Van Den Eeden, Stephen K.
Research interests include etiologic and outcomes studies in cancer.
Levin, Theodore R.
Research interests include health services research in gastroenterology.
Herrinton, Lisa J.
Research interests include inflammatory bowel disease epidemiology.
Allison, James E.
Research interests include colon cancer screening.
Gastrointestinal Symptoms in 2- to 5-Year-Old Children in the Study to Explore Early Development
Gastrointestinal symptoms (GIS) are commonly reported in children with autism spectrum disorder (ASD). This multi-site study evaluated the prevalence of…
AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review
The purpose of this Clinical Practice Update Expert Review is to provide clinicians with guidance on the diagnosis and management…
Improving health outcomes and reducing healthcare costs in individuals with Helicobacter pylori infection in a large, community-based population
Optimization of Diagnosis and Surveillance of Colonic Sessile Serrated Adenomas by Pathologists and Gastroenterologists at KPNC.
Validation of Tools for Predicting Incident Adenocarcinoma of the Esophagus or Esophagogastric Junction
Guidelines suggest screening of individuals who are at increased risk of esophageal adenocarcinoma (EAC). Tools for identifying patients at risk…
Five-year Longitudinal Cohort Study of Reinterventions After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass
To compare the long-term risks of reintervention following sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) in a large surgical…
Urban-Rural Disparities and Temporal Trends in Peptic Ulcer Disease Epidemiology, Treatment, and Outcomes in the United States
The incidence of peptic ulcer disease (PUD) has been decreasing over time with Helicobacter pylori eradication and use of acid-suppressing…
Sex-Specific Genetic Associations for Barrett’s Esophagus and Esophageal Adenocarcinoma
Esophageal adenocarcinoma (EA) and its premalignant lesion, Barrett's esophagus (BE), are characterized by a strong and yet unexplained male predominance…
Association Between Levels of Hormones and Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus
Esophageal adenocarcinoma (EAC) occurs most frequently in men. We performed a Mendelian randomization analysis to investigate whether genetic factors that…
Diagnostic Performance of Emergency Physician Gestalt for Predicting Acute Appendicitis in Patients Age 5 to 20 Years
Pediatric appendicitis remains a challenging diagnosis in the emergency department (ED). Available risk prediction algorithms may contribute to excessive ED…
The Colonic Microbiome Preceding Parkinson’s Disease: A Pilot Study
Gut changes, including evidence of alpha synuclein and the microbiome, appear to differ between people with and without Parkinson's disease.…
Time-to-event analysis when the event is defined on a finite time interval
Acute graft-versus-host disease (GVHD) is a frequent complication following hematopoietic cell transplantation (HCT). Research on risk factors for acute GVHD…
Red blood cell transfusions for emergency department patients with gastrointestinal bleeding within an integrated health system
To assess trends over time in red blood cell (RBC) transfusion practice among emergency department (ED) patients with gastrointestinal (GI)…
Neonatal Thyroid Stimulating Hormone and Subsequent Diagnosis of Autism Spectrum Disorders and Intellectual Disability
Hypothyroid conditions in early life, if left untreated, are associated with adverse neurodevelopmental outcomes, including intellectual disability (ID). However, evidence…
A Scalable Database of Organ Doses for Common Diagnostic Fluoroscopy Procedures of Children: Procedures of Historical Practice for Use in Radiation Epidemiology Studies
Assessment of health effects from low-dose radiation exposures in patients undergoing diagnostic imaging is an active area of research. High-quality…
Diabetes in relation to Barrett’s esophagus and adenocarcinomas of the esophagus: A pooled study from the International Barrett’s and Esophageal Adenocarcinoma Consortium
Diabetes is positively associated with various cancers, but its relationship with tumors of the esophagus/esophagogastric junction remains unclear. Data were…
Proton Pump Inhibitors, H2 Blocker Use, and Risk of Inflammatory Bowel Disease in Children
Evidence suggests use of proton pump inhibitors (PPIs) and H2 blockers may provoke disease flares in individuals with established inflammatory…
No Association Between Vitamin D Status and Risk of Barrett’s Esophagus or Esophageal Adenocarcinoma-a Mendelian Randomization Study
Epidemiology studies of circulating concentrations of 25 hydroxy vitamin D (25(OH)D) and risk of esophageal adenocarcinoma (EAC) have produced conflicting…
Systematic review and meta-analysis: efficacy and safety of oral Janus kinase inhibitors for inflammatory bowel disease
Janus kinase (JAK) inhibitors represent a novel therapeutic class for treatment of inflammatory bowel disease. To determine the efficacy and…
The Association Between Change in Serum Bicarbonate and Change in Thyroid Hormone Levels in Patients Receiving Conventional or More Frequent Maintenance Hemodialysis
Correction of metabolic acidosis in patients with chronic kidney disease has been associated with improvement in thyroid function. We examined…
Gastroesophageal Reflux Frequency, Severity, Age of Onset, Family History and Acid Suppressive Therapy Predict Barrett Esophagus in a Large Population
To identify risk factors associated with Barrett esophagus (BE) for potential improved surveillance and risk reduction. Gastroesophageal reflux disease (GERD)…
Validation and Extension of the Michigan Barrett’s Esophagus pREdiction Tool (M-BERET)
This project will validate whether a clinical tool can predict the presence of Barrett's esophagus and the development of esophageal…
Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED)
The goal of the PROCEED study is to determine the early markers or predictors of progression among individuals with pancreatitis.…
Helicobacter pylori Infection Is Associated With Reduced Risk of Barrett’s Esophagus: An Analysis of the Barrett’s and Esophageal Adenocarcinoma Consortium
Epidemiological studies of Helicobacter pylori infection and risk of Barrett's esophagus (BE) have reported conflicting results. We examined the association…
Determining Risk of Barrett’s Esophagus and Esophageal Adenocarcinoma Based on Epidemiologic Factors and Genetic Variants
We developed comprehensive models to determine risk of Barrett's esophagus (BE) or esophageal adenocarcinoma (EAC) based on genetic and non-genetic…
Hispanic Chronic Renal Insufficiency Cohort (HCRIC) Study
This is a renewal of an ongoing ancillary study to the Chronic Renal Insufficiency Cohort (CRIC) Study to examine whether…
Urine leakage during sexual activity among ethnically diverse, community-dwelling middle-aged and older women
Urinary incontinence is associated with decreased female sexual function, but little is known about the prevalence, predictors, and impact of…
Germline variation in inflammation-related pathways and risk of Barrett’s oesophagus and oesophageal adenocarcinoma
Oesophageal adenocarcinoma (OA) incidence has risen sharply in Western countries over recent decades. Local and systemic inflammation is considered an…
Treatment Effectiveness in Heart Failure with Comorbidity: Lung Disease and Kidney Disease
To assess the clinical effectiveness of beta-blocker therapy in individuals with heart failure (HF) and chronic lung disease and of…
Dietary sugar/starches intake and Barrett’s esophagus: a pooled analysis
Barrett's esophagus (BE) is the key precursor lesion of esophageal adenocarcinoma, a lethal cancer that has increased rapidly in westernized…
Lipoprotein(a) and Risk of Myocardial Infarction and Death in Chronic Kidney Disease: Findings From the CRIC Study (Chronic Renal Insufficiency Cohort)
To investigate the effect of LPA gene variants and renal function on lipoprotein(a) [Lp(a)] levels in people with chronic kidney…
Marijuana Use and Estimated Glomerular Filtration Rate in Young Adults
Marijuana use has become more widely accepted in the United States and has been legalized in many areas. Although it…
Rates and Predictors of Vaccinations Among Inflammatory Bowel Disease Patients Receiving Anti-Tumor Necrosis Factor Agents
As an important quality measure, the rates of recommended immunizations among immunocompromised inflammatory bowel disease (IBD) patients in community practice…
Blood Pressure and Risk of Cardiovascular Events in Patients on Chronic Hemodialysis: The CRIC Study (Chronic Renal Insufficiency Cohort)
We recently reported a linear association between higher systolic blood pressure (SBP) and risk of mortality in hemodialysis patients when…
Endoscopy is of low yield in the identification of gastrointestinal neoplasia in patients with dermatomyositis: A cross-sectional study.
