology features in placentas from an autism-enriched cohort as compared to those from…
Impaired fasting glucose in pregnancy: improved perinatal outcomes with active glycemic management
To assess the association between active glycemic management and large for gestational age (LGA) neonates and cesarean delivery (CD) among…
A Web-Based mHealth Intervention With Telephone Support to Increase Physical Activity Among Pregnant Patients With Overweight or Obesity: Feasibility Randomized Controlled Trial
Pregnant patients with overweight or obesity are at high risk for perinatal complications. Excess gestational weight gain (GWG) further exacerbates…
Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression
We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through…
Associations between antenatal corticosteroid exposure and neurodevelopment in infants
It has been well recognized that antenatal administration of dexamethasone to pregnant women at risk of preterm delivery may significantly…
Uptake of guideline-recommended postpartum diabetes screening among diverse women with gestational diabetes: associations with patient factors in an integrated health system in USA
Clinical guidelines urge timely postpartum screening for diabetes among women with gestational diabetes mellitus (GDM), yet patient factors associated with…
Effect of Electronic and Mail Outreach From Primary Care Physicians for COVID-19 Vaccination of Black and Latino Older Adults: A Randomized Clinical Trial
COVID-19 morbidity is highest in Black and Latino older adults. These racial and ethnic groups initially had lower vaccination uptake…
The Association of Prenatal Vitamins and Folic Acid Supplement Intake with Odds of Autism Spectrum Disorder in a High-Risk Sibling Cohort, the Early Autism Risk Longitudinal Investigation (EARLI)
We examined maternal prenatal vitamin use or supplemental folic acid intake during month one of pregnancy for association with autism…
Maternal Serotonergic Antidepressant Use in Pregnancy and Risk of Seizures in Children
To evaluate whether children born to women who use serotonergic antidepressants during pregnancy have higher risk of neonatal seizures and…
The Effect of Readmission for Phototherapy on Early Breast Milk Feeding
To estimate the effect of readmission for inpatient phototherapy on parent-reported exclusive and any breast milk feeding at 2-month well-child…
Prenatal exposure to pesticide residues in the diet in association with child autism-related traits: Results from the EARLI study
Prior work has suggested associations between prenatal exposure to several classes of pesticides and child autism spectrum disorder (ASD). We…
Contribution of Maternal Cardiometabolic Risk Factors to Racial-Ethnicity Disparities in Preterm Birth Subtypes
There are recognized racial-ethnic disparities in preterm birth and in maternal cardiometabolic risk factors likely linked to systemic racism. However,…
Perinatal Complications in Individuals in California With or Without SARS-CoV-2 Infection During Pregnancy
Additional research from population-based studies is needed to inform the treatment of SARS-CoV-2 infection during pregnancy and to provide health…
Motivational Determinants of Postpartum Lifestyle Behaviors, Weight Retention, and Metabolic Syndrome
The proposed study aims to identify affective influences on key lifestyle behaviors (healthy eating and objectively measured self-weighing and physical…
Comparative Effectiveness of Treating Genital Herpes Infection to Reduce Racial Disparities in the Risk of Severe Maternal Morbidity (SMM)
The goals of the study are to determine whether treating GHSV infection in pregnancy, especially earlier in pregnancy, is effective…
The Autism Intervention Research Network on Physical Health (AIR-P) Research Agenda
In the United States, autistic individuals experience disproportionate physical and mental health challenges relative to non-autistic individuals, including higher rates…
Youth Well-being During the COVID-19 Pandemic
The family stress model proposes economic hardship results in caregiver distress and relational problems, which negatively impact youth outcomes. We…
Emotional and Behavioral Problems in Youth with Autism: High Prevalence and Impact on Functioning
Emotional and behavioral problems (EBPs) may co-occur with autism spectrum disorder (ASD) and impair children's functioning beyond autism symptomatology. We…
Intrapartum antibiotics and childhood asthma and allergic rhinitis: a retrospective cohort study
This study aimed to evaluate the association between intrapartum antibiotics (IABX) and asthma and allergic rhinitis among children by ages…
Associations between infant growth and pubertal onset timing in a multiethnic prospective cohort of girls
Early puberty increases risk of adverse health conditions throughout the life course. US girls are experiencing earlier puberty without clear…
A retrospective, observational study on medication for opioid use disorder during pregnancy and risk for neonatal abstinence syndrome
The prevalence of opioid use disorder (OUD) among pregnant women is increasing. Research consistently demonstrates the efficacy of medications for…
Association of Glyburide and Subcutaneous Insulin With Perinatal Complications Among Women With Gestational Diabetes
Nearly 30% of individuals with gestational diabetes (GDM) do not achieve glycemic control with lifestyle modification alone and require medication…
Maternal tobacco smoking and offspring autism spectrum disorder or traits in ECHO cohorts
Given inconsistent evidence on preconception or prenatal tobacco use and offspring autism spectrum disorder (ASD), this study assessed associations of…
Maternal blood metal concentrations and whole blood DNA methylation during pregnancy in the Early Autism Risk Longitudinal Investigation (EARLI)
The maternal epigenome may be responsive to prenatal metals exposures. We tested whether metals are associated with concurrent differential maternal…
Cumulative Lactation and Clinical Metabolic Outcomes at Mid-Life among Women with a History of Gestational Diabetes
Lactation is associated with a lower risk of subsequent cardiometabolic disease among parous women; however, the underlying mechanisms are unknown.…
Predictive Analytics for Newborn Bilirubin Management
Our objective is to integrate the bilirubin risk prediction model into the automated bilirubin assessment in the laboratory results and…
Optimizing a Scalable Intervention to Maximize Guideline-Recommended Diabetes Testing after GDM
We will leverage the multiphase optimization strategy (MOST) to efficiently identify, in a single experiment, which of four components of…
Harnessing Electronic Health Records to Identify Participants and to Study Health Outcomes in Transition-Age Youth and Adults with Autism Spectrum Disorder
The goal of this K18 award is to determine changes in prevalence of common medical and psychiatric conditions and measures…
The Impact of Racial Residential Segregation on the Mental Health of Pregnant Women
We will create a large diverse cohort of more than 360,000 pregnant Black, Hispanic, Asian and white women to: examine…
Understanding the risk of ectopic pregnancies among people seeking abortion: a retrospective case control study
This study aims to assess the incidence of ectopic pregnancy among people wanting pregnancy compared to people seeking abortion. The…
Longitudinal Associations of Plasma Phospholipid Fatty Acids in Pregnancy with Neonatal Anthropometry: Results from the NICHD Fetal Growth Studies-Singleton Cohort
Despite increasing interest in the health effects of polyunsaturated FAs (PUFAs), their roles in fetal and neonatal growth remain understudied.…
Respiratory Viral Infections and Infection Prevention Practices among Women with Acute Respiratory Illness during Delivery Hospitalizations during the 2019-2020 Influenza Season
We conducted a cross-sectional study of pregnant women with acute respiratory illness during delivery hospitalizations during influenza season to describe…
Identifying hypertensive disorders of pregnancy, a comparison of two epidemiologic definitions
Studies of hypertension in pregnancy that use electronic health care data generally identify hypertension using hospital diagnosis codes alone. We…
Maternal and neonatal outcomes of antihypertensive treatment in pregnancy: A retrospective cohort study
To compare maternal and infant outcomes with different antihypertensive medications in pregnancy. Retrospective cohort study. Kaiser Permanente, a large healthcare…
A longitudinal study on associations of moderate-to-vigorous physical activity with plasma monounsaturated fatty acids in pregnancy
Physical activity (PA) during pregnancy influences women and offspring's health via fatty acids metabolism. However, studies on associations of PA…
Rates of cardiovascular events among patients with moderate-to-severe atopic dermatitis in an integrated health care system: A retrospective cohort study
Patients with versus without atopic dermatitis may have a greater risk of cardiovascular events, and the risk increases with severity…
Prenatal Exposure to Ambient Air Pollution and Epigenetic Aging at Birth in Newborns
In utero air pollution exposure has been associated with adverse birth outcomes, yet effects of air pollutants on regulatory mechanisms…
Associations of COVID-19-Related Health, Healthcare and Economic Factors With Prenatal Depression and Anxiety
Objective: This study evaluated whether COVID-19 pandemic-related health, healthcare and economic factors during pregnancy are associated with prenatal depression and…
Contributions of COVID-19 Pandemic-Related Stressors to Racial and Ethnic Disparities in Mental Health During Pregnancy
This study aimed to identify racial and ethnic disparities in prenatal mental health and identify COVID-19 pandemic-related health/healthcare and economic…
A Nation-Wide Swedish Cohort Study on Early Maternal Age at First Childbirth and Risk for Offspring Deaths, Accidents, and Suicide Attempts
In a sample of over one million Swedish first-born offspring, we examined associations between early maternal age at first childbirth…
The Role of Childhood Asthma in Obesity Development: A Nationwide U.S. Multi-cohort Study
Asthma and obesity often co-occur. It has been hypothesized that asthma may contribute to childhood obesity onset. To determine if…
Plasma Acylcarnitines during Pregnancy and Neonatal Anthropometry: A Longitudinal Study in a Multiracial Cohort
As surrogate readouts reflecting mitochondrial dysfunction, elevated levels of plasma acylcarnitines have been associated with cardiometabolic disorders, such as obesity,…
Regional and sociodemographic differences in average BMI among US children in the ECHO program
The aim of this study was to describe the association of individual-level characteristics (sex, race/ethnicity, birth weight, maternal education) with…
Tooth biomarkers to characterize the temporal dynamics of the fetal and early-life exposome
Teeth have unique histology that make this biomatrix a time-capsule for retrospective exposure analysis of fetal and early life. However,…
Changes of Plasma Phospholipid Fatty Acids Profiles in Pregnancy in Relation to the Diagnosis and Treatment of Gestational Diabetes Mellitus
Plasma phospholipid fatty acids (FAs) in early and mid-pregnancy have been prospectively related to gestational diabetes mellitus (GDM) risk. Yet,…
Disparities in Risks of Inadequate and Excessive Intake of Micronutrients during Pregnancy
Inadequate or excessive intake of micronutrients in pregnancy has potential to negatively impact maternal/offspring health outcomes. The aim was to…
Treatment Initiation for New Episodes of Depression in Pregnant Women
This study will use rigorous methods and rich health care data from a diverse, multi-site study population to study psychotherapy…
Update on Phototherapy and Childhood Cancer in a Northern California Cohort
We aimed to reassess the relationship between phototherapy and cancer in an extended version of a previous cohort and to…
Prevalence of prescription opioid use during pregnancy in 8 U.S. health plans during 2001-2014
To estimate prevalence of prescription opioid use during pregnancy in eight US health plans during 2001-2014. We conducted a cohort…
The effect of hospital phototherapy on early breastmilk feeding
The effect of phototherapy on breastmilk feeding is unclear. To estimate the effect of inpatient phototherapy on breastmilk feeding at…
Gastrointestinal Symptoms in 2- to 5-Year-Old Children in the Study to Explore Early Development
Gastrointestinal symptoms (GIS) are commonly reported in children with autism spectrum disorder (ASD). This multi-site study evaluated the prevalence of…
Maternal Proinflammatory Adipokines Throughout Pregnancy and Neonatal Size and Body Composition: A Prospective Study
Increased maternal adiposity and inflammation have impacts on fetal growth. The purpose of this prospective study was to investigate the…
Methods-Motivational Interviewing Approach for Enhanced Retention and Attendance
Suboptimal and differential participant engagement in randomized trials-including retention at primary outcome assessments and attendance at intervention sessions-undermines rigor, internal…
Ultrasound characteristics of early stage high-grade serous ovarian cancer
Survival from ovarian cancer is strongly dependent on the stage at diagnosis. Therefore, when confronted with a woman with an…
Associations of household food insufficiency with childhood depression and anxiety: a nationwide cross-sectional study in the USA
Household food insufficiency (HFIS) is a major public health threat to children. Children may be particularly vulnerable to HFIS as…
Longitudinal Plasma Metabolomics Profile in Pregnancy-A Study in an Ethnically Diverse U.S. Pregnancy Cohort
Amino acids, fatty acids, and acylcarnitine metabolites play a pivotal role in maternal and fetal health, but profiles of these…
Association of Habitual Alcohol Consumption With Long-term Risk of Type 2 Diabetes Among Women With a History of Gestational Diabetes
Women with gestational diabetes are at high risk for type 2 diabetes. Identifying modifiable dietary and lifestyle factors, such as…
Steps per Day and All-Cause Mortality in Middle-aged Adults in the Coronary Artery Risk Development in Young Adults Study
Steps per day is a meaningful metric for physical activity promotion in clinical and population settings. To guide promotion strategies…
Maternal prepregnancy weight and gestational weight gain in association with autism and developmental disorders in offspring
Maternal prepregnancy BMI and gestational weight gain (GWG) are examined in relation to autism spectrum disorder (ASD) and other developmental…
Use of Complete Blood Cell Count Components to Screen for Hereditary Spherocytosis in Neonates
The neonatal hereditary spherocytosis (HS) index, defined as the mean corpuscular hemoglobin concentration divided by the mean corpuscular volume, has…
Longitudinal bidirectional associations of physical activity and depressive symptoms: The CARDIA study
Depression affects many aspects of health and may be attenuated through increases in physical activity. While bidirectional associations between physical…
Improving clinical utility of GAD65 autoantibodies by electrochemiluminescence assay and clinical phenotype when identifying autoimmune adult-onset diabetes
It is important to differentiate the two major phenotypes of adult-onset diabetes, autoimmune type 1 diabetes and non-autoimmune type 2…
Associations of accelerometer-determined sedentary behavior and physical activity with physical performance outcomes by race/ethnicity in older women
To determine the cross-sectional associations of accelerometer-measured time spent in physical activity intensity categories (sedentary, low and high light intensity,…
Lifestyle-related education and counseling resource utilization and cardiovascular biomarkers in midlife women with low physical activity
Health plan-based resources are promising avenues for decreasing cardiovascular disease risk. This study examined associations of lifestyle-related resource utilization within…
Cardiovascular risk and functional burden at midlife: Prospective associations of isotemporal reallocations of accelerometer-measured physical activity and sedentary time in the CARDIA study
Cardiovascular risk and functional burden, or the accumulation of cardiovascular risk factors coupled with functional decline, may be an important…
Maternal Psychiatric Conditions, Treatment With Selective Serotonin Reuptake Inhibitors, and Neurodevelopmental Disorders
This study aims to clarify relationships of maternal psychiatric conditions and selective serotonin reuptake inhibitor (SSRI) use during preconception and…
Associations between longitudinal trajectories of insomnia symptoms and sleep duration with objective physical function in postmenopausal women: the Study of Women’s Health Across the Nation
Examine the association between trajectories of self-reported insomnia symptoms and sleep duration over 13 years with objective physical function. We…
Healthy preconception and early-pregnancy lifestyle and risk of preterm birth: a prospective cohort study
Preterm birth (PTB) remains a leading cause of neonatal mortality and long-term morbidity. Individual factors have been linked to PTB…
A longitudinal study of plasma acylcarnitines throughout pregnancy and associations with risk of gestational diabetes mellitus
Prospective and longitudinal data on the association between acylcarnitines and gestational diabetes (GDM) are lacking. This study aims to prospectively…
Cardiovascular risk and midlife cognitive decline in the Study of Women’s Health Across the Nation
Cardiovascular risk factors in midlife have been linked to late life risk for Alzheimer's disease and related dementias (ADRD). The…
Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and Neurodevelopment – DUPLICATED DO NOT ACTIVATE
This study is evaluating whether in-utero exposures to maternal PFCs and PBDEs, individually and/or in combination, are associated with infant…
mHealth Mindfulness Intervention for Pregnant Black and Latina Women at Risk of Postpartum Depression
This randomized controlled trial of an mHealth mindfulness intervention designed for Black and Latinx pregnant women at risk of developing…
Standardized ultrasound-based risk stratification for detection of ovarian cancer
This project, initiated in 2014, led to the development and large-scale implementation of a system for risk stratifying ovarian abnormalities…
Implementation of large-scale HPV self-testing for cervical cancer screening
The goal of this project is to determine the best strategy for integrating a home-testing option for cervical cancer screening.…
Cervical Cancer Screening Follow-up
This study will use follow-up data on women with cervical specimens collected in the KPNC/NCI HPV biorepository and women in…
Engagement in perinatal depression treatment: a qualitative study of barriers across and within racial/ethnic groups
To better understand previously observed racial/ethnic disparities in perinatal depression treatment rates we examined care engagement factors across and within…
Perceived Barriers and Motivators for Physical Activity in Women With Perinatal Depression
Physical activity (PA) can help reduce depression symptom severity in women with perinatal depression. However, PA is low, and barriers…
Mediating Effects of Cardiometabolic Risk Factors on the Association Between Maternal Race-Ethnicity and Cesarean Delivery Among Low-Risk Women
Background: While racial-ethnic disparities in cesarean delivery rates among nulliparous women delivering a term singleton in the vertex position (NTSV)…
Distributional Properties and Criterion Validity of a Shortened Version of the Social Responsiveness Scale: Results from the ECHO Program and Implications for Social Communication Research
Prior work proposed a shortened version of the Social Responsiveness Scale (SRS), a commonly used quantitative measure of social communication…
Exploring the evidence for epigenetic regulation of environmental influences on child health across generations
Environmental exposures, psychosocial stressors and nutrition are all potentially important influences that may impact health outcomes directly or via interactions…
Pharmacists’ knowledge, perspectives, and experiences with mifepristone dispensing for medication abortion
The U.S. Food and Drug Administration (FDA) restricts dispensing of mifepristone for medication abortion to certified health care providers at…
Genetic and Epigenetic Variations of HPV52 in Cervical Precancer
The goal of this study was to identify human papillomavirus (HPV) type 52 genetic and epigenetic changes associated with high-grade…
Bidirectional associations of accelerometer-derived physical activity and stationary behavior with self-reported mental and physical health during midlife
Moderate-to-vigorous intensity physical activity (MVPA) is associated with favorable self-rated mental and physical health. Conversely, poor self-rated health in these…
A prognostic information system for real-time personalized care: Lessons for embedded researchers
Embedded researchers could play a central role in developing tools to personalize care using electronic medical records (EMRs). However, few…
Bidirectional associations of accelerometer measured sedentary behavior and physical activity with knee pain, stiffness, and physical function: The CARDIA study
The objective was to examine bidirectional associations of accelerometer estimated sedentary time and physical activity with reported knee symptoms. Participants…
Design of the Association of Uterine Perforation and Expulsion of IUD (APEX-IUD) Study: A Multisite Retrospective Cohort Study
Intrauterine devices are effective and safe, long-acting reversible contraceptives, but the risk of uterine perforation occurs with an estimated incidence…
Strategies for optimizing video care in a diverse population
This study will describe factors associated with the effective adoption of video visits in adult and family medicine after the…
The Epidemiology of SARS-CoV-2 in Pregnancy and Infancy (ESPI) Network: ESPI-Electronic Cohort
Multisite study to describe the incidence, clinical presentation, treatment, clinical course, and outcomes of COVID-19 among pregnant women and up…
The Study of Women’s Health Across the Nation (SWAN)
SWAN VI aims to elucidate menopause transition characteristics and trajectories of midlife health markers (inflammation, metabolic and cardiovascular risk factors,…
Blood Pressure, Obesity, and Diabetes in Relation to Perinatal and Postpartum Complications
By leveraging the KPNC Gestational diabetes and Glucose Tolerance Registry, which includes rich data on blood glucose levels, obesity, gestational…
Can hydroxychloroquine prevent preeclampsia and preterm delivery in lupus pregnancy?
