Presti, Joseph
Research interests include refining strategies for prostate cancer screening and detection of high-risk tumors.
Long-term effectiveness of BPH/LUTS pharmacological therapies and using machine learning based predictive analytics to tailor treatment.
This career development award project will compare the effectiveness of pharmacological therapy for lower urinary tract symptoms secondary to benign…
Precision Prostate Cancer Screening with Genetically Adjusted Prostate-Specific Antigen Levels – DUPLICATED DO NOT ACTIVATE
An effort to more comprehensively determine the genetic factors associated with prostate-specific antigen (PSA) levels, and to develop and apply…
Why Do Epidemiologic Studies Find an Inverse Association Between Intraprostatic Inflammation and Prostate Cancer: A Possible Role for Colliding Bias?
Inflammation is an emerging risk factor for prostate cancer based largely on evidence from animal models and histopathologic observations. However,…
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry…
Changing Provider PSA Screening Behavior Using Best Practice Advisories: Interventional Study in a Multispecialty Group Practice
Most guidelines recommend against PSA-based screening for prostate cancer in men ≥ 70 years of age. Adherence to these guidelines…
A Genome-wide Association Study of Prostate Cancer in Latinos
Latinos represent
Changes in Prostate Cancer Presentation Following the 2012 USPSTF Screening Statement: Observational Study in a Multispecialty Group Practice
In 2012, the US Preventive Services Task Force (USPSTF) recommended against PSA-based screening for prostate cancer in men of all…
Haloperidol and Prostate Cancer Prevention: More Epidemiologic Research Needed
The antipsychotic drug haloperidol has antiproliferative and growth-inhibiting properties on prostate cancer cell lines in vitro by binding the sigma…
Selecting Active Surveillance: Decision-Making Factors for Men with a Low-Risk Prostate Cancer
Background. Men with a low-risk prostate cancer (PCa) should consider observation, particularly active surveillance (AS), a monitoring strategy that avoids…
A Systematic Review and Meta-analysis of Associations between Clinical Prostatitis and Prostate Cancer: New Estimates Accounting for Detection Bias.
BACKGROUND: Previous meta-analyses have estimated summary positive associations between clinical prostatitis and prostate cancer. However, none have accounted for detection…
Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms
Here we train cis-regulatory models of prostate tissue gene expression and impute expression transcriptome-wide for 233,955 European ancestry men (14,616…
Diet-related inflammation and risk of prostate cancer in the California Men’s Health Study
The purpose of the study was to examine the relationship between proinflammatory diet and prostate cancer risk. Energy-adjusted Dietary Inflammatory…
Patterns of medication adherence in a multi-ethnic cohort of prevalent statin users diagnosed with breast, prostate, or colorectal cancer
To investigate the implications of a cancer diagnosis on medication adherence for pre-existing comorbid conditions, we explored statin adherence patterns…
Risk of diabetes complications among those with diabetes receiving androgen deprivation therapy for localized prostate cancer
Androgen deprivation therapy (ADT), used increasingly in the treatment of localized prostate cancer, is associated with substantial long-term adverse consequences,…
Development of the Kaiser Permanente Prostate Cancer Risk Calculator
Much of the controversy surrounding prostate cancer screening is due to the poor predictive value of PSA blood tests and…
LSD1 activates a lethal prostate cancer gene network independently of its demethylase function
Medical castration that interferes with androgen receptor (AR) function is the principal treatment for advanced prostate cancer. However, clinical progression…
Identification of fluorescence in situ hybridization assay markers for prediction of disease progression in prostate cancer patients on active surveillance
Prostate Cancer (PCa) is the second most prevalent cancer among U.S. males. In recent decades many men with low risk…
A Biopsy-based 17-gene Genomic Prostate Score as a Predictor of Metastases and Prostate Cancer Death in Surgically Treated Men with Clinically Localized Disease
A 17-gene biopsy-based reverse transcription polymerase chain reaction assay, which provides a Genomic Prostate Score (GPS-scale 0-100), has been validated…
Decision making processes among men with low-risk prostate cancer: a survey study
To characterize decision-making processes and outcomes among men expressing early-treatment preferences for low-risk prostate cancer. We conducted telephone surveys of…
Disparities in Prostate, Lung, Breast, and Colorectal Cancer Survival and Comorbidity Status among Urban American Indians and Alaskan Natives
Cancer is the second leading cause of death among American Indians and Alaskan Natives (AIAN), although cancer survival information in…