AIM: To determine the prevalence of gastrointestinal neoplasia among dermatomyositis patients who underwent an esophagogastroduodenoscopy and/or colonoscopy.METHODS: A cross-sectional study…
The Troublesome Epidemiology of Barrett’s Esophagus and Esophageal Adenocarcinoma
Barrett's esophagus and esophageal adenocarcinoma diagnoses have increased markedly in recent decades. Recent research with patients diagnosed with Barrett's esophagus…
Recommendations on Surveillance and Management of Biallelic Mismatch Repair Deficiency (BMMRD) Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer
The US Multi-Society Task Force on Colorectal Cancer, with invited experts, developed a consensus statement and recommendations to assist health care providers…
Testosterone Levels in Pre-Menopausal Women are Associated With Nonalcoholic Fatty Liver Disease in Midlife
Young women with hyperandrogenism have high risk of metabolic co-morbidities, including increased risk of nonalcoholic fatty liver disease (NAFLD). Whether…
Proton Pump Inhibitor and Histamine-2 Receptor Antagonist Use and Iron Deficiency
Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) suppress gastric acid production, which can inhibit iron absorption. However, few…
Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease
The inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn's disease (CD) cause significant morbidity and are increasing in prevalence…
Risk of Acute Liver Injury With Antiretroviral Therapy by Viral Hepatitis Status
The risk of hepatotoxicity with antiretroviral therapy (ART) remains unknown. We determined the comparative risk of acute liver injury (ALI)…
Recommendations on Fecal Immunochemical Testing to Screen for Colorectal Neoplasia: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer
The use of the fecal occult blood test (FOBT) for colorectal cancer (CRC) screening is supported by randomized trials demonstrating…
Nonsteroidal Anti-Inflammatory Drug Use is Not Associated With Reduced Risk of Barrett’s Esophagus
Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced risk of esophageal adenocarcinoma. Epidemiological studies examining the…
Genome-wide association studies in oesophageal adenocarcinoma and Barrett’s oesophagus: a large-scale meta-analysis
Oesophageal adenocarcinoma represents one of the fastest rising cancers in high-income countries. Barrett's oesophagus is the premalignant precursor of oesophageal…
Association Between Primary Care Visits and Colorectal Cancer Screening Outcomes in the Era of Population Health Outreach
Population outreach strategies are increasingly used to improve colorectal cancer (CRC) screening. The influence of primary care on cancer screening…
Inverse Association Between Gluteofemoral Obesity and Risk of Barrett’s Esophagus in a Pooled Analysis
Gluteofemoral obesity (determined by measurement of subcutaneous fat in the hip and thigh regions) could reduce risks of cardiovascular and…
Consequences of Increasing Time to Colonoscopy Examination Following Positive Result From Fecal Colorectal Cancer Screening Test
Delays in diagnostic testing after a positive result from a screening test can undermine the benefits of colorectal cancer (CRC)…
Leukocyte telomere length in relation to the risk of Barrett’s esophagus and esophageal adenocarcinoma
Chronic inflammation and oxidative damage caused by obesity, cigarette smoking, and chronic gastroesophageal reflux disease (GERD) are major risk factors…
Influence of Age and Comorbidity on Colorectal Cancer Screening in the Elderly
Expert recommendations differ for colorectal cancer screening in the elderly. Recent studies suggest that healthy adults aged >75 years may…
Racial disparities in renal cell carcinoma: a single-payer healthcare experience
Significant racial disparities in survival for renal cell carcinoma (RCC) exist between white and black patients. Differences in access to…
A nested case-control study of dietary factors and the risk of incident cytological abnormalities of the cervix
Several earlier case-control studies reported inverse associations of cervical squamous intraepithelial lesions (SIL) with high dietary or biomarker levels of…
Characteristics of women refusing follow-up for tests or symptoms suggestive of breast cancer
BACKGROUND: Delay in diagnosis of breast cancer can occur at several points on the diagnostic pathway. We examined characteristics of…
Late-stage breast cancer among women with recent negative screening mammography: do clinical encounters offer opportunity for earlier detection?
BACKGROUND: Opportunities to prevent late-stage breast cancer within the course of usual care are needed. We evaluate whether clinical encounters…
Variation in Screening Abnormality Rates and Follow-Up of Breast, Cervical and Colorectal Cancer Screening within the PROSPR Consortium
Primary care providers and health systems have prominent roles in guiding effective cancer screening. To characterize variation in screening abnormality…
Polymorphisms in genes in the androgen pathway and risk of Barrett’s esophagus and esophageal adenocarcinoma
The strong male predominance in Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) remains inadequately explained, but sex hormones might be…
Colonoscopy Surveillance after Colorectal Cancer Resection: Recommendations of the US Multi-Society Task Force on Colorectal Cancer
The US Multi-Society Task Force has developed updated recommendations to guide health care providers with the surveillance of patients after…
Oral Azole Antifungal Medications and Risk of Acute Liver Injury, Overall and by Chronic Liver Disease Status
Reports on associations between azole antifungal medications and acute liver injury are inconsistent and have not been based on liver-related…
Ten-year incidence of colorectal cancer following a negative screening sigmoidoscopy: an update from the Colorectal Cancer Prevention (CoCaP) programme
To examine the rates of colorectal cancer (CRC) following a negative screening sigmoidoscopy. Cohort study. An integrated healthcare delivery organisation…
Bridging the Gap: Determinants of Undiagnosed or Untreated Urinary Incontinence in Women
More than a third of middle-aged or older women suffer from urinary incontinence, but less than half undergo evaluation or…
Ghrelin and Leptin Have a Complex Relationship with Risk of Barrett’s Esophagus
Abdominal obesity is a risk factor for Barrett's esophagus independent of GERD symptoms, but little is understood about the biological…
Risk of gastric cancer, gastrointestinal cancers and other cancers: a comparison of treatment with pantoprazole and other proton pump inhibitors
Proton pump inhibitors (PPIs) have been shown to be carcinogenic in rodent studies. As part of a long-term post-marketing surveillance…
Adiponectin may modify the risk of Barrett’s esophagus in patients with gastroesophageal reflux disease
Abdominal obesity and increasing body mass index are risk factors for esophageal adenocarcinoma and its main precursor, Barrett's esophagus; however,…
Risk of Acute Liver Failure in Patients with Drug-Induced Liver Injury: Evaluation of Hy’s Law and a New Prognostic Model
Few studies have evaluated the ability of laboratory tests to predict risk of acute liver failure (ALF) among patients with…
Comparative Effectiveness of Statin Therapy in Chronic Kidney Disease and Acute Myocardial Infarction: a Retrospective Cohort Study
Whether there is a kidney function threshold to statin effectiveness in patients with acute myocardial infarction is poorly understood. Our…
Observational methods to assess the effectiveness of screening colonoscopy in reducing right colon cancer mortality risk: SCOLAR
Screening colonoscopy's effectiveness in reducing risk of death from right colon cancers remains unclear. Methodological challenges of existing observational studies…
Quality Indicators for the Management of Barrett’s Esophagus, Dysplasia and Esophageal Adenocarcinoma: International Consensus Recommendations from AGA Symposium
The development of and adherence to quality indicators in gastroenterology, as in all of medicine, is increasing in importance to…
Pleiotropic analysis of cancer risk loci on esophageal adenocarcinoma risk