Pregnant women with lupus are at high risk to develop preeclampsia and preterm delivery. This work leverages three large population-based…
Maternal Health in Pregnancy and Autism Risk – Genetic and Non-genetic Mechanisms
This study will systematically identify maternal diagnoses in pregnancy associated with autism spectrum disorder (ASD) in offspring; test if the…
Autism Specific Patterns of DNA Methylation from Birth to Age 5
This study will examine potential differences in DNA methylation (DNAm) in early life, from birth through age 5, between children…
Autism Intervention Research Network on Physical Health
Establish an interdisciplinary Autism Intervention Research Network on Physical Health node that will lead, promote, and coordinate national research activities…
Interactions of Environmental Chemical Mixtures, Genetics, and Immune Pathways in Autism Spectrum Disorder
The goal of this K99/R00 Pathway to Independence Award is to receive mentored training in polygenic GWAS tools and complex…
Understanding Barriers to Reproductive Health Care among Women with Autism Spectrum Disorder
This project will examine both reproductive health disparities and OB/GYN health care gaps for 2300 adolescent and adult women with…
Predicting the Need for Phototherapy After Discharge
Bilirubin screening before discharge is performed to identify neonates at risk for future hyperbilirubinemia. The American Academy of Pediatrics recommends…
DISCARDED MEDICATIONS IN VIALS ARE A SYMPTOM OF OUR HEALTH CARE SYSTEM: A CALL TO ACTION
DISCLOSURES: No funding was received for the writing of this letter. All authors were members of the National Academies study…
Evaluation of sex differences in preschool children with and without autism spectrum disorder enrolled in the study to explore early development
Research in school-aged children, adolescents, and adults with autism spectrum disorder (ASD) has found sex-based differences in behavioral, developmental, and…
Prenatal Air Pollution Exposure and Neurodevelopment: A Review and Blueprint for a Harmonized Approach within ECHO
Air pollution exposure is ubiquitous with demonstrated effects on morbidity and mortality. A growing literature suggests that prenatal air pollution…
Physician Stress During Electronic Health Record Inbox Work: In Situ Measurement With Wearable Sensors
Increased work through electronic health record (EHR) messaging is frequently cited as a factor of physician burnout. However, studies to…
Physicians’ electronic inbox work patterns and factors associated with high inbox work duration
Electronic health record systems are increasingly used to send messages to physicians, but research on physicians' inbox use patterns is…
Development and psychometric testing of the AASPIRE Adult Autism Healthcare Provider Self-Efficacy Scale
The adult healthcare system is ill-prepared to provide high-quality care to autistic adults. Lack of provider training may contribute to…
Dual trajectories of physical activity and blood lipids in midlife women: The Study of Women’s Health Across the Nation
Physical activity (PA) has the potential to attenuate cardiovascular disease risk in midlife women through multiple pathways, including improving lipid…
Household mold, pesticide use, and childhood asthma: A nationwide study in the U.S
To investigate the associations of household mold and pesticide use with risk of childhood asthma and examine the potential effect…
Psychometric testing of a set of patient-reported instruments to assess healthcare interventions for autistic adults
Interventions to improve healthcare for autistic adults are greatly needed. To evaluate such interventions, researchers often use surveys to collect…
Healthcare service utilization and cost among transition-age youth with autism spectrum disorder and other special healthcare needs
Youth with autism spectrum disorder often have complex medical needs. Disruptions of healthcare during the transition from pediatric to adult…
Transitioning youth with autism spectrum disorders and other special health care needs into adult primary care: A provider survey
The transition from pediatric to adult care is a critical inflection point for the long-term health of youth with autism…
Maternal health around pregnancy and autism risk: a diagnosis-wide, population-based study
Many studies have reported an increased risk of autism spectrum disorder (ASD) associated with some maternal diagnoses in pregnancy. However,…
A profile and review of findings from the Early Markers for Autism study: unique contributions from a population-based case-control study in California
The Early Markers for Autism (EMA) study is a population-based case-control study designed to learn more about early biologic processes…
mHealth Mindfulness Intervention for Women with Moderate-to-Moderately-Severe Antenatal Depressive Symptoms: a Pilot Study Within an Integrated Health Care System
Traditional mindfulness-based interventions have been shown to reduce depression symptoms in pregnant women, although in-person classes may pose significant accessibility…
Plasma lipidomics profile in pregnancy and gestational diabetes risk: a prospective study in a multiracial/ethnic cohort
Disruption of lipid metabolism is implicated in gestational diabetes (GDM). However, prospective studies on lipidomics and GDM risk in race/ethnically…
Gestational weight gain and adverse pregnancy outcomes by pre-pregnancy BMI category in women with chronic hypertension: A cohort study
It is important to understand relationships of gestational weight gain with adverse pregnancy outcomes in women with chronic hypertension, given…
Persistent organic pollutants and couple fecundability: a systematic review
Despite increasing regulation, exposure to persistent organic pollutants (POPs) remains a serious public health concern due to their accumulation in…
Prenatal Exposure to Mixtures of Phthalates, Parabens, and Other Phenols and Obesity in Five-Year-Olds in the CHAMACOS Cohort
Exposures to phthalates, parabens, and other phenols are often correlated due to their ubiquitous use in personal care products and…
Bayesian Weighted Sums: A Flexible Approach to Estimate Summed Mixture Effects
Methods exist to study exposure mixtures, but each is distinct in the research question it aims to address. We propose…
COVID-19 Related Changes in Health Care Delivery and Health Outcomes Among Pregnant Women and Their Newborns
This study will examine the impacts that COVID-19 pandemic related changes in health care delivery had on health outcomes among…
Barriers to Obstetric/Gynecological Health Care for Women with Autism Spectrum Disorders
This study will identify the sociodemographic and health factors associated with low utilization of obstetrics/gynecology services among adult women with…
Longitudinal Associations of Midlife Accelerometer Determined Sedentary Behavior and Physical Activity With Cognitive Function: The CARDIA Study
Background To determine if accelerometer measured sedentary behavior (SED), light-intensity physical activity (LPA), and moderate-to-vigorous-intensity physical activity (MVPA) in midlife…
Exercise During the First Trimester of Pregnancy and the Risks of Abnormal Screening and Gestational Diabetes Mellitus
To estimate the effects of exercise during the first trimester on the risks of abnormal screening and gestational diabetes mellitus…
The Association Between Maternal Prenatal Fish Intake and Child Autism-Related Traits in the EARLI and HOME Studies
We examined the association between prenatal fish intake and child autism-related traits according to Social Responsiveness Scale (SRS) and cognitive…
Gestational Exposure to Phthalates and Social Responsiveness Scores in Children Using Quantile Regression: The EARLI and HOME Studies
Linear regression is often used to estimate associations between chemical exposures and neurodevelopment at the mean of the outcome. However,…
Associations of diet, physical activity and polycystic ovary syndrome in the Coronary Artery Risk Development in Young Adults Women’s Study
Current evidence supports the adoption of healthy diet and physical activity (PA) behaviors in patients with polycystic ovary syndrome (PCOS),…
Evaluation of Attention Switching and Duration of Electronic Inbox Work Among Primary Care Physicians
Primary care physicians (PCPs) report multitasking during workdays while processing electronic inbox messages, but scant systematic information exists on attention…
Autism-Associated DNA Methylation at Birth From Multiple Tissues Is Enriched for Autism Genes in the Early Autism Risk Longitudinal Investigation
Background: Pregnancy measures of DNA methylation, an epigenetic mark, may be associated with autism spectrum disorder (ASD) development in children.…
Development and Validation of an Obstetric Comorbidity Risk Score for Clinical Use
Background: A comorbidity summary score may support early and systematic identification of women at high risk for adverse obstetric outcomes.…
COVID-19 prevalence, symptoms, and sociodemographic disparities in infection among insured pregnant women in Northern California
Research on COVID-19 during pregnancy has mainly focused on women hospitalized for COVID-19 or other reasons during their pregnancy. Little…
Racial and geographic variation in effects of maternal education and neighborhood-level measures of socioeconomic status on gestational age at birth: Findings from the ECHO cohorts
Preterm birth occurs at excessively high and disparate rates in the United States. In 2016, the National Institutes of Health…
Association between self-reported caffeine intake during pregnancy and social responsiveness scores in childhood: The EARLI and HOME studies
Maternal nutrition during gestation has been investigated for its role in child neurodevelopment. However, little is known about the potential…
Incidence and predictors of type 1 diabetes among younger adults aged 20-45 years: The diabetes in young adults (DiYA) study
To estimate incidence of type 1 diabetes (T1D) and to develop a T1D prediction model among young adults. Adults 20-45 years…
Maternal immune response and air pollution exposure during pregnancy: insights from the Early Markers for Autism (EMA) study
Perinatal exposure to air pollution and immune system dysregulation are two factors consistently associated with autism spectrum disorders (ASD) and…
Prenatal Multivitamin Use and MTHFR Genotype Are Associated with Newborn Cord Blood DNA Methylation
Fetal development involves cellular differentiation and epigenetic changes-complex processes that are sensitive to environmental factors. Maternal nutrient levels during pregnancy…
Rethinking ethical oversight in the era of the learning health system
Opportunities to advance science increasingly arise through investigations embedded within routine clinical practice in the form of learning health systems.…
Maternal Vitamin D Levels During Pregnancy in Association With Autism Spectrum Disorders (ASD) or Intellectual Disability (ID) in Offspring; Exploring Non-linear Patterns and Demographic Sub-groups
Increasing vitamin D deficiency and evidence for vitamin D's role in brain and immune function have recently led to studies…
Antibiotic stewardship for early-onset sepsis
Antibiotics are administered to the vast majority of preterm newborns and to a substantial proportion of term infants in the…
Impact of nulliparity, hypertensive disorders of pregnancy, and gestational diabetes on vasomotor symptoms in midlife women
To determine whether women with a history of nulliparity, hypertensive disorders of pregnancy (HDP), or gestational diabetes mellitus (GDM) have…
Meconium androgens are correlated with ASD-related phenotypic traits in early childhood in a familial enriched risk cohort
Prenatal exposure to increased androgens has been suggested as a risk factor for autism spectrum disorder (ASD). This hypothesis has…
Plasma Phospholipid n-3/n-6 Polyunsaturated Fatty Acids and Desaturase Activities in Relation to Moderate-to-Vigorous Physical Activity through Pregnancy: A Longitudinal Study within the NICHD Fetal Growth Studies
Maternal plasma phospholipid polyunsaturated fatty acids (PUFAs) play critical roles in maternal health and fetal development. Beyond dietary factors, maternal…
A Mobile Health Mindfulness Intervention for Women With Moderate to Moderately Severe Postpartum Depressive Symptoms: Feasibility Study
Approximately 20% of women suffer from postpartum depression (PPD). Due to barriers such as limited access to care, half of…
Translating Research on Diabetes and Obesity in Pregnancy Into Prevention: The 2019 Norbert Freinkel Award Lecture
Epidemiological studies on the intergenerational transmission of hyperglycemia and obesity via in utero exposure have established the scientific foundation for…
Validity of diagnosis and procedure codes for identifying neural tube defects in infants
The use of validated criteria to identify birth defects in electronic healthcare databases can avoid the cost and time-intensive efforts…
Using a 24-Hour Movement Framework to Improve Pregnancy Outcomes
The goal of this K99/R00 Pathway to Independence Award is to better understand associations of 24-hour movement profiles during pregnancy…
Comparing the Effects of Prenatal Depression and its Treatment on Developmental Outcomes of the Offspring
This study will test the hypothesis that the underlying prenatal depression and use of SSRIs are independent risk factors for…
Understanding Racial/Ethnic Disparities in Physical Performance in Mid-Life Women: Findings from SWAN (Study of Women’s Health Across the Nation)
Evaluate degree to which racial/ethnic differences in physical performance are mediated by sociodemographic, health, behavioral, and psychosocial factors. Physical performance…
Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex heritability and higher prevalence in males. The neonatal epigenome has…
Gestational weight gain, birthweight and early-childhood obesity: between- and within-family comparisons
Associations of excessive gestational weight gain (GWG) with greater birthweight and childhood obesity may be confounded by shared familial environment…
Feasibility of Measuring Preferences for Chemotherapy Among Early-Stage Breast Cancer Survivors Using a Direct Rank Ordering Multicriteria Decision Analysis Versus a Time Trade-Off
Chemotherapy is increasingly a preference-based choice among women diagnosed with early-stage breast cancer. Multicriteria decision analysis (MCDA) is a promising…
Variation in physician-directed immunohistochemistry screening among women with endometrial cancer
Immunohistochemistry screening is a reliable method for identifying women with endometrial cancer who are at risk for Lynch syndrome, but…
Cesarean Delivery and the Risk of Allergic Rhinitis in Children
Cesarean delivery (C-section) may influence the infant microbiome and affect immune system development and subsequent risk for allergic rhinitis (AR).…
Nut Consumption and Renal Function Among Women With a History of Gestational Diabetes
Nut intake has been associated with reduced cardiometabolic risk, but few studies have examined its association with renal function. We…
Body mass index versus bioelectrical impedance analysis for classifying physical function impairment in a racially diverse cohort of midlife women: the Study of Women’s Health Across the Nation (SWAN)
Body composition strongly influences physical function in older adults. Bioelectrical impedance analysis (BIA) differentiates fat mass from skeletal muscle mass,…
Racial/Ethnic Disparities in Perinatal Depression Treatment Utilization
The study will characterize racial/ethnic differences in perinatal depression treatment utilization, treatment engagement, and continued care by assembling a retrospective…
Understanding racial-ethnic disparities in preterm birth sub-types and prenatal care utilization
The study will examine racial-ethnic disparities in the risk of preterm birth overall and by preterm birth sub-types. It will…
Study protocol: Using peer support to aid in prevention and treatment in prediabetes (UPSTART)
There is an urgent need to develop and evaluate effective and scalable interventions to prevent or delay the onset of…
Maternal Marijuana Use During Pregnancy, Marijuana Legalization, and Adverse Obstetrical and Neonatal Outcomes: A 12-year Cohort Study (COVID-19 Revision)
As of March 26, 2020, there have been more than 80,000 cases and 1,000 deaths in the US due to…
COVID-19 Response Grant
Adults with intellectual or developmental disabilities may be especially impacted by the ways the COVID-19 pandemic has led to drastic…
Impact of In Utero Marijuana Exposure on Neurodevelopment, Behavior and Mental Health: A Longitudinal Birth Cohort Study
This study will investigate whether maternal prenatal marijuana use increases the risk of impairments in a child's executive functioning and…
Adipokines in early and mid-pregnancy and subsequent risk of gestational diabetes: a longitudinal study in a multiracial cohort
Several adipokines are implicated in the pathophysiology of gestational diabetes mellitus (GDM), however, longitudinal data in early pregnancy on many…
Comparison of two Lynch screening strategies in endometrial cancer in a California health system
Compare detection of Lynch syndrome in endometrial cancer between regions of a health care system with different screening strategies. A…
Time to Positivity of Neonatal Blood Cultures for Early-onset Sepsis
In newborns at risk for early-onset sepsis, empiric antibiotics are often initiated while awaiting the results of blood cultures. The…
Cesarean Delivery and the Risk of Atopic Dermatitis in Children
Caesarean delivery (C-section) may disrupt maternal-infant microbial transfer and alter immune system development and subsequent risk for atopic dermatitis. Investigate…
Breast cancer risk after hysterectomy with and without salpingo-oophorectomy for benign indications
Breast cancer risk has been extensively studied in women with genetic predisposition, i.e. BRCA1/2. Though there are guidelines for performing…
Prenatal bisphenol A exposure, fetal thyroid hormones and neurobehavioral development in children at 2 and 4 years: A prospective cohort study
Findings about the association between prenatal Bisphenol A (BPA) exposure and neurobehavioral development in children are still inconsistent. In addition,…
Alternative Wear-time Estimation Methods Compared to Traditional Diary Logs for Wrist-Worn ActiGraph Accelerometers in Pregnant Women
This study sought to compare three sensor-based wear-time estimation methods to conventional diaries for ActiGraph wGT3X-BT accelerometers worn on the…
Behavioural and psychosocial factors associated with 5-year weight trajectories within the PORTAL Overweight/Obesity Cohort
The purpose of this study was to model weight trajectories over a 5-year time period (2012-2016) and their association with…
A telehealth lifestyle intervention to reduce excess gestational weight gain in pregnant women with overweight or obesity (GLOW): a randomised, parallel-group, controlled trial
Excess gestational weight gain (GWG) among women with overweight or obesity synergistically increases their already elevated risk of having gestational…
Association between Objective Activity Intensity and Heart Rate Variability: Cardiovascular Disease Risk Factor Mediation (CARDIA)
We evaluated the associations between accelerometer-estimated physical activity (PA) intensity and heart rate variability (HRV) and examined mediation of these…
Prenatal Depression and Diet Quality During Pregnancy
Maternal nutrition during pregnancy has a significant effect on the health of the offspring and mother, highlighting the need for…
Comparative Effectiveness of 2 Diabetes Prevention Lifestyle Programs in the Workplace: The City and County of San Francisco Diabetes Prevention Trial
Data on the comparative effectiveness of Diabetes Prevention Programs (DPPs) in the workplace are limited. Between September 2015 and July…
Neurodevelopmental outcomes in infants receiving opioid-replacement
Infants with Neonatal Opioid Withdrawal Syndrome (NOWS) are often treated with prolonged opioid-replacement pharmacotherapy. Whether opioid exposure in-utero or significant…
MAESTRA: Maternal Antecedents of Encephalopathy in Term Infants
This study tests the hypothesis that established NICHD-approved electronic fetal monitoring (EFM) features used as standard care in the U.S. and…
Association of HPV35 with cervical carcinogenesis among women of African ancestry: Evidence of viral-host interaction with implications for disease intervention
HPV35 has been found in only ∼2% of invasive cervical cancers (ICC) worldwide but up to 10% in Sub-Saharan Africa,…
Chronic psychosocial and financial burden accelerates 5-year telomere shortening: findings from the Coronary Artery Risk Development in Young Adults Study
Leukocyte telomere length, a marker of immune system function, is sensitive to exposures such as psychosocial stressors and health-maintaining behaviors.…
Does Centering Pregnancy impact patient satisfaction with prenatal care and maternal health and behavioral outcomes?