Cardiovascular disease risk and androgen deprivation therapy in patients with localised prostate cancer: a prospective cohort study
As androgen deprivation therapy (ADT) is increasingly being used in men with localised prostate cancer, our goal was to examine…
Physicians’ Perceptions of Factors Influencing the Treatment Decision-Making Process for Men with Low-Risk Prostate Cancer
To assess physicians' attitudes regarding multiple factors that may influence recommendations for active surveillance (AS) vs active treatment (AT) given…
Mortality and Androgen-Deprivation Therapy as Salvage Treatment for Biochemical Recurrence after Primary Therapy for Clinically Localized Prostate Cancer
Androgen deprivation therapy is often used as salvage treatment in men with rising prostate specific antigen after initial radical prostatectomy…
Physicians’ perspectives on the informational needs of low-risk prostate cancer patients
Despite the evidence indicating that decision aids (DA) improve informed treatment decision making for prostate cancer (PCa), physicians do not…
Association between the Genomic Prostate Score and Metastatic Recurrence
The primary goal of the study is to confirm that the pre-specified Genomic Prostate Score (GPS) from biopsy tumor tissue…
Modeling to Improve Prostate Cancer Outcomes across Diverse Populations
The CISNET prostate group has been adapting and applying models of prostate cancer natural history and survival to understand how…
Grant Development Work for Molecular Assay in Prostate Cancer
The goal of the study is to perform a retrospective study to evaluate biomarkers predictive of aggressive disease using Florescence…
Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer
Prostate-specific antigen (PSA) levels have been used for detection and surveillance of prostate cancer (PCa). However, factors other than PCa-such…
Identification of DNA Methylation Markers for Risk of Metastasis in Localized Prostate Cancer
The overarching goal of this study is to develop DNA methylation marker-based prediction algorithms that will pave the way for…
5-Alpha Reductase Inhibitors and the Risk of Prostate Cancer Mortality in Men Treated for Benign Prostatic Hyperplasia
To compare the risk of prostate cancer mortality among men treated with 5- alpha reductase inhibitors (5-ARIs) with those treated…
Sociodemographic and clinical predictors of switching to active treatment among a large ethnically diverse cohort of men with low-risk prostate cancer on observational management
We determined the clinical and sociodemographic predictors of beginning active treatment in an ethnically diverse population of men with low…
Treatment Preferences for Active Surveillance vs. Active Treatment Among Men with Low-Risk Prostate Cancer
Due to the concerns about the overtreatment of low-risk prostate cancer, active surveillance (AS) is now a recommended alternative to…
A meta-analysis of individual participant data reveals an association between circulating levels of IGF-I and prostate cancer risk
The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between…
A large multi-ethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences
A genome-wide association study (GWAS) of prostate cancer in Kaiser Permanente health plan members (7,783 cases, 38,595 controls; 80.3% non-Hispanic…
Prostate Cancer Incidence and Prostate-Specific Antigen Testing Among HIV-Positive and HIV-Negative Men
We investigated whether the reported lower incidence of prostate cancer in HIV-positive men is a result of confounding factors or…
Association of body mass index and prostate cancer mortality
Inconsistent evidence exists on whether obesity is associated with an increased risk of prostate cancer death post-radical prostatectomy. We examined…
Effectiveness of Primary Androgen-Deprivation Therapy for Clinically Localized Prostate Cancer
Primary androgen-deprivation therapy (PADT) is often used to treat clinically localized prostate cancer, but its effects on cause-specific and overall…
Intussusception Risk after Rotavirus Vaccination in U.S. Infants
International postlicensure studies have identified an increased risk of intussusception after vaccination with the second-generation rotavirus vaccines RotaTeq (RV5, a…
Predictive value of prostate-specific antigen for prostate cancer: a nested case-control study in EuroSIDA
Although prostate cancer (PCa) incidence is lower in HIV+ men than in HIV- men, the usefulness of prostate-specific antigen (PSA)…
Cohort Study of Insulin Glargine and Risk of Breast, Prostate, and Colorectal Cancer Among Patients With Diabetes
To examine whether use of insulin glargine, compared with another long-acting insulin, is associated with risk of breast, prostate, colorectal…
Immunohistochemical Expression of ERG in the Molecular Epidemiology of Fatal Prostate Cancer Study
BACKGROUND: Gene fusions between the ERG transcription factor and the androgen-regulated gene TMPRSS2 occur in a subset of prostate cancers…
Efficacy of Intermittent Androgen Deprivation Therapy vs Conventional Continuous Androgen Deprivation Therapy for Advanced Prostate Cancer: A Meta-analysis