Several cancer-associated loci identified from genome-wide association studies (GWAS) have been associated with risks of multiple cancer sites, suggesting pleiotropic…
METFORMIN USE AND RISK OF COLORECTAL ADENOMA AFTER POLYPECTOMY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Existing literature suggests that metformin, the most commonly used biguanide, may lower colorectal cancer risk. Because most colorectal cancers originate…
A newly identified susceptibility locus near FOXP1 modifies the association of gastroesophageal reflux with Barrett’s esophagus
Important risk factors for esophageal adenocarcinoma and its precursor, Barrett's esophagus, include gastroesophageal reflux disease, obesity, and cigarette smoking. Recently,…
Public health impact of achieving 80% colorectal cancer screening rates in the United States by 2018
The National Colorectal Cancer Roundtable, a national coalition of public, private, and voluntary organizations, has recently announced an initiative to…
Variation in Adenoma Detection Rate and the Lifetime Benefits and Cost of Colorectal Cancer Screening: A Microsimulation Model
Colonoscopy is the most commonly used colorectal cancer screening test in the United States. Its quality, as measured by adenoma…
Population-representative Incidence of Drug-induced Acute Liver Failure Based on an Analysis of an Integrated Healthcare System
Medications are a major cause of acute liver failure (ALF) in the United States, but no population-based studies have evaluated…
Diet and Upper Gastrointestinal Malignancies
Diet is believed to modulate cancer risk and this relationship has been widely studied in the gastrointestinal tract. Observational epidemiologic…
Development and validation of an algorithm for classifying colonoscopy indication
Accurate determination of colonoscopy indication is required for managing clinical programs and performing research; however, existing algorithms that use available…
Aspirin and Nonsteroidal Anti-Inflammatory Drug Use and the Risk of Barrett’s Esophagus
The use of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) may decrease the risk of esophageal adenocarcinoma; however, it is unknown…
A review of the epidemiology of Barrett’s oesophagus and oesophageal adenocarcinoma
While the incidence rates of many cancers have decreased in past decades, the incidence of oesophageal adenocarcinoma continues to increase.…
Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett’s Esophagus
Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated…
Lack of significant association between serum inflammatory cytokine profiles and the presence of colorectal adenoma
Inflammatory cytokines in the colonic microenvironment have been shown to increase with advance colorectal cancer disease state. However, the contribution…
Gastrointestinal symptoms, inflammation and hypoalbuminemia in chronic kidney disease patients: a cross-sectional study
Few studies have focused on investigating hypoalbuminemia in patients during earlier stages of chronic kidney disease (CKD). In particular, little…
Polymorphisms in Genes of Relevance for Oestrogen and Oxytocin Pathways and Risk of Barrett’s Oesophagus and Oesophageal Adenocarcinoma: A Pooled Analysis from the BEACON Consortium
The strong male predominance in oesophageal adenocarcinoma (OAC) and Barrett's oesophagus (BO) continues to puzzle. Hormonal influence, e.g. oestrogen or…
Oral Bisphosphonate Exposure and the Risk of Upper Gastrointestinal Cancers
The association between oral bisphosphonate use and upper gastrointestinal cancer has been controversial. Therefore, we examined the association with esophageal…
Progression and treatment of incident lower urinary tract symptoms among men in the California Men’s Health Study
To characterise the progression and treatment of lower urinary tract symptoms (LUTS) among men aged 45-69 years in the California…
Chronic Kidney Disease and Risk of Renal Cell Carcinoma: Differences by Race
The incidence of renal cell carcinoma in the United States differs by race/ethnicity. To better understand these disparities, we conducted…
MiRNA-Related SNPs and Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus: Post Genome-Wide Association Analysis in the BEACON Consortium
Incidence of esophageal adenocarcinoma (EA) has increased substantially in recent decades. Multiple risk factors have been identified for EA and…
Infections Requiring Hospitalization as Predictors of Pediatric-Onset Crohn’s Disease and Ulcerative Colitis
Objectives. To assess the relationship between infections and the risk of pediatric-onset inflammatory bowel disease (IBD). Methods. We conducted a…
The burden of nocturia among middle-aged and older women
To examine the prevalence, predictors, and effects of nocturia in women and evaluate overlaps with established urinary tract disorders. This…
Advances in Fecal Occult Blood Tests: the FIT revolution.
There is a wide choice of fecal occult blood tests (FOBTs) for colorectal cancer screening. GOAL: To highlight the issues…
Integrative post-genome-wide association analysis of CDKN2A and TP53 SNPs and risk of esophageal adenocarcinoma
Incidence of esophageal adenocarcinoma (EA) in Western countries has increased markedly in recent decades. Although several risk factors have been…
Comparative Effectiveness of Laparoscopic Adjustable Gastric Banding vs Laparoscopic Gastric Bypass
Laparoscopic Roux-en-Y gastric bypass (RYGB) and laparoscopic adjustable gastric banding (AGB) are 2 of the most commonly performed bariatric procedures…
Obesity and Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus: A Mendelian Randomization Study
Data from observational studies suggest that body mass index (BMI) is causally related to esophageal adenocarcinoma (EAC) and its precursor,…
Assessing bowel preparation quality using the mean number of adenomas per colonoscopy
The quality of the bowel preparation directly influences colonoscopy effectiveness. Quality indicators are widely employed to monitor operator performance and…
Alcohol and the Risk of Barrett’s Esophagus: A Pooled Analysis from the International BEACON Consortium
Results from studies examining the association between alcohol consumption and the risk of Barrett's esophagus have been inconsistent. We assessed…
Risk of Esophageal Adenocarcinoma Decreases with Height, Based on Consortium Analysis and Confirmed by Mendelian Randomization
Risks for some cancers increase with height. We investigated the relationship between height and risk of esophageal adenocarcinoma (EAC) and…
Guidelines on Genetic Evaluation and Management of Lynch Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer
The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision…
Guidelines on Genetic Evaluation and Management of Lynch Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer
The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision…
Guidelines on Genetic Evaluation and Management of Lynch Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer
The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision…
The Colorectal Cancer Screening Process in Community Settings: A Conceptual Model for the Population-Based Research Optimizing Screening through Personalized Regimens Consortium
Reducing colorectal cancer mortality by promoting screening has been a national goal for two decades. The NCI's Population-Based Research Optimizing…
Aspirin and non-aspirin NSAIDs increase risk of colonic diverticular bleeding: a systematic review and meta-analysis
Lower gastrointestinal bleeding is a frequent cause of hospitalization, particularly in the elderly, and its incidence appears to be on…
Mortality caused by chronic liver disease among american indians and alaska natives in the United States, 1999-2009
We compared chronic liver disease (CLD) mortality from 1999 to 2009 between American Indians and Alaska Natives (AI/ANs) and Whites…
Multitarget Stool DNA Testing for Colorectal-Cancer Screening
An accurate, noninvasive test could improve the effectiveness of colorectal-cancer screening. We compared a noninvasive, multitarget stool DNA test with…
Pharmacologic Therapies for the Management of Crohn’s Disease: Comparative Effectiveness
The purpose of this review was to compare the efficacy and safety of biologics, immunomodulators, corticosteroids, and aminosalicylates in the…