This longitudinal study of 350 women seeking prenatal care in Kaiser Permanente Northern California will compare patient satisfaction with prenatal…
A study of type-specific HPV natural history and implications for contemporary cervical cancer screening programs
HPV testing is replacing cytology for cervical cancer screening because of greater sensitivity and superior reassurance following negative tests for…
The Association Between Parental Age and Autism-Related Outcomes in Children at High Familial Risk for Autism
Advanced parental age is a well-replicated risk factor for autism spectrum disorder (ASD), a neurodevelopmental condition with a complex and…
A Study of Partial Human Papillomavirus Genotyping in Support of the 2019 ASCCP Risk-Based Management Consensus Guidelines
The 2019 ASCCP Risk-Based Management Consensus Guidelines include recommendations for partial human papillomavirus (HPV) genotyping in management of abnormal cervical…
Genetic Contributions to Maternal and Neonatal Vitamin D Levels
Vitamin D is essential for several physiological functions and biological processes. Increasing levels of maternal vitamin D are required throughout…
Maternal infection and antibiotic use in pregnancy and the risk of childhood obesity in offspring: a birth cohort study
The reported association between maternal antibiotic use and childhood obesity, if true, could change obstetric practice. However, it is unclear…
Food insecurity and the extremes of childhood weight: defining windows of vulnerability
Weight extremes and food insecurity (FIS) represent public-health challenges, yet their associations in childhood remain unclear. We aimed to investigate…
The impact of breast cancer on physical activity from midlife to early older adulthood and predictors of change post-diagnosis
To examine physical activity (PA) patterns from pre- to post-diagnosis, and compare these changes to women without breast cancer. To…
Association Between Maternal Exposure to Magnetic Field Nonionizing Radiation During Pregnancy and Risk of Attention-Deficit/Hyperactivity Disorder in Offspring in a Longitudinal Birth Cohort
An association between maternal exposure to magnetic field (MF) nonionizing radiation during pregnancy and the risk of attention-deficit/hyperactivity disorder (ADHD)…
Cytological sampling of fallopian tubes using a hysteroscopic catheter: A multi-center study
To assess the feasibility of a novel hysteroscopic catheter to collect fallopian tube cytologic samples and to correlate cytologic findings…
Neonatal Thyroid Stimulating Hormone and Subsequent Diagnosis of Autism Spectrum Disorders and Intellectual Disability
Hypothyroid conditions in early life, if left untreated, are associated with adverse neurodevelopmental outcomes, including intellectual disability (ID). However, evidence…
Understanding childhood obesity in the US: the NIH environmental influences on child health outcomes (ECHO) program
Few resources exist for prospective, longitudinal analysis of the relationships between early life environment and later obesity in large diverse…
Trivalent inactivated influenza vaccine (IIV3) during pregnancy and six-month infant development
Despite recommendations by professional organizations that all pregnant women receive inactivated influenza vaccine, safety concerns remain a barrier. Our objective…
Exercise During the First Trimester and Infant Size at Birth: Targeted Maximum Likelihood Estimation of the Causal Risk Difference
This cohort study sought to estimate the differences in risk of delivering infants who were small or large for gestational…
Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance
HPV16 causes half of cervical cancers worldwide; for unknown reasons, most infections resolve within two years. Here, we analyze the…
The Effect of Gestational Weight Gain Across Reproductive History on Maternal Body Mass Index in Midlife: The Study of Women’s Health Across the Nation
Background: Excessive weight gain during pregnancy is common and has been shown to be associated with increased long-term maternal weight.…
Sexual function, menopausal symptoms, depression and cancer worry in women with BRCA mutations
Assess sexual function, menopausal symptoms, and depression in women with BRCA mutations associated with oophorectomy and menopause status. Women age…
Individualized Relative Intensity Physical Activity Accelerometer Cut-points
Physical activity (PA) intensity is expressed as either absolute or relative intensity. Absolute intensity refers to the energy required to…
Neonatal jaundice in association with autism spectrum disorder and developmental disorder
To examine the association between neonatal jaundice and autism spectrum disorder (ASD) and non-ASD developmental disorder (DD). We analyzed data…
ECHO Coordinating Center: Opportunities and Infrastructure Fund Component
The overall goal of this project is to demonstrate that the newly FDA-approved Airwave Oscillometry System (tremoFlo c-100, Thorasys) can…
Exogenous surfactant utilization for respiratory failure in late and moderately preterm infants: impact on short- and long-term outcomes
The goal is to define and refine the current epidemiology, clinical characteristics, and treatment practices in respiratory failure in late…
Preventing Postpartum Depression: Exercise as Medicine
This intervention study will randomize 200 postpartum women at increased risk of postpartum depression to an eHealth physical activity intervention…
Background rates of maternal, fetal, neonatal, and infant outcomes and events of interest to inform maternal immunization clinical trials
GlaxoSmithKline Vaccines is currently preparing for clinical trials that evaluate the safety/reactogenicity and immunogenicity of a respiratory syncytial virus maternal…
Longitudinal epigenomic study of gestational diabetes mellitus and cardiac structure and function
The goal of this study is to identify epigenetic changes (evaluation of DNA methylation over time) associated with a previous…
Association Between Objective Activity Intensity & Heart Rate Variability: CVD Risk Factor Mediation (CARDIA)
We evaluated the associations between accelerometer-estimated physical activity (PA) intensity and heart rate variability (HRV) and examined mediation of these…
Sex Hormone-binding Globulin, Cardiometabolic Biomarkers, and Gestational Diabetes: A Longitudinal Study and Meta-analysis
This study investigated the prospective associations of circulating levels of sex hormone-binding globulin (SHBG) levels with cardiometabolic biomarkers and risk…
Factors Influencing Participation in Biospecimen Research among Parents of Youth with Mental Health Conditions
Biospecimens are tools that have the potential to improve early identification and treatment for autism spectrum disorders (ASD) and bipolar…
Family Environment, Neurodevelopmental Risk, and the Environmental Influences on Child Health Outcomes (ECHO) Initiative: Looking Back and Moving Forward
The family environment, with all its complexity and diverse components, plays a critical role in shaping neurodevelopmental outcomes in children.…
Leisure Time Physical Activity, Sedentary Time in Pregnancy, and Infant Weight at Approximately 12 Months
Background: Maternal leisure time physical activity (LTPA) and sedentary time during pregnancy may influence programming of infant growth in a…
Plasma Prolactin and Progesterone Levels and the Risk of Gestational Diabetes: A Prospective and Longitudinal Study in a Multiracial Cohort
Objective: Prolactin and progesterone are implicated in glucose homeostasis in and outside of pregnancy. However, their associations with gestational diabetes…
Identifying hypertension in pregnancy using electronic medical records: The importance of blood pressure values
To incorporate blood pressure (BP), diagnoses codes, and medication fills from electronic medical records (EMR) to identify pregnant women with…
Early Life Exposure to Air Pollution and Autism Spectrum Disorder: Findings from a Multisite Case-Control Study
Epidemiologic studies have reported associations between prenatal and early postnatal air pollution exposure and autism spectrum disorder (ASD); however, findings…
Primary Care Physicians’ Experiences With and Strategies for Managing Electronic Messages
The increasing use of electronic communications has enhanced access to physicians for patients and clinical staff. Primary care physicians (PCPs)…
Identifying and Prioritizing Chemicals with Uncertain Burden of Exposure: Opportunities for Biomonitoring and Health-Related Research
The National Institutes of Health's Environmental influences on Child Health Outcomes (ECHO) initiative aims to understand the impact of environmental…
Racial/Ethnic Disparities in the Prevalence of Diabetes and Prediabetes by BMI: Patient Outcomes Research To Advance Learning (PORTAL) Multisite Cohort of Adults in the U.S
To examine racial/ethnic disparities in the prevalence of diabetes and prediabetes by BMI category. In a consortium of three U.S.…
Prenatal Depression and Antidepressant Exposure: Effects on Child Speech and Language Disorders
The aims of this study are to 1) Assess the relationship between untreated prenatal depression and the risk of speech…
Detection of early stage ovarian cancer in a large community cohort
Although detecting ovarian cancer at early stage is a highly meaningful clinical goal, no studies have evaluated early stage disease…
A Prospective Study of Leukocyte Telomere Length and Risk of Gestational Diabetes in a Multiracial Cohort
Short telomere length (TL), an indicator of cellular aging and oxidative stress, has been implicated in glucose homeostasis. Additionally, studies…
Community-based service use in preschool children with autism spectrum disorder and associations with insurance status
ASD-related services can improve outcomes for children, but less is known about service outside of school settings during preschool age.…
Air pollution, neighborhood deprivation, and autism spectrum disorder in the Study to Explore Early Development
To examine whether neighborhood deprivation modifies the association between early life air pollution exposure and autism spectrum disorder (ASD), we…
Infection and Fever in Pregnancy and Autism Spectrum Disorders: Findings from the Study to Explore Early Development
Maternal infection and fever during pregnancy have been implicated in the etiology of autism spectrum disorder (ASD); however, studies have…
Simple Adnexal Cysts: SRU Consensus Conference Update on Follow-up and Reporting.
This multidisciplinary consensus update aligns prior Society of Radiologists in Ultrasound (SRU) guidelines on simple adnexal cysts with recent large…
Fetal Programming of Growth and Obesity: A Metabolomics Approach
This proposal uses a novel holistic framework that leverages both targeted and untargeted metabolomics approach, electronic health records data, and…
Cluster-randomized Trial of a Mobile Health Intervention to Achieve Appropriate Gestational Weight Gain in Overweight and Obese Women
This randomized trial will test whether the implementation of an mHealth tool in the health-plan setting increases the proportion of…
Investigation of Prevalence of and Barriers to Achieving Optimal Glycemic Control among Women with Gestational Diabetes
This project aims to demonstrate that sufficient, high quality glycemic control data are available for investigating the determinants of and…
Risk Prediction of Gestational Diabetes Treatment Modalities Utilizing Clinical and Laboratory Data in the EHR
This study aims to utilize data from the Kaiser Permanente Northern California Gestational Diabetes and Pregnancy Glucose Tolerance Registry for…
Walking for health during pregnancy: A literature review and considerations for future research
Walking is the most commonly chosen type of physical activity (PA) during pregnancy and provides several health benefits to both…
Plasma phospholipid n-3 and n-6 polyunsaturated fatty acids in relation to cardiometabolic markers and gestational diabetes: A longitudinal study within the prospective NICHD Fetal Growth Studies
Despite dietary recommendations of polyunsaturated fatty acids (PUFAs) for cardiometabolic health, n-3 and n-6 PUFAs and their interplay in relation…
Enhanced Recovery After Surgery to Change Process Measures and Reduce Opioid Use After Cesarean Delivery: A Quality Improvement Initiative
To evaluate implementation of an enhanced recovery after surgery (ERAS) program for patients undergoing elective cesarean delivery by comparing opioid…
Prenatal Opioid Exposure: Neurodevelopmental Consequences and Future Research Priorities
Neonatal opioid withdrawal syndrome (NOWS) has risen in prevalence from 1.2 per 1000 births in 2000 to 5.8 per 1000…
Pre- and Early Pregnancy Onset Depression and Subsequent Rate of Gestational Weight Gain
Background:Depression is associated with weight change outside of pregnancy. We assessed associations of prepregnancy or early pregnancy onset depression with…
Bidirectional 10-year associations of accelerometer-measured sedentary behavior and activity categories with weight among middle-aged adults
Although higher sedentary behavior (SB) with low light intensity (LPA) and moderate-to-vigorous intensity physical activity (MVPA) are thought to increase…
A Seat at the Table: Strategic Engagement in Service Activities for Early Career Faculty From Underrepresented Groups in the Academy
Many academic institutions strive to promote more diverse and inclusive campuses for faculty, staff, and students. As part of this…
An Exploratory Examination of Neonatal Cytokines and Chemokines as Predictors of Autism Risk: The Early Markers for Autism Study
The identification of an early biomarker for autism spectrum disorder (ASD) would improve the determination of risk, leading to earlier…
Viral coinfection analysis using a MinHash toolkit
Human papillomavirus (HPV) is a common sexually transmitted infection associated with cervical cancer that frequently occurs as a coinfection of…
A prospective study of artificially sweetened beverage intake and cardiometabolic health among women at high risk
Artificially sweetened beverages (ASBs) are commonly consumed and recommended for individuals at high risk for cardiometabolic diseases; however, the health…
A Randomized Study of Values Affirmation to Promote Interest in Diabetes Prevention Among Women With a History of Gestational Diabetes
The objective of this study was to test whether 2 interventions promote interest in diabetes prevention among women with a…
Understanding periviable birth: A microeconomic alternative to the dysregulation narrative
Periviable infants (i.e., those born in the 20th through 26th weeks of gestation) suffer much morbidity and approximately half die…
Maternal Marijuana Use During Pregnancy, Marijuana Legalization, and Adverse Obstetrical and Neonatal Outcomes: A 12-year Cohort Study
The goal of this application is to examine the association between maternal marijuana use during pregnancy and adverse obstetrical and…
Risk factors for low birth weight among rural and urban Malaysian women
Low birth weight prevalence in Malaysia remains high. Socioeconomic background may lead to differences in physical activity and maternal nutritional…
Associations of pre-pregnancy body mass index, middle-upper arm circumference, and gestational weight gain
An optimal gestational weight gain is essential for maternal health and to reduce adverse birth outcomes. Current guidelines to monitor…
Perceived and objective characteristics of the neighborhood environment are associated with accelerometer-measured sedentary time and physical activity, the CARDIA Study
We investigated cross-sectional and longitudinal associations of neighborhood environment characteristics with accelerometer-measured sedentary time (SED), light-intensity physical activity (LPA), and…
Maternal diabetes and hypertensive disorders in association with autism spectrum disorder
Previous studies have shown complications of pregnancy, often examined in aggregate, to be associated with autism spectrum disorder (ASD). Results…
Newborn vitamin D levels in relation to autism spectrum disorders and intellectual disability: A case-control study in california
Vitamin D deficiency has been increasing concurrently with prevalence of autism spectrum disorders (ASD), and emerging evidence suggests vitamin D…
Strategies for Building Delivery Science in an Integrated Health Care System
Health systems today have increasing opportunities and imperatives to conduct delivery science, which is applied research that evaluates clinical or…
Factors associated with recruitment, surveillance participation, and retention in an observational study of pregnant women and influenza
This report describes the results of recruitment efforts and the subsequent participation of pregnant women in study activities in a…
Epigenetic marks of prenatal air pollution exposure found in multiple tissues relevant for child health
Prenatal air pollution exposure has been linked to many adverse health conditions in the offspring. However, little is known about…
Prenatal exposure to endocrine disrupting chemicals in relation to autism spectrum disorder and intellectual disability
Exposure to endocrine disruptors is unavoidable. Many such compounds are suspected to impact neurologic development of children, but most studies…
Iodinated Contrast Agents and Risk of Hypothyroidism in Young Children in the United States
Although it is generally acknowledged that exposure to iodine contrast agents can interfere with thyroid function, little is known about…
Gestational weight gain and optimal wellness (GLOW): rationale and methods for a randomized controlled trial of a lifestyle intervention among pregnant women with overweight or obesity
Excess gestational weight gain (GWG) is common among women with overweight or obesity, increasing their risks for pregnancy complications, delivering…
Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis…
Poor diet quality in pregnancy is associated with increased risk of excess fetal growth: a prospective multi-racial/ethnic cohort study
Nutritional perturbations during pregnancy may impact fetal and long-term childhood growth, although there are limited data on overall diet quality.…
Shared Antecedents to Preterm Birth and Cardiovascular Disease in Women
This study will conduct a secondary data analysis of CARDIA women that leverages existing data to evaluate the relation of…
Developing a Prognostic Information System for Personalized Care in Real Time
Electronic medical records hold promise to transform clinical practice. However, technological and other barriers may preclude using them to guide…
Maternal Gestational Weight Gain, Obesity, and the Timing of Pubertal Onset in Daughters
Early puberty is associated with adverse health outcomes, but little is known regarding early life determinants influencing pubertal timing. We…
Changes in body composition and weight during the menopause transition
The relation between the menopause transition (MT) and changes in body composition or weight remains uncertain. We hypothesized that, independent…
Health Care Service Utilization and Cost Among Adults with Autism Spectrum Disorders in a U.S. Integrated Health Care System
To compare health care utilization patterns and cost among insured adults with autism spectrum disorder (ASD), adults with attention-deficit and…
Trends in marijuana use among pregnant women with and without nausea and vomiting in pregnancy, 2009-2016
Cross-sectional studies indicate an elevated prevalence of prenatal marijuana use in women with nausea and vomiting in pregnancy (NVP). However,…
Timing of household food insecurity exposures and asthma in a cohort of US school-aged children
Food insecurity is positively associated with asthma, the most common chronic childhood disease, yet directionality is unclear. The objective was…
Human papillomavirus 16 sub-lineage dispersal and cervical cancer risk worldwide: Whole viral genome sequences from 7116 HPV16-positive women
Human papillomavirus (HPV)16 can be separated into genetic sub-lineages (A1-4, B1-4, C1-4, D1-4) which may have differential cervical cancer risk.…
Maternal Pre-pregnancy Body Mass Index and Gestational Weight Gain in Relation to Autism Spectrum Disorder and other Developmental Disorders in Offspring
Most prior studies examining maternal pre-pregnancy body mass index (BMI) in relation to offspring autism spectrum disorders (ASD) have reported…
Pregnancy-Associated Cancer: A U.S. Population-Based Study
The incidence of pregnancy-associated cancer (PAC) is expected to increase as more women delay childbearing until later ages. However, information…
Dietary Quality and Glycemic Control Among Women with Gestational Diabetes Mellitus
Poor dietary quality, measured by the Healthy Eating Index 2010 (HEI-2010), is associated with risk of gestational diabetes mellitus (GDM)…
Atopic Dermatitis Standing Cohort Using a Cohort of Kaiser Permanente Northern California Members