OBJECTIVE: To compare the efficacy of intermittent androgen deprivation therapy (IADT) vs continuous androgen deprivation therapy (CADT) for the treatment…
Complementary and Alternative Medicine Use, Patient-reported Outcomes, and Treatment Satisfaction Among Men With Localized Prostate Cancer
OBJECTIVE: To evaluate the association between complementary and alternative medicine (CAM) use, satisfaction with treatment, and patient-reported outcomes after treatment.…
Unanticipated and underappreciated outcomes during management of local stage prostate cancer: a prospective survey
PURPOSE: Due to the complexity of factors that must be considered when choosing a therapy for prostate cancer, we hypothesized…
Increased risk of high-grade prostate cancer among infertile men
BACKGROUND: It has been reported that fatherhood status may be a risk factor for prostate cancer. In the current study,…
Red wine consumption and risk of prostate cancer: the California men’s health study
Red wine contains polyphenol antioxidants that inhibit prostate cancer development in animal studies. We investigated the effect of red wine…
Prostatitis, sexually transmitted diseases, and prostate cancer: the California Men’s Health Study
BACKGROUND: Prostatitis and sexually transmitted diseases (STDs) have been positively associated with prostate cancer in previous case-control studies. However, results…
Medical history, body size, and cigarette smoking in relation to fatal prostate cancer
OBJECTIVES: Prostate cancer has few known risk factors. As part of a population-based case-control study conducted in four health maintenance…
Correlates of prostate-specific antigen testing in a large multiethnic cohort
OBJECTIVE: To examine factors associated with prostate-specific antigen (PSA) testing in the multiethnic California Men's Health Study. STUDY DESIGN: Cross-Sectional…
Access to information sources and treatment considerations among men with local stage prostate cancer
OBJECTIVES: To determine the role of information sources in the treatment decision-making process of men diagnosed with local stage prostate…
Insulin-like growth factors, their binding proteins, and prostate cancer risk: analysis of individual patient data from 12 prospective studies
BACKGROUND: Some, but not all, published results have shown an association between circulating blood levels of some insulin-like growth factors…
Association of Preexisting Symptoms with Treatment Decisions among Newly Diagnosed Prostate Cancer Patients
BACKGROUND: The choice between surgical versus non-surgical treatment options is a fundamental decision for men with local stage prostate cancer…
Racial differences in treatment of early-stage prostate cancer
OBJECTIVES: To determine whether differences existed in prostate cancer treatment received by white and African American men at a health…
Glycemic status and risk of prostate cancer
BACKGROUND: To examine the risk of prostate cancer and glucose tolerance in a large, racially diverse cohort. METHODS: We conducted…
Statin use and risk of prostate cancer in the California Men’s Health Study cohort
Statins have known anticarcinogenic effects, however, evidence for long-term statin use as effective chemoprevention for prostate cancer is inconsistent. We…
California Men’s Health Study (CMHS): a multiethnic cohort in a managed care setting
BACKGROUND: We established a male, multiethnic cohort primarily to study prostate cancer etiology and secondarily to study the etiologies of…
Screening by prostate-specific antigen and digital rectal examination in relation to prostate cancer mortality: a case-control study
BACKGROUND: The potential role of prostate cancer screening in reducing mortality is uncertain. To examine whether screening with the prostate-specific…
Initial treatment for prostate carcinoma in relation to comorbidity and symptoms
BACKGROUND: Evidence suggests the type of treatment received for prostate carcinoma is associated with comorbidity, but little information is available…
Daily aspirin use and prostate cancer risk in a large, multiracial cohort in the US
OBJECTIVE: To examine the relationship between daily aspirin use and risk of prostate cancer in a large, racially diverse cohort…
Body size, age at shaving initiation, and prostate cancer in a large, multiracial cohort
BACKGROUND: The purpose of this study was to examine the potential relationship between body size, self-reported age at initiation of…
Prostate cancer treatment and ten-year survival among group/staff HMO and fee-for-service Medicare patients
OBJECTIVE: To compare treatment patterns and the ten-year survival of prostate cancer patients in two large, nonprofit, group/staff HMOs to…
Cause of death in men diagnosed with prostate carcinoma
BACKGROUND: Prostate carcinoma is one of the leading causes of death in men. Although the mortality rate is high, it…
Race, prostate cancer survival, and membership in a large health maintenance organization
BACKGROUND: Population-based cancer registry data have shown that black men with prostate cancer have poorer stage-specific survival than white men,…