Gastroesophageal Reflux in Relation to Adenocarcinomas of the Esophagus: A Pooled Analysis from the Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON)
Previous studies have evidenced an association between gastroesophageal reflux and esophageal adenocarcinoma (EA). It is unknown to what extent these…
Dietary guideline adherence for gastroesophageal reflux disease
Gastroesophageal reflux disease (GERD) is the most common gastrointestinal disease, and the cost of health care and lost productivity due…
Approaches for classifying the indications for colonoscopy using detailed clinical data
Accurate indication classification is critical for obtaining unbiased estimates of colonoscopy effectiveness and quality improvement efforts, but there is a…
Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency
IMPORTANCE: Proton pump inhibitors (PPIs) and histamine 2 receptor antagonists (H2RAs) suppress the production of gastric acid and thus may…
Glycemic Control and Urinary Incontinence in Women with Diabetes Mellitus
Although many studies have shown that diabetes increases the risk for urinary incontinence, it is unclear whether poor glycemic control…
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett’s esophagus
Esophageal adenocarcinoma is a cancer with rising incidence and poor survival. Most such cancers arise in a specialized intestinal metaplastic…
Sex-specific associations between body mass index, waist circumference and the risk of Barrett’s oesophagus: a pooled analysis from the international BEACON consortium
Barrett's oesophagus is a precursor lesion of oesophageal adenocarcinoma, a cancer that, in the USA, has increased in incidence over…
Uncontrolled confounding in studies of screening effectiveness: an example of colonoscopy
To estimate the expected magnitude of error produced by uncontrolled confounding from health behaviours in observational medical record-based studies evaluating…
Germline Genetic Contributions to Risk for Esophageal Adenocarcinoma, Barrett’s Esophagus, and Gastroesophageal Reflux
Esophageal adenocarcinoma (EA) is an increasingly common cancer with poor survival. Barrett's esophagus (BE) is the main precursor to EA,…
Health Benefits and Cost-Effectiveness of a Hybrid Screening Strategy for Colorectal Cancer
Colorectal cancer (CRC) screening guidelines recommend screening schedules for each single type of test except for concurrent sigmoidoscopy and fecal…
Impact of Endoscopic Surveillance on Mortality from Barrett’s Esophagus-Associated Esophageal Adenocarcinomas
BACKGROUND & AIMS: Although patients with Barrett's esophagus commonly undergo endoscopic surveillance, its effectiveness in reducing mortality from esophageal/gastroesophageal junction…
Clinical predictors and significance of postvoid residual volume in women with diabetes
To identify women with diabetes at risk of increased postvoid residual volume (PVR) and investigate the relationship of increased PVR…
Dietary fiber and the risk of precancerous lesions and cancer of the esophagus: a systematic review and meta-analysis
Dietary fiber has several anticarcinogenic effects and is thought to be protective against esophageal cancer. The aim of this systematic…
Effectiveness and Reach of the FLU-FIT Program in an Integrated Health Care System: A Multisite Randomized Trial
OBJECTIVES: We tested the effectiveness of offering home fecal immunochemical tests (FITs) during influenza vaccination clinics to increase colorectal cancer…
Meta-analysis: the risk of venous thromboembolism in patients with inflammatory bowel disease
Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is a systemic disorder that predominantly affects…
Recurrence of subsquamous dysplasia and carcinoma after successful endoscopic and radiofrequency ablation therapy for dysplastic Barrett’s esophagus.
Barrett's esophagus with dysplasia is commonly treated with radiofrequency ablation (RFA). Despite its effectiveness, a concern of any ablative technique…
Screening colonoscopy and risk for incident late-stage colorectal cancer diagnosis in average-risk adults: a nested case-control study
BACKGROUND: The effectiveness of screening colonoscopy in average-risk adults is uncertain, particularly for right colon cancer. OBJECTIVE: To examine the…
Impact of type 2 diabetes on lower urinary tract symptoms in men: a cohort study
BACKGROUND: Studies of the impact of type 2 diabetes on the prevalence and incidence of lower urinary tract symptoms (LUTS)…
Surviving Colorectal Cancer: Long-term, Persistent Ostomy-Specific Concerns and Adaptations
The purpose of this article was to describe persistent ostomy-specific concerns and adaptations in long-term (>5 years) colorectal cancer survivors…
Body mass index in relation to oesophageal and oesophagogastric junction adenocarcinomas: a pooled analysis from the International BEACON Consortium
BACKGROUND: Previous studies suggest an association between obesity and oesophageal (OA) and oesophagogastric junction adenocarcinomas (OGJA). However, these studies have…
Irrigation practices in long-term survivors of colorectal cancer with colostomies
For some patients diagnosed with rectal cancer, surgery will involve the creation of a temporary or permanent ostomy. When the…
Fecal Incontinence Decreases Sexual Quality of Life, But Does Not Prevent Sexual Activity in Women
BACKGROUND: The impact of anal incontinence on women's sexual function is poorly understood. OBJECTIVE: The aim of this study was…
Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett’s esophagus
Barrett's esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus…
A Combination of Esomeprazole and Aspirin Reduce Tissue Concentrations of Prostaglandin E2 in Patients with Barrett’s Esophagus
BACKGROUND& AIMS: Proton pump inhibitors and nonsteroidal anti-inflammatory drugs might prevent esophageal adenocarcinoma in patients with Barrett's esophagus (BE), but…
Prenatal and Perinatal Characteristics Associated with Pediatric-Onset Inflammatory Bowel Disease
BACKGROUND: The majority of studies that report early life risk factors for pediatric-onset inflammatory bowel disease (IBD) do not account…
Diabetes, Hypertension and Hyperlipidemia: Prevalence Over Time and Impact on Long-Term Survival After Liver Transplantation
With increasing short-term survival, the transplant community has turned its focus to delineating the impact of medical comorbidities on long-term…
Consensus Statements for Management of Barrett’s Dysplasia and Early-Stage Esophageal Adenocarcinoma, Based on a Delphi Process
BACKGROUND & AIMS: Esophageal adenocarcinoma (EA) is increasingly common among patients with Barrett's esophagus (BE). We aimed to provide consensus…
Incidence and Mortality of Colorectal Adenocarcinoma in Persons with Inflammatory Bowel Disease from 1998 to 2010
BACKGROUND & AIMS: The relationship between inflammatory bowel disease (IBD) and the incidence and mortality of colorectal adenocarcinoma (CRC) has…
Automated phone and mail population outreach to promote colorectal cancer screening
OBJECTIVES: To evaluate a population outreach program to promote screening for colorectal cancer (CRC) among average-risk insured men and women.…
The importance of exposure rate on odds ratios by cigarette smoking and alcohol consumption for esophageal adenocarcinoma and squamous cell carcinoma in the Barrett’s Esophagus and Esophageal Adenocarcinoma Consortium
BACKGROUND: Cigarette smoking is associated with esophageal adenocarcinoma (EAC), esophagogastric junctional adenocarcinoma (EGJA) and esophageal squamous cell carcinoma (ESCC), and…
Gastrointestinal Disease Outbreak Detection Using Multiple Data Streams from Electronic Medical Records
BACKGROUND: Passive reporting and laboratory testing delays may limit gastrointestinal (GI) disease outbreak detection. Healthcare systems routinely collect clinical data…
Total Serum Bilirubin Exceeding Exchange Transfusion Thresholds in the Setting of Universal Screening
OBJECTIVE: To describe the incidence and predictors of total serum bilirubin (TSB) levels that meet or exceed American Academy of…
Does increased experience with laparoscopic cholecystectomy yield more complex bile duct injuries?