A cohort study of Kaiser Permanente Northern California patients with moderate-to-severe atopic dermatitis (AD) will be used to estimate baseline…
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these…
Motivational Determinants of Postpartum Lifestyle Behaviors, Weight Retention, and Metabolic Syndrome – DUPLICATED DO NOT ACTIVATE
The Pregnancy Environment and Lifestyle Study-2 (PETALS-2) aims to identify psychosocial influences on healthy lifestyle behaviors — such as healthy…
Prenatal exposure to extremely low frequency magnetic field and its impact on fetal growth
Studies on the effect of prenatal exposure to magnetic field (MF) on fetal growth is inconclusive and subject to some…
Bisphenol A Exposure and Sperm ACHE Hydroxymethylation in Men
Exposure to bisphenol A (BPA) has been shown to impact human sperm quality. The epigenetic mechanisms underlying the effect remain…
Associations of Accelerometer-Measured Sedentary Time and Physical Activity With Prospectively Assessed Cardiometabolic Risk Factors: The CARDIA Study
Background Isotemporal substitution examines the effect on health outcomes of replacing sedentary time with light-intensity physical activity or moderate-to-vigorous intensity…
Family history of immune conditions and autism spectrum and developmental disorders: Findings from the study to explore early development
Numerous studies have reported immune system disturbances in individuals with autism and their family members; however, there is considerable variability…
A meta-analysis of two high-risk prospective cohort studies reveals autism-specific transcriptional changes to chromatin, autoimmune, and environmental response genes in umbilical cord blood
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects more than 1% of children in the USA. ASD risk…
Identification and validation of uterine perforation, intrauterine device expulsion, and breastfeeding in four health care systems with electronic health records
To validate algorithms identifying uterine perforations and intrauterine device (IUD) expulsions and to ascertain availability of breastfeeding status at the…
Incremental Cost of Prematurity by Week of Gestational Age
Objective This study was aimed to compare health care costs and utilization at birth through 1 year, between preterm and term…
Diagnostic thresholds for pregnancy hyperglycemia, maternal weight status and the risk of childhood obesity in a diverse Northern California cohort using health care delivery system data
To estimate the risk of childhood obesity associated with the various criteria proposed for diagnosis of gestational diabetes (GDM), and…
A Randomized Controlled Trial of mHealth Mindfulness Intervention for Cancer Patients and Informal Cancer Caregivers: A Feasibility Study Within an Integrated Health Care Delivery System
To assess feasibility and preliminary efficacy of a mobile/online-based (mHealth) mindfulness intervention for cancer patients and their caregivers to reduce…
Links between age at menarche, antral follicle count, and body mass index in African American and European American women
To examine the relationships between age at menarche, antral follicle count (AFC), and body mass index (BMI) in a multi-ethnic…
Infections in children with autism spectrum disorder: Study to Explore Early Development (SEED)
Immune system abnormalities have been widely reported among children with autism spectrum disorder (ASD), which may increase the risk of…
The impact of gene expression profile testing on confidence in chemotherapy decisions and prognostic expectations
Little is known about whether gene expression profile (GEP) testing and specific recurrence scores (e.g., medium risk) improve women's confidence…
Weight estimation among multi-racial/ethnic infants and children aged 0-5·9 years in the USA: simple tools for a critical measure
In resource-constrained facilities or during resuscitation, immediate paediatric weight estimation remains a fundamental challenge. We aimed to develop and validate…
Bisphenol A and pubertal height growth in school-aged children
Bisphenol A (BPA) is an environmental endocrine disruptor and is found in many consumer products. Studies suggest that BPA may…
Brief Report: Maternal Opioid Prescription from Preconception Through Pregnancy and the Odds of Autism Spectrum Disorder and Autism Features in Children
Opioid use during pregnancy is associated with suboptimal pregnancy outcomes. Little is known about child neurodevelopmental outcomes. We examined associations…
Brief Report: Low Rates of Herpesvirus Detection in Blood of Individuals with Autism Spectrum Disorder and Controls
Previous research indicates that infection, especially from viruses in the family Herpesviridae, may play a role in the etiology of…
Expansion of Division of Research Perinatal Research Unit (EXPPRU)
Dedicated quantitative analytic support for obstetrics has not been available in Kaiser Permanente Northern California. An unusual opportunity has appeared:…
Optimizing a Scalable Intervention to Maximize Guideline-recommended Diabetes Testing after Gestational Diabetes Mellitus
Guideline-recommended postpartum screening is a critical step toward diabetes prevention after a diagnosis of gestational diabetes mellitus (GDM). However, patient…
Study on the Association of Uterine Perforation and IUD expulsion With Breastfeeding Status at the Time of IUD insertion and Postpartum Timing of IUD Insertion in Electronic Medical Record Databases – A Post-marketing Requirement for Mirena
The Food and Drug Administration (FDA) has required Bayer AG to conduct a post-marketing study in the U.S. to determine…
Healthy Lifestyle During the Midlife Is Prospectively Associated With Less Subclinical Carotid Atherosclerosis: The Study of Women’s Health Across the Nation
Background Measures of subclinical atherosclerosis are predictors of future cardiovascular outcomes as well as of physical and cognitive functioning. The…
Antenatal and Intrapartum Risk Factors for Hypoxic-Ischemic Encephalopathy in a US Birth Cohort
To identify risk factors for hypoxic-ischemic encephalopathy (HIE) within a recent US birth cohort. In a retrospective cohort study of…
Risk of cardiovascular disease in women with BRCA1 and BRCA2 mutations
Estimate the prevalence of cardiovascular disease risk factors and endpoints in women with BRCA mutations. Women, age 40 and older,…
Maternal exposure to bisphenol A and anogenital distance throughout infancy: A longitudinal study from Shanghai, China
Bisphenol A (BPA) is one of the most common endocrine-disrupting compounds (EDCs) with a ubiquitous presence. Both animal and human…
Central Obesity Increases the Risk of Gestational Diabetes Partially Through Increasing Insulin Resistance
This study examined the associations of central obesity measures, waist to hip ratio (WHR) and waist circumference (WC), in early…
Longitudinal Maternal Vitamin D Status during Pregnancy Is Associated with Neonatal Anthropometric Measures
Findings on maternal 25-hydroxyvitamin D (25[OH]D) and neonatal anthropometry are inconsistent, and may at least be partly due to variations…
Maternal Inflammation during Pregnancy and Neurodevelopmental Disorders
This study will utilize the Pregnancy Cohort from the Kaiser Permanente Northern California Research Program on Genes, Environment and Health…
Prospective Validation of a Standardized Ultrasonography-Based Ovarian Cancer Risk Assessment System
To evaluate the performance of a system that standardizes ovarian cancer risk assessment and reporting on ultrasonography. We conducted a…
Long-term postmenopausal estrogen therapy may be associated with increased risk of breast cancer: a cohort study
Reports of a role of postmenopausal estrogen replacement therapy in the development of breast cancer have been inconsistent. Although many…
Continuation of postmenopausal hormone replacement therapy: comparison of cyclic versus continuous combined schedules
Discontinuation of hormone replacement therapy (HRT) is much more common than what is reported in randomized, double-blind clinical trials. Our…
The Utility and Cross-Validation of a Composite Physical Activity Score in Relation to Cardiovascular Health Indicators: Coronary Artery Risk Development in Young Adults
Single-method assessment of physical activity (PA) has limitations. The utility and cross-validation of a composite PA score that includes reported…
Optimizing Social Communication Measurement with the Social Responsiveness Scale
This project aims to: 1) compare the psychometric characteristics (including distributional properties, agreement with gold-standard diagnostic measures, and sensitivity and…
Incidence and Trend of Ectopic Pregnancy and Contraceptive Use
Incidence and management of ectopic pregnancy have undergone significant changes in recent decades. There is a general consensus that available…
A Pre-Pregnancy Biomarker Risk Score Improves Prediction of Future Gestational Diabetes
Previous studies have not examined the ability of multiple preconception biomarkers, considered together, to improve prediction of gestational diabetes mellitus…
Hyperbilirubinemia, Phototherapy, and Childhood Asthma
Our aim was to quantify the associations of both hyperbilirubinemia and phototherapy with childhood asthma using a population-based cohort with…
Childhood Seizures After Phototherapy
: media-1vid110.1542/5804915133001PEDS-VA_2018-0648Video Abstract BACKGROUND AND OBJECTIVES: In a recent Danish study, researchers found an increased risk of childhood epilepsy after…
Contraception after Abortion and Risk of Repeated Unintended Pregnancy among Health Plan Members
Optimizing access to effective contraception at the time of abortion can reduce repeated unintended pregnancies. To assess contraception initiation and…
The Seveso accident: A look at 40 years of health research and beyond.
A 1976 chemical factory explosion near Seveso, Italy exposed residents to high levels of 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD or dioxin). Dioxin is…
Placental gross shape differences in a high autism risk cohort and the general population
A growing body of evidence suggests that prenatal environment is important in Autism Spectrum Disorder (ASD) etiology. In this study,…
Cross-genetic determination of maternal and neonatal immune mediators during pregnancy
The immune system plays a fundamental role in development during pregnancy and early life. Alterations in circulating maternal and neonatal…
Association of Nausea and Vomiting in Pregnancy With Prenatal Marijuana Use
Use of marijuana, an antiemetic, is increasing among pregnant women,1,2 and data from 2 small surveys3,4 indicate that women self-report…
Association of Bisphenol A Exposure with LINE-1 Hydroxymethylation in Human Semen
Bisphenol A (BPA), an exogenous endocrine-disrupting chemical, has been shown to alter DNA methylation. However, little information is available about…
AHR gene-dioxin interactions and birthweight in the Seveso Second Generation Health Study.
Background: 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) is proposed to interfere with fetal growth via altered activity of the aryl hydrocarbon…
Research Gaps in Gestational Diabetes Mellitus: Executive Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop
The National Institute of Diabetes and Digestive and Kidney Diseases convened a workshop on research gaps in gestational diabetes mellitus…
Breastfeeding and growth during infancy among offspring of mothers with gestational diabetes mellitus: a prospective cohort study
Breastfeeding (BF) may protect against obesity and type 2 diabetes mellitus in children exposed to maternal diabetes in utero, but…
Health Care Utilization in the First Month after Birth and Its Relationship to Newborn Weight Loss and Method of Feeding
Guidelines recommend closer outpatient follow-up for exclusively breastfed newborns, especially those with pronounced weight loss, because of increased risk of…
Scientific abstracts featured research at the 2018 North American Forum on Family Planning
The Society of Family Planning (SFP), Planned Parenthood Federation of America (PPFA), and the Association of Reproductive Health Professionals (ARHP)…
Comparison of Collaborative Versus Single-Site Quality Improvement to Reduce NICU Length of Stay
There is unexplained variation in length of stay (LOS) across NICUs, suggesting that there may be practices that can optimize…
The Relationship Between Prescription Copayments and Contraceptive Adherence in a New-user Cohort
Contraceptive nonadherence is an important contributor to unintended pregnancy in the United States. While the elimination of patient cost sharing…
Gestational Diabetes Mellitus and Renal Function: A Prospective Study With 9- to 16-Year Follow-up After Pregnancy
To examine whether gestational diabetes mellitus (GDM), independent of subsequent diabetes, is an early risk factor for renal impairment long…
Genetic Variants in CPA6 and PRPF31 are Associated with Variation in Response to Metformin in Individuals with Type 2 Diabetes
Metformin is the first-line treatment for type 2 diabetes (T2D). Although widely prescribed, the glucose-lowering mechanism for metformin is incompletely…
A Tailored Letter Based on Electronic Health Record Data Improves Gestational Weight Gain Among Women With Gestational Diabetes: The Gestational Diabetes’ Effects on Moms (GEM) Cluster-Randomized Controlled Trial
Evaluate whether a tailored letter improved gestational weight gain (GWG) and whether GWG mediated a multicomponent intervention's effect on postpartum…
Associations Between Maternal Obesity and Pregnancy Hyperglycemia and Timing of Pubertal Onset in Adolescent Girls: A Population-Based Study
Early puberty is associated with adverse health outcomes. We investigated whether in utero exposure to maternal obesity is associated with…
Associations Between the 2nd to 4th Digit Ratio and Autism Spectrum Disorder in Population-Based Samples of Boys and Girls: Findings from the Study to Explore Early Development
The ratio of the index (2nd) finger to ring (4th) finger lengths (2D:4D) is a proxy for fetal testosterone and…
Maternal sedentary behavior during pre-pregnancy and early pregnancy and mean offspring birth size: a cohort study
Sedentary behavior is associated with adverse health outcomes in the general population. Whether sedentary behavior during pregnancy is associated with…
A Longitudinal Study of Thyroid Markers across Pregnancy and the Risk of Gestational Diabetes
Triiodothyronine (T3) is the biologically-active thyroid hormone involved in glucose metabolism. fT3:fT4 ratio, a marker indicating conversion of free thyroxine…
A prospective and longitudinal study of plasma phospholipid saturated fatty acid profile in relation to cardiometabolic biomarkers and the risk of gestational diabetes
Data on saturated fatty acids (SFAs) in relation to metabolic function and glucose homeostasis remain controversial. Such data are lacking…
Comparison of Two Generations of ActiGraph Accelerometers: The CARDIA Study
This study aimed to examine the comparability of the ActiGraph 7164 and wGT3X-BT wear time, count-based estimates, and average time…
Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study
Abnormal lipid profiles have been associated with gestational diabetes mellitus (GDM), but studies with longitudinal measures of lipids throughout pregnancy…
Large-Scale Implementation of Structured Reporting of Adnexal Masses on Ultrasound
The aim of this article is to describe the development and implementation of structured reporting of adnexal mass findings on…
Recent Intrauterine device use and the risk of precancerous cervical lesions and cervical cancer
Understanding the effect of contraceptives on the development of precancerous lesions of the cervix and cervical cancer may provide information…
Automated Cervical Screening and Triage, Based on HPV Testing and Computer-Interpreted Cytology
State-of-the-art cervical cancer prevention includes human papillomavirus (HPV) vaccination among adolescents and screening/treatment of cervical precancer (CIN3/AIS and, less strictly,…
Improving Post-Discharge Bilirubin Management in Newborns
There is variation and overuse in bilirubin testing among newborns. Multiple repeat testing occurs despite most newborns being at low…
Psychiatric and Medical Conditions in Transition-Aged Individuals With ASD
Children with autism spectrum disorder (ASD) have a variety of medical and psychiatric conditions and an increased use of health…
Efficacy of Subthreshold Newborn Phototherapy During the Birth Hospitalization in Preventing Readmission for Phototherapy
Treatment of jaundiced newborns with subthreshold phototherapy (phototherapy given to newborns with bilirubin levels below those recommended in American Academy…
Association between paternal alcohol consumption before conception and anogenital distance of offspring
There are limited studies on the effects of paternal alcohol consumption, before conception, on the reproductive development of offspring. Anogenital…
Racial disparities in family-provider interactions for pediatric asthma care
Black and Latino children experience significantly worse asthma morbidity than their white peers for multifactorial reasons. This study investigated differences…
Extremely Premature Births Cohort Study
The goal of this study is to understand the incidence of extremely preterm birth and associated adverse health conditions and…
Email Management Strategies and Stress Among Primary Care Physicians
Email between patients and physicians has enhanced health care service but has made many primary care physicians feel overloaded. Many…
Risk Prediction of Gestational Diabetes Treatment Modalities Utilizing Clinical and Laboratory Data in the EHR – DUPLICATED DO NOT ACTIVATE
This study will utilize data from the Kaiser Permanente Northern California Gestational Diabetes and Pregnancy Glucose Tolerance Registry for a…
Associations of overweight/obesity and socioeconomic status with hypertension prevalence across racial and ethnic groups
Racial/ethnic disparities in the prevalence of diagnosed hypertension are persistent but may be partially explained by racial/ethnic differences in weight…
Bone loss in women with BRCA1 and BRCA2 mutations
Estimate the prevalence and identify risk factors for bone loss in women with BRCA mutations. Women, age 40 and older,…
Acute Associations between Outdoor Temperature and Premature Rupture of Membranes
Extreme ambient temperatures have been linked to preterm birth. Preterm premature rupture of membranes is a common precursor to preterm…
Validation of an HPV DNA cervical screening test that provides expanded HPV typing
Background/Purpose As cervical cancer screening shifts from cytology to human papillomavirus (HPV) testing, a major question is the clinical value…
Cost Effectiveness of Gene Expression Profile Testing in Community Practice
Purpose Gene expression profile (GEP) testing can support chemotherapy decision making for patients with early-stage, estrogen receptor-positive, human epidermal growth…
Human Papillomavirus DNA methylation as a biomarker for cervical precancer: Consistency across 12 genotypes and potential impact on management of HPV-positive women
Human papillomavirus (HPV) DNA methylation testing is a promising triage option for women testing HPV-positive during cervical cancer screening. However,…
Impact of Copayment Changes on Children’s Albuterol Inhaler Use and Costs after the Clean Air Act Chlorofluorocarbon Ban
To examine changes in children's albuterol use and out-of-pocket (OOP) costs in response to increased copayments after the Food and…
Pregravid Biomarkers and Risk of Gestational Diabetes Mellitus Risk, Fetal Growth and Progression to Diabetes
This study will examine pregravid biomarkers of metabolic risk (adiponectin, high molecular weight adiponectin, c-reactive protein, liver enzymes, fetuin-A and…
Iodinated Contrast Agents and Risk of Hypothyroidism in Young Children in the United States
This study will estimate the incidence of pulmonary hypothyroid in a pediatric population of children under age 4, based on…
Glyburide Versus Insulin for the Treatment of Women with Gestational Diabetes in Kaiser Permanente Northern California
We aim to compare the effectiveness and safety of glyburide and insulin at improving neonatal and maternal outcomes among women…
Development and Testing of a Mobile-Health (m-health) Intervention tool to Help Obese Women Achieve Appropriate Gestational Weight Gain
To determine whether a mobile-health (m-health) tool (accessible via smartphone or website) intervention for obese pregnant improves patient satisfaction with…
Study to Assess the Incidence of Type 1 Diabetes in Young Adults
This project with multiple principal investigators will address the following aims: 1) Develop and implement a case ascertainment strategy for…
New Opportunities to Prevent Diabetes in the Workplace
The study seeks to compare weight loss outcomes and patient engagement in two interventions derived from Diabetes Prevention Programs.