BACKGROUND: Two decades since the advent of laparoscopic cholecystectomy, the rate of bile duct injuries still remains higher than in…
Cigarette Smoking Increases Risk of Barrett’s Esophagus: an Analysis of the Barrett’s and Esophageal Adenocarcinoma Consortium
BACKGROUND & AIMS: Cigarette smoking has been implicated in the etiology of esophageal adenocarcinoma, but it is not clear if…
Non-Steroidal Anti-Inflammatory Drug Use Reduces Risk for Adenocarcinomas of the Esophagus and Esophagogastric Junction in a Pooled Analysis
BACKGROUND & AIMS: Regular use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) has been reported to reduce risks of…
Evaluating Racial/Ethnic Disparities in Lower Urinary Tract Symptoms in Men
PURPOSE: We examined whether there are racial/ethnic disparities in lower urinary tract symptoms in men. MATERIALS AND METHODS: Racial/ethnic disparities…
Diagnosis, Comorbidities, and Management of Irritable Bowel Syndrome in Patients in a Large Health Maintenance Organization
BACKGROUND & AIMS: Irritable bowel syndrome (IBS) imposes significant clinical and economic burdens. We aimed to characterize practice patterns for…
Editorial: Taking FIT to the People: Out of the Office and Into the Mail
Colorectal cancer (CRC) screening is most commonly performed in the United States using an opportunistic approach: patients coming to a…
Urinary incontinence self-report questions: reproducibility and agreement with bladder diary
INTRODUCTION AND HYPOTHESIS: This study aims to measure self-report urinary incontinence questions' reproducibility and agreement with bladder diary. METHODS: Data…
Role of Thiopurine and Anti-TNF Therapy in Lymphoma in Inflammatory Bowel Disease
OBJECTIVES: The objective of this study was to assess inflammatory bowel disease (IBD) medications in relation to lymphoma risk. METHODS:…
Is Diabetes Mellitus an Independent Risk Factor for Colon Cancer and Rectal Cancer?
OBJECTIVES: Diabetes mellitus (DM) has been associated with an increased risk of colorectal cancer (CRC). The American College of Gastroenterology…
Parturition events and risk of urinary incontinence in later life
AIMS: To examine the association between specific events during vaginal deliveries and urinary incontinence later in life. METHODS: A retrospective…
Alcohol intake and risk of oesophageal adenocarcinoma: a pooled analysis from the BEACON Consortium
BACKGROUND AND AIMS: Alcohol intake is a strong and well established risk factor for oesophageal squamous cell carcinoma (OSCC), but…
HIV status is an independent risk factor for reporting lower urinary tract symptoms
PURPOSE: HIV/AIDS is a worldwide epidemic. Limited evidence suggests that men infected with HIV/AIDS are at increased risk for lower…
Interpreting conjugated bilirubin levels in newborns
OBJECTIVE: To examine the clinical significance of elevated conjugated bilirubin (CB) levels in newborns. STUDY DESIGN: This retrospective study evaluated…
The American Society for Gastrointestinal Endoscopy PIVI (Preservation and Incorporation of Valuable Endoscopic Innovations) on real-time endoscopic assessment of the histology of diminutive colorectal polyps
The PIVI (Preservation and Incorporation of Valuable endoscopic Innovations) initiative is an ASGE program whose objectives are to identify important…
Organized colorectal cancer screening in integrated health care systems
Colorectal cancer (CRC) is an ideal target for early detection and prevention through screening. Noninvasive screening options are the guaiac…
Lack of association between insulin sensitivity and colorectal adenoma risk
Insulin resistance is thought to mediate the association between obesity and colorectal neoplasia, but no prior studies have assessed stimulated…
Dietary factors and the risks of oesophageal adenocarcinoma and Barrett’s oesophagus
Incidence rates for oesophageal adenocarcinoma have increased by over 500% during the past few decades without clear reasons. Gastro-oesophageal reflux…
Serial glycosylated hemoglobin levels and risk of colorectal neoplasia among patients with type 2 diabetes mellitus
BACKGROUND: Hyperglycemia may increase the risk of colorectal neoplasia by serving as an energy source for neoplastic growth. We sought…
Prevalence of colorectal cancer surveillance for ulcerative colitis in an integrated health care delivery system
BACKGROUND & AIMS: The absence of grade A supporting evidence for surveillance colonoscopy in patients with ulcerative colitis (UC) has…
Women with diabetes: understanding urinary incontinence and help seeking behavior
PURPOSE: We examined the association of urinary incontinence with diabetes status and race, and evaluated beliefs about help seeking for…
Incidence of and risk factors for change in urinary incontinence status in a prospective cohort of middle-aged and older women: the reproductive risk of incontinence study in Kaiser
PURPOSE: Urinary incontinence is a dynamic condition that can progress and regress but few groups have examined risk factors for…
Cigarette smoking and adenocarcinomas of the esophagus and esophagogastric junction: a pooled analysis from the international BEACON consortium
BACKGROUND: Previous studies that showed an association between smoking and adenocarcinomas of the esophagus and esophagogastric junction were limited in…
Urinary incontinence, fecal incontinence and pelvic organ prolapse in a population-based, racially diverse cohort: prevalence and risk factors
OBJECTIVES: : We investigated the prevalence of and risk factors for combinations of urinary incontinence (UI), fecal incontinence (FI) and…
Reproductive and sex hormonal factors and oesophageal and gastric junction adenocarcinoma: a pooled analysis
BACKGROUND: The rapidly rising incidence and the striking male predominance are as yet unexplained features of oesophageal and gastric junction…
Proton pump inhibitors and histamine-2 receptor antagonists are associated with hip fractures among at-risk patients
BACKGROUND & AIMS: Drugs that inhibit gastric acid might increase the risk of hip fracture. However, little long-term exposure data…
Achalasia, alcohol-stasis, and acute necrotizing esophagitis: connecting the dots.
Acute necrotizing esophagitis (ANE) or “black esophagus” is defined as a circumferential dark pigmentation of the esophagus on endoscopy and…
Effect of neonatal jaundice and phototherapy on the frequency of first-year outpatient visits
OBJECTIVE: The objective of this study was to determine whether either hyperbilirubinemia or inpatient phototherapy is associated with increased subsequent…
Early and late complications among long-term colorectal cancer survivors with ostomy or anastomosis
PURPOSE: Among long-term (>or=5 y) colorectal cancer survivors with permanent ostomy or anastomosis, we compared the incidence of medical and…
Complementary and alternative medicine use in chronic liver disease patients
GOALS: To examine a wide range of sociodemographic and clinical characteristics as potential predictors of complementary and alternative medicine (CAM)…
Pelvic floor disorders and quality of life in women with self-reported irritable bowel syndrome
BACKGROUND: Quality of life among women with irritable bowel syndrome may be affected by pelvic floor disorders. AIM: To assess…
Citalopram provides little or no benefit in nondepressed patients with irritable bowel syndrome
BACKGROUND & AIMS: Data on the benefit of selective serotonin reuptake inhibitors (SSRIs) in irritable bowel syndrome (IBS) are conflicting.…
Racial differences in pelvic organ prolapse
OBJECTIVE: To compare the estimated prevalence of, risk factors for, and level of bother associated with subjectively reported and objectively…
Timing of myelosuppression during thiopurine therapy for inflammatory bowel disease: implications for monitoring recommendations
BACKGROUND & AIMS: Thiopurines (azathioprine and 6-mercaptopurine) can induce life-threatening myelosuppression. This study determined the frequency, timing, and outcomes of…
Validity of computerized diagnoses, procedures, and drugs for inflammatory bowel disease in a northern California managed care organization
PURPOSE: Resources for studying inflammatory bowel disease (IBD) are needed in evaluations of drug safety including traditional drugs and new…
Association between menopausal transition stages and developing urinary incontinence
OBJECTIVE: To estimate whether menopause transition stage is independently associated with the development of incontinence symptoms. METHODS: We conducted a…
Impact of universal bilirubin screening on severe hyperbilirubinemia and phototherapy use
OBJECTIVE: The goal was to assess the impact of universal bilirubin screening on severe hyperbilirubinemia and phototherapy use. METHODS: In…
Health-related quality of life among long-term rectal cancer survivors with an ostomy: manifestations by sex
PURPOSE: Intestinal stomas can pose significant challenges for long-term (> or = 5 years) rectal cancer (RC) survivors. Specifying common…
ArterioVenous Malformation within Jejunal Diverticulum: an unusual cause of massive gastrointestinal bleeding.
Massive gastrointestinal (GI) bleeding can occur with multiple jejunal diverticulosis. However, significant bleeding in the setting of few diverticulae is…
Survival differences by race/ethnicity and treatment for localized hepatocellular carcinoma within the United States
Racial differences among hepatocellular carcinoma survival have been reported, but the etiology behind these disparities remains unclear. Using multi-variable logistic…
The inflammatory response in transgastric surgery: gastric content leak leads to localized inflammatory response and higher adhesive disease.
BACKGROUND: Risk of gastric spillage during transgastric surgery is a potential complication of NOTES procedures. The aim of this study…
Gender differences in sleep disruption and fatigue on quality of life among persons with ostomies
STUDY OBJECTIVES: The aim of this study is to examine differences in sleep disruption and fatigue of men and women…
Time trends in therapies and outcomes for adult inflammatory bowel disease, Northern California, 1998-2005
BACKGROUND & AIMS: The management of inflammatory bowel disease (IBD) has become increasingly complicated, and it is unknown whether poor…
Mixed urinary incontinence: greater impact on quality of life
PURPOSE: We compared the impact of mixed, stress and urge urinary incontinence on quality of life in middle-aged or older…
The impact of proton-pump inhibitors on intraperitoneal sepsis: a word of caution for transgastric NOTES procedures.
BACKGROUND: During transgastric natural orifice transluminal endoscopic surgery (NOTES), there is an iatrogenic perforation of the gastric wall with leakage…
Numbers needed to treat with phototherapy according to American Academy of Pediatrics guidelines
OBJECTIVES: Our aims were to estimate the efficacy of hospital phototherapy for neonatal jaundice and the number needed to treat…
Editorial: It’s time to make organized colorectal cancer screening convenient and easy for patients
Colorectal cancer (CRC) screening is widely recommended, but underused. To increase screening rates, we need to implement organized and population-based…
Exploring household income as a predictor of psychological well-being among long-term colorectal cancer survivors
PURPOSE: The purpose of this analysis was to determine the unique contribution of household income to the variance explained in…
Alcohol types and sociodemographic characteristics as risk factors for Barrett’s esophagus
BACKGROUND & AIMS: Little is known about the effects of alcohol use and sociodemographics on the risk of Barrett's esophagus,…
Race, ethnicity, sex and temporal differences in Barrett’s oesophagus diagnosis: a large community-based study, 1994-2006
OBJECTIVE: To evaluate the demographics and incidence of Barrett's oesophagus diagnosis using community-based data. DESIGN: Observational study. SETTING: Kaiser Permanente,…
Effects of dietary fiber, fats, and meat intakes on the risk of Barrett’s esophagus
Animal and human models suggest associations between fat intake, fiber intake, and the risk of esophageal adenocarcinoma. We evaluated whether…
Hemochromatosis gene status as a risk factor for Barrett’s esophagus
Conditions causing high iron levels, such as hemochromatosis, are proposed risk factors for esophageal adenocarcinoma. Although this hypothesis is supported…
Stool DNA and occult blood testing for screen detection of colorectal neoplasia
BACKGROUND: Stool DNA testing is a new approach to colorectal cancer detection. Few data are available from the screening setting.…
Helicobacter pylori and gastroesophageal reflux disease: a case-control study
BACKGROUND: Gastric colonization with Helicobacter pylori is a proposed protective factor against gastroesophageal reflux disease (GERD), but little population-based data…
Obstructive defecation in middle-aged women
Obstructive defecation, a significant contributor to constipation, is frequently reported in middle-aged women, yet few population-based studies have established prevalence…
Natural history of severe ulcerative colitis in a community-based health plan
BACKGROUND & AIMS: We sought to evaluate long-term outcomes of patients with severe ulcerative colitis (UC) after their first hospitalization…
Screening differences and risk of cervical cancer in inflammatory bowel disease
BACKGROUND: Cervical cancer risk is high among immune suppressed women. AIM: To evaluate inflammatory bowel disease (IBD) with medications and…
Patterns of infliximab use among Crohn’s disease patients in a community setting
BACKGROUND: Information on infliximab use in a community setting is important to understand patterns of medication use and to anticipate…
Incidence and prevalence of inflammatory bowel disease in a Northern California managed care organization, 1996-2002
OBJECTIVE: There are few estimates of the incidence and prevalence of inflammatory bowel disease in North American communities. We sought…
Risk factors for severe hyperbilirubinemia among infants with borderline bilirubin levels: a nested case-control study
OBJECTIVE: To estimate the effect of phototherapy and other predictors on the risk of total serum bilirubin (TSB) >or= 25…
Predicting significant hyperbilirubinaemia using birth weight
BACKGROUND: A recent study proposed a risk factor scoring system for prediction of hyperbilirubinaemia that assigned increased risk to infants…
Gastroenterologists’ attitudes and self-reported practices regarding inflammatory bowel disease
BACKGROUND: The purpose was to assess organization-, physician-, and patient-based aspects of inflammatory bowel disease (IBD) practice variation within an…
Dietary antioxidants, fruits, and vegetables and the risk of Barrett’s esophagus
OBJECTIVE: The present study evaluated the associations among antioxidants, fruit and vegetable intake, and the risk of Barrett's esophagus (BE),…
Helicobacter pylori infection and the risk of Barrett’s oesophagus: a community-based study
OBJECTIVE: Gastric colonisation with the Helicobacter pylori bacterium is a proposed protective factor against oesophageal adenocarcinoma, but its point of…
Helicobacter pylori infection and development of pancreatic cancer
BACKGROUND: Infection with Helicobacter pylori is an established risk factor for gastric cancer. Results from two studies suggest that it…
Factors associated with worsening and improving urinary incontinence across the menopausal transition
OBJECTIVE: To evaluate whether the menopausal transition is associated with worsening of urinary incontinence symptoms over 6 years in midlife…
Abdominal obesity and the risk of esophageal and gastric cardia carcinomas
BACKGROUND: Esophageal adenocarcinoma is rapidly increasing in incidence. Body mass index (BMI) is a risk factor, but its distribution does…
Effects of urinary incontinence, comorbidity and race on quality of life outcomes in women
PURPOSE: We investigated the effects of comorbidity and urinary incontinence on both generic and incontinence specific quality of life outcome…
Hepatic effects of lovastatin exposure in patients with liver disease: a retrospective cohort study
BACKGROUND: Little is known about the potential adverse hepatic effects of HMG-CoA reductase inhibitors ('statins') in patients with existing liver…
Urinary incontinence in women: Direct costs of routine care
OBJECTIVE: The purpose of this study was to estimate the direct costs of routine care for urinary incontinence (UI) in…
Mortality by medication use among patients with inflammatory bowel disease, 1996-2003
BACKGROUND & AIMS: Most previous population-based studies of mortality in inflammatory bowel disease (IBD) did not account for medication use.…
Medical therapy for diabetes is associated with increased use of lower endoscopy
BACKGROUND: Diabetes mellitus is associated with an increased risk of colorectal neoplasia and diabetes medications may further influence the risk.…
Meta-analysis of antioxidant intake and the risk of esophageal and gastric cardia adenocarcinoma
OBJECTIVE: The incidence of esophageal adenocarcinoma has been increasing rapidly among many countries. Antioxidant intake is a potentially modifiable protective…
Pregnancy outcomes in women with inflammatory bowel disease: a large community-based study from Northern California
BACKGROUND & AIMS: The aim of this study was to determine whether pregnancy outcomes differ between women with and without…
Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet
This study investigated associations between CpG island methylator phenotype (CIMP) colon cancer and genetic polymorphisms relevant to one-carbon metabolism and…
Dealing with uncertainty: surveillance colonoscopy after polypectomy
Post-polypectomy surveillance is often done sooner than guideline recommendations. This practice is driven by physician intolerance of uncertainty. The accompanying…
Abdominal obesity and body mass index as risk factors for Barrett’s esophagus
BACKGROUND: Barrett's esophagus is a strong risk factor for esophageal adenocarcinoma, but little is known about its associations with body…
Clustering of inflammatory bowel disease with immune mediated diseases among members of a northern california-managed care organization
BACKGROUND AND AIMS: Previous studies provide evidence that some immune-mediated diseases occur at greater frequency among inflammatory bowel disease (IBD)…
Serum ghrelin levels and risk of subsequent adenocarcinoma of the esophagus