Comparative Effectiveness of Diabetes Prevention Strategies in Women with Gestational Diabetes Mellitus
It is a cluster randomized lifestyle intervention trial that assesses the effect of an organizational-level intervention on weight management in…
Prenatal Maternal Serum Concentrations of Per- and Polyfluoroalkyl Substances in Association with Autism Spectrum Disorder and Intellectual Disability
Emerging work has examined neurodevelopmental outcomes following prenatal exposure to per- and polyfluoroalkyl substances (PFAS), but few studies have assessed…
Liver Enzymes in Early to Mid-pregnancy, Insulin Resistance, and Gestational Diabetes Risk: A Longitudinal Analysis
Background: Liver enzymes may be implicated in glucose homeostasis; liver enzymes progressively change during pregnancy but longitudinal data during pregnancy…
Case-control meta-analysis of blood DNA methylation and autism spectrum disorder
Several reports have suggested a role for epigenetic mechanisms in ASD etiology. Epigenome-wide association studies (EWAS) in autism spectrum disorder…
A cohort study of maternal cardiometabolic risk factors and primary cesarean delivery in an integrated health system
Maternal cardiometabolic risk factors (i.e., hyperglycemia, pre-existing hypertension and high body mass index) impact fetal growth and risk of having…
Cord blood buffy coat DNA methylation is comparable to whole cord blood methylation
Cord blood DNA methylation is associated with numerous health outcomes and environmental exposures. Whole cord blood DNA reflects all nucleated…
Autism spectrum disorder and birth spacing: Findings from the study to explore early development (SEED)
Previous studies of autism spectrum disorder (ASD) and birth spacing had limitations; few examined phenotypic case subtypes or explored underlying…
Neurocognitive and physical functioning in the Seveso Women’s Health Study.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is neurotoxic in animals but few studies have investigated its effects on the human brain. Related dioxin-like compounds…
Exposure to Magnetic Field Non-Ionizing Radiation and the Risk of Miscarriage: A Prospective Cohort Study
Magnetic field (MF) non-ionizing radiation is widespread and everyone is exposed to some degree. This prospective cohort study of 913…
Autism Adaptive Community-Based Treatment to Improve Outcomes Using Navigators (ACTION) Network
One of the greatest challenges in autism treatment is how to bridge the health care science-to-service gap and address disparities…
Autism risk classification using placental chorionic surface vascular network features
Autism Spectrum Disorder (ASD) is one of the fastest-growing developmental disorders in the United States. It was hypothesized that variations…
Barriers to Health Care in a Latino Population with Autism Spectrum Disorder
This study will identify barriers to the use of recommended assessment, diagnostic, and treatment services among Latino children and adolescents…
Cross-tissue integration of genetic and epigenetic data offers insight into autism spectrum disorder
Integration of emerging epigenetic information with autism spectrum disorder (ASD) genetic results may elucidate functional insights not possible via either…
Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium
Pre-pregnancy maternal obesity is associated with adverse offspring outcomes at birth and later in life. Individual studies have shown that…
Scaling of the surface vasculature on the human placenta
The networks of veins and arteries on the chorionic plate of the human placenta are analyzed in terms of Voronoi…
Offspring risk of obesity in childhood, adolescence and adulthood in relation to gestational diabetes mellitus: a sex-specific association
Animal data suggest sexually dimorphic programming of obesity in response to altered intrauterine environment, but the longitudinal impact of gestational…
Adjuvant gemcitabine-docetaxel chemotherapy for stage I uterine leiomyosarcoma: Trends and survival outcomes
To assess recent trends of administering adjuvant gemcitabine-docetaxel (GD) chemotherapy for Stage I uterine leiomyosarcoma, and to compare disease-free and…
Urine leakage during sexual activity among ethnically diverse, community-dwelling middle-aged and older women
Urinary incontinence is associated with decreased female sexual function, but little is known about the prevalence, predictors, and impact of…
Spontaneous and indicated preterm delivery risk is increased among overweight and obese women without prepregnancy chronic disease
To investigate the independent impact of prepregnancy obesity on preterm delivery among women without chronic diseases by gestational age, preterm…
Maternal and Paternal Infertility Disorders and Treatments and Autism Spectrum Disorder: Findings from the Study to Explore Early Development
Previous studies of associations between ASD and conception using assisted reproductive technology (ART) are inconsistent and few studies have examined…
Prenatal Alcohol Exposure in Relation to Autism Spectrum Disorder: Findings from the Study to Explore Early Development (SEED)
Prenatal alcohol exposure can affect neurodevelopment, but few studies have examined associations with autism spectrum disorder (ASD). We assessed the…
HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis
Although most cervical human papillomavirus type�16 (HPV16) infections become undetectable within 1-2 years, persistent HPV16 causes half of all cervical…
Validation of Self-Reported Diagnosis of Gestational Diabetes at Six Weeks Postpartum
Self-report is often used in identifying gestational diabetes events in epidemiologic studies; however, validity data are limited, with little to…
Prenatal Serum Concentrations of Brominated Flame Retardants and Autism Spectrum Disorder and Intellectual Disability in the Early Markers of Autism Study: A Population-Based Case-Control Study in California
Prior studies suggest neurodevelopmental impacts of polybrominated diphenyl ethers (PBDEs), but few have examined diagnosed developmental disorders. Our aim was…
Rates and Predictors of Vaccinations Among Inflammatory Bowel Disease Patients Receiving Anti-Tumor Necrosis Factor Agents
As an important quality measure, the rates of recommended immunizations among immunocompromised inflammatory bowel disease (IBD) patients in community practice…
Healthy Lifestyle During Early Pregnancy and Risk of Gestational Diabetes Mellitus
Previous studies have found associations between individual healthy behaviors and reduced risk of gestational diabetes mellitus (GDM); however, the association…
Peripubertal dietary flavonol and lignan intake and age at menarche in a longitudinal cohort of girls
BackgroundDietary phytoestrogens may alter hormonal activity in childhood. Flavonols and lignans are the most prevalent phytoestrogens in the Western diet.…
Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study
Animal studies suggest that bisphenol A (BPA) may perturb pubertal development in females. However, evidence from human studies is limited.…
Demographic and Clinical Characteristics Associated with Engagement in Behavioral Health Treatment Among Children with Autism Spectrum Disorders
This study investigates demographic and clinical factors associated with initiation, continuation, and adherence to behavioral health treatment (BHT) among children…
Chronic and Acute Ozone Exposure in the Week Prior to Delivery Is Associated with the Risk of Stillbirth
Chronic and acute air pollution has been studied in relation to stillbirth with inconsistent findings. We examined stillbirth risk in…
Leveraging EHRs for patient engagement: perspectives on tailored program outreach
Electronic health records (EHRs) present healthcare delivery systems with scalable, cost-effective opportunities to promote lifestyle programs among patients at high…
Maternal dietary intakes of refined grains during pregnancy and growth through the first 7 y of life among children born to women with gestational diabetes
Background: Refined grains, a major source of dietary carbohydrates, have been related to impaired glucose homeostasis and obesity. Emerging animal…
Medical Conditions in the First Years of Life Associated with Future Diagnosis of ASD in Children
This study examines medical conditions diagnosed prior to the diagnosis of autism spectrum disorder (ASD). Using a matched case control…
Diabetes and Women’s Health Study: Long Term Health Implications of GDM
To examine the intergenerational impact of hyperglycemia and diet in pregnancy on long-term offspring cardio-metabolic outcomes; and to identify modifiable…
Pathogenesis of Gestational Diabetes
To investigate the etiology for gestational diabetes mellitus and adverse birth outcomes using pathway-driven biomarkers and metabolites in the NICHD…
Maternal consumption of artificially sweetened beverages during pregnancy, and offspring growth through 7 years of age: a prospective cohort study
Artificial sweeteners are widely replacing caloric sweeteners. Data on long-term impact of artificially sweetened beverage (ASB) consumption during pregnancy on…
Variants in Pharmacokinetic Transporters and Glycaemic Response to Metformin: A MetGen Meta-Analysis
Therapeutic response to metformin, a first-line drug for type 2 diabetes (T2D), is highly variable, in part likely due to…
Minimally Invasive Hysterectomy and Power Morcellation Trends in a West Coast Integrated Health System
To examine trends in minimally invasive hysterectomy and power morcellation use over time and associated clinical characteristics. We conducted a…
Understanding Patient Engagement in Lifestyle Programs for Diabetes Prevention among Women with a Recent History of GDM
While lifestyle programs to prevent type 2 diabetes are increasingly available, the drivers of patient engagement in them remain poorly…
Ambient air pollution and risk of gestational hypertension
Air pollution has been linked to hypertension in the general population, but data on gestational hypertension (GH) are limited. We…
Prenatal Exposure to Metals and Risk for Autism Spectrum Disorder in MARBLES and EARLI
The peri-conceptual and prenatal periods of gestation are the most likely window of susceptibility for ASD; thus, maternal exposures and…
Are Health Plan Design and Prior Use of Long-Acting Reversible Contraception Associated with Pregnancy Intention?
In 2007, high-deductible plans were added to the primarily nondeductible Kaiser Permanente Northern California (KPNC) integrated health plan, which had…
Predictors of Breastfeeding Initiation and Maintenance in an Integrated Healthcare Setting
The American Academy of Pediatrics recommends exclusive breastfeeding to age 6 months. Although breastfeeding rates in the United States have…
Health System Integration of Tools to Improve Primary Care for Autistic Adults
The objective of this project is to use a CBPR approach to understand how to best integrate the AASPIRE Healthcare…
Understanding Family Economic Impact of Chronic Child Health Conditions
This study will address an important knowledge gap by estimating financial and time costs for families of children with autism.…
The Pregnancy Environment and Lifestyle Study (PETALS): a population-based longitudinal multi-racial birth cohort
Increasing recognition has been received regarding the proven and suggested links between multi-level environmental exposures on a broad scale (e.g.,…
Maternal healthy lifestyle during early pregnancy and offspring birthweight: differences by offspring sex
PURPOSE: Individual maternal lifestyle factors during pregnancy have been associated with offspring birthweight; however, associations of combined lifestyle factors with…
Outcomes of Admissions for Preterm Labor
Objective This study aims to quantitate the incidence of preterm labor (PTL) admissions and determine the frequency and predictors of…
A Quantitative, Risk-Based Approach to the Management of Neonatal Early-Onset Sepsis
Current algorithms for management of neonatal early-onset sepsis (EOS) result in medical intervention for large numbers of uninfected infants. We…
Risk of NTD among Live Births Exposed to Maternal Rx Opioids during Early Pregnancy
The objectives of this study are: 1) To measure the association between in utero exposure to prescription opioids during early…
Cardiometabolic Risk Factors Among 1.3 Million Adults With Overweight or Obesity, but Not Diabetes, in 10 Geographically Diverse Regions of the United States, 2012-2013
Various phenotypes of overweight and obesity pose various health risks. The objective of this study was to determine the prevalence…
Over-the-Counter Access to Oral Contraceptives for Adolescents
Oral contraceptives (OCs) are used by millions of women in the U.S. The requirement to obtain OCs by prescription from…
A Clinical Prediction Rule for Rebound Hyperbilirubinemia Following Inpatient Phototherapy
The American Academy of Pediatrics provides little guidance on when to discontinue phototherapy in newborns treated for hyperbilirubinemia. We sought…
Polychlorinated Biphenyl and Organochlorine Pesticide Concentrations in Maternal Mid-Pregnancy Serum Samples: Association with Autism Spectrum Disorder and Intellectual Disability
Polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) are neurodevelopmental toxicants, but few studies have examined associations with autism spectrum disorder…
Parents’ Perspectives on How to Improve the Childhood Vaccination Process
Few national studies have asked parents how to improve the childhood vaccination process. We surveyed a nationally representative online panel…
Independent Maternal and Fetal Genetic Effects on Mid-gestational Circulating Levels of Environmental Pollutants
Maternal exposure to environmental pollutants could affect fetal brain development and increase autism spectrum disorder (ASD) risk in conjunction with…
Moderate intensity sports and exercise is associated with glycaemic control in women with gestational diabetes
To assess the association of regular, unsupervised sports and exercise during pregnancy, by intensity level, with glycaemic control in women…
The impact of preterm birth <37 weeks on parents and families: a cross-sectional study in the 2 years after discharge from the neonatal intensive care unit
Little is known about the quality of life of parents and families of preterm infants after discharge from the neonatal…
Feasibility Study to Assess whether Use of Topiramate during Pregnancy Increases the Risk of Cleft Lips/Palates
To conduct a feasibility study to see if topiramate use during pregnancy increases the risk of cleft palates.
Prenatal SSRI Exposure, Maternal and Child Genotype, and Autism Spectrum Disorders
The prevalence of Autism Spectrum Disorders (ASD) has increased rapidly over recent decades. Among many environmental exposures that have also…
Prospective Evaluation of Air Pollution, Cognition and Autism from Birth Onward
This study will examine the relationship between perinatal and early life air pollution exposure and early longitudinal measures of cognitive…
Neurodevelopment of Cognitive Control in Autism: Adolescence to Young Adulthood
This study compares the developmental trajectory of behavioral measures of cognitive control from adolescence into young adulthood in typical individuals…
Prenatal, Intrapartum and Infant Antibiotic Use and Atopic Diseases in Childhood
This study has the following aims: 1) Assess prenatal, intrapartum and infant antibiotic exposure in relation to atopic dermatitis, allergic…
Discovery of Pharmacogenomic Biomarkers for Metformin Response
The primary goal of this multi-site study is to identify genetic variants that impact response to metformin in patients with…
Incidence of Osteoporosis and Abnormal Lipid Profiles in Women Over Age 40, Who Test Positive for a BRCA1 or BRCA2 Mutation and Have Had a Risk-Reducing Salpingo-oophorectomy
This cohort study will use DXA scans to: 1) establish the incidence of abnormal DXA scans in women post testing…
Folic Acid Prevention Pathways for ASD in High Risk Families
Autism spectrum disorders affect 1 in 68 children in the US. There is evidence for a potentially large role for…
Creation of an ASD Family Biobank for Genomic and Epidemiologic Analysis of Autism Spectrum Disorders
The central aim of the ASD Family Biorepository is to act as a resource to promote and facilitate research on…
Kaiser Permanente and Strategic Partners Patient Outcomes Research to Advance Learning (PORTAL)
This network participates in PCORI's Clinical Data Research Network (CDRN) program to enhance the nation's capacity to conduct comparative effectiveness…
Transitioning Pediatric Patients with ASD to Adult Care
This study includes the following aims: 1) Investigate prevalence of medical and psychiatric co-morbidities and rate of service and medication…
Iodinated contrast agents and risk of hypothyroidism in young children
The objective of this study is to estimate the rate of hypothyroidism in children under age 4 years who have…
Study to Assess the Incidence of Type 1 Diabetes in Young Adults – DUPLICATED DO NOT ACTIVATE
This multiple PIs project addresses the following aims: 1. Develop and implement a case ascertainment strategy for the rapid, timely,…
Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and Neurodevelopment
We hypothesize that in-utero exposures to commonly used endocrine disrupting chemicals, such as PFCs and PBDEs, individually and/or in combination,…
Design of study of fetal pharmaceutical use of the 1950s through 70s
This study will explore the feasibility of accessing information on the nature and extent of prenatal pharmaceutical usage in the…
Moderate Hypertension in Pregnancy: Safety and Effectiveness of Treatment
The aims of this study are to: 1. Estimate risks of adverse pregnancy outcomes after antihypertensive medication exposure compared to…
Role of Pre-natal Vitamin D and Gene Interactions in Autism Spectrum Disorders: Leveraging an Existing Case-Control Study
This study is the first to investigate the role of perinatal vitamin D deficiency or insufficiency in ASD etiology, as…
Impact of Folate, Obesity and Genetics on Maternal Depression
Research is desperately needed to inform safe and effective interventions for the prevention and treatment of maternal depression. An important…
Trends and racial and ethnic disparities in the prevalence of pregestational type 1 and type 2 diabetes in Northern California: 1996-2014
Despite concern for adverse perinatal outcomes in women with diabetes mellitus before pregnancy, recent data on the prevalence of pregestational…
The impact of high apparent temperature on spontaneous preterm delivery: a case-crossover study
The impact of high apparent temperature on spontaneous preterm delivery: a case-crossover studyBACKGROUND: Despite the prediction that temperatures are expected…
Newborn Weight Loss During Birth Hospitalization and Breastfeeding Outcomes Through Age 1 Month
Weight loss is universal for exclusively breastfed newborns in the first few days after birth. Many newborns exclusively breastfed during…
Patient perceptions of a decision support tool to assist with young women’s contraceptive choice
Contraceptive decision support tools (DSTs) have been suggested as a way to provide patient-centered contraceptive care, but little is known…
Autism with intellectual disability is associated with increased levels of maternal cytokines and chemokines during gestation
Immune abnormalities have been described in some individuals with autism spectrum disorders (ASDs) as well as their family members. However,…
Engaging At-Risk Minority Women in Health System Diabetes Prevention Programs
The potential for efficacious lifestyle interventions to prevent type 2 diabetes hinges on patient engagement in real-world healthcare settings. Yet…
Comparing Effectiveness of Treating Depression With and Without Comorbidity to Improve Fetal Health
The study is to determine (1) whether treating depression during pregnancy will reduce the risk of adverse pregnancy and pediatric…
Contraceptive Clinical Trials Network – DUPLICATED DO NOT ACTIVATE
The NICHD Contraceptive Clinical Trials Network (CCTN) will consist of up to 16 sites capable of performing female contraceptive clinical…
Medical Burden Associated with Preterm Labor and Preterm Birth in Kaiser Northern California
The aims of this study are to: 1) Characterize women in the Northern California Kaiser Permanente Medical Care Program (KPMCP)…
Effectiveness of Treating Prenatal Depression to Reduce Postpartum Depression
This is a population-based two-stage cohort study that will take advantage of a new KPNC region-wide program of peripartum screening…
Climate Change and Health: Assessing the Risk of Preterm Delivery
The overall objective of this study is to examine the impact of climate change on the risk of preterm delivery…
Feasibility Study to Assess whether Use of Topiramate during Pregnancy Increases the Risk of Cleft Lips/Palates
To conduct a feasibility study to see if topiramate use during pregnancy increases the risk of cleft palates.
California CADDRE-SEED Phase II
The goal of this project is to continue the SEED study, a case-control study of genetic and environmental risk factors…
Prenatal Depression: Registry, Treatment Effectiveness to Reduce Preterm Delivery
The goal of this study is to develop a perinatal depression registry to assess the relationship between prenatal depression and…
Appropriate Gestational Weight Gain in Overweight/Obese Women
Among overweight/obese pregnant women, we propose to develop and evaluate a randomized diet and physical activity intervention tailored to mothers…
Plan B 1.5 Actual Use Emergency Contraception Study
Guidance on the use of data collected for the clinical trial of Protocol DR-LEV-302 for clinical audits with the sponsor,…
Engaging At-Risk Minority Women in Health System Diabetes Prevention Programs – DUPLICATED DO NOT ACTIVATE
The potential for efficacious lifestyle interventions to prevent type 2 diabetes hinges on patient engagement in real-world healthcare settings. Yet…
Comparing Effectiveness of Treating Depression With & Without Comorbidity to Improve Fetal Health
This study is to determine: 1) whether treating depression during pregnancy will reduce the risk of adverse pregnancy and pediatric…
Contraceptive Clinical Trials Network
The NICHD Contraceptive Clinical Trials Network (CCTN) will consist of up to 16 sites capable of performing female contraceptive clinical…
Pharmacogenomics Study of Extreme Response to Metformin
In this collaboration with GlaxoSmithKline, University of California San Francisco and Kaiser Permanente Northern California, we propose to perform a…
Optimizing Personalized Care Using Economic Studies of Genomic Testing
Personalized medicine uses diagnostic tests to improve patient outcomes and reduce harms of therapy. This project's objective is to develop…
Prenatal Bisphenol A Exposure and Risk of Gestational Diabetes
This study will enroll 3,350 pregnant women during their first trimester, among whom a prospective nested case-control study of 300…
Cohort Study of Pioglitazone and Bladder Cancer in Patients with Diabetes
This cohort study examines the possible association of pioglitazone use with the incidence of new bladder cancer in the Kaiser…
Cohort Study of Pioglitazone and Cancer Incidence in Patients with Diabetes Mellitus
The objective of this study is to conduct exploratory analysis of the potential association between treatment with pioglitazone and risk…
Translational Diabetes Prevention in GDM
This is a lifestyle intervention project tailored to pregnant and postpartum women with gestational diabetes (GDM) and designed to reduce…
The impact of maternal factors on the association between temperature and preterm delivery
Few studies have examined maternal modifiers of temperature and adverse birth outcomes because of lack of data. We assessed the…
Urine bisphenol A and pubertal development in boys
Bisphenol A (BPA) is an environmental endocrine disruptor and is found in many consumer products. Animal studies suggest that BPA…
Risk of Type 2 Diabetes Mellitus following Gestational Diabetes Pregnancy in Women with Polycystic Ovary Syndrome
This study examines gestational diabetes mellitus (GDM) in women with polycystic ovary syndrome (PCOS) and the risk of type 2…
Genome-wide alteration in DNA hydroxymethylation in the sperm from bisphenol A-exposed men
Environmental BPA exposure has been shown to impact human sperm concentration and motility, as well as rodent spermatogenesis. However, it…
A Survey of Parents with Children on the Autism Spectrum: Experience with Services and Treatments
Autism spectrum disorders (ASD) are lifelong neurodevelopmental disorders, and little is known about how parents address the health and psychosocial…
Perceived psychosocial stress and gestational weight gain among women with gestational diabetes
Growing evidence links perceived stress-a potentially modifiable psychosocial risk factor-with health behaviors and obesity. Yet little is known about the…
Umbilical cord blood androgen levels and ASD-related phenotypes at 12 and 36 months in an enriched risk cohort study
Autism spectrum disorder (ASD) affects more than 1% of children in the USA. The male-to-female prevalence ratio of roughly 4:1…
Psychotropic Medication Use among Insured Children with Autism Spectrum Disorder
This study examined psychotropic medication use among 7901 children aged 1-17 with autism spectrum disorder (ASD) in five health systems,…
Infection and antibiotic use in infancy and risk of childhood obesity: a longitudinal birth cohort study
Data from previous studies have suggested a possible association between antibiotic use in infancy and risk of childhood obesity, with…
The autism symptom interview, school-age: A brief telephone interview to identify autism spectrum disorders in 5-to-12-year-old children
This study reports on the initial validation of the Autism Symptom Interview (ASI), School-Age, a brief (15-20 min) phone interview…
Placental genetic variations in vitamin D metabolism and birthweight
INTRODUCTION: Vitamin D has pleiotropic functions that regulate fetal growth and development. We investigated associations of common placental genetic variations…
The Changing Epidemiology of Autism Spectrum Disorders
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with lifelong impacts. Genetic and environmental factors contribute to ASD etiology,…
Parental weighting of seizure risks vs. fever risks in vaccination tradeoff decisions
As part of a survey of about vaccination beliefs, a nationally representative sample of parents of young children answered a…
Weight Change Nomograms for the First Month After Birth
Clinicians expect newborns to surpass birth weight by age 10 to 14 days, yet few studies have examined the natural…
Deep sequencing of HPV16 genomes: A new high-throughput tool for exploring the carcinogenicity and natural history of HPV16 infection
For unknown reasons, there is huge variability in risk conferred by different HPV types and, remarkably, strong differences even between…
Prospective Case-Control Study of Abnormal Bleeding after Outpatient Corticosteroid Injection
This study is aimed at evaluating the incidence of bleeding among women having outpatient corticosteroid injection compared to matched controls,…
Differences in testosterone and its precursors by sex of the offspring in meconium
Prenatal metabolism exerts profound effects on development. The first stool of the newborn, meconium, provides a window into the prenatal…
A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin
One-third of type-2 diabetic patients respond poorly to metformin. Despite extensive research, the impact of genetic and nongenetic factors on…
Phototherapy and Risk of Type 1 Diabetes
Increases in both phototherapy use and the incidence of type 1 diabetes mellitus (DM-1) have been reported. One large study…
Pleiotropic Mechanisms Indicated for Sex Differences in Autism
Sexual dimorphism in common disease is pervasive, including a dramatic male preponderance in autism spectrum disorders (ASDs). Potential genetic explanations…
Maternal Exposure to Occupational Asthmagens During Pregnancy and Autism Spectrum Disorder in the Study to Explore Early Development
Maternal immune activity has been linked to children with autism spectrum disorder (ASD). We examined maternal occupational exposure to asthma-causing…
Risk of Autism Associated With Hyperbilirubinemia and Phototherapy
Whether neonatal hyperbilirubinemia and/or phototherapy increase the risk of autism spectrum disorder (ASD) is unclear. We sought to quantify the…
Effects of maternal folic acid supplementation on gene methylation and being small for gestational age
Being small for gestational age (SGA), a foetal growth abnormality, has a long-lasting impact on childhood health. Its aetiology and…
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin
Metformin is the first-line antidiabetic drug with over 100 million users worldwide, yet its mechanism of action remains unclear. Here…
Mismatching Among Guidelines, Providers, and Parents on Controller Medication Use in Children With Asthma
Underuse of controller medicines among children with asthma remains widespread despite national guidelines. To (1) assess provider prescribing patterns for…
HPV16 Sublineage Associations With Histology-Specific Cancer Risk Using HPV Whole-Genome Sequences in 3200 Women
HPV16 is a common sexually transmitted infection although few infections lead to cervical precancer/cancer; we cannot distinguish nor mechanistically explain…
Experience With Opportunistic Salpingectomy in a Large, Community-Based Health System in the United States
To evaluate the trend in uptake of salpingectomy at the time of hysterectomy and assess physicians' attitudes toward the practice.…
Validity of Self-Reported Pre-Pregnancy Weight and Body Mass Index Classification in an Integrated Health Care Delivery System
Self-reported weight prior to pregnancy is prone to error. We utilised a measured pre-conceptional weight from the electronic health record…
Pre-pregnancy adverse lipid profile and subsequent risk of gestational diabetes
Lower low-density lipoprotein (LDL) peak diameter and a predominance of small, dense LDL are associated with type 2 diabetes, but…
Lifestyle behaviors and ethnic identity among diverse women at high risk for type 2 diabetes
Diet and physical activity lifestyle behaviors are modifiable risk factors for type 2 diabetes and are shaped by culture, potentially…
Demographic profile of families and children in the Study to Explore Early Development (SEED): Case-control study of autism spectrum disorder
The Study to Explore Early Development (SEED) is designed to enhance knowledge of autism spectrum disorder characteristics and etiologies. This…
The role of human papillomavirus (HPV) genotyping in cervical cancer screening: A large-scale evaluation of the cobas HPV test
The cobas?HPV Test ("cobas", Roche Molecular Systems) detects HPV16 and HPV18 individually, and a pool of 12 other high-risk (HR)…
Development of a Brief Questionnaire to Assess Contraceptive Intent
We sought to develop and validate an instrument that can enable providers to identify young women who may be at…
Moderate and Vigorous Intensity Exercise During Pregnancy and Gestational Weight Gain in Women with Gestational Diabetes
Objectives To estimate the associations of moderate and vigorous intensity exercise during pregnancy with the rate of gestational weight gain…
Association Between Laboratory Calibration of a Serum Bilirubin Assay, Neonatal Bilirubin Levels, and Phototherapy Use
The American Academy of Pediatrics treatment recommendations for neonatal jaundice are based on age-specific total serum bilirubin (TSB) levels. In…
Leisure Time Physical Activity and Gestational Diabetes Mellitus in the Omega Study
PURPOSE: Findings of studies investigating associations of leisure time physical activity (LTPA) with gestational diabetes mellitus (GDM) risk have been…
Neonatal Phototherapy and Infantile Cancer
To determine whether neonatal phototherapy is associated with cancer in the first year after birth. We analyzed a data set…
Retrospective Cohort Study of Phototherapy and Childhood Cancer in Northern California
To investigate the association between neonatal phototherapy use and childhood cancer. This retrospective cohort study included 499?621 children born at…
Perinatal Obstetric Office Depression Screening and Treatment: Implementation in a Health Care System
Perinatal depression affects between 12% and 20% of pregnant and postpartum women and is underdiagnosed. The American College of Obstetricians…
Improved Perinatal Depression Screening, Treatment, and Outcomes With a Universal Obstetric Program
To evaluate whether universal prenatal and early postnatal screening for depression leads to increased detection, subsequent intervention, and improved depressive…
Breast cancer multigene testing trends and impact on chemotherapy use
A 21-gene test that predicts recurrence risk among women with hormone receptor positive (HR+), localized breast cancer was nationally recommended…
A Description of Midlife Women Experiencing Intimate Partner Violence Using Electronic Medical Record Information
Intimate partner violence (IPV) is an important health problem affecting women of all ages, but is often not addressed during…
Maternal mid-pregnancy C-reactive protein and risk of autism spectrum disorders: the early markers for autism study
Maternal pregnancy levels of the inflammatory marker C-reactive protein (CRP) has been previously associated with autism spectrum disorder (ASD) in…
Building the new schoolhouse: the Massachusetts school building authority.
In a 2010 special issue of New Solutions on school health and environment, Paulson and Barnett asked who is responsible…
Sewer Gas: An Indoor Air Source of PCE to Consider During Vapor Intrusion Investigations.
The United States Environmental Protection Agency (USEPA) is finalizing its vapor intrusion guidelines. One of the important issues related to…
Field data and numerical modeling: A multiple lines of evidence approach for assessing vapor intrusion exposure risks.
USEPA recommends a multiple lines of evidence approach to make informed decisions at vapor intrusion sites because the vapor intrusion…
Health Services Utilization Among Children With and Without Autism Spectrum Disorders
Using data from multiple health systems (2009-2010) and the largest sample to date, this study compares health services use among…
HPV16 methyl-haplotypes determined by a novel next-generation sequencing method are associated with cervical precancer
AbstractWe have developed and evaluated a next-generation bisulfite sequencing (NGS) assay to distinguish HPV16 cervical precancer (CIN2-3; N=59) from HPV16-positive…
The Value of Ultrasound Monitoring of Adnexal Masses for Early Detection of Ovarian Cancer
Although ultrasound has so far been found to be ineffective as a screening tool for ovarian cancer, it is commonly…
Is heart rate variability associated with frequency and intensity of vasomotor symptoms among healthy perimenopausal and postmenopausal women?