OBJECTIVE: Several large studies have shown a negative association between Helicobacter pylori (H. pylori) infection and esophageal adenocarcinoma. Diminution of…
Symptomatic pelvic organ prolapse: prevalence and risk factors in a population-based, racially diverse cohort
OBJECTIVE: To estimate the prevalence of and identify risk factors associated with symptomatic pelvic organ prolapse and level of distress…
Abdominal obesity, ethnicity and gastro-oesophageal reflux symptoms
OBJECTIVE: To evaluate the associations between abdominal obesity and gastro-oesophageal reflux disease (GORD), and their interactions with ethnicity and gender.…
Standardized colonoscopy reporting and data system: report of the Quality Assurance Task Group of the National Colorectal Cancer Roundtable
BACKGROUND: Standardized reporting systems for diagnostic and screening tests facilitate quality improvement programs and clear communication among health care providers.…
Estimation of the period prevalence of inflammatory bowel disease among nine health plans using computerized diagnoses and outpatient pharmacy dispensings
BACKGROUND: There are few contemporary estimates of prevalence rates for inflammatory bowel disease (IBD) in diverse North American communities. METHODS:…
Change in body size and the risk of colorectal adenomas
Adiposity has been recognized as a risk factor for colorectal adenoma, but the influence of weight gain, adipose tissue distribution,…
Diet and lifestyle factor associations with CpG island methylator phenotype and BRAF mutations in colon cancer
It has been proposed that dietary factors such as folate, alcohol and methionine may be associated with colon cancer because…
Telephone management of presumed cystitis in women: Factors associated with recurrence
Objective: To determine the factors associated with short-term risk for urinary tract infection (UTI) recurrence after telephone management of cystitis.…
Complications of colonoscopy in an integrated health care delivery system
BACKGROUND: Information about colonoscopy complications, particularly postpolypectomy bleeding, is limited. OBJECTIVE: To quantify the magnitude and severity of colonoscopy complications.…
New-onset diabetes and pancreatic cancer
BACKGROUND & AIMS: Although many individuals with pancreatic cancer have diabetes, the association between new-onset diabetes mellitus and the subsequent…
Urinary incontinence and pelvic floor dysfunction in Asian-American women
OBJECTIVE: The objective of the study was to describe the prevalence, risk factors, and impact of urinary incontinence and other…
Body mass index and gastroesophageal reflux disease: a systematic review and meta-analysis
BACKGROUND: Gastroesophageal reflux disease (GERD) is a common cause of morbidity and health-care utilization in many countries. Obesity is a…
Quality-of-life impact and treatment of urinary incontinence in ethnically diverse older women
OBJECTIVE: To identify the factors associated with greater quality-of-life impact, treatment seeking, and use of treatments for urinary incontinence in…
Interactions between CYP2C9 and UGT1A6 polymorphisms and nonsteroidal anti-inflammatory drugs in colorectal cancer prevention
BACKGROUND AND AIMS: Variant genotypes of uridine diphosphate glucuronsyltransferase isoenzyme 1A6 (UGT1A6) associated with decreased metabolic activity have been associated…
Fecal incontinence in females older than aged 40 years: who is at risk?
PURPOSE: This study was designed to estimate the prevalence of, and identify risk factors associated with, fecal incontinence in racially…
Guidelines for colonoscopy surveillance after cancer resection: a consensus update by the American Cancer Society and the US Multi-Society Task Force on Colorectal Cancer
Patients with resected colorectal cancer are at risk for recurrent cancer and metachronous neoplasms in the colon. This joint update…
Barrett’s esophagus and medications that relax the lower esophageal sphincter
OBJECTIVES: Medications that may increase gastroesophageal reflux could be risk factors for esophageal adenocarcinoma; however, epidemiologic studies present conflicting results.…
Body mass index and adenocarcinomas of the esophagus or gastric cardia: a systematic review and meta-analysis
BACKGROUND: The incidence of esophageal adenocarcinoma has increased markedly in recent decades in many countries. Obesity is a potential risk…
Guidelines for colonoscopy surveillance after polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society
Adenomatous polyps are the most common neoplastic findings uncovered in people who undergo colorectal screening or have a diagnostic workup…
PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States)
We hypothesize that the peroxisome proliferator-activated receptor-gamma (PPARgamma) is associated with colorectal cancer given its association with insulin, diabetes, obesity,…
Childhood urinary symptoms predict adult overactive bladder symptoms
PURPOSE: A relationship between childhood urinary symptoms and adult lower urinary tract symptoms in women is often clinically suspected. In…
Differences in prevalence of urinary incontinence by race/ethnicity
PURPOSE: We compared the prevalence of urinary incontinence by type among white, black, Hispanic and Asian-American women. MATERIALS AND METHODS:…
Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer
BACKGROUND & AIMS: The concept of a CpG island methylator phenotype (CIMP), especially in microsatellite stable colon cancer, is not…
Incomplete screening flexible sigmoidoscopy associated with female sex, age, and increased risk of colorectal cancer
BACKGROUND: Several previous studies have found that females and older individuals are at greater risk of having incomplete flexible sigmoidoscopy.…
Associations between apoE genotype and colon and rectal cancer
Apolipoprotein E (apoE) plays a major role in the metabolism of bile acids, cholesterol and triglycerides, and has recently been…
Quality in the technical performance of screening flexible sigmoidoscopy: recommendations of an international multi-society task group
BACKGROUND: Flexible sigmoidoscopy (FS) is a complex technical procedure performed in a variety of settings, by examiners with diverse professional…
Cervical cancer in women with comprehensive health care access: attributable factors in the screening process
BACKGROUND: Invasive cervical cancer is highly preventable, yet it continues to occur, even among women who have access to cancer…
Helicobacter pylori infection and the risk of development of esophageal adenocarcinoma
BACKGROUND: An increase in the incidence of esophageal adenocarcinoma has coincided with a decrease in the prevalence of Helicobacter pylori…
Racial and ethnic distribution of nonalcoholic fatty liver in persons with newly diagnosed chronic liver disease
We performed a cross-sectional study of newly diagnosed cases of nonalcoholic fatty liver disease (NAFLD) identified between December 1998 and…
Combining clinical risk factors with serum bilirubin levels to predict hyperbilirubinemia in newborns
OBJECTIVES: (1) To validate a previously reported risk index for predicting total serum bilirubin (TSB) levels of 25 mg/dL (428…
Reason for late-stage breast cancer: absence of screening or detection, or breakdown in follow-up?
BACKGROUND: Mammography screening increases the detection of early-stage breast cancers. Therefore, implementing screening should reduce the percentage of women who…
Influence of site classification on cancer incidence rates: an analysis of gastric cardia carcinomas
BACKGROUND: Recent reports suggest that the incidences of cardia and gastroesophageal junction carcinomas have increased markedly. The influence of improvements…
Processes of care in cervical and breast cancer screening and follow-up–the importance of communication
BACKGROUND: Given limited research, we investigated patient reports of processes of care related to screening follow-up, timing of result notification,…
The evolution to stool DNA testing for colorectal cancer
Despite a variety of screening strategies and recent trends showing death rate stabilization, colorectal cancer still remains the second leading…
Screening in liver disease: report of an AASLD clinical workshop
This report summarizes an AASLD Clinical Workshop that was presented at Digestive Diseases Week 2003 on screening in liver diseases.…
Marked multi-ethnic variation of esophageal and gastric cardia carcinomas within the United States
OBJECTIVE: No prior studies have contrasted esophageal and gastric cardia carcinoma incidence rates among multiple ethnicities. We evaluated whether these…
Factors associated with colorectal cancer screening in a population-based study: the impact of gender, health care source, and time
INTRODUCTION: The effectiveness of colorectal cancer screening in reducing incident colorectal cancer and the risk of death has been shown.…
Family history and colorectal cancer: predictors of risk
INTRODUCTION: While the association between family history of colorectal cancer in first-degree relatives and risk of developing colon cancer has…
Improvement of gastroesophageal reflux symptoms after radiofrequency energy: a randomized, sham-controlled trial
BACKGROUND & AIMS: Gastroesophageal reflux disease is a prevalent disorder that often requires long-term medical therapy or surgery. The United…
How should we select health professionals for studies?