Research has suggested that the autonomic nervous system (ANS) is involved in the experience of vasomotor symptoms (VMS) during menopause.…
Trimethoprim-sulfonamide use during the first trimester of pregnancy and the risk of congenital anomalies
Sulfonamide antibacterials are widely used in pregnancy, but evidence about their safety is mixed. The objective of this study was…
Growth and obesity through the first 7 years of life in association with levels of maternal glycemia during pregnancy: a prospective cohort study
BACKGROUND: Given the long-term adverse sequelae of childhood obesity, identification of early life factors related to fetal growth and childhood…
Interacting effects of obesity, race, ethnicity and sex on the incidence and control of adult-onset asthma
To improve care and control for patients with adult-onset asthma, a better understanding of determinants of their risk and outcomes…
Building a Governance Strategy for CER: The Patient Outcomes Research to Advance Learning (PORTAL) Network Experience
The Patient Outcomes Research to Advance Learning (PORTAL) Network was established with funding from the Patient-Centered Outcomes Research Institute (PCORI)…
Maternal Leisure Time Physical Activity and Infant Birth Size
BACKGROUND: Associations of maternal leisure time physical activity with birth size are inconsistent. Roles of infant sex and maternal prepregnancy…
Prevalence of Gestational Diabetes and Risk of Progression to Type 2 Diabetes: A Global Perspective
Despite the increasing epidemic of diabetes mellitus affecting populations at different life stages, the global burden of gestational diabetes mellitus…
Occult Uterine Sarcoma and Leiomyosarcoma: Incidence of and Survival Associated With Morcellation
To estimate the incidence of occult uterine sarcoma and leiomyosarcoma in hysterectomies for leiomyomas and the risk associated with their…
The Comparative Effectiveness of Diabetes Prevention Strategies to Reduce Postpartum Weight Retention in Women With Gestational Diabetes Mellitus: The Gestational Diabetes’ Effects on Moms (GEM) Cluster Randomized Controlled Trial
To compare the effectiveness of diabetes prevention strategies addressing postpartum weight retention for women with gestational diabetes mellitus (GDM) delivered…
Altered Gut Microbiota Composition Associated with Eczema in Infants
Eczema is frequently the first manifestation of an atopic diathesis and alteration in the diversity of gut microbiota has been…
Peripheral Blood Leukocyte Production of BDNF following Mitogen Stimulation in Early Onset and Regressive Autism
Brain-derived neurotrophic factor (BDNF) is critical for neuronal differentiation and synaptic development. BDNF is also implicated in the development of…
Trimester-Specific Gestational Weight Gain and Infant Size for Gestational Age
Gestational weight gain is known to influence fetal growth. However, it is unclear whether the associations between gestational weight gain…
The Patient Outcomes Research To Advance Learning (PORTAL) Network Adult Overweight and Obesity Cohort: Development and Description
The Patient-Centered Outcomes Research Institute (PCORI) created a new national network infrastructure to enable large-scale observational comparative effectiveness research across…
Prenatal and Newborn Immunoglobulin Levels from Mother-Child Pairs and Risk of Autism Spectrum Disorders
An etiological role for immune factors operating during early brain development in children with autism spectrum disorders (ASD) has not…
Predictors of impact of vaginal symptoms in postmenopausal women
This study aims to identify factors associated with greater impact of vaginal symptoms on the functioning and well-being of postmenopausal…
Presence of an epigenetic signature of prenatal cigarette smoke exposure in childhood
Prenatal exposure to tobacco smoke has lifelong health consequences. Epigenetic signatures such as differences in DNA methylation (DNAm) may be…
Lactation and Progression to Type 2 Diabetes Mellitus After Gestational Diabetes Mellitus: A Prospective Cohort Study
Lactation improves glucose metabolism, but its role in preventing type 2 diabetes mellitus (DM) after gestational diabetes mellitus (GDM) remains…
Maternal Infection During Pregnancy and Autism Spectrum Disorders
We conducted a nested case-control study including 407 cases and 2,075 frequency matched controls to investigate the association between maternal…
A Study of Physician Knowledge and Experience with Autism in Adults in a Large Integrated Healthcare System
We conducted an online survey of adult health care providers at Kaiser Permanente Northern California and semi-structured interviews with a…
External Validation of Early Weight Loss Nomograms for Exclusively Breastfed Newborns
Nomograms that show hour-by-hour percentiles of weight loss during the birth hospitalization were recently developed to aid clinical care of…
Associations of Early and Late Gestational Weight Gain with Infant Birth Size
OBJECTIVES: Associations of gestational weight gain (GWG) during specific periods of pregnancy with infant birth size have been inconsistent. Infant…
Relationship between self-reported residential indoor remodeling and semen quality: a case-control study
The present study examined the association between residential indoor remodeling and poor semen quality. Sperm donors aged 18-45 years old…
Incidence of Dravet Syndrome in a US Population
De novo mutations of the gene sodium channel 1? (SCN1A) are the major cause of Dravet syndrome, an infantile epileptic…
Thyroid Hormones and Moderate Exposure to Perchlorate during Pregnancy in Women in Southern California
Findings from national surveys suggest that everyone in the US is exposed to perchlorate. At high doses, perchlorate, thiocyanate, and…
The health status of adults on the autism spectrum
Compared to the general pediatric population, children with autism have higher rates of co-occurring medical and psychiatric illnesses, yet very…
Autism Spectrum Disorder Symptoms Among Children Enrolled in the Study to Explore Early Development (SEED)
This study examined the phenotypic profiles of children aged 30-68 months in the Study to Explore Early Development (SEED). Children classified…
Associations between Bisphenol A Exposure and Reproductive Hormones among Female Workers
The associations between Bisphenol-A (BPA) exposure and reproductive hormone levels among women are unclear. A cross-sectional study was conducted among…
Potential harms outweigh benefits of indefinite monitoring of stable adnexal masses
The management of women with asymptomatic adnexal masses should aim to balance potential benefit with potential harm. While masses with…
Risk of Sensorineural Hearing Loss and Bilirubin Exchange Transfusion Thresholds
High bilirubin levels are associated with sensorineural hearing loss (SNHL). However, few large studies of relative and excess risk exist.…
Prevalence and Predictors of Complementary and Alternative Medicine Use in a Large Insured Sample of Children with Autism Spectrum Disorders
The purpose of the present study was to examine the prevalence and predictors of complementary and alternative medicine (CAM) use…
Neonatal Neurocritical Care Service Is Associated With Decreased Administration of Seizure Medication
This cohort study examines medication use in term neonates with hypoxic-ischemic encephalopathy and seizures before and after implementation of a…
Paternal sperm DNA methylation associated with early signs of autism risk in an autism-enriched cohort
Epigenetic mechanisms such as altered DNA methylation have been suggested to play a role in autism, beginning with the classical…
Pooled Analysis of Six Pharmacologic and Nonpharmacologic Interventions for Vasomotor Symptoms
To describe the effects of six interventions for menopausal vasomotor symptoms relative to control in a pooled analysis, facilitating translation…
Validation of Autism Spectrum Disorder Diagnoses in Large Healthcare Systems with Electronic Medical Records
To identify factors associated with valid Autism Spectrum Disorder (ASD) diagnoses from electronic sources in large healthcare systems. We examined…
Effects of estrogen and venlafaxine on menopause-related quality of life in healthy postmenopausal women with hot flashes: a placebo-controlled randomized trial
This study aims to evaluate the effects of low-dose estradiol (E2) or venlafaxine on menopause-related quality of life and associated…
The Association Between Influenza Vaccination and Other Preventative Health Behaviors in a Cohort of Pregnant Women
Although pregnant women are a high-priority group for seasonal influenza vaccination, vaccination rates in this population remain below target levels.…
Asthma Treatments and Mental Health Visits After a Food and Drug Administration Label Change for Leukotriene Inhibitors
In 2009, the US Food and Drug Administration (FDA) mandated a label change for leukotriene inhibitors (LTIs) to include neuropsychiatric…
Factors Associated with Seasonal Influenza Vaccination in Pregnant Women
This observational study followed a cohort of pregnant women during the 2010-2011 influenza season to determine factors associated with vaccination.…
Immune mediated conditions in autism spectrum disorders
We conducted a case-control study among members of Kaiser Permanente Northern California (KPNC) born between 1980 and 2003 to determine…
Results of a Pilot Study using Self-Collected Mid-Turbinate Nasal Swabs for Detection of Influenza Virus Infection among Pregnant Women
We evaluated the feasibility of asking pregnant women to self-collect and ship respiratory specimens. In a preliminary laboratory study, we…
Early weight loss nomograms for formula fed newborns
To develop nomograms depicting percentiles of weight loss by hour of age for both vaginal and cesarean-delivered newborns who are…
A Vaccine Study Design Selection Framework for the Postlicensure Rapid Immunization Safety Monitoring Program
The Postlicensure Rapid Immunization Safety Monitoring Program, the vaccination safety monitoring component of the US Food and Drug Administration's Mini-Sentinel…
Maternal caffeine intake during pregnancy and risk of obesity in offspring: a prospective cohort study
In-utero exposures through adverse fetal programming are emerging as an important contributing factor to the epidemic of childhood obesity. This…
A Randomized Clinical Trial of Therapeutic Hypothermia Mode during Transport for Neonatal Encephalopathy
To determine if temperature regulation is improved during neonatal transport using a servo-regulated cooling device when compared with standard practice.…
Reproductive health outcomes of insured adolescent and adult women who access oral levonorgestrel emergency contraception
To assess the level of risk for adolescents and women who seek emergency contraception through various clinical routes and the…
Topiramate use during pregnancy and major congenital malformations in multiple populations
We measured birth prevalence of major congenital malformations (MCMs) after topiramate use during pregnancy to screen for a possible signal…
Simple physical performance measures and vascular health in late midlife women: the Study of Women’s Health across the nation
Physical performance measures have been shown to predict mortality and incident cardiovascular disease (CVD) mainly in elderly populations. We evaluated…
Parents’ Choices and Rationales for Alternative Vaccination Schedules: A Qualitative Study
A growing number of parents adopt alternative vaccination schedules for their children. A better understanding of parents' rationales for these…
Risk for Cerebral Palsy in Infants With Total Serum Bilirubin Levels at or Above the Exchange Transfusion Threshold: A Population-Based Study
Exchange transfusion is recommended for newborns with total serum bilirubin (TSB) levels thought to place them at risk for cerebral…
Prenatal and Neonatal Thyroid Stimulating Hormone Levels and Autism Spectrum Disorders
Thyroid hormones are critical for normal brain development. This study examined autism spectrum disorders (ASD) and thyroid stimulating hormone (TSH)…
Exposure to bisphenol-A and reproductive hormones among male adults
Bisphenol A (BPA) is a suspected human endocrine disruptor which is widely used. In order to determine whether urine BPA…
Increased female autosomal burden of rare copy number variants in human populations and in autism families
Autosomal genetic variation is presumed equivalent in males and females and makes a major contribution to disease risk. We set…
Primary Adherence to Controller Medications for Asthma is Poor
Few previous studies have evaluated primary adherence (whether a new prescription is filled within 30 d) to controller medications in…
Geographic Clusters in Underimmunization and Vaccine Refusal
Parental refusal and delay of childhood vaccines has increased in recent years and is believed to cluster in some communities.…
Severity of influenza and non-influenza acute respiratory illness among pregnant women, 2010-12
The objective of the study was to identify characteristics of influenza illness contrasted with noninfluenza acute respiratory illness (ARI) in…
Antidepressant medication use, depression, and the risk of preeclampsia
To assess the effects of depression and antidepressant medication use during pregnancy on the risk of preeclampsia. We conducted a…
Recent evidence exploring the associations between physical activity and menopausal symptoms in midlife women: perceived risks and possible health benefits
Although the health benefits of physical activity are well established, the prevalence of midlife women accumulating sufficient physical activity to…
A STUDY OF GENOTYPING FOR THE MANAGEMENT OF HUMAN PAPILLOMAVIRUS-POSITIVE, CYTOLOGY-NEGATIVE CERVICAL SCREENING RESULTS
The effective management of women with human papillomavirus (HPV)-positive, cytology-negative results is critical to the introduction of HPV testing into…
Early weight loss nomograms for exclusively breastfed newborns
The majority of newborns are exclusively breastfed during the birth hospitalization, and weight loss is nearly universal for these neonates.…
The burden of nocturia among middle-aged and older women
To examine the prevalence, predictors, and effects of nocturia in women and evaluate overlaps with established urinary tract disorders. This…
Outcomes from ultrasound follow-up of small complex adnexal masses in women over 50
The discovery of a complex adnexal mass in an older woman often raises concern for cancer. We evaluate outcomes for…
Genital herpes and its treatment in relation to preterm delivery
To examine the risks of genital herpes and antiherpes treatment during pregnancy in relation to preterm delivery (PTD), we conducted…
Familial Recurrence of Autism Spectrum Disorder: Evaluating Genetic and Environmental Contributions
This study was designed to examine the pattern of familial recurrence of autism spectrum disorder (ASD) in terms of genetic…
Trends in Elective Labor Induction for Six United States Health Plans, 2001-2007
To describe trends in labor induction, including elective induction, from 2001 to 2007 for six U.S. health plans and to…
Maternal Hyperglycemia During Pregnancy Predicts Adiposity of the Offspring
To investigate associations between maternal pregnancy hyperglycemia, gestational diabetes mellitus (GDM), and offspring adiposity. We evaluated these associations in a…
The Impact of Multimorbidity on Sexual Function in Middle-Aged and Older Women: Beyond the Single Disease Perspective
Little is known about sexual activity and function in women with multiple chronic health conditions. To examine the impact of…
Topiramate use in pregnancy and the birth prevalence of oral clefts
First marketed in the USA in 1996, topiramate (TPM) is an antiepileptic drug later approved for migraine prophylaxis, and in…
Volume and Type of Alcohol During Early Pregnancy and the Risk of Miscarriage
Research on alcohol consumption during pregnancy and miscarriage spans over three decades, yet the relationship is still not well-understood. To…
Use of leukotriene receptor antagonists are associated with a similar risk of asthma exacerbations as inhaled corticosteroids
Based on results of clinical trials, inhaled corticosteroids (ICS) are the most-effective controller medications for preventing asthma-related exacerbations, yet few…
Incidence, Etiology, and Outcomes of Hazardous Hyperbilirubinemia in Newborns
Total serum bilirubin (TSB) levels ? 30 mg/dL are rare but potentially hazardous. A better understanding of their incidence, causes,…
Maternal gestational weight gain and offspring risk for childhood overweight or obesity
The objective of the study was to evaluate the association between gestational weight gain, per the 2009 Institute of Medicine…
Genetic Variants in Transcription Factors Are Associated With the Pharmacokinetics and Pharmacodynamics of Metformin
One-third of type 2 diabetes patients do not respond to metformin. Genetic variants in metformin transporters have been extensively studied…
Genetic risk score for prediction of newborn adiposity and large-for-gestational-age birth
CONTEXT: Macrosomic infants are at increased risk for adverse metabolic outcomes. Improving prediction of large-for-gestational-age (LGA) birth may help prevent…
Evidence of Reproductive Stoppage in Families With Autism Spectrum Disorder: A Large, Population-Based Cohort Study
Few studies have examined the curtailment of reproduction (ie, stoppage) after the diagnosis of a child with autism spectrum disorder…
Prenatal and neonatal peripheral blood mercury levels and autism spectrum disorders
Prenatal and early-life exposures to mercury have been hypothesized to be associated with increased risk of autism spectrum disorders (ASDs).…
Lactation intensity and fasting plasma lipids, lipoproteins, non-esterified free fatty acids, leptin and adiponectin in postpartum women with recent gestational diabetes mellitus: The SWIFT cohort
Lactation may influence future progression to type 2 diabetes after gestational diabetes mellitus (GDM). However, biomarkers associated with progression to…
Prenatal and perinatal risk factors in a twin study of autism spectrum disorders
Multiple studies associate prenatal and perinatal complications with increased risks for autism spectrum disorders (ASDs). The objectives of this study…
Post-partum weight loss and glucose metabolism in women with gestational diabetes: the DEBI Study
Women with gestational diabetes are at high risk for developing diabetes; post-partum weight loss may reduce the risk of diabetes.…
Pregravid Liver Enzyme Levels and Risk of Gestational Diabetes During a Subsequent Pregnancy
Liver enzymes are independent predictors of type 2 diabetes. Although liver fat content correlates with features of insulin resistance, a…
Low-Dose Estradiol and the Serotonin-Norepinephrine Reuptake Inhibitor Venlafaxine for Vasomotor Symptoms: A Randomized Clinical Trial
Estrogen therapy is the gold standard treatment for hot flashes and night sweats, but some women are unable or unwilling…
Prevention of Vertical Transmission of Hepatitis B: An Observational Study
For mothers with chronic hepatitis B virus (HBV) infection, the Centers for Disease Control and Prevention recommends immunoprophylaxis to decrease…
Proteinuria testing among patients with diabetes mellitus is associated with bladder cancer diagnosis: potential for unmeasured confounding in studies of pioglitazone and bladder cancer
The observed association between pioglitazone and bladder cancer could be causal or because of bias in the design of prior…
Determining Source Strength of Semivolatile Organic Compounds using Measured Concentrations in Indoor Dust
Consumer products and building materials emit a number of semivolatile organic compounds (SVOCs) in the indoor environment. Because indoor SVOCs…
Safety of influenza vaccination during pregnancy: A review of subsequent maternal obstetric events and findings from two recent cohort studies
Pregnant women and their infants are vulnerable to severe disease and secondary complications from influenza infection. For this reason, annual…
Adaptation of the ‘ten questions’ to screen for autism and other neuro-developmental disorders in Uganda
Neurodevelopmental disorders are recognized to be relatively common in developing countries but little data exist for planning effective prevention and…
Does antidepressant exposure in pregnancy affect maternal serum markers for aneuploidy?
The objective of this study was to examine the effect of maternal antidepressant exposure on first- and second-trimester maternal serum…
Challenges conducting comparative effectiveness research: The Clinical and Health Outcomes Initiative in Comparative Effectiveness (CHOICE) experience
The Clinical and Health Outcomes Initiative in Comparative Effectiveness (CHOICE) program, which includes 12 ongoing comparative effectiveness research (CER) trials…
Efficacy of yoga for vasomotor symptoms: a randomized controlled trial
This study aims to determine the efficacy of yoga in alleviating vasomotor symptoms (VMS) frequency and bother. This study was…
Efficacy of omega-3 for vasomotor symptoms treatment: a randomized controlled trial
This study aims to determine the efficacy and tolerability of omega-3 fatty acids in reducing vasomotor symptoms (VMS) frequency and…
Efficacy of exercise for menopausal symptoms: a randomized controlled trial
This study aims to determine the efficacy of exercise training for alleviating vasomotor and other menopausal symptoms. Late perimenopausal and…
Gestational weight gain and neonatal adiposity in the Hyperglycemia and Adverse Pregnancy Outcome study-North American region
OBJECTIVE: To examine the associations between gestational weight gain (GWG) exceeding Institute of Medicine (IOM) guidelines and neonatal adiposity in…
Oral Bisphenol A (BPA) given to rats at moderate doses is associated with erectile dysfunction, cavernosal lipofibrosis and alterations of global gene transcription
Bisphenol A (BPA), a suspected reproductive biohazard and endocrine disruptor, released from plastics is associated with ED in occupationally exposed…
Menopausal Quality of Life: A RCT of Yoga, Exercise and Omega-3 Supplements
The purpose of this study was to determine the efficacy of 3 nonhormonal therapies for the improvement of menopause-related quality…
Intussusception Risk after Rotavirus Vaccination in U.S. Infants
International postlicensure studies have identified an increased risk of intussusception after vaccination with the second-generation rotavirus vaccines RotaTeq (RV5, a…
Brief report: risk of adverse fetal outcomes associated with immunosuppressive medications for chronic immune-mediated diseases in pregnancy
To assess the risk of adverse fetal outcomes following exposure to individual immunosuppressive drugs in pregnant women with chronic immune-mediated…
Effectiveness of seasonal trivalent influenza vaccine for preventing influenza virus illness among pregnant women: a population-based case-control study during the 2010-2011 and 2011-2012 influenza seasons
Although vaccination with trivalent inactivated influenza vaccine (TIV) is recommended for all pregnant women, no vaccine effectiveness (VE) studies of…
Risk management options elected by women after testing positive for a BRCA mutation
To assess the uptake of risk-reducing options for the management of ovarian and breast cancer risk in BRCA mutation carriers…
A pragmatic cluster randomized clinical trial of diabetes prevention strategies for women with gestational diabetes: design and rationale of the Gestational Diabetes’ Effects on Moms (GEM) study
Women with gestational diabetes (GDM) are at high risk of developing diabetes later in life. After a GDM diagnosis, women…
Correlation between Exposure to Magnetic Fields and Embryonic Development in the First Trimester
To explore the correlation between maternal magnetic field (MF) exposure in daily life and embryonic development. A cross-sectional study was…
Responding to Vaccine Safety Signals during Pandemic Influenza: A Modeling Study
Managing emerging vaccine safety signals during an influenza pandemic is challenging. Federal regulators must balance vaccine risks against benefits while…
Feasibility and acceptability of a novel, computerized screening and brief intervention (SBI) for alcohol and sweetened beverage use in pregnancy
Recommended screening and brief intervention (SBI) for alcohol use during pregnancy is impeded by high patient loads and limited resources…
Prepregnancy SHBG Concentrations and Risk for Subsequently Developing Gestational Diabetes Mellitus
Lower levels of sex hormone-binding globulin (SHBG) have been associated with increased risk of diabetes among postmenopausal women; however, it…
Neonatal cytokines and chemokines and risk of Autism Spectrum Disorder: the Early Markers for Autism (EMA) study: a case-control study
Biologic markers of infection and inflammation have been associated with Autism Spectrum Disorders (ASD) but prior studies have largely relied…
LINE-1 hypomethylation in spermatozoa is associated with Bisphenol A exposure
Bisphenol A (BPA) is an endocrine disruptor with potentially harmful effects on humans. However, epigenetic mechanisms that modulate the effects…
Prevalence and Neonatal Factors Associated with Autism Spectrum Disorders in Preterm Infants
To determine the prevalence of autism spectrum disorders (ASD) across gestational age, examine the risk of ASD by gestational age…
The Multigroup Ethnic Identity Measure-Revised: Measurement Invariance Across Racial and Ethnic Groups
The Multigroup Ethnic Identity Measure-Revised (MEIM-R), a brief instrument assessing affiliation with one's ethnic group, is a promising advance in…
The Prevalence and Trends of Antiviral Medication Use During Pregnancy in the US: A Population-Based Study of 664,297 Deliveries in 2001-2007
To evaluate the prevalence, trends, timing and duration of exposure to antiviral medications during pregnancy within a US cohort of…
Post-licensure rapid immunization safety monitoring program (PRISM) data characterization
The Post-Licensure Rapid Immunization Safety Monitoring (PRISM) program is the immunization safety monitoring component of FDA's Mini-Sentinel project, a program…
Invited Commentary: Does Neonatal Hyperbilirubinemia Cause Asthma?
In an analysis of data from the US Collaborative Perinatal Project, Huang et al. (Am J Epidemiol. 2013;178(12):1691-1697) report an…
Levels of Cotinine in Dried Blood Specimens from Newborns as a Biomarker of Maternal Smoking Close to the Time of Delivery
The precise quantitation of smoking during pregnancy is difficult in retrospective studies. Routinely collected blood specimens from newborns, stored as…
Low Prepregnancy Adiponectin Concentrations Are Associated With a Marked Increase in Risk for Development of Gestational Diabetes Mellitus
To examine whether circulating total and high-molecular weight (HMW) adiponectin concentrations, measured before pregnancy, are associated with subsequent risk of…
Cohort Study of Insulin Glargine and Risk of Breast, Prostate, and Colorectal Cancer Among Patients With Diabetes
To examine whether use of insulin glargine, compared with another long-acting insulin, is associated with risk of breast, prostate, colorectal…
Chronic High Dose Intraperitoneal Bisphenol A (BPA) Induces Substantial Histological and Gene Expression Alterations in Rat Penile Tissue Without Impairing Erectile Function
Bisphenol A (BPA), released from plastics and dental sealants, is a suspected endocrine disruptor and reproductive toxicant. In occupationally exposed…
Counseling and provision of long-acting reversible contraception in the US: National survey of nurse practitioners
Nurse practitioners (NPs) provide frontline care in women's health, including contraception, an essential preventive service. Their importance for contraceptive care…
Medication Exposure in Pregnancy Risk Evaluation Program: The Prevalence of Asthma Medication Use During Pregnancy
Asthma is one of the most common chronic diseases in women of reproductive age, occurring in up to 8 % of…
Childbirth and female sexual function later in life
To examine relationships among parity, mode of delivery, and other parturition-related factors with women's sexual function later in life. Self-administered…
Statin Exposure is Associated with Decreased Asthma-Related Emergency Department Visits and Oral Corticosteroid Use
Statins, or HMG-CoA reductase inhibitors, may aid in the treatment of asthma through their pleiotropic antiinflammatory effects. To examine the…
Head Circumferences in Twins With and Without Autism Spectrum Disorders
To determine the genetic relationship between head circumference (HC) and Autism Spectrum Disorders (ASDs). Twin pairs with at least one…
Abnormal vaginal bleeding after epidural steroid injection: a paired observation cohort study
OBJECTIVE: The use of epidural steroid injections has increased dramatically, but knowledge of potential adverse effects is lacking. An association…
Clinical predictors and significance of postvoid residual volume in women with diabetes
To identify women with diabetes at risk of increased postvoid residual volume (PVR) and investigate the relationship of increased PVR…
Methods of linking mothers and infants using health plan data for studies of pregnancy outcomes
Research on medication safety in pregnancy often utilizes health plan and birth certificate records. This study discusses methods used to…
Evaluation of e-mail contact to conduct follow-up among adolescent women participating in a longitudinal cohort study of contraceptive use
The purpose of this study was to determine whether e-mail contact is a viable method for gathering information from adolescent…
Risk of Large-for-Gestational-Age Newborns in Women With Gestational Diabetes by Race and Ethnicity and Body Mass Index Categories
OBJECTIVE: To compare the prevalence of large-for-gestational-age (LGA) newborns across categories of body mass index (BMI) in five racial and…
Black Race Is Not Protective Against Hazardous Bilirubin Levels
Although black race is considered protective against hyperbilirubinemia, black infants appear at increased risk of kernicterus. We found that although…
Pregnancy Glycemia in Mexican-American Women Without Diabetes or Gestational Diabetes and Programming for Childhood Obesity
In the present study, we estimated the association between pregnancy glucose levels and offspring body mass index (BMI) z scores…
Prevalence and trends in the use of antipsychotic medications during pregnancy in the U.S., 2001-2007: a population-based study of 585,615 deliveries
This study aims to estimate the prevalence of and temporal trends in prenatal antipsychotic medication use within a cohort of…
Five-year risks of CIN 3+ and cervical cancer among women with HPV-positive and HPV-negative high-grade Pap results
High-grade Pap results (e.g., atypical glandular cells [AGC], atypical squamous cells cannot rule out HSIL [ASC-H], and high-grade squamous intraepithelial…
Follow-up testing after colposcopy: five-year risk of CIN 2+ after a colposcopic diagnosis of CIN 1 or less
Most women referred for colposcopy are not diagnosed with cervical intraepithelial neoplasia grade 2 or worse (CIN 2+) but, nonetheless,…
Five-year risk of recurrence after treatment of CIN 2, CIN 3, or AIS: performance of HPV and Pap cotesting in posttreatment management
After excisional treatment, cervical intraepithelial neoplasia grade 2 or worse (CIN 2+) can recur. It is not clear how many…
Five-year risk of CIN 3+ to guide the management of women aged 21 to 24 years
Current US national guidelines recommend beginning screening at age 21 using Pap tests only, with cotesting starting at age 30.…
Five-year risks of CIN 3+ and cervical cancer among women with HPV testing of ASC-US Pap results
New screening guidelines recommend that human papillomavirus (HPV)-negative/atypical squamous cells of undetermined significance (ASC-US) results be considered as equivalent to…
Benchmarking CIN 3+ risk as the basis for incorporating HPV and Pap cotesting into cervical screening and management guidelines
In 2012, the US Preventive Services Task Force (USPSTF) and a consensus of 25 organizations endorsed concurrent cytology and human…
Five-year risks of CIN 2+ and CIN 3+ among women with HPV-positive and HPV-negative LSIL Pap results
Low-grade squamous intraepithelial lesion (LSIL) Pap results do not typically lead to human papillomavirus (HPV) testing. HPV triage is not…
Surgical outcomes of total knee replacement according to diabetes status and glycemic control, 2001 to 2009
BACKGROUND: Poor glycemic control in patients with diabetes may be associated with adverse surgical outcomes. We sought to determine the…
Is Infertility Associated with Childhood Autism?
Concerns persist about a possible link between infertility and risk of autism spectrum disorders (ASD). Interpretation of existing studies is…
Use of Birth Certificates to Examine Maternal Occupational Exposures and Autism Spectrum Disorders in Offspring
The continuing rise in the prevalence of autism spectrum disorders has led to heightened interest in the role of nongenetic…
Impact of type 2 diabetes on lower urinary tract symptoms in men: a cohort study
BACKGROUND: Studies of the impact of type 2 diabetes on the prevalence and incidence of lower urinary tract symptoms (LUTS)…
Validity of health plan and birth certificate data for pregnancy research
PURPOSE: To evaluate the validity of health plan and birth certificate data for pregnancy research. METHODS: A retrospective study was…
Prevalence, Trends, and Patterns of Use of Antidiabetic Medications Among Pregnant Women, 2001-2007
OBJECTIVE:: To describe the prevalence, trends, and patterns in use of antidiabetic medications to treat hyperglycemia and insulin resistance before…
A genome-wide survey of transgenerational genetic effects in autism
Effects of parental genotype or parent-offspring genetic interaction are well established in model organisms for a variety of traits. However,…
Sequencing of the IL6 gene in a case–control study of cerebral palsy in children
Cerebral palsy (CP) is a group of nonprogressive disorders of movement and posture caused by abnormal development of, or damage…
Urine bisphenol-a level in relation to obesity and overweight in school-age children
Bisphenol-A (BPA) is a potential endocrine disruptor impacting metabolic processes and increasing the risk of obesity. To determine whether urine…
With pills, patches, rings, and shots: who still uses condoms? A longitudinal cohort study
PURPOSE: To describe women's condom use patterns over time and assess predictors of dual method use 12 months after initiating…
Genetic risk factors for perinatal arterial ischemic stroke
The cause of perinatal arterial ischemic stroke is unknown in most cases. We explored whether genetic polymorphisms modify the risk…
Pregnancy Glucose Levels in Women without Diabetes or Gestational Diabetes and Childhood Cardiometabolic Risk at 7 Years of Age
OBJECTIVE: To estimate the association between pregnancy glucose values in women without recognized pregestational diabetes or gestational diabetes and cardiometabolic…
Neisseria gonorrhea and Chlamydia trachomatis Screening at Intrauterine Device Insertion and Pelvic Inflammatory Disease
OBJECTIVE: To evaluate the relationship between Neisseria gonorrhea and Chlamydia trachomatis screening strategies and risk of pelvic inflammatory disease (PID)…
Trends in the Use of Antiepileptic Drugs among Pregnant Women in the US, 2001-2007: A Medication Exposure in Pregnancy Risk Evaluation Program Study
BACKGROUND: Little is known about the extent of antiepileptic drug (AED) use in pregnancy, particularly for newer agents. Our objective…
Alcohol, tobacco and drug use as reasons for abortion
AIMS: Concern about the effects of alcohol and drug use during pregnancy is intertwined with debates about abortion. There is…
Success Of Program Linking Data Sources To Monitor H1N1 Vaccine Safety Points To Potential For Even Broader Safety Surveillance
In response to the 2009 H1N1 pandemic and subsequent vaccination program, the Department of Health and Human Services and collaborators…
The Study to Explore Early Development (SEED): A Multisite Epidemiologic Study of Autism by the Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) Network
The Study to Explore Early Development (SEED), a multisite investigation addressing knowledge gaps in autism phenotype and etiology, aims to:…
A Large, Population-Based Study of 2009 Pandemic Influenza A Virus Subtype H1N1 Infection Diagnosis During Pregnancy and Outcomes for Mothers and Neonates
BACKGROUND: Pregnant women were at increased risk for serious outcomes of 2009 pandemic influenza A virus subtype H1N1 (influenza A[H1N1]pdm09)…
Fecal Incontinence Decreases Sexual Quality of Life, But Does Not Prevent Sexual Activity in Women
BACKGROUND: The impact of anal incontinence on women's sexual function is poorly understood. OBJECTIVE: The aim of this study was…
Increased risk for respiratory distress among white, male, late preterm and term infants
OBJECTIVE: To determine whether race/ethnicity and sex independently increase risk of respiratory distress syndrome (RDS) in late preterm and term…
Risk of preterm delivery in non-diabetic women with polycystic ovarian syndrome
OBJECTIVE: To examine the risk and etiology of preterm delivery in women with polycystic ovary syndrome (PCOS). STUDY DESIGN: Retrospective…
Sex ratio variations among the offspring of women with diabetes in pregnancy
AIMS: It has long been hypothesized that natural selection would favour a reproductive strategy biased towards females under adverse circumstances…
Prenatal and Perinatal Characteristics Associated with Pediatric-Onset Inflammatory Bowel Disease
BACKGROUND: The majority of studies that report early life risk factors for pediatric-onset inflammatory bowel disease (IBD) do not account…
Diabetes mellitus and sexual function in middle-aged and older women
Diabetes mellitus is an established risk factor for sexual dysfunction in men, but its effect on female sexual function is…
Influence of breastfeeding during the postpartum oral glucose tolerance test on plasma glucose and insulin
OBJECTIVE: To examine the effect of breastfeeding during the postpartum oral glucose tolerance test (OGTT) on maternal blood glucose and…
Prepregnancy cardiometabolic and inflammatory risk factors and subsequent risk of hypertensive disorders of pregnancy
OBJECTIVE: The purpose of this study was to examine prepregnancy cardiometabolic and inflammatory markers and the subsequent risk of hypertensive…
Racial/Ethnic Disparities in the Prevalence of Gestational Diabetes by BMI
OBJECTIVE: To examine whether the association between gestational diabetes mellitus (GDM) and BMI category varies by racial/ethnic group. RESEARCH DESIGN…
A systematic review to calculate background miscarriage rates using life table analysis
The objectives of the current study were to calculate: (1) the expected rates of miscarriage by gestational week; (2) the…
Referral to telephonic nurse management improves outcomes in women with gestational diabetes
OBJECTIVE: We sought to determine whether, among women with gestational diabetes mellitus, referral to a telephonic nurse management program was…
The value of additional pathology comments indicating suspicion of adenocarcinoma among women diagnosed preoperatively with complex atypical endometrial hyperplasia
Over 40% of women with a preoperative diagnosis of complex atypical hyperplasia (CAH) will have endometrial cancer at hysterectomy. CAH…
California Very Preterm Birth Study: design and characteristics of the population- and biospecimen bank-based nested case-control study
Very preterm birth (VPTB) is a leading cause of infant mortality, morbidity and racial disparity in the US. The underlying…
Social support for healthy behaviors: scale psychometrics and prediction of weight loss among women in a behavioral program
Social support could be a powerful weight-loss treatment moderator or mediator but is rarely assessed. We assessed the psychometric properties,…
An Over-the-Counter Simulation Study of a Single-Tablet Emergency Contraceptive in Young Females
OBJECTIVES: To evaluate use of a single-tablet (levonorgestrel 1.5 mg) emergency contraceptive administered to young females under simulated over-the-counter conditions.…
Provision of Contraceptive Services to Women with Diabetes Mellitus
BACKGROUND: Women with diabetes mellitus who delay pregnancy until glycemic control is achieved experience lower rates of adverse pregnancy outcomes.…
Lactation Intensity and Postpartum Maternal Glucose Tolerance and Insulin Resistance in Women With Recent GDM: The SWIFT cohort
OBJECTIVE: To examine the association between breastfeeding intensity in relation to maternal blood glucose and insulin and glucose intolerance based…
Evaluating Changes in the Prevalence of the Autism Spectrum Disorders (ASDs)
Autism spectrum disorders (ASDs) are estimated to occur among about one percent of children in the United States. This estimate…
A genome-wide association search for type 2 diabetes genes in african americans
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches…
Early start: a cost-beneficial perinatal substance abuse program
OBJECTIVE: To conduct a cost-benefit analysis of Early Start, an integrated prenatal intervention program for stopping substance use in pregnancy.…
Infant siblings and the investigation of autism risk factors
ABSTRACT: Infant sibling studies have been at the vanguard of autism spectrum disorders (ASD) research over the past decade, providing…
A Prospective Study of In-utero Exposure to Magnetic Fields and the Risk of Childhood Obesity
We conducted a prospective study to examine whether in-utero exposure to magnetic fields (MFs) increases the risk of childhood obesity.…
Candidate Genes and Risk for Cerebral Palsy: a Population-Based Study
Studies suggest that genetic polymorphisms may increase an individual's susceptibility to CP. Most findings have yet to be corroborated in…
Urinary incontinence self-report questions: reproducibility and agreement with bladder diary
INTRODUCTION AND HYPOTHESIS: This study aims to measure self-report urinary incontinence questions' reproducibility and agreement with bladder diary. METHODS: Data…
Prenatal exposure to beta2-adrenergic receptor agonists and risk of autism spectrum disorders
This study aims to investigate the association between prenatal exposure to terbutaline and other beta2 adrenergic receptor (B2AR) agonists and…
ADHD drugs and serious cardiovascular events in children and young adults
BACKGROUND: Adverse-event reports from North America have raised concern that the use of drugs for attention deficit-hyperactivity disorder (ADHD) increases…
Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism
CONTEXT: Autism is considered the most heritable of neurodevelopmental disorders, mainly because of the large difference in concordance rates between…
Antidepressant Use During Pregnancy and Childhood Autism Spectrum Disorders
CONTEXT: The prevalence of autism spectrum disorders (ASDs) has increased over recent years. Use of antidepressant medications during pregnancy also…
Parturition events and risk of urinary incontinence in later life
AIMS: To examine the association between specific events during vaginal deliveries and urinary incontinence later in life. METHODS: A retrospective…
Does Lack of Multinutrient Supplementation During Early Pregnancy Increase Vulnerability to Alcohol-Related Preterm or Small-for-Gestational-Age Births?
The objective of this study was to assess whether women who do not take multinutrient supplements during early pregnancy are…
Birth Prevalence of Autism Spectrum Disorders in the San Francisco Bay Area by Demographic and Ascertainment Source Characteristics
Using standardized methods for multi-source surveillance, we calculated the prevalence of autism spectrum disorders (ASD) among children born in a…
In utero exposure to bisphenol-A and anogenital distance of male offspring
BACKGROUND: Bisphenol-A (BPA) is an endocrine disruptor with widespread human exposure. The effect of in utero BPA exposure on human…
Maternal exposure to magnetic fields during pregnancy in relation to the risk of asthma in offspring
OBJECTIVE: To determine whether maternal exposure to high levels of magnetic fields (MFs) during pregnancy is associated with the risk…
Epidemiology of peripartum cardiomyopathy: incidence, predictors, and outcomes
OBJECTIVES: To estimate the incidence, describe the mortality, and identify independent predictors of peripartum cardiomyopathy, a very serious cardiovascular complication…
Increased midgestational IFN-gamma, IL-4 and IL-5 in women bearing a child with autism: A case-control study
ABSTRACT: BACKGROUND: Immune anomalies have been documented in individuals with autism spectrum disorders (ASDs) and their family members. It is…
Preservation of fertility after partial resection of bilateral ovarian cystadenofibromas: a case report
BACKGROUND: Benign cystadenofibromas and adenofibromas may represent precursors to malignant lesions. CASE: A 20-year-old woman undergoing infertility treatment was found…
Pregravid cardiometabolic risk profile and risk for gestational diabetes mellitus
OBJECTIVE: The purpose of this study was to examine pregravid cardiometabolic profile and subsequent risk of gestational diabetes mellitus (GDM).…
In utero exposure to bisphenol-A and its effect on birth weight of offspring
To examine the effect of in utero BPA exposure on the birth weight of offspring, a total of 587 children…
A pregnancy and postpartum lifestyle intervention in women with gestational diabetes mellitus reduces diabetes risk factors: a feasibility randomized control trial
OBJECTIVE: To pilot, among women with gestational diabetes mellitus (GDM), the feasibility of a prenatal/postpartum intervention to modify diet and…
The Pregnancy and Influenza Project: design of an observational case-cohort study to evaluate influenza burden and vaccine effectiveness among pregnant women and their infants
The US Centers for Disease Control and Prevention is conducting an observational study of 300-500 women infected with influenza during…
Change in body mass index between pregnancies and the risk of gestational diabetes in a second pregnancy
OBJECTIVE: To estimate the association between interpregnancy change in body mass index (BMI) and the risk of gestational diabetes mellitus…
Population-based ectopic pregnancy trends, 1993-2007
BACKGROUND: The accuracy of ectopic pregnancy rates based on nationally representative data has been compromised for many years, impairing surveillance…
Polychlorinated biphenyl (PCB) exposure in mothers and time to pregnancy in daughters
Developmental exposure to polychlorinated biphenyls (PCBs) disrupts reproduction in animals. Human data are lacking. We measured PCBs in preserved mothers'…
Diabetes and risk of bladder cancer: evidence from a case-control study in New England
BACKGROUND: Diabetes is an emerging public health issue in the US, affecting 11% of Americans over the age of 20,…
Vitamin D, pregnancy, breastfeeding, and postpartum multiple sclerosis relapses
OBJECTIVE: To determine whether low levels of 25-hydroxyvitamin D (25[OH]D) contribute to the increased risk of postpartum multiple sclerosis (MS)…