The investigation of healthcare professionals' practice patterns has increased sharply, in part driven by the development of practice guidelines; however,…
A randomized controlled trial of test-and-treat strategy for Helicobacter pylori: clinical outcomes and health care costs in a managed care population receiving long-term acid suppression therapy for physician-diagnosed peptic ulcer disease
BACKGROUND: Guidelines recommend Helicobacter pylori (HP) testing and treatment for patients with a history of peptic ulcer disease (PUD), assuming…
Phototherapy use in jaundiced newborns in a large managed care organization: do clinicians adhere to the guideline?
OBJECTIVE: In 1994, the American Academy of Pediatrics (AAP) published a practice guideline with age-specific thresholds for phototherapy for healthy…
Colorectal cancer screening and surveillance: clinical guidelines and rationale-Update based on new evidence
We have updated guidelines for screening for colorectal cancer. The original guidelines were prepared by a panel convened by the…
Protective association of aspirin/NSAIDs and esophageal cancer: a systematic review and meta-analysis
BACKGROUND & AIMS: Esophageal carcinomas have high fatality rates, making chemoprevention agents desirable. We performed a systematic review with meta-analysis…
Flexible sigmoidoscopy for colorectal cancer screening: valid approach or short-sighted?
Flexible sigmoidoscopy is a safe, effective test that may be delivered feasibly on a large scale for mass colorectal cancer…
Jaundice noted in the first 24 hours after birth in a managed care organization
OBJECTIVE: To investigate the significance of jaundice noted in the first 24 hours after birth in a community setting. DESIGN:…
Complications of screening flexible sigmoidoscopy
BACKGROUND & AIMS: Flexible sigmoidoscopy (FS) is recommended for mass screening for colorectal cancer (CRC), yet little is known about…
Marked regional variation in adenocarcinomas of the esophagus and the gastric cardia in the United States
BACKGROUND: Adenocarcinomas of the esophagus and the gastric cardia recently have experienced rapidly increasing incidence rates. Although these sites frequently…
Healthcare utilization by women in a comprehensive managed care population subsequent to diagnosis of a sexually transmitted disease
BACKGROUND: Healthcare utilization (HCU) following a sexually transmitted disease (STD) diagnosis is poorly characterized. GOAL: The goal was to quantify…
Gastric and duodenal safety of daily alendronate
BACKGROUND: Isolated case reports of gastric ulcers after alendronate sodium use raised concern about the gastroduodenal safety of daily alendronate.…
Pelvic organ prolapse surgery in the United States, 1997
OBJECTIVE: Our purpose was to describe the prevalence, regional rates and demographic characteristics, morbidity, and mortality of pelvic organ prolapse…
Hereditary nonpolyposis colorectal cancer in young colorectal cancer patients: high-risk clinic versus population-based registry
BACKGROUND & AIMS: Early onset colorectal cancer (CRC) is an important feature of hereditary nonpolyposis colorectal cancer (HNPCC). We sought…
Surveillance and survival in Barrett’s adenocarcinomas: a population-based study
BACKGROUND & AIMS: Guidelines recommend periodic endoscopic surveillance of Barrett's esophagus (BE) patients to detect and treat early esophageal adenocarcinomas;…
CagA status of Helicobacter pylori infection and p53 gene mutations in gastric adenocarcinoma
Infection with Helicobacter pylori (H. pylori) increases stomach cancer risk. Helicobacter pylori strains with the cag pathogenicity island (PAI) induce…
Validation of diagnoses of peptic ulcers and bleeding from administrative databases: a multi-health maintenance organization study
The automated health plan data and data from medical chart abstractions from eight large health maintenance organizations were used to…
Flexible sigmoidoscopy: an important screening option for average-risk individuals
Colorectal cancer screening techniques should be effective, acceptable to patients, affordable, widely available, and safe. For average-risk adults aged more…
Atypical glandular cells of undetermined significance (AGUS): Interobserver reproducibility in cervical smears and corresponding thin-layer preparations
Five panelists independently reviewed 135 consecutive conventional cervical smears (CPs) originally classified as atypical glandular cells of undetermined significance (AGUS).…
Oesophageal and gastric cardia adenocarcinomas: analysis of regional variation using the Cancer Incidence in Five Continents database
BACKGROUND: Adenocarcinomas of the oesophagus and proximal stomach are the most rapidly increasing malignancies in some countries; however, there are…
A community-based collaboration to assess and improve medical insurance status and access to health care of Latino children
OBJECTIVES: Despite eligibility for subsidized insurance, low-income Latino children are at high risk of being medically uninsured. The authors sought…
Quality of life measurement clarifies the cost-effectiveness of Helicobacter pylori eradication in peptic ulcer disease and uninvestigated dyspepsia
OBJECTIVES: Previous economic studies of Helicobacter pylori eradication in dyspepsia and peptic ulcer disease have not measured quality of life…
Histological classification of gastric adenocarcinoma for epidemiological research: concordance between pathologists
Epidemiology of gastric adenocarcinoma suggests that intestinal-type and diffuse-type cancers develop through distinct causal pathways. To examine the differences in…
Prediction and prevention of extreme neonatal hyperbilirubinemia in a mature health maintenance organization
OBJECTIVE: To investigate biological and health services predictors of extreme neonatal hyperbilirubinemia in a health maintenance organization. DESIGN: Nested case-control…
Work loss costs due to peptic ulcer disease and gastroesophageal reflux disease in a health maintenance organization
OBJECTIVE: The aim of this study was to estimate the value of work time and productivity loss because of peptic…
Colorectal cancer screening: new opportunities
Colorectal cancer is the third most common cancer among men and women in the United States, and the third leading…
Predicting advanced proximal colonic neoplasia with screening sigmoidoscopy
CONTEXT: Indications are not well defined for follow-up colonoscopy for all patients with distal colonic tubular adenomas (TAs) found at…
Identifying women with cervical neoplasia: using human papillomavirus DNA testing for equivocal Papanicolaou results
CONTEXT: A Papanicolaou (Pap) test result of atypical squamous cells of undetermined significance (ASCUS) presents a clinical challenge. Only 5%…
Cholecystectomy and the risk of colon cancer
OBJECTIVE: The relationship between cholecystectomy and the occurrence of subsequent colon cancer has been controversial. Using data collected as part…
Where’s the high-grade cervical neoplasia? The importance of minimally abnormal Papanicolaou diagnoses
OBJECTIVE: To characterize the relative contributions of the different abnormal Papanicolaou smear cytologic diagnoses in the Bethesda System to the…
Cancer of the large bowel after cholecystectomy
The possibility that cholecystectomy may increase the risk of developing cancer of the large bowel has been a matter of…
Cholecystectomy and large bowel cancer
The records of 5898 patients with colorectal cancer and 27,687 controls were examined for previous cholecystectomy. The estimated relative risks…
Problems in determining the prognosis of asymptomatic gallstones
Decisions as to whether to perform prophylactic cholecystectomy on patients with asymptomatic gallstones require better information on the rate of…